Evaluation of APACHE II score as predictor of outcome in patients with ruptured liver abscess: prospective study in a tertiary care hospital.

Ruptured liver abscess is a critical condition with high morbidity and mortality, especially in patients with systemic comorbidities. This 18-month observational cohort study at Safdarjung Hospital, New Delhi, evaluated the prognostic value of the Acute Physiology and Chronic Health Evaluation II (APACHE II) score in predicting outcomes for patients with radiologically confirmed ruptured liver abscesses. A total of 69 patients (88.

Expert Opinion on Management Advancements in Sarcopenia: From Muscle Wasting to Recovery.

Sarcopenia, an age-related condition marked by the decline of skeletal muscle mass, strength, and function, often leads to loss of function, disability, and diminished quality of life (QoL) in the elderly population. Despite its growing prevalence, sarcopenia is frequently underdiagnosed and inadequately managed. Timely detection and appropriate interventions are crucial to slowing disease progression and minimizing associated risks.

Plasmid DNA and mRNA delivery: Approaches and challenges.

for delivery of plasmid DNA and mRNA transform biology and medicine, offering powerful tools for gene therapy, vaccine development, cancer immunotherapy, and regenerative medicine. Plasmid DNA provides a relatively stable and sustained expression of the genes which also provides the basic groundwork for long-lasting therapeutic. At the same time, mRNA has also demonstrated more appropriateness for dynamic and time-sensitive applications due to its short-lived and accurate translation capabilities, such as during the development of mRNA-based COVID-19 vaccines.

Mapping genomic regions for reproductive stage drought tolerance in rice from exotic landrace-derived population.

In the rapid climate change scenario and subsequent rainfall patterns, drought has emerged as a bottleneck for crop production across crops, especially in rainfed rice. Drought significantly affects the development and production of most modern rice cultivars. Thus, recent breeding efforts have aimed to integrate drought tolerance traits in existing rice varieties through conventional and molecular approaches.

Advances and Challenges of Microneedle Assisted Drug Delivery for Biomedicals Applications: A Review.

Microneedles have been explored as a novel way of delivering active ingredients into the skin. They have various advantages, such as quick and efficient drug delivery, mechanical stability, minimal pain, variable capacity and easy use. Microneedles are enabled for the delivery of vaccine, peptides, medicinal components and in cosmetology, which couldn't go unnoticed.

Osteogenic citric acid linked chitosan coating of 3D-printed PLA scaffolds for preventing implant-associated infections.

>25 % of the patients who receive orthopedic implants have been reported with implant-associated osteomyelitis, which can result in inflammation, osteolysis, and aseptic loosening of implants. Current treatment methods doesn't ensure defect healing and prevention from reinfection. Thermoplastic-based 3D-printed scaffolds offer a bioresorbable, biocompatible, and mechanical strong implant system.

Retinoic acid in Parkinson's disease: Molecular insights, therapeutic advances, and future prospects.

Parkinson's disease (PD) is a common and progressively worsening neurodegenerative disorder characterized by abnormal protein homeostasis and the degeneration of dopaminergic neurons, particularly in the substantia nigra pars compacta. The prevalence of PD has doubled in the past 25 years, now affecting over 8.5 million individuals worldwide, underscoring the need for effective management strategies.

Correction: Singh et al. Nanotechnology-Aided Advancement in Combating the Cancer Metastasis. 2023, , 899.

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Review of computer-assisted diagnosis model to classify follicular lymphoma histology.

The field of image processing is experiencing significant advancements to support professionals in analyzing histological images obtained from biopsies. The primary objective is to enhance the process of diagnosis and prognostic evaluations. Various forms of cancer can be diagnosed by employing different segmentation techniques followed by postprocessing approaches that can identify distinct neoplastic areas.

Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications.

Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has devastating effects on individuals, often resulting in dementia. AD is primarily defined by the presence of extracellular plaques containing insoluble β-amyloid peptide (Aβ) and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein (P-tau). In addition, individuals afflicted by these age-related illnesses experience a diminished state of health, which places significant financial strain on their loved ones.

