Forms of interventions for problematic usage of the internet: A scoping review.

Background And Aims: This scoping review aims to identify current forms of interventions for Problematic Usage of the Internet (PUI) to inform more effective intervention and policy-making initiatives grounded in robust empirical evidence.

Methods: The search was conducted in the PubMed, Scopus, and PsycINFO databases until October 12, 2024. Empirical research presenting data on interventions for PUI and written in English was included without restrictions of age groups, types of interventions, or types of PUI.

The impact of clinically insignificant residual fragments following endourological management of urolithiasis: a systematic review of complications and re-intervention rates.

Introduction: Achieving stone-free status (SFS) is a key goal of endourological treatment, yet definitions of SFS and clinically insignificant residual fragments (CIRF) remain controversial. While CIRF is frequently defined as residual fragments ≤4 mm, there is no consensus on its clinical significance regarding complications and re-intervention needs. We evaluate the risk of complications and the need for re-intervention associated with the presence of CIRF following endourological treatment for urolithiasis.

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS.

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6-mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose-limiting toxicities can significantly disrupt treatment.

Sublethal effects of road dust particles in the yellow mealworm beetle Tenebrio molitor.

High-traffic areas generate road dusts (RD) including tyre road wear particles (TRWPs), a significant source of microplastics in the environment. These particles, which persist in sediments, soil, and vegetation, can adsorb pollutants such as heavy metals and hydrocarbons, facilitating their widespread dispersal. Despite concerns about their potential ecotoxicity, their effects on soil organisms remain underexplored.

Photochemical H dissociation for nearly quantitative CO reduction to ethylene.

Producing olefins by carbon dioxide (CO) hydrogenation is a long-standing goal. The usual products are multicarbon mixtures because the critical step of heterolytic hydrogen (H) dissociation at high temperatures complicates selectivity control. In this study, we report that irradiating gold-titanium dioxide at 365 nanometers induces heterolytic H dissociation at ambient temperature.

Reply to: Comment on: Risk of malignant transformation and infections in congenital lung malformations in adults: a systematic review.

https://bit.ly/40QmKIf

Enhanced recovery and survival after elective surgery for colorectal cancer - propensity score weighting analysis of 2,865 prospective patients.

Background: The impact of enhanced recovery pathway (ERP) on survival after colorectal cancer surgery (CCS) remains controversial.

Materials And Methods: A total of 2865 adults enrolled in a multicenter cohort study (iCral3 study) after CCS were followed up. The percentage adherence to the ERP was recorded, and the patients were grouped according to their quartiles.

Clinical care of family members of patients with dilated cardiomyopathy.

Genetic family screening following the detection of a pathogenic or likely pathogenic variant in a proband with dilated cardiomyopathy (DCM) remains one of the main applications of genetic testing. While cardiac screening is recommended for all first-degree relatives, the a priori risk among family members varies. Consequently, screening regimens should be tailored according to both genetic and clinical information at the individual and familial level.

Diagnostic methods for managing dry eyes.

Background: Dry eye disease (DED) represents a multifactorial condition characterized by ocular discomfort and visual disturbances. The management of DED relies heavily on accurate diagnosis to tailor effective treatments. Diagnostic approaches encompass both subjective and objective assessments.

The Complex Pathway of Conventional Investigations before the Diagnosis of Functional Motor Disorders.

Background: Functional motor disorder (FMD) is a diagnosis of inclusion based on the presence of positive signs on clinical examination, and only a few tests are validated as biomarkers for FMD identification.

Objectives: The aim of this study was to assess the relative frequency of different types of conventional instrumental investigations (such as magnetic resonance imaging/computed tomography [MRI/CT] scan, dopamine transporter single-photon emission computed tomography (DaT-SPECT), electroencephalography (EEG), neurophysiological tests, and other tests) in FMD patients before diagnosis and to identify the clinical and demographic features associated with their use.

Methods: Data were obtained from the Italian Registry of Functional Motor Disorders, a multicenter initiative involving patients with a diagnosis of clinically definite FMD.

Recombinant human hyaluronidase-facilitated subcutaneous immunoglobulin (hf-SCIg) for inflammatory myositis: a multicenter retrospective real-world observational study.

Background: Subcutaneous immunoglobulin (SCIg) is a promising alternative to intravenous Ig (IVIg) for the treatment of idiopathic inflammatory myositis (IIM), thanks to its more favorable safety profile, reduced costs, and lower impact on patients' quality of life. We assessed the short- and long-term effectiveness and safety of recombinant human hyaluronidase-facilitated SCIg (hf-SCIg) in patients with IIM treated at different referral centers in Italy.

Methods: A multicenter, retrospective, real-life cohort study was conducted on consecutive adult patients diagnosed with IIM according to the EULAR/ACR criteria, treated with hf-SCIg for remission induction or maintenance.

The current landscape of single-port robotic surgery in urology.

The advent of the purpose-built da Vinci single-port robotic platform marks a pivotal advancement in minimally invasive urological surgery. Designed to overcome the ergonomic and technical limitations of prior single-site approaches, the single-port system enables complex procedures through a single incision, with enhanced dexterity, optimized use of confined spaces and improved cosmetic and peri-operative outcomes. The single-port system has been increasingly used across a wide range of urological indications, including robot-assisted radical prostatectomy, partial nephrectomy, nephroureterectomy and reconstructive surgeries such as pyeloplasty and ureteral re-implantation.

