Energy burden and asthma prevalence in U.S. cities: An emerging social determinant of health.

Background: Energy burden, defined as the inability to afford residential energy consumption, is a pressing public health issue globally and in the U.S. However, its impact on asthma remains largely unknown.

The Risk of Gastrointestinal Bleeding with Dual Antiplatelet Therapy in Cirrhotics Undergoing Liver Transplant Evaluation.

Background: Metabolic dysfunction-associated steatohepatitis (MASH) cirrhosis is now the second leading indication for liver transplantation (LT) worldwide and is associated with increased risk of cardiovascular events before and after LT. Cirrhotics who undergo left heart catheterization (LHC) with coronary artery stenting for LT evaluation require dual-antiplatelet therapy (DAPT). Data regarding the safety, risk of gastrointestinal (GI) bleeding, and mortality risk of cirrhotics receiving DAPT is limited.

Prenatal exposure to per- and polyfluoroalkyl substances: Association with child behavior in the environmental influences on child health outcomes (ECHO) Cohort.

Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may adversely impact child neurodevelopment; however, epidemiologic findings remain inconclusive because of small sample sizes, limited exposure variability, and differing neurodevelopmental measures. We aimed to investigate the relationship between prenatal PFAS exposure and child behavior.

Methods: We pooled data from nine study sites in the nationwide Environmental influences on Child Health Outcomes (ECHO) Cohort.

Forest soil properties regulate arsenic mobility and life stage-specific ecotoxicity in Collembola: Implications for early-stage contamination risk.

Arsenic (As) contamination from abandoned gold mines threatens adjacent ecosystems through leaching and erosion. This study investigated how soil physicochemical properties regulate As binding forms upon initial contamination and associated ecotoxicological effects on soil invertebrates. Forest soils (0-10 cm depth) were collected from four mountainous sites across Korea with varying physicochemical properties.

Elevated Risk of Postoperative Complications With Non-tobacco Nicotine Use Following Open Reduction and Internal Fixation of Ankle Fractures.

Background: Smoking is a well-established risk factor for postoperative complications following open reduction and internal fixation (ORIF) for rotational ankle fractures. However, the effect of non-tobacco nicotine (NTN) use on these outcomes remains unclear, despite the increasing use of products such as vapes. This retrospective cohort study investigates whether perioperative NTN use is associated with increased postoperative complications following ankle ORIF compared with a nicotine-independent (NI) control group.

Perceptions about the use of Behavioral (Eco)Toxicology to protect human health and the environment.

The One Health concept strongly brings into focus the important connections for human and ecosystem health. However, the incorporation of behaviour method guidelines in risk assessment and regulation/policy is not equal between human and ecological disciplines. A survey was conducted on the perceptions and role of behavioural (eco)toxicology in the protection of the human and ecosystem health.

Medical Screening Beliefs and Behaviors of Physical Therapist Clinical Instructors: An Assessment of Essential Skill Performance and Importance.

Background: Assessing the delivery of medical screening content in entry-level doctor of physical therapy (DPT) educational programs is essential to inform curricula as physical therapists (PTs) are called upon to fill broader roles in the healthcare system. The purpose of this study was to survey clinical instructors (CIs) across three DPT programs as a practice analysis regarding beliefs toward medical screening, the frequency performing medical screening skills, and the importance placed on the skills for their clinical students.

Methods: CIs from three DPT programs were recruited via e-mail to participate in this survey study over a total duration of 4 weeks.

Avoiding Electrocautery: Hemostatic Agents for Perioperative Bleeding in Mohs Micrographic Surgery.

Background: Bleeding remains a frequent complication during Mohs micrographic surgery, particularly among patients receiving anticoagulant or antiplatelet therapy. The growing use of these medications has prompted increased exploration of adjunctive methods to improve perioperative hemostasis.

Objective: To systematically review the literature on topically and locally administered hemostatic agents used to reduce bleeding in Mohs micrographic surgery.

Clinical outcomes and independently adjudicated results of M2 aspiration thrombectomy: a subgroup analysis from the Imperative Trial.

Background: The ESCAPE-MeVO (Endovascular Treatment to Improve Outcomes for Medium Vessel Occlusions) and DISTAL (Endovascular Therapy plus Best Medical Treatment vs Best Medical Treatment Alone for Medium Vessel Occlusion Stroke) trials failed to demonstrate the superiority of endovascular thrombectomy over best medical management for medium and small vessel occlusions. Potential limitations of these trials include older patient populations, lower presenting National Institutes of Health Stroke Scale (NIHSS) scores, higher rates of premorbid disability, delayed revascularization times, inclusion of both medium and small vessel occlusions, and widespread use of stent retrievers. Here we present M2 occlusion data from the Imperative Trial, evaluating aspiration thrombectomy with the Zoom System.

Outcomes from a posttraumatic growth-oriented program among veterans: A quasi-experimental retrospective study.

Objective: The present study is a retrospective quasi-experimental study to evaluate the effectiveness of the Warrior PATHH (WP) program at improving posttraumatic growth (PTG) outcomes and reducing PTSD symptoms compared to a waitlist control among a sample of Veterans.

Method: Participants (n = 164) were U.S.

Perinephric Myxoid Pseudotumor of Fat: A Series of 29 Cases Demonstrating Inconsistent Associations With Underlying Kidney Disease.

Perinephric myxoid pseudotumor of fat (PMPTF) is a recently characterized lesion typically associated with non-neoplastic renal disease. Its pathogenesis is thought to result from chronic renal "irritation," either due to mass effect from renal carcinoma or inflammation related to benign renal conditions. Prompted by several cases arising in the absence of underlying renal pathology, we conducted a multi-institutional study of 29 mass-forming cases with detailed clinical, histologic, and molecular characterization.

