Pacing to pink noise enhances gait recovery from a mechanical perturbation.

Effective locomotion requires physiological systems to adapt to instabilities. While gait perturbation recovery often appears rapid, it is possible that longer-lasting effects may be present. Therefore, this study explored recovery trends of gait dynamics following an experimenter-induced perturbation.

Presynaptic ATP Decreases During Physiological-Like Activity in Neurons Tuned for High-Frequency Transmission.

Recent evidence indicates that the concentration of ATP remains stable during neuronal activity due to activity-dependent ATP production. However, the mechanisms of activity-dependent ATP production remain controversial. To stabilize the ATP concentration, feedforward mechanisms, which may rely on calcium or the sodium-potassium pump, do not require changes in the ATP and ADP concentrations.

The critical role of clinical placement professionals in academic-practice partnerships for nurse education.

Clinical Placement Professionals (CPPs) are instrumental in seamlessly connecting academic learning with practical clinical experiences in nursing education. This paper describes the role, responsibilities, challenges, and recommendations for the CPP profession and explores how the utilization of CPPs across academic disciplines varies significantly, with diverse titles, team structures, and fundamental duties among schools of nursing and healthcare systems. As nursing program enrollments surge and clinical placements remain scarce, the value and standardization of the CPP role become paramount in increasing the number of adequately prepared nurses nationwide.

Skeletal Muscle Alpha Actin (ACTA1) Acetylation Enhances Myosin Binding and Increases Calcium Sensitivity.

Skeletal muscle alpha actin (ACTA1) is important for muscle contraction and relaxation, with historical studies focused on ACTA1 mutations in muscle dysfunction. Proteomics reports have consistently observed that actin, including ACTA1, is acetylated at multiple lysine sites. However, few reports have studied the effects of actin acetylation on cellular function, and fewer have examined ACTA1 acetylation on skeletal muscle function.

The feasibility and acceptability of height-adjustable stand-up desks in a self-contained classroom for students with emotional disturbances: A crossover pilot study.

Background: Using height-adjustable stand-up (stand-up) desks within classrooms for students with emotional disturbances may be beneficial for reducing sedentary behavior and promoting positive classroom behaviors.

Aims: To investigate the feasibility and acceptability of stand-up desks for students with emotional disturbances and determine the preliminary effects of stand-up desks on sedentary time (SED), physical activity (PA), and classroom behaviors.

Methods And Procedures: Four participants aged 12-14 years alternated using traditional or stand-up desks in a 10-week crossover design across one school year.

Associations Between Gestational Polybrominated Diphenyl Ether (PBDE) Serum Concentrations and Child Sleep Outcomes from Ages 2 to 8 Years.

Gestational polybrominated diphenyl ethers (PBDEs) exposures have been associated with thyroid disruption in pregnant women and adverse neurobehavioral outcomes in their children, but it is unknown if they interfere with children's sleep patterns. We assessed gestational PBDE exposure (16 weeks) and child sleep patterns from ages 2 to 8 years using 410 mother-child dyads in the Health Outcomes and Measures of the Environment (HOME) Study. Gestational biomarkers of serum PBDEs include PBDE-153 (GM±GSD: 5.

Ameliorating risks of maltreatment for adults with intellectual and developmental disabilities.

Although health care access among adults with Intellectual and Developmental Disabilities (IDD) improved in the past decade, persistent challenges still exist in obtaining care coordination and supportive services. As the life expectancy of individuals living with IDD increases and care succession occurs from family's community care to institutional care, the risk of maltreatment among adults with IDD is growing. Health conditions, for example, cognitive impairment pose a risk of maltreatment in adults with IDD.

Food Insecurity and Rural Child and Family Functioning.

Importance: In the US, children in food-insecure households are at risk for adverse psychological outcomes despite being shielded from hunger and malnutrition by their caregivers and school- and community-based programs. Parenting stress may be an important mechanism through which food insecurity is associated with negative outcomes for child mental health.

