Preoperative nutritional status and obesity are associated with muscle atrophy and fatty infiltration in degenerative rotator cuff tears.

Background: Rotator cuff tear is a degenerative condition that has been previously linked to metabolic factors such as obesity and diabetes. However, the relationship between patients' nutritional status and rotator cuff pathology remains unclear.

Method: We retrospectively reviewed data from patients with degenerative rotator cuff tears who underwent arthroscopic rotator cuff repair at our institution between June and December 2024.

l-Threonine Catabolism Driven Flavor Formation: A Key Pathway for Soy Sauce-Like Aroma in Bacillus subtilis Fermentation.

The globalization of food culture has driven the growth of the flavor market, with Bacillus subtilis-fermented soybean products widely used as traditional Asian condiments due to their distinctive soy sauce-like aroma. However, the molecular mechanism underlying aroma formation remains incompletely understood. Building on previous systematic multi-omics studies, this study identifies a key role for l-threonine catabolism in regulating pyrazine biosynthesis.

Integrating gene knockout, GC-O-MS and multivariate statistical analysis: revealing the impact of and genes on the aroma characteristics of BJ3-2 fermented soybeans.

Fermented soybean products are an integral part of the Chinese diet, valued for their distinctive aroma. () BJ3-2 is a highly effective fermentation strain widely used in the industrial production of bacterial-type douchi. However, the specific aroma characteristics of soybeans fermented by this strain remain unclear.

Wild exhibits far lower arsenic accumulation and hepatorenal in mice compared to equivalent dose of inorganic arsenic.

Introduction: Wild Cordyceps sinensis () is a Chinese medicinal material known for its renal and pulmonary benefits. However, inorganic arsenic in wild Cordyceps sinensis may accumulate in the body following prolonged consumption; therefore, rigorous safety evaluations are needed.

Methods: This study compared the impacts of wild Cordyceps sinensis at the maximum clinical dose and equivalent doses of inorganic arsenic (16.

Characterization of Baijiu by gas chromatography-olfactometry, quantitative measurements, aroma recombination, and omission experiments.

ngxiang () Baijiu is a subtype of () Baijiu and is a distilled spirit widely favored by consumers in central and southwestern China. The aroma compounds in Baijiu were analyzed using aroma extract dilution analysis, resulting in the identification of 55 compounds. Among them, 32 were further identified as important odorants based on their odor activity values.

Impact of pepper varieties on microbial succession and correlation with physicochemical properties and volatile compounds during pickled pepper fermentation.

This study investigates the microbial succession dynamics and volatile compound formation during pickled pepper fermentation using two pepper varieties. Between (XML) and (ZZJ) fermentation process, salinity reduction from 9 % to 4.12 %, pH stabilization at 3.

Study on the inhibitory mechanism of combined ultrasound and capsaicin against Listeria monocytogenes.

Listeria monocytogenes (LM) is a critical foodborne pathogen, whose exceptional environmental adaptability and biofilm-forming capacity render it resistant to effective control during food processing and storage. Sonodynamic therapy (SDT), as an emerging sterilization approach, has rapidly emerged demonstrating potent microbicidal efficacy against microorganisms. The development of novel sonosensitizers is of crucial significance for the further advancement and application of SDT.

Overexpression of NtMYB306c reduces the glandular trichomes density in tobacco.

Trichomes, as multicellular structures with diverse functions, play a crucial role in protecting plants against various stresses. Nicotiana tabacum (tobacco) leaves are characterized by numerous glandular trichomes, which are responsible for the production of substantial quantities of secondary metabolites and are critical determinants of tobacco quality. Although their importance is well established, the molecular regulatory mechanisms governing the development of tobacco glandular trichomes remain poorly characterized.

An atypical bHLH transcription factor NtPRE4.1 negatively regulates tobacco glandular trichome density.

As the world's largest producer and consumer of tobacco, it holds significant socio-economic value in China. Trichomes, specialized hair-like structures on the epidermal cells of tobacco, play a crucial role in the synthesis and secretion of defense-related secondary metabolites, such as terpenoids and alkaloids, which directly influence leaf quality. However, the molecular mechanisms underlying trichome development remain poorly understood.

A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death.

Background And Purpose: Signal transducer and activator of transcription 3 (STAT3) has emerged as a promising therapeutic target for triple-negative breast cancer (TNBC) and multiple myeloma (MM), yet no STAT3-selective drugs have been approved for clinical use.

