Publications by authors named "Santosh Kumar Singh"

Background: Endodontically treated teeth are susceptible to fractures due to loss of structural integrity. Reinforcing these teeth with appropriate restorative materials is crucial for restoring their function and longevity. The study was undertaken to compare the fracture resistance of endodontically treated teeth restored with different restorative materials.

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Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern. MASLD is strongly linked to obesity, sedentary lifestyles, and metabolic syndrome. In India, the prevalence of MASLD exhibits regional variations because of genetic, dietary, and socioeconomic factors.

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Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential for new drug development. Their ability to address the growing issue of drug resistance has drawn attention from researchers seeking novel, nature-derived lead molecules that can be produced on a large scale to meet global demand. Recent advancements in genomics, metabolomics, bioinformatics, and improved cultivation techniques have significantly aided the identification and characterization of fungal endophytes and their metabolites.

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The Ganga river, one of the largest and most culturally significant rivers in India, supports millions of people living along its banks. However, extensive use and untreated wastewater discharge have led to significant contamination. This study utilizes land use and land cover (LULC) analysis, along with regular water sampling from 2021 to 2222, to assess variations in physical, chemical, and biological characteristics and evaluate health risks posed by heavy metals across eight monitoring sites in the Ganga and Yamuna rivers, Prayagraj, India.

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MWCNT is being explored in various sectors like medical healthcare, electronics, aerospace, defence research, and many more leading to the continuous generation of waste discharged into water sources. Once introduced into the environment it may adversely affect flora and fauna. It is high time MWCNT should be recovered, treated, and degraded from wastewater.

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Introduction: Fungal endophytes have mutualistic associations with the plant's host, communicating through genetic and metabolic processes. As a result, they gain the ability to generate therapeutically effective metabolites and their derivatives.

Methods: The current study aims to assess antioxidant potential along with the identification of robust metabolites within the crude extract of a potent endophytic fungus isolated from leaf tissues of the Linn.

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  • The study investigates multi-drug resistant Acinetobacter baumannii, focusing on rare clinical isolates from India that produce the pigment pyomelanin.
  • Researchers utilized methods like REP-PCR for genotyping and whole genome sequencing to analyze the genomic features of these isolates.
  • Findings reveal that pyomelanin-producing strains are not only multidrug-resistant but also form strong biofilms with specific virulence and resistance genes, indicating advanced adaptability and potential health risks.
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Dengue virus is an arbovirus transmitted through the bite of infected Aedes mosquitoes. Many unusual clinical features are being reported in dengue. Dengue complicated with hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal condition.

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Introduction: Mucoid degeneration of the cruciate ligament is a well-known entity, but symptomatic lesions are rare. It is even rarer to find symptomatic posterior cruciate ligament mucoid degeneration than the anterior cruciate ligament.

Case Report: A 63-year-old male presented to our hospital complaining of posterior knee pain was induced when the knee approached full flexion without episodes of trauma, despite conservative treatment over the preceding 8 months, his symptoms persisted.

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Introduction: Osteonecrosis of femoral head (ONFH) is a disabling condition of the hip joint with multifactorial etiology and is associated with genetic predilection and exposure to certain risk factors most commonly being chronic alcohol or steroid intake. Total hip arthroplasty (THA) remains the gold standard for end-stage femoral head osteonecrosis. The outcome after the surgery is mainly affected by age, activity levels and other factors that affect the development of ONFH.

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Ovarian cancer, often referred to as the "silent killer," is notoriously difficult to detect in its early stages, leading to a poor prognosis for many patients. Diagnosis is often delayed until the cancer has advanced, primarily due to its ambiguous and frequently occurring clinical symptoms. Ovarian cancer leads to more deaths than any other cancer of the female reproductive system.