Splicing DNA Damage Adaptations for the Management of Cancer Cells.

Maintaining a tumour cell's resistance to apoptosis (organized cell death) is essential for cancer to metastasize. Signal molecules play a critical function in the tightly regulated apoptotic process. Apoptosis may be triggered by a wide variety of cellular stresses, including DNA damage, but its ultimate goal is always the same: the removal of damaged cells that might otherwise develop into tumours.

Impact of secondary infections on dengue presentation: A cross-sectional study in a tertiary care hospital in Uttar Pradesh, India.

Background: Recently, a wide range variety of manifestations, including a self‑limiting to severe illness, has been increasingly reported in dengue. Few studies attract attention to severe dengue, mainly observed in secondary infection. With this background, this study aims to provide a comprehensive overview to differentiate primary from secondary dengue using serology (IgG) and the possible association of severity of illness in secondary dengue.

Association of adipokines with insulin resistance and metabolic syndrome including obesity and diabetes.

Adipose tissue (AT) acts as a highly active endocrine organ, which secretes a wide range of adipokine hormones. In the past few years, several adipokines (leptin, adiponectin, resistin .) have been discovered showing metabolic consequences in relation to insulin resistance (IR), obesity and diabetes.

Pharmaceutical and Pharmacokinetic Aspects of Nanoformulation Based Drug Delivery Systems for Anti-cancer Drugs.

Many nanodrug delivery systems used with various routes of administration have been developed recently. These may be dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, or polymeric nanoparticles. The nanodrug delivery systems may improve effectiveness, safety, physicochemical qualities, and pharmacokinetic/pharmacodynamic profile.

ROBOTONT - Open-source and ROS-supported omnidirectional mobile robot for education and research.

In order to achieve visionary concepts such as Society 5.0 and Industry 5.0, there is a growing need for people who are able to create innovative robotic technologies.

Nanotechnology-Aided Advancement in Combating the Cancer Metastasis.

Modern medicine has been working to find a cure for cancer for almost a century, but thus far, they have not been very successful. Although cancer treatment has come a long way, more work has to be carried out to boost specificity and reduce systemic toxicity. The diagnostic industry is on the cusp of a technological revolution, and early diagnosis is essential for improving prognostic outlook and patient quality of life.

Utilization of Stimuli-Responsive Biomaterials in the Formulation of Cancer Vaccines.

Immunology research has focused on developing cancer vaccines to increase the number of tumor-specific effector cells and their ability to fight cancer over the last few decades. There is a lack of professional success in vaccines compared to checkpoint blockade and adoptive T-cell treatment. The vaccine's inadequate delivery method and antigen selection are most likely to blame for the poor results.

Leveraging health information helpline to sustain health-care delivery during the COVID pandemic: Experiences from a State in Eastern India.

Background: The unprecedented demands on health-care systems due to the COVID-19 pandemic made countries including India to switch toward alternative modes of health-care delivery.

Objectives: The aim of this study was to describe the various COVID-related services delivered through 104 health information helpline (HIHL), located in Jharkhand during the pandemic.

Methods: The de-identified secondary data from February 2020 to December 2021 related to COVID services delivered through HIHL were analyzed.

Human-derived Biomaterials for Biomedical and Tissue Engineering Applications.

Biomaterials have been utilised since the dawn of time to aid wound healing and to try to restore damaged tissues and organs. Many different materials are now commercially accessible for maintaining and restoring biological functioning, and many more are being researched. New biomaterials have to be developed to meet growing clinical demands.

Diagnostic Accuracy of the Government of India Mother and Child Protection Card for Developmental Screening of Indian Children Aged 2-36 Months: A Hospital-based Mixed Method Study.

Objective: Universal developmental screening is recommen-ded at 9, 18, 24 and 36 months. The Government of India Mother and Child Protection (MCP) card is an immunization record that is used to monitor child development, and identify children requiring further evaluation.

Objectives: To determine the diagnostic accuracy of the MCP card for developmental screening, and perform its item analysis.