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http://dx.doi.org/10.3967/bes2024.035 | DOI Listing |
Front Oncol
August 2025
Department of Pathology, Institute of Clinical Pathology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Despite the generally favorable prognosis of differentiated thyroid carcinoma (DTC) following surgery and radioactive iodine (RAI) therapy, approximately 10% of cases eventually develop resistance to RAI. This condition, known as radioiodine-refractory differentiated thyroid carcinoma (RAIR-DTC), is associated with a poor prognosis, with a 10-year survival rate of only 10% from the time of metastasis detection. The limited availability of safe and effective alternative treatments poses a significant challenge to clinical management.
View Article and Find Full Text PDFJ Inflamm Res
September 2025
The Second Clinical College of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People's Republic of China.
Purpose: Autoimmune thyroiditis (AIT) is the most common organ-specific autoimmune disease, and its pathogenesis is closely related to the inflammatory microenvironment driven by immune cell penetration. The role of the newly proposed concept of PANoptosis in immune-related diseases is gradually being revealed. However, there is currently a lack of reports on PANoptosis in AIT.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Objective: This study aimed to investigate comorbidity patterns and potential pathogenic mechanisms in patients with Hashimoto's thyroiditis (HT).
Methods: Patients with HT who visited the outpatient clinic of the Thyroid Department at Dongzhimen Hospital, Beijing University of Chinese Medicine, between June 2021 and December 2024 were included. Association rule analysis and logistic regression analysis were performed using SPSS 25.
Cureus
August 2025
College of Medicine, King Saud University, Riyadh, SAU.
Background Subclinical hypothyroidism (SCH) in pregnancy poses serious maternal and fetal risks, including miscarriage, gestational diabetes, and neurodevelopmental impairment. Despite clear international guidelines like those from the American Thyroid Association (ATA), global practice remains inconsistent. In Saudi Arabia, where SCH prevalence among pregnant women is notably high (13%), there is limited national data on how closely physicians follow these guidelines.
View Article and Find Full Text PDFJ Appl Toxicol
September 2025
School of Public Health, Key Laboratory of Special Environmental and Health Research, Xinjiang Medical University, Urumqi, China.
Humans' exposure to arsenic (As) has been associated with the development of various diseases. Some health effects may be mediated by arsenic-induced toxicity to the thyroid and endocrine systems, but its underlying mechanisms remain unclear. The overall aim of our study was focused on using sodium arsenite (NaAsO)-exposed rats to investigate the involvement of the phosphatidylinositol 3-kinase (PI3K) and transcription factor NF-E2-related factor 2 (Nrf2) pathways in toxicity to the thyroid and endocrine systems.
View Article and Find Full Text PDF