Objective: To investigate associations of household food insecurity with child mental health, parenting stress, and family functioning.

Distinct Microbial Communities Within and On Seep Carbonates Support Long-term Anaerobic Oxidation of Methane and Divergent pMMO Diversity.

At methane seeps worldwide, syntrophic anaerobic methane-oxidizing archaea and sulfate-reducing bacteria promote carbonate precipitation and rock formation, acting as methane and carbon sinks. Although maintenance of anaerobic oxidation of methane (AOM) within seep carbonates has been documented, its reactivation upon methane exposure remains uncertain. Surface-associated microbes may metabolize sulfide from AOM, maintain carbonate anoxia, contribute to carbonate dissolution, and support higher trophic levels; however, these communities are poorly described.

Breaking new ground in heart failure management: novel therapies and future frontiers.

Heart failure (HF) management is advancing in the field of cardiology, driven by the increasing availability of progressive medications. Emerging pharmacological therapies in heart failure management include SGLT-2 inhibitors, ARNI, Vericiguat, and Omecamtiv. Other novel therapies that are changing the scope of HF management include IV Iron therapy and new antifibrotic agents, such as pirfenidone and pamrevlumab.

Density-dependent network structuring within and across wild animal systems.

Theory predicts that high population density leads to more strongly connected spatial and social networks, but how local density drives individuals' positions within their networks is unclear. This gap reduces our ability to understand and predict density-dependent processes. Here we show that density drives greater network connectedness at the scale of individuals within wild animal populations.

Concurrent- not independent- M1 anodal and cerebellar cathodal tDCS enhances skill acquisition of a dexterous rhythmic-timing videogame.

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can alter the excitability of targeted brain regions and influence motor learning. For the first experiment, we studied the effects of several individual stimulation montages (2mA) on motor learning in a complex rhythm-timing video game task (n=79, M1 anodal tDCS [M1 a-tDCS], Cerebellar anodal tDCS [CB a-tDCS], Cerebellar cathodal tDCS [CB c-tDCS], and SHAM). Performance was assessed using a performance index (PI) incorporating keystroke timing accuracy, tap distribution ratio, and key error rate.

Cannabis vape product advertising exposure is associated with cannabis vape product use and frequency among U.S. Young adults.

Introduction: Cannabis vape products (CVPs) have gained significant popularity as a method of cannabis consumption among U.S. young adults (YAs), raising concerns about associated health risks.

Human Telephone vs Text Message Counseling and Physical Activity Among Midlife and Older Adults: A Randomized Clinical Trial.

Importance: While walking and similar physical activities provide numerous health benefits, particularly for aging inactive adults, many interventions are not accessible or relevant for all populations. Expanding the range of effective programs represents a critical goal.

Objective: To test whether counseling delivered by a customized, computer-driven short message service (SMS) system is comparable to standard human telephone counseling for increasing 12-month walking among inactive Hispanic or Latino/a adults.

Immune Tuning in Extreme Environments: Protein Citrullinome and Extracellular Vesicle Signatures Comparing Hibernating Versus Active States in the Heterothermic and Heterometabolic Tenrec ().

Tenrecs are heterothermic burrowing mammals, which are capable of withstanding extreme environmental stressors, including during hibernation. Their phylogenetic position as reminiscent of an ancestral placental mammal makes tenrecs a unique model for evolutionarily conserved traits, with potential translatability to human physiology and pathobiology, including adaptations to extreme environments. In this study, we compared tenrec plasma for post-translational protein citrullination profiles (citrullinomes) and extracellular vesicle (EV) characteristics, including selected microRNA cargoes (miR-21, miR-155, miR-206, miR-210), between baseline active and hibernating states at low (12 °C) and high (28 °C) ambient temperatures.

Hospital Patient and Family Advisory Council Accelerators and Barriers: A Qualitative Study.

