Application of superresolution ultrasound imaging for assessing microvascular structure and hemodynamic changes in rabbit VX2 models.

Background: Noninvasive and functional tumor vascular system imaging at the microscopic scale is greatly significant. Using animal models, we investigated the feasibility of using superresolution ultrasound (SR-US) imaging to visualize and quantify the microvessels during tumor growth.

Methods: This study established nine rabbit VX2 tumor models.

Refractory chronic diarrhea complicated with optic neuritis in a young woman: A case report.

Background: Collagenous sprue is a serious intestinal malabsorption disorder characterized by dull and flattened intestinal villi with subepithelial collagen deposition. At present, fewer than 100 cases have been reported in the literature. Owing to the rarity of this disease, clinicians and pathologists have insufficient understanding of it.

Low Resistivity and High Carrier Concentration in SnO Thin Films: The Impact of Nitrogen-Hydrogen Annealing Treatments.

The tin dioxide (SnO) thin films in this work were prepared by using plasma-enhanced atomic layer deposition (PEALD), and a systematic analysis was conducted to evaluate the influence of post-deposition annealing at various temperatures in a nitrogen-hydrogen mixed atmosphere on their surface morphology, optical behavior, and electrical performance. The SnO films were characterized by using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Hall effect measurements. With increasing annealing temperatures, the SnO films exhibited enhanced crystallinity, a higher oxygen vacancy (O) peak area ratio, and improved mobility and carrier concentration.

Glycyrrhiza plastid paternal inheritance and a new DNA barcode provide new strategies for molecular identification of three medicinal licorice hybrid complexes.

Background: The widespread hybridization and introgression of L. medicinal plants ( Fisch., Bat.

Clinical features and risk factors for pelvic metastasis after microwave ablation of hepatocellular carcinoma: a nested case-control study.

Background: Pelvic metastasis (PM) from hepatocellular carcinoma (HCC) remains understudied. Clarifying its risk factors after microwave ablation (MWA) is essential for optimizing surveillance strategies and guiding personalized management.

Materials And Methods: This retrospective study included patients with HCC who underwent MWA between January 2006 and August 2018.

Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging.

Background: Noninvasive and functional imaging of the focal liver lesion (FLL) vasculature at microscopic scales is clinically challenging. We investigated the feasibility of using super-resolution ultrasound (SR-US) imaging for visualizing and quantifying the microvasculature of intraparenchymal FLLs.

Methods: Patients with FLLs between June 2022 and February 2023 were prospectively screened.

A framework for selecting and assessing soil quality indicators for sustainable soil management in waste dumps.

The primary objective of this study was to develop soil quality indexes (SQIs) to reveal the changes in SQ during the restoration of vegetation in the reclaimed waste dumps of the Hequ open-pit coal mine. The study built an SQI evaluation model for waste dumps based on the soil management assessment framework. The total data set (TDS) consisted of nine physicochemical property indicators.

C9orf72 functions in the nucleus to regulate DNA damage repair.

The hexanucleotide GGGGCC repeat expansion in the intronic region of C9orf72 is the most common cause of Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeat expansion-generated toxic RNAs and dipeptide repeats (DPRs) including poly-GR, have been extensively studied in neurodegeneration. Moreover, haploinsufficiency has been implicated as a disease mechanism but how C9orf72 deficiency contributes to neurodegeneration remains unclear.

Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury.

Ischemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a promising target for neuroprotection in many neurological disorders, including ischemic stroke. However, the mechanism by which HDAC6 inhibition protects neurons after ischemic stroke remains unclear.

Analysis of Spatial Heterogeneity and Influencing Factors of Ecological Environment Quality in China's North-South Transitional Zone.

The ecological environment is important for the natural disaster prevention of human society. The monitoring of ecological environment quality has far-reaching practical significance for the functional construction of ecosystem services and policy coordination. Based on Landsat 8 operational land image (OLI)/thermal infrared sensor (TIRS) remote sensing image data, this study selected the normalized vegetation (NDVI), tasseled cap transformation humidity (WI), bare soil (SI), construction index (NDSI), and land surface temperature (LST) indexes from the aspects of greenness, humidity, dryness, and heat.

Effective, angle-independent radiative cooler based on one-dimensional photonic crystal.

A simple and low-cost radiative cooler based on one-dimensional photonic crystal is proposed in this work, which has an average emissivity of 96% within the atmospheric transparency window (8-13μm). The ultra-broadband emissivity property is realized by constructing the strongly overlapped optical resonances with a tandem structure composed of two lossy materials while an additional lossless material is adopted as the top layer to reduce the Fresnel reflection of the whole structure. The maximum cooling power density of the fabricated radiative cooler can reach 113.

Spatiotemporal Changes in PM and Their Relationships with Land-Use and People in Hangzhou.

Increases in the extent and level of air pollution in Chinese cities have become a major concern of the public and burden on the government. While ample literature has focused on the status, changes and causes of air pollution (particularly on PM and PM), significantly less is known on their effects on people. In this study we used Hangzhou, China, as our testbed to assess the direct impact of PM on youth populations that are more vulnerable to pollution.

Optical constants acquisition and phase change properties of GeSbTe thin films based on spectroscopy.

In this work, phase change chalcogenide GeSbTe (GST) thin films were fabricated by magnetron sputtering. The optical properties, especially the optical constants (refractive index and extinction coefficient), of such alloys were systematically studied by investigating their thermally and photo-thermally induced switching between different phases. The results show that GST films are highly tunable in microstructure and optical constants, either by post-annealing at 160 °C, 200 °C, 250 °C and 350 °C, respectively, or by laser irradiation of 1 mW, 3 mW, 5 mW and 10 mW power with beam diameter of 7 μm at 532 nm, respectively.

