The effect of oral belzutifan on retinal hemangioblastomas in von Hippel-Lindau syndrome.

Objective: To assess the effect of belzutifan, a first-in-class oral hypoxia-inducible factor 2α inhibitor, on retinal hemangioblastoma (RH) outcomes.

Subjects/methods: This is a single-centre retrospective cohort study of patients with confirmed von Hippel-Lindau syndrome (VHLS) and RH. Subjects were taking oral belzutifan for renal cell carcinoma, central nervous system hemangioblastoma, or pancreatic neuroendocrine tumours.

Perinatal depressive symptoms and child temperament at two years: The moderating role of child sleep duration.

Background: Perinatal depression has been linked to higher negative affectivity (NA) in children, though the strength of this association is variable. Infant sleep, a known protective factor, may moderate this relationship though this has not been tested.

Objective: To examine whether within-person changes in depressive symptoms across pregnancy and postpartum were linked to child NA, and whether infant sleep duration moderated these effects.

The Role of the Midbrain Tegmentum in the Regulation of Breathing Patterns in Carp (Cyprinus carpio) and Trout (Onchorhynchus mykiss).

In vertebrates, the basic respiratory rhythm is modified by both sensory feedback and input from higher centers to produce a broad range of breathing patterns. In carp (Cyprinus carpio L.), breathing is often episodic while in trout (Onchorhynchus mykiss) it is continuous and rhythmic except when water is hyperoxic.

Clinical Phenotype, Predictors and Early Biomarkers of Dyskinetic Cerebral Palsy Prognosis.

Background: Dyskinetic cerebral palsy (DCP) is a severe subtype of cerebral palsy in which children often present substantial functional impairment and multiple comorbidities. Our knowledge of the clinical picture of DCP is limited and our understanding of which markers best predict later impairment is scarce. This study aims to describe the presentation of DCP and examine the value of gestational age (GA) and magnetic resonance imaging (MRI) findings as early markers of eventual DCP prognosis.

Perspectives on Accessing Mental Health Supports for Youth Living With Post-Traumatic Stress Symptoms After a Solid Organ Transplant.

Background: Many children and adolescents who undergo solid organ transplants (SOT) develop post-traumatic stress (PTS) symptoms. Despite its prevalence and strong association with long-term impairments in quality of life, PTS is often overlooked as a major co-morbidity in many transplant programs. To address this unmet need, the purpose of this study was to explore the factors that impede or facilitate awareness of PTS, access to resources, and readiness to engage with mental health services.

Omics Insights Into the Effects of Highbush Blueberry and Cranberry Crop Agroecosystems on Honey Bee Health and Physiology.

Honey bees (Apis mellifera) are vital pollinators in fruit-producing agroecosystems like highbush blueberry (HBB) and cranberry (CRA). However, their health is threatened by multiple interacting stressors, including pesticides, pathogens, and nutritional changes. We tested the hypothesis that distinct agricultural ecosystems-with different combinations of agrochemical exposure, pathogen loads, and floral resources-elicit ecosystem-specific, tissue-level molecular responses in honey bees.

Impact of Population Pharmacogenomics on Cisplatin-Induced Neurotoxicities in Testicular Cancer Survivors.

Background: Cisplatin is a commonly used chemotherapeutic across numerous cancer types that can cause neurotoxicities in patients, including peripheral sensory neuropathy, tinnitus, hearing loss, and vertigo.

Objective: We aimed to evaluate, for the first time, how genetic ancestry impacts cisplatin-induced neurotoxicities and if disparities are related to population differences in allele frequency.

Methods: In a cohort of cisplatin-treated testicular cancer survivors, relationships between genetic ancestry and neurotoxicities, medications, and lifestyle factors were assessed using logistic regression and Kruskal-Wallis tests and multiple pairwise comparisons using the Wilcoxon rank-sum test (Benjamini-Hochberg adjustment).

Pridopidine in early-stage manifest Huntington's disease: a phase 3 trial.

Huntington's disease (HD) is a rare, neurodegenerative disorder for which only symptomatic treatments are available. The PROOF-HD study was a randomized, double-blind, placebo-controlled phase 3 trial evaluating the efficacy and safety of pridopidine, a selective Sigma-1 receptor agonist, in HD. The primary and key secondary endpoints, change in total functional capacity (TFC) and composite Unified Huntington's Disease Rating Scale (cUHDRS) score at week 65, were not met in the overall population.

Antibiotic exposure and drug-induced intracranial hypertension: a systematic review and meta-analysis.

Background/objectives: Drug-induced intracranial hypertension (DIH) is a rare condition that has been associated with several risk factors, including exposure to certain medications. Herein, we synthesised the literature-pooled quantitative risk of developing DIH with antibiotics use.

Subjects/methods: Medline, Embase, and Cochrane Library were searched (inception to June 2024).

Impact of non-surgical OR time on efficiency and costs with Hugo™ RAS.

Robot-assisted surgery is increasingly preferred. New systems such as the Hugo™RAS enter the market, offering different pricing and modular architecture. While daVinci systems dominate U.

Early preschool wheeze trajectories are predominantly non-allergic with distinct biologic and microbiome traits.

Background: Disentangling preschool wheezing heterogeneity in terms of clinical traits, temporal patterns, and collective healthcare burden is critical for precise and effective interventions.