Experimental Approach: Newly synthesized compounds were screened by docking, surface plasmon resonance (SPR) and cellular thermal shift assay (CETSA) to measure the binding activity with STAT3. RNA-Seq, luciferase assays, western blot and immunofluorescence assays were conducted to detect the impact of RDp002 on STAT3 signalling.

Konjac glucomannan/sodium alginate/ε-poly-l-lysine hydrogel promotes esophageal and colonic wound healing.

Endoscopic submucosal dissection (ESD) is widely used to treat gastrointestinal mucosal and submucosal lesions. However, it may cause bleeding, perforation, and stricture. Although these complications can be avoided by introducing materials such as polyglycolic acid and carboxymethyl cellulose sheets, such approaches are expensive and time-consuming.

Intraoperative tranexamic acid reduces postoperative haemarthrosis and improves early functional outcomes in double-bundle anterior cruciate ligament reconstruction.

Introduction: Double-bundle anterior cruciate ligament reconstruction (ACLR) has biomechanical advantages but is associated with increased intraoperative bleeding. The role of tranexamic acid (TXA) in reducing postoperative joint haemarthrosis and improving the short-term outcomes of double-bundle ACLR has not yet been thoroughly investigated. This study aimed to assess the effects of intraoperative TXA on postoperative joint haemarthrosis and short-term functional outcomes in patients who underwent double-bundle ACLR.

The insights into sour flavor and organic acids in alcoholic beverages.

Alcoholic beverages have developed unique flavors over millennia, with sourness playing a vital role in their sensory perception and quality. Organic acids, as crucial flavor compounds, significantly impact flavor. This paper reviews the sensory attribute of sour flavor and key organic acids in alcoholic beverages.

Potential effects of aerosol generation and transmission during bedside endoscope cleaning.

Airborne transmission is among the most frequent types of nosocomial infection. Recent years have witnessed frequent outbreaks of airborne diseases, such as severe acute respiratory syndrome (SARS) in 2002, Middle East respiratory syndrome (MERS) in 2012, and coronavirus disease 2019 (COVID-19), with the latter being on the rampage since the end of 2019 and bringing the effect of aerosols on health back to the fore (Gralton et al., 2011; Wang et al.

Alterations in physico-chemical properties, microstructure, sensory characteristics, and volatile compounds of red pepper ( var. conoides) during various thermal drying durations.

Red pepper ( var. conoides) is commonly used for dried pepper production in China, and the drying process, particularly the during duration, profoundly affects its quality. The findings indicate that prolonged exposure to high temperatures during thermal drying results in significant darkening, an evident decrease in red and yellow tones, and gradual transformation of the pepper's microscopic structure from granular to compact, along with 88% reduction in moisture content and 81% decrease in thickness.

A ratiometric SERS aptasensor based on catalytic hairpin self-assembly mediated cyclic signal amplification strategy for the reliable determination of E. coli O157:H7.

A ratiometric SERS aptasensor based on catalytic hairpin self-assembly (CHA) mediated cyclic signal amplification strategy was developed for the rapid and reliable determination of Escherichia coli O157:H7. The recognition probe was synthesized by modifying magnetic beads with blocked aptamers, and the SERS probe was constructed by functionalizing gold nanoparticles (Au NPs) with hairpin structured DNA and 4-mercaptobenzonitrile (4-MBN). The recognition probe captured E.

Improvement in Noodle Quality and Changes in Microstructure and Disulfide Bond Content through the Addition of Pepper Straw Ash Leachate.

Every year, a significant amount of pepper stalks are wasted due to low utilization. The ash produced from pepper stalks contains a significant amount of alkaline salts, which are food additives that can enhance the quality of noodles. Therefore, utilizing natural pepper straw ash to improve the quality of noodles shows promising development prospects.

Characterization of key aroma compounds of fried pepper sauce under different pretreatment processes.

Fried pepper sauce (FPS) is renowned among consumers for its distinct aroma profile and rich nutritional composition. However, the primary aroma components of FPSs, crucial for quality assurance, remain unclear. Therefore, this study aimed to delve deeper into the unique aroma profile of FPSs by analyzing samples subjected to various pretreatment methods (including three heat-moisture treatment processes: soaking at 60 °C, soaking at 100 °C, and steaming, and three crushing processes: mashing, mincing, and horizontal knife cutting).