Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium.

Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain itself. An increasingly popular approach to address this is by combining epigenetic and neuroimaging data; yet, research in this area is almost entirely comprised of cross-sectional studies in adults.

Prenatal exposure to per- and polyfluoroalkyl substances: Association with child behavior in the environmental influences on child health outcomes (ECHO) Cohort.

Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may adversely impact child neurodevelopment; however, epidemiologic findings remain inconclusive because of small sample sizes, limited exposure variability, and differing neurodevelopmental measures. We aimed to investigate the relationship between prenatal PFAS exposure and child behavior.

Methods: We pooled data from nine study sites in the nationwide Environmental influences on Child Health Outcomes (ECHO) Cohort.

The Influence of Social Vulnerability and Race on Diabetes Control.

Context: Social determinants of health (SDoH) and race are both well-established factors that influence diabetes outcomes. However, less is understood about how social vulnerability (SV) and race intersect to impact diabetes control.

Objective: To examine the additive impact of SV and race on diabetes control.

Impact of Population Pharmacogenomics on Cisplatin-Induced Neurotoxicities in Testicular Cancer Survivors.

Background: Cisplatin is a commonly used chemotherapeutic across numerous cancer types that can cause neurotoxicities in patients, including peripheral sensory neuropathy, tinnitus, hearing loss, and vertigo.

Objective: We aimed to evaluate, for the first time, how genetic ancestry impacts cisplatin-induced neurotoxicities and if disparities are related to population differences in allele frequency.

Methods: In a cohort of cisplatin-treated testicular cancer survivors, relationships between genetic ancestry and neurotoxicities, medications, and lifestyle factors were assessed using logistic regression and Kruskal-Wallis tests and multiple pairwise comparisons using the Wilcoxon rank-sum test (Benjamini-Hochberg adjustment).

Leveraging dynamic stability to infer regulation in protein-protein interaction networks: A study of infectious vulnerability in COPD.

The fourth leading cause of death in the US, Chronic Obstructive Pulmonary Disease (COPD) is punctuated by frequent viral and bacterial infections causing severe acute exacerbations (AECOPD) and increased mortality. In previous work we have shown that altered immune cell signaling may confer increased and persistent susceptibility to infection. Here we continue this investigation by conducting broad-spectrum proteomic profiling of circulating white blood cells to assemble an empirical protein-protein interaction network associated with frequency of infectious exacerbation.

Deriving a Theory for Nursing on Uncertainty in Cardiac Inherited Disease: Integrating Self-Organized Criticality and Parse's Human Becoming Theory.

Existential uncertainty dominates the patient experience in cardiac inherited diseases due to unpredictable disease course and the risk of sudden cardiac death. Traditional uncertainty theoretical models inadequately capture the unique facets of uncertainty associated with these diseases. Using Walker and Avant's theory derivation method, an uncertainty theory for nursing practice was developed by adapting concepts from self-organized criticality and grounding them with Parse's Human Becoming Theory within the Unitary Transformative Paradigm.

Evaluating the Effectiveness of Transforaminal Epidural Steroid Injections for Lumbar Radiculopathy Due to a Herniated Nucleus Pulpous Utilizing PROMIS as an Outcome Measure.

Objective: The purpose of this study was to evaluate the effect of transforaminal epidural steroid injection (TFESIs) for patients with lumbosacral radiculopathy secondary to a lumbosacral herniated nucleus pulposus (HNP).

Design: A retrospective review of adult patients who received a fluoroscopically guided TSNRI for a HNP was performed. Patient Reported Outcome Measurement Information System (PROMIS) domains of Physical Function (PF), Pain Interference (PI), and Depression (D) were collected at baseline and post-procedure short-term (1-3 months post-procedure) and long-term follow-up (6-12 months post-procedure).

Prospective assessment of prognostic significance of malignant peritoneal cytology in endometrial cancer: An NRG Oncology / Gynecologic Oncology Group study on GOG-210 protocol.

Objective: To examine the association between malignant peritoneal cytology and survival outcomes in endometrial cancer.

Methods: This was an ancillary analysis of prospectively collected surgical-pathological data in the NRG Oncology / Gynecologic Oncology Group study on GOG-210 protocol. The study population included 2383 patients with stage I-III endometrial cancer from 2003 to 2011.

A Delayed Presentation of a Sinus Venosus Atrial Septal Defect.

Sinus venosus atrial septal defects (ASDs) are rare congenital anomalies that result from an abnormality of the junction between the right atrium, superior vena cava (SVC), and pulmonary veins. This defect causes right-to-left shunting, which can lead to progressive right heart enlargement. We present a case of a 59-year-old man with a history of hypertension and hyperlipidemia who presented with dyspnea and newly diagnosed atrial flutter.

Perinephric Myxoid Pseudotumor of Fat: A Series of 29 Cases Demonstrating Inconsistent Associations With Underlying Kidney Disease.

Perinephric myxoid pseudotumor of fat (PMPTF) is a recently characterized lesion typically associated with non-neoplastic renal disease. Its pathogenesis is thought to result from chronic renal "irritation," either due to mass effect from renal carcinoma or inflammation related to benign renal conditions. Prompted by several cases arising in the absence of underlying renal pathology, we conducted a multi-institutional study of 29 mass-forming cases with detailed clinical, histologic, and molecular characterization.

Blood Clock Correlation Distance (BloodCCD) as a novel marker to detect circadian rhythm disruption in cancer survivors with insomnia.

Background: Insomnia is a toxicity of cancer and treatment for survivors without an objective biochemical measure. Circadian rhythms are 24-h cycles that influence physiologic processes including sleep, and disrupted rhythms may contribute to insomnia. Here, we use BloodCCD to assess circadian rhythms from RNA-sequencing of blood from cancer survivors with insomnia from the YOCAS-II trial.