Objective: We aimed to collectively define contributions and distinct characteristics of respiratory phenotypes based on longitudinal wheeze and atopic sensitization patterns in the first 5 years of life.

Methods: Group-based trajectory analysis was performed in the CHILD Cohort study to identify distinct wheeze and allergic sensitization trajectories.

From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony.

While current stem cell differentiation protocols generate β cell-enriched islets that reverse hyperglycemia post-implantation, they can cause hypoglycemia. Meng et al. reconstruct endocrine subtype-complete islets, which restore counterregulatory responses and protect against hypoglycemia in diabetic mice, highlighting the importance of endocrine diversity in designing physiologically regulated cell therapies for diabetes.

The OTTER framework: Willful ignorance as the greatest barrier to allyship at work and five steps to overcome it.

Despite growing equity, diversity, and inclusion (EDI) efforts in organizations, many socially advantaged individuals remain inactive as potential allies. To understand why, the present article introduces willful ignorance-the conscious avoidance of knowledge about inequality-as a core psychological barrier to allyship. Reviewing and synthesizing insights from existing research, we show how two forms of willful ignorance manifest at work (passively overlook among the "left" and actively turn away among the "right" on the ideological spectrum) and propose the OTTER framework to address them: Observe, Think, Talk, Examine, and Reorient.

Triggered: Qualitatively exploring structural and social drivers of firearm violence exposure among LGBTQ+ young adults of color in Detroit.

Firearm violence is a leading cause of injury and death among youth and young adults in the U.S. with notable inequities across race and ethnicity, geography, and gender.

Leveraging port state measures to combat illegal, unreported, and unregulated fishing.

Illegal, unreported, and unregulated (IUU) fishing threatens the sustainability of fisheries and communities dependent on them. The Port State Measures Agreement (PSMA) is a key tool for combatting IUU fishing by foreign fleets, requiring standardized inspections, information sharing, and port denial. Using satellite data, we characterized how PSMA has affected high seas vessel behavior and identify opportunities to strengthen its impact.

TBX3 advances the developmental chromatin landscape toward the hepatic fate.

By mapping histone modifications in a human stem cell model of hepatic differentiation, we identified an enhancer landscape that is dynamic and stage specific, with many primed at the definitive endoderm stage. While hepatic enhancers gained active histone modifications, non-hepatic enhancers lost H3K4me1 after hepatic specification. T-box transcription factor 3 (TBX3) was found to bind to hepatic enhancers and promoters.

The Organization of Central Retinal Projections in Anna's Hummingbirds (Calypte anna) and Zebra Finches (Taeniopygia castanotis).

Hummingbirds (family Trochilidae) are easily recognized due to their unique ability to hover. Critical to hovering flight is head and body stabilization. In birds, stabilization during flight is mediated, among other things, by the detection of optic flow, the motion that occurs across the entire retina during self-motion.

Using eDNA tools to examine the impact of kelp farming on underlying sediments.

Using environmental DNA (eDNA)-based tools, we examined sediments underlying a ~ 1.25 hectare commercial kelp farm in the Gulf of Maine growing sugar kelp (Saccharina latissima) for two farming seasons, post-harvest. Two eDNA methods were used: a newly designed S.

The Risk of Rheumatic Disorders Among Patients With Rhinosinusitis: A Systematic Review and Meta-Analysis.

Background: Emerging evidence suggests a possible link between rhinosinusitis and systemic rheumatic diseases; however, no meta-analysis has comprehensively examined this association to date. We aimed to investigate if patients with rhinosinusitis have a predisposition to unmasking rheumatic diseases compared to individuals without rhinosinusitis.

Methods: A comprehensive search in MEDLINE, Embase, Cochrane Library, and Web of Science was conducted until February 2025 for studies characterizing rheumatic disease incidence, prevalence, and risk in cohorts of rhinosinusitis patients.

A provincial survey of patient experiences while receiving care from pharmacists in team-based primary care in British Columbia, Canada.

Introduction: The Pharmacists in PCN Program integrated primary care clinical pharmacists as a core members of the interprofessional team in Primary Care Networks (PCNs) across British Columbia (BC), Canada. Patient experiences after receiving care from pharmacists in a team-based primary care setting have not been extensively studied.

Aim: To describe patient experiences while receiving care from a pharmacist as a member of the interprofessional team in PCNs across BC.

Reducing post-cesarean sepsis: Current best practice in prevention and treatment.

Cesarean section is the most common surgical procedure performed worldwide. It is associated with good perinatal and maternal outcomes when indicated. The rising global cesarean birth rate has coincided with an increase in post-cesarean sepsis - specifically site infections, which have an incidence of 7% worldwide.

Metabolomics reveal distinct molecular pathways associated with future risk of Crohn's Disease.

Host - microbiome interactions are central to Crohn'sdisease (CD) pathogenesis; yet the early metabolic alterations that precededisease onset remain poorly defined. To explore preclinical metabolicsignatures of CD, we analyzed baseline serum metabolomic profiles in a nestedcase-control study within the Crohn's and Colitis Canada - Genetics, Environment, Microbiome (CCC-GEM) Project, a prospective cohort of 5,122 healthyfirst-degree relatives (FDRs) of CD patients. We included 78 individuals wholater developed CD and 311 matched FDRs who remained disease-free.