Integrated control of cancer stemness by σ receptor in advanced prostate cancer.

Cancer stem cells (CSCs) are pervasively present in human cancers and have a fundamental role in treatment failure and disease recurrence. Identifying critical elements that sustain the CSC phenotype may lead to novel strategies for cancer treatment. Here, we provide evidence of an essential link between the σ receptor (σR), a ligand-regulated chaperone protein residing preferentially at the endoplasmic reticulum-mitochondria contact sites, and CSCs in castration-resistant prostate cancers (CRPCs).

ROS-induced modifications of fibrin clots connect immune responses to atherothrombosis in systemic lupus erythematosus.

Objective: Cardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. While oxidative stress has been implicated in driving vascular and renal damage in SLE, the specific mechanisms remain unclear. This study investigated the potential role of oxidative stress-induced alterations in fibrinogen structure and function in the pathogenesis of atherothrombosis in SLE.

Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain.

Brain aging is a major risk for neurodegeneration, yet the underlying molecular mechanisms remain poorly understood. Here we performed an integrative proteo-transcriptomic analysis of the aging mouse brain, uncovering molecular signatures of aging through the assessment of protein aggregation, mRNA relocalization, and comparative proteomics across eight models of premature aging and neurodegeneration. We identified dynamic changes in physiological aging highlighting differences in synaptic maintenance and energy-allocation.

The role of non-linear viscoelastic hydrogel mechanics in cell culture and transduction.

The mechanical complexity of the extracellular matrix (ECM) is central to how cells sense and respond to their environment, yet hydrogel design has often focused narrowly on stiffness. Emerging evidence highlights the importance of viscoelastic stress relaxation and plasticity in cell mechanotransduction. However, a key aspect remains underexplored: non-linear viscoelasticity, where stress relaxation and plasticity depend on the magnitude of applied stress or strain.

Fatal Asphyxia in the Head-down Position: An Uncommon Case of Accidental Work-related Death.

Positional asphyxia is a rare but potentially fatal condition where an individual's body assumes a position interfering with normal respiratory movements and leading to asphyxiation. We report a case of an 83-year-old farmer trapped in the tank of a vineyard spray atomizer while attempting maintenance and stuck in the opening of the tank with his upper body inside and legs outside. He was unable to extricate himself, and rescuers, who arrived 2 hours later, found the victim dead.

Risk factors for cephalic necrosis after plate and screw osteosynthesis of 3- and 4-part proximal humerus fractures: prospective cohort study of 121 patients.

Purpose: Avascular necrosis (AVN) of the humeral head is a relatively frequent complication after proximal humerus fractures (PHF), often leading to poor outcomes and reoperation. This study investigates both non-modifiable (fracture type, trauma energy, age, sex, Charlson comorbidity index) and modifiable (surgical access, bone graft use, reduction quality) risk factors for post-operative AVN in Neer 3-4-part PHFs.

Methods: Patients with Neer 3-4-part PHFs treated using angular stable plates and followed for at least 6 months were included.

The majority of elite and professional athletes return to the preinjury level of activity after ACL reconstruction: A systematic review and meta-analysis.

Purpose: To compare return to play (RTP), time to RTP, level of RTP, and anterior cruciate ligament (ACL) graft failure among elite and professional athletes from different sports after anterior cruciate ligament reconstruction (ACLR).

Methods: The PubMed, Embase and Cochrane Library databases were searched to identify potentially relevant research articles that analysed RTP, time to RTP, level of RTP, and graft failure rate in elite and professional athletes after ACLR. An elite or professional athlete was defined as one who participates in national- or international-level competitions in professional or amateur sports-including academy players aged 15 years or over.

MALNUTRITION, SARCOPENIA AND NUTRITION THERAPY FOR PATIENTS WITH DIABETES - A GENERAL FRAMEWORK AND FOCUS ON HOSPITAL CARE.

Background & Aims: The prevalence of diabetes is increasing globally and is particularly high among hospitalized patients, presenting challenges for inpatient care. While traditional inpatient management emphasizes glycemic control, medication adjustments, and comorbidity management, malnutrition and muscle loss remain underrecognized factors that significantly influence clinical outcomes. This review aims to highlight the role of malnutrition and muscle dysfunction in hospitalized patients with diabetes and to evaluate the potential of medical nutrition therapy (MNT), particularly diabetes-specific nutrition formulas (DSNFs), to improve patient outcomes.

Ishihara color plates utilized as an assessment for simultanagnosia in posterior cortical atrophy: A case report.

Background: Simultanagnosia is a neurological disorder that impairs an individual's ability to perceive more than one object at a time visually. While the individual may acknowledge the presence of multiple objects in his field of view, he cannot generally summarize the overall percept.

Case Summary: We describe a case of simultanagnosia in Posterior Cortical Atrophy, evidenced by the Ishihara color test.

Severe tenosynovitis with rapidly fluctuating power Doppler activity, a clue for the diagnosis of Blau syndrome: a case report.

Background: Blau Syndrome is a rare monogenic disorder characterized by granulomatous polyarthritis, dermatitis, and uveitis. The diagnosis can be challenging as symptoms may not always align with the classic triad.

Case Description: An 8-year-old girl presented with fluctuant swellings in the wrists and ankles, strength reduction and stiffness.