98%
921
2 minutes
20
Background: Health limitations, defined as problems in life that limit an individual from activities of daily living, have been associated with human flourishing, globally. However, how health problems leading to functional limitations vary across multiple demographic characteristics and how these vary across countries requires additional exploration.
Methods: The Global Flourishing Study is a 5-year longitudinal study of human flourishing among 202,898 individuals across 22 countries. The purpose of this analysis was to assess the regional and demographic variation of health limitations in life associated with health problems in wave 1 of the Global Flourishing Study. The study explored the distributions and descriptive statistics of key demographic features (age, gender, marital status, employment, religious service attendance, education, immigration status) across and within countries. The following hypotheses were tested: (1) the distributions and descriptive statistics of key demographic factors will reveal diverse patterns across the international sample, (2) the proportions of health limitations will vary meaningfully across different countries, and (3) health limitations will exhibit variations across different demographic categories such as age, gender, marital status, employment, religious service attendance, education, and immigration status. These differences across demographic categories will vary by country.
Results: The proportion of health limitations was greater among older age individuals and those with fewer years of education. Being widowed and retired showed higher proportions of having a health limitation compared to those married and working, respectively. The Philippines (0.34), United Kingdom (0.31), and Germany (0.30) had the highest proportions of health problems, while Israel (0.14), Turkey (0.14), and Poland (0.13) had the lowest.
Conclusions: Understanding key demographic associations of such health problems and daily functioning could help inform policy, programs, and practices aimed at addressing the well-being of individuals who experience health limitations.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406540 | PMC |
http://dx.doi.org/10.1186/s44263-025-00190-6 | DOI Listing |
Nutr Rev
September 2025
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Pomegranate (Punica granatum L) is a rich source of bioactive compounds, including punicalagin, ellagic acid, anthocyanins, and urolithins, which contribute to its broad pharmacological potential. This review summarizes evidence from in vitro and in vivo experiments, as well as clinical studies, highlighting pomegranate's therapeutic effects in inflammation, metabolic disorders, cancer, cardiovascular disease, neurodegeneration, microbial infections, and skin conditions. Mechanistic insights show modulation of pathways such as nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK), alpha serine/threonine-protein kinase (AKT1), and nuclear factor erythroid 2-related factor 2 (Nrf2).
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
University of Nevada, Las Vegas, Las Vegas, NV, United States.
Background: In-hospital cardiac arrest (IHCA) remains a public health conundrum with high morbidity and mortality rates. While early identification of high-risk patients could enable preventive interventions and improve survival, evidence on the effectiveness of current prediction methods remains inconclusive. Limited research exists on patients' prearrest pathophysiological status and predictive and prognostic factors of IHCA, highlighting the need for a comprehensive synthesis of predictive methodologies.
View Article and Find Full Text PDFJMIR Hum Factors
September 2025
Media Psychology Lab, Department of Communication Science, KU Leuven, Leuven, Belgium.
Background: Out-of-hospital cardiac arrests (OHCAs) are a leading cause of death worldwide, yet first responder apps can significantly improve outcomes by mobilizing citizens to perform cardiopulmonary resuscitation before professional help arrives. Despite their importance, limited research has examined the psychological and behavioral factors that influence individuals' willingness to adopt these apps.
Objective: Given that first responder app use involves elements of both technology adoption and preventive health behavior, it is essential to examine this behavior from multiple theoretical perspectives.
Anal Chem
September 2025
Jiaxing Key Laboratory of Molecular Recognition and Sensing, College of Biological and Chemical Engineering, Jiaxing University, Jiaxing 314001, China.
Despite the promise of electrochemical biosensors in amplified nucleic acid diagnostics, existing high-sensitivity platforms often rely on a multilayer surface assembly and cascade amplification confined to the electrode interface. These stepwise strategies suffer from inefficient enzyme activity, poor mass transport, and inconsistent probe orientation, which compromise the amplification efficiency, reproducibility, and practical applicability. To address these limitations, we report a programmable dual-phase electrochemical biosensing system that decouples amplification from signal transduction.
View Article and Find Full Text PDFPurpose: In Armenia, a lower-middle-income country, cancer causes 21% of all deaths, with over half of cases diagnosed at advanced stages. Without universal health insurance, patients rely on out-of-pocket payments or black-market channels for costly immunotherapies, underscoring the need for real-world data to inform equitable policy reforms.
Methods: We conducted a multicenter, retrospective cohort study of patients who received at least one dose of an immune checkpoint inhibitor (ICI) between January 2017 and December 2023 across six Armenian oncology centers.