Severe allergic reaction to contrast dye during emergent coronary angiogram.

We present a case of a middle-aged woman with an extensive history of adverse reactions to iodinated contrast media (ICM) despite premedication. The patient presented from an outside hospital with an ST elevation myocardial infarction in the inferior and anterior leads. She received thrombolytics and was transferred to our hospital.

Annual Hospital Surgical Volume and Patient Medical Complexity Affect Length of Stay for rTSA but not Overall Risk of Complications Following TSA, rTSA and Revision TSA.

Introduction: Total shoulder arthroplasty (TSA) volume has significantly increased over the last several decades, especially in the outpatient setting. Performing TSA in lower volume hospital facilities may offset demand, especially when treating medically complex patients. The purpose of this study is to assess the association of annual hospital volume and patient medical complexity with postoperative complications, readmissions, and length of stay in patients undergoing TSA, rTSA, and revision TSA.

The expanding application of geospatial research methods within emergency medicine.

Geographic information system (GIS)-driven research, while relatively early in its tenure, has already reconceptualized the kinds of questions vetted by the Emergency Medicine (EM) researcher. This narrative review provides an overview of geographic information systems and identifies and discusses specific papers with differing methodologic approaches within the published GIS-driven EM literature. GIS applications within three discrete threads of inquiry are described: Access to Health Services, Spatial Epidemiology, and Proactive Resource Allocation.

Real World Data Identifies Care Needs in Adolescent and Young Adult Patients with Lymphoma: A Matched Cohort Study.

Adolescent and young adult (AYA) cancer patients have unique nononcologic challenges compared to adult and pediatric counterparts. National guidelines highlight unmet care needs in mental, physical, and sexual/reproductive health domains. We present a single institution retrospective matched cohort study exploring the feasibility of using electronic medical record (EMR) to identify nononcologic domains correlating to unmet care needs in AYA patients with lymphoma compared with matched controls.

The current landscape of single-port robotic surgery in urology.

The advent of the purpose-built da Vinci single-port robotic platform marks a pivotal advancement in minimally invasive urological surgery. Designed to overcome the ergonomic and technical limitations of prior single-site approaches, the single-port system enables complex procedures through a single incision, with enhanced dexterity, optimized use of confined spaces and improved cosmetic and peri-operative outcomes. The single-port system has been increasingly used across a wide range of urological indications, including robot-assisted radical prostatectomy, partial nephrectomy, nephroureterectomy and reconstructive surgeries such as pyeloplasty and ureteral re-implantation.

Patterns of Childhood Maltreatment and Intimate Partner Violence: Associations with Prenatal Depression and Anxiety.

Purpose: Childhood maltreatment (CM) and intimate partner violence (IPV) are two deleterious relational experiences that have significant negative consequences during the prenatal period. The current study had two aims: a) use person-centered analyses to identify classes of pregnant individuals based on exposure to different types of CM and IPV and b) examine the associations between patterns of CM, IPV, prenatal anxiety and prenatal depression symptoms.

Methods: Participants were a majority Black sample of 222 pregnant individuals who completed self-report measures of CM, IPV in the last year, depression and anxiety.

Safety and Feasibility of Serial Lumbar Punctures: Long-term Results from the Parkinson's Progression Markers Initiative.

Background: Cerebrospinal fluid (CSF) serves an essential role in biomarker research. New Parkinson's disease (PD) classifications incorporate CSF α-synuclein status into trial design. This study evaluated the safety and feasibility of serial CSF collection in participants enrolled in the Parkinson's Progression Markers Initiative (PPMI).

Cellular and Molecular Architecture of Renin-Angiotensin System Signaling in the PVN Under Cardiometabolic Stress.

The hypothalamic paraventricular nucleus (PVN) integrates neuroendocrine and autonomic signals that regulate blood pressure and metabolism. Although the renin-angiotensin system (RAS) is implicated in neurogenic hypertension and obesity, cell-type-specific expression and regulation of its components within the PVN remain poorly understood. Here, we employed single-nucleus RNA sequencing (snRNA-seq) to profile the transcriptomic landscape of the PVN in male mice under baseline conditions and in models of DOCA-salt-induced hypertension and high-fat diet (HFD)-induced obesity.

Associations between enroller demographics and participant enrollment into an emergency department-based cancer prevention trial.

Background: Inadequate diversity among clinical trial participants threatens external validity. Potential explanations for disparities in participation include staff bias, lack of access to studies, and racial discordance between staff and patients.

Objectives: We examined associations between patient and enroller demographics and enrollment into a randomized controlled trial (RCT) on cancer screening among Emergency Department (ED) patients.

Cerebrospinal fluid flow modulates brain health.

Cerebrospinal fluid dynamics play an important role in maintaining brain health and clearing metabolic waste from the brain. In this issue of the JCI, Gursky et al. investigate how CSF distribution is affected when its primary efflux pathway - the deep cervical lymph nodes - is disrupted by cauterization.

CRIF counteracts oncogenic Ras and regulates heterochromatin.

Oncogenic Ras mutations are prevalent in human cancers, yet the mechanisms by which Ras promotes tumorigenesis remain incompletely understood. In Drosophila, oncogenic Ras (Ras) induces tissue overgrowth and metastasis, but the cellular restraints it must overcome are unclear. We have identified Drosophila CRIF, the homolog of mammalian CR6-interacting factor 1 (CRIF1), as a modifier of Ras-induced lethality and Ras-induced overgrowth and cell proliferation.