Patient and Family Advisory Councils (PFACs), comprised of patients who have used the hospital's services and their family members, provide hospitals with input on a wide range of initiatives. This qualitative study aims to uncover the facilitators that accelerate and the barriers that inhibit councils and provide hospitals with a blueprint to help them start and strengthen PFACs. Grounded in partnership theory, this exploratory qualitative study used a thematic analysis framework to examine first-person accounts of launching and sustaining a PFAC.

Real-world observations of GLP-1 receptor agonists and SGLT-2 inhibitors as potential treatments for Alzheimer's disease.

Introduction: Glucagon-like peptide-1 (GLP-1) receptor agonists, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, and dipeptidyl peptidase-4 (DPP-4) inhibitors have potential beneficial effects in Alzheimer's disease (AD).

Methods: We conducted pharmacoepidemiologic studies using two large-scale real-world databases. We fitted covariate-adjusted Cox models to compare the risks of AD among initiators of GLP-1 receptor agonists, SGLT-2 inhibitors, and DPP-4 inhibitors.

Impacts of a fungicide and an insecticide on pollinator visitation and wildflower fitness.

Pesticide use has become widespread around the globe, and mounting evidence has demonstrated health impacts on non-target insects such as bees. However, less is known about whether the presence of these chemicals in plant tissue can alter interactions between plants, pollinators, and floral microbes. Here we asked if the presence of an insecticide and fungicide alters pollinator visitation, the abundance of floral fungi, and seed set.

Task effectiveness, usability, and acceptability of mHealth technologies among older adults at risk for cardiovascular disease: a feasibility study.

Purpose: New research shows the benefits of mobile health (mHealth) interventions for older adults. However, older adults adopt digital technology less than younger ones. This study measures the task effectiveness, perceived usability, and acceptability of a mHealth intervention (i.

Cellular and Molecular Architecture of Renin-Angiotensin System Signaling in the PVN Under Cardiometabolic Stress.

The hypothalamic paraventricular nucleus (PVN) integrates neuroendocrine and autonomic signals that regulate blood pressure and metabolism. Although the renin-angiotensin system (RAS) is implicated in neurogenic hypertension and obesity, cell-type-specific expression and regulation of its components within the PVN remain poorly understood. Here, we employed single-nucleus RNA sequencing (snRNA-seq) to profile the transcriptomic landscape of the PVN in male mice under baseline conditions and in models of DOCA-salt-induced hypertension and high-fat diet (HFD)-induced obesity.

A Motivational Framework to Connect Traditional Feminine Gender Roles to Alcohol Use and Consequences Among Latina Young Adults in the United States.

Traditional feminine gender roles (TFGRs) may be important sociocultural predictors of drinking among U.S. Latinas; however, examining the explanatory role of drinking motives will improve current understanding of the connection between TFGRs and alcohol use.

Speciation and Complex Formation of Zirconium(IV) with Tc(VII) and Re(VII) in Liquid-Liquid Extraction Systems.

The formation of Tc-(VII)-Zr-(IV) species in nitric acid and their extraction in kerosene/tributyl phosphate (TBP) phases was studied. The technetium distribution coefficient ( ) was evaluated as a function of nitric acid concentration (1-7 M) and is in the range of 25-37, which is significantly higher compared to solutions that do not contain zirconium and confirms the synergism of their coextraction. Emphasis was placed on 1 M HNO solution, which is the initial concentration used in uranium extraction during spent nuclear fuel reprocessing.

All-in-one vectors for epigenetic CRISPR inhibition of in facioscapulohumeral muscular dystrophy.

Facioscapulohumeral muscular dystrophy (FSHD) is caused by incomplete epigenetic silencing of the disease locus, leading to pathogenic misexpression of in skeletal muscle. Previously, we showed that CRISPR inhibition (CRISPRi) using several epigenetic regulators successfully targets and represses in FSHD myocytes with no adverse effects on the muscle transcriptome. However, for translatability, adeno-associated virus (AAV)-mediated gene therapies must include all components within a single vector that expresses at therapeutic levels in all target tissues.