ITO-TiN-ITO Sandwiches for Near-Infrared Plasmonic Materials.

Indium tin oxide (ITO)-based sandwich structures with the insertion of ultrathin (<10 nm) titanium nitride (TiN) are investigated as near-infrared (NIR) plasmonic materials. The structural, electrical, and optical properties reveal the improvement of the sandwich structures stemmed from TiN insertion. TiN is a well-established alternative to noble metals such as gold, elevating the electron conductivity of sandwich structures as its thickness increases.

Tunable near-infrared epsilon-near-zero and plasmonic properties of Ag-ITO co-sputtered composite films.

Series of co-sputtered silver-indium tin oxide (Ag-ITO) films are systematically fabricated. By tuning the atomic ratio of silver, composite films are manifested to have different microstructures with limited silver amount (<3 at.%).

Characterization of a recombinant d-allulose 3-epimerase from Agrobacterium sp. ATCC 31749 and identification of an important interfacial residue.

d-Allulose 3-epimerase (DAEase) catalyzes the epimerization between d-fructose and d-allulose. We had PCR-cloned and overexpressed the gene encoding Agrobacterium sp. ATCC 31749 DAEase (AsDAEase) in Escherichia coli.

An environment-friendly approach to isolate and purify glucan from spent cells of recombinant and the bioactivity characterization of the purified glucan.

While the methylotrophic yeast enables the industrial-scale biosynthesis of many recombinant products, large amount of nutrient-rich biomass emerged along this process. Polysaccharides, especially glucans that are abundant in the cell wall of , are yet to be better utilized owing to their various biological activities. However, the isolation and purification of cell wall glucan from has not been reported.

Factors related to recurrence of the benign non-functioning thyroid nodules after percutaneous microwave ablation.

Purpose: To determine the factors affecting the recurrence of the solitary benign thyroid nodules (BTN) after microwave ablation (MWA).

Materials And Methods: Between January 2013 and January 2015, a total of 110 patients with at least one solid thyroid nodule (solid component ≥ 80%) were enrolled. MWA was performed under continuous ultrasound (US) guidance.

Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors.

Novel dasatinib analogues as DDR1 and DDR2 inhibitors were designed and synthesized. The synthesized compounds were screened for DDR1 and DDR2 kinase inhibitory and cancer cell proliferation inhibitory activities. Some of the compounds showed the potent inhibitory activities against both DDR1 and DDR2, as well as anticancer activity in low nanomolar range against K562 cell line; especially, compound 3j demonstrated significantly better inhibitory potency than the parental dasatinib against both DDRs and also demonstrated the potent inhibitory activity against K562 cell lines (IC values of 2.

Contrast-enhanced ultrasound-guided percutaneous microwave ablation of renal cell carcinoma that is inconspicuous on conventional ultrasound.

Purpose: This study was designed to determine the safety, effectiveness and feasibility of contrast-enhanced ultrasound (CEUS)-guided percutaneous microwave ablation (MWA) of renal cell carcinoma (RCC) that is inconspicuous on conventional ultrasound (US).

Materials And Methods: A total of 32 RCC nodules in 29 patients (23 men and 6 women) were treated with CEUS-guided percutaneous MWA between January 2010 and September 2014. The median maximum diameter of the nodules was 2.

Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors.

A series of 3,5-disubstitute-4-alkynylisoxazole derivatives were designed and synthesized through palladium(II)-copper(I) catalyzed Sonogashira cross-coupling reaction of an alkynyl moiety and an isoxazole scaffold as novel HSP90 inhibitors. The resultant compounds displayed moderate to potent binding affinity to HSP90 proteins, and also demonstrated good cell growth inhibitory activity against various cancer cell lines (A549, K562, MCF-7, DU145 and Hela). Some compounds (18d, 18e, 19a, 19d, 20c and 20q) show similar or better binding affinity towards HSP90α and HSP90β comparing to NVP-AUY922.

Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor.

The triazolopyrimidine-2-sulfonanilide, discovered from preparing bioisosteres of the sulfonylurea herbicides, is an important class of acetohydroxyacid synthase (AHAS, EC 4.1.3.

Synthesis and fungicidal activities of new 1,2,4-triazolo[1,5-a]pyrimidines.

A series of new acetohydrazone-containing 1,2,4-triazolo[1,5-a]pyrimidine derivatives were designed and synthesized for the purpose of searching for novel agrochemicals with higher fungicidal activity. Their in vitro fungicidal activities against Rhizoctonia solani were evaluated, and the most promising compound, 2-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-2'-[(2-hydroxyphenyl)methylidene]acetohydrazide (2-17), showed a lower EC(50) value (5.34 microg ml(-1)) than that of commercial carbendazim (EC(50)=7.

Design and synthesis of N-2,6-difluorophenyl-5-methoxyl-1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamide as acetohydroxyacid synthase inhibitor.

Triazolopyrimidine-2-sulfonamide belongs to a herbicide group called acetohydroxyacid synthase inhibitors. With the aim to discover new triazolopyrimidine sulfonanilide compounds with high herbicidal activity and faster degradation rate in soil, the methyl group of Flumetsulam (FS) was modified into a methoxy group to produce a new herbicidal compound, N-2,6-difluorophenyl-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide (experimental code: Y6610). The enzymatic kinetic results indicated that compound Y6610 and FS have k(i) values of 3.