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  • Ayurveda suggests that each person has a unique entity that affects their physical, physiological, and psychological traits, influencing their reactions to stimuli beyond just genetics.
  • This research seeks to validate this Ayurvedic concept by exploring the KCNJ11 gene's role in type 2 diabetes susceptibility through an analysis of patient and control groups.
  • The study found that specific protein mutations were linked to diabetes in particular groups, indicating that variations in amino acids can impact protein function and contribute to the development of the disease.
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  • - The study investigates how trace elements (like zinc and magnesium) relate to inflammation markers (TNF-α and IL-6) in children with short stature, aiming to identify potential causes for this condition.
  • - Researchers analyzed 220 samples, revealing lower levels of zinc and magnesium and higher copper levels in short-statured individuals, with a notable correlation between these trace elements and inflammation markers.
  • - The findings suggest that monitoring the Cu/Zn ratio and inflammation markers could help identify children at risk for short stature, and zinc supplementation might improve growth by reducing inflammation.
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Seasonal variations directly impact the biochemical and microbial properties of the soil, influence carbon and nutrient cycling within the soil system. Soils under tree plantation (TP) are rich in organic matter and microbial population, making them more susceptible to seasonal variation. We studied the effect of seasonal variations in soil chemical properties (pH, electrical conductivity (EC), total organic carbon (TOC), total nitrogen (TN), C/N ratio etc) and microclimate (moisture and temperature) on microbial respiration (SR), biomass, and carbon (C) utilization efficiency under 13 years old Kadamb ( Miq.

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  • Researchers developed transferosomes (TRANS) for delivering epigallocatechin-3-gallate (EGCG) and ascorbic acid (AA) to the brain, confirming their composition through various analyses, indicating safe and effective formulations.
  • Particle sizes were measured for different TRANS formulations, showing variation, while microscopic images revealed a crystalline structure and minimal surface irregularities, suggesting a lipid layer.
  • In vivo studies demonstrated that EGCG-AA-TRANS significantly inhibited acetylcholinesterase and improved memory in animal models, suggesting its potential as a treatment for Alzheimer's disease.
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Rheumatoid arthritis (RA) and associated inflammatory complications are the most prevalent illnesses and can turn into fatal conditions if left untreated. Allopathic medicine is not satisfactory for curing RA. Scientific literature reports reveal that several phyto-compounds viz.

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  • Climate change significantly threatens global agricultural sustainability, especially in developing countries where it plays a crucial role in their economy.
  • Extreme weather events and changing climatic conditions disrupt agricultural productivity, affecting farmers’ socioeconomic status and leading to increased vulnerability.
  • Adopting climate-smart practices and innovative strategies, including advanced technologies, is essential for improving resilience, productivity, and reducing the negative effects of climate change on food systems.
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Biofuels have emerged as a promising and eco-friendly alternative to conventional fossil fuels. Biofuel sourced from rice straw (RS) and municipal solid waste (MSW), which are abundant residues from agricultural and municipal activities, present a sustainable solution to address waste management challenges. Utilizing life cycle assessment, this study quantifies the environmental advantages by assessing the reduction in greenhouse gas emissions, energy consumption, and other environmental impacts linked with employing these waste materials for biofuel production.

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  • - Parkinson's disease (PD) is characterized by misfolded α-synuclein (αSyn) proteins, leading to both motor symptoms (like stiffness and tremors) and nonmotor symptoms that can vary among individuals due to progressive neuron and synapse loss.
  • - While medical and surgical treatments, such as deep brain stimulation, can improve well-being and survival, they do not stop the disease from progressing.
  • - The complexity of the brain and the blood-brain barrier (BBB) make delivering drugs for PD treatment difficult, but this article explores the potential of chitosan-based drug delivery systems as a solution.
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Ventriculoperitoneal shunt (VPS) is the most common procedure done for hydrocephalus in the paediatric population. While shunt infection and shunt malfunction remain the most common complications, shunt migration is not frequently observed. Being present in a large peritoneal cavity, theoretically, a shunt can travel to a variety of locations.

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Finger millet, an important 'Nutri-Cereal' and climate-resilient crop, is cultivated as a marginal crop in calcareous soils. Calcareous soils have low organic carbon content, high pH levels, and poor structure. Such a situation leads to poor productivity of the crop.

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Non-small cell lung cancer (NSCLC) presents a complex and diverse disease, exhibiting variations at individuals' cellular and histological levels. This complexity gives rise to different subtypes and genetic mutations, posing challenges for accurate diagnosis and effective treatment. Nevertheless, continuous progress in medical research and therapies is continually shaping the landscape of NSCLC diagnosis and management.

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