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Article Abstract
Three new arthrichitin derivatives I-K (-) and three known congeners (-) were isolated from a coculture of mangrove-derived fungi sp. and sp. using H NMR-guided fractionation. Their structures were determined by comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS, ESI-MS/MS), Marfey's analysis, DP4+ probability, and experimental/computed ECD comparison. All compounds were evaluated for antibacterial effects and cytotoxicity. Notably, compounds and showed weak cytotoxicity against MHCC-97H cells (IC = 20.1 ± 0.9 and 25.8 ± 0.4 μM, respectively). Compound exhibited potent anti-BPH activity (IC = 0.36 ± 0.02 μM).
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