Influence of Type 2 Diabetes on the Effects of Tirzepatide in Patients With Heart Failure and a Preserved Ejection Fraction With Obesity: A Prespecified Stratification-Based Analysis.

Background: Incretin-based therapies are used to treat type 2 diabetes and obesity, but the presence of diabetes diminishes the magnitude of weight loss produced by these drugs in people with obesity. It is not known whether this attenuated weight change is relevant to the clinical benefits of these drugs in heart failure.

Objectives: The goal of this study was to assess the influence of diabetes on the efficacy and safety of tirzepatide in the SUMMIT trial.

Antibacterial activity and mechanistic insights of gallium-based nanoparticles: an emerging frontier in metal-based antimicrobials.

The global rise of antimicrobial resistance has intensified the search for novel therapeutic agents that act through non-conventional mechanisms. Gallium-based nanoparticles (GaNPs) represent a promising yet underexplored class of metal-based antimicrobials. Owing to their unique ability to mimic iron(iii), GaNPs disrupt key bacterial metabolic processes, particularly those dependent on iron acquisition and utilization.

Validation of the Learning and Study Strategies Inventory (LASSI) in Doctor of Physical Therapy Learners: A Retrospective Observational Study.

Importance: The Learning and Study Strategies Inventory (LASSI) is an instrument that measures self-regulated learning. However, it has not been validated for use in entry-level Doctor of Physical Therapy (DPT) learners.

Objective: The objective of this study was to investigate the validity and reliability of the LASSI in DPT learners.

A cross-sectional study of demographic variation in health problem-related limitations in life across 22 countries: a cross-national analysis.

Background: Health limitations, defined as problems in life that limit an individual from activities of daily living, have been associated with human flourishing, globally. However, how health problems leading to functional limitations vary across multiple demographic characteristics and how these vary across countries requires additional exploration.

Methods: The Global Flourishing Study is a 5-year longitudinal study of human flourishing among 202,898 individuals across 22 countries.

Vasomotor Symptoms of Menopause, Sympathetic Activity, and Blood Pressure in Postmenopausal Females.

Objectives: While evidence suggests an association between vasomotor symptoms (VMS; hot flushes and night sweats) and elevated blood pressure (BP), it remains unknown whether females who experience VMS have elevated muscle sympathetic nerve activity (MSNA), a major modulator of BP. We hypothesized that postmenopausal females with VMS would have elevated BP and MSNA at rest and during stress compared to age-matched females without VMS.

Methods: Participants were grouped based on whether they currently or previously experienced VMS (n=43) or never experienced VMS (non-VMS; n=26).

Task effectiveness, usability, and acceptability of mHealth technologies among older adults at risk for cardiovascular disease: a feasibility study.

Purpose: New research shows the benefits of mobile health (mHealth) interventions for older adults. However, older adults adopt digital technology less than younger ones. This study measures the task effectiveness, perceived usability, and acceptability of a mHealth intervention (i.

Post-liver transplantation outcomes in acute-on-chronic liver failure: Impact of alcohol as a precipitant and etiology of chronic liver disease.

Background: Acute-on-chronic liver failure (ACLF) has been associated with excellent post- liver transplant (LT) outcomes at one year, however the impact of alcohol as ACLF precipitant, specifically alcohol-associated hepatitis (AH), and as etiology of chronic liver disease (CLD) remains uncertain. This study aimed to assess the effect of alcohol as ACLF precipitant and CLD etiology (alcohol-associated liver disease (ALD) vs. non-ALD) on post-transplant outcomes.

Do obesity and visceral adiposity promote heart failure with reduced ejection fraction?

Obesity or excess visceral adiposity plays a fundamental role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF), but it is not clear that an expanded adipose tissue mass contributes importantly to the evolution and progression of heart failure with reduced ejection fraction (HFrEF). Whereas central adiposity characterizes most patients with HFpEF, obesity was not a remarkable feature of HFrEF in the large-scale trials carried out in the 1980s and 1990s, and studies typically characterized obesity as a protective factor against adverse outcomes. In the general community without apparent heart disease, the finding of obesity or central adiposity precedes and predicts the subsequent occurrence of HFpEF, but not HFrEF.

Comparison of Early Versus Delayed Initiation of Vasopressin in Post-Cardiothoracic Surgery Vasoplegic Shock and the Effect on Post-Operative Atrial Fibrillation.

Post-operative complications of cardiothoracic surgery include vasoplegic shock and post-operative atrial fibrillation (POAF). Use of catecholamines for vasoplegic shock may enhance the risk of POAF; thus, use of non-catecholamine vasopressors is reasonable. This retrospective, single-center cohort study compared early to delayed initiation of vasopressin in vasoplegic shock and assessed the association with POAF.

Army Medic Performance in Trauma Sonography: The Impact of Artificial Intelligence Assistance in Focused Assessments With Sonography in Trauma-A Prospective Randomized Controlled Trial.

Introduction: Noncompressible truncal hemorrhage is a leading cause of preventable death in military prehospital settings, particularly in combat environments where advanced imaging is unavailable. The Focused Assessment with Sonography in Trauma (FAST) exam is critical for diagnosing intra-abdominal bleeding. However, Army medics typically lack formal ultrasound training.

Bayesian variable selection for logistic regression with a differentially misclassified binary covariate.

A Bayesian approach for variable selection is developed for use in models with a misclassified binary predictor variable. We define the main outcome model containing the latent predictor, the measurement model associated with the prevalence of the predictor, and the sensitivity and specificity models of the fallible classifier conditioned on the true value of the predictor. We use binary indicator variables to execute the Gibbs sampler-based variable selection process, and we identify the highest posterior probability model given the data.