Parent and practitioner experiences of opt-out consent in neonatal intensive care: a mixed methods study within a trial.

Background: In neonatal trials, verbal opt-out consent has been used to reduce burden on families and make recruitment more efficient and representative. It involves information provision through posters and leaflets before randomisation, and parents can verbally 'opt out' of their baby being randomised to the trial. There is limited understanding of how opt-out consent is operationalised in a multicentre neonatal trial, and its acceptability to staff and parents.

Correction: The auditory outcomes in non-blast related traumatic brain injury and the role of severity, aetiology and gender: a scoping review.

[This corrects the article DOI: 10.3389/fneur.2025.

Use of a shared decision-making intervention to support treatment decision-making for patients following an anterior cruciate ligament rupture: a mixed methods feasibility study.

Objectives: To understand feasibility, acceptability and indicators of effectiveness of a shared decision-making (SDM) intervention with patients following an anterior cruciate ligament (ACL) rupture.

Design: Non-randomised feasibility study with embedded qualitative interviews.

Setting: Orthopaedic and physiotherapy service at an acute National Health Service (NHS) Teaching Hospital in the Midlands, UK, between 29 January and 5 June 2024.

Hybrid closed-loop systems in UK type 1 diabetes care: National survey of healthcare professional awareness, confidence, and training needs.

Aims: Hybrid closed-loop (HCL) systems significantly improve glycaemia and have become the standard of care for type 1 diabetes (T1D), leading to the recent widescale implementation programme in England and Wales. Limited data exist regarding UK healthcare professionals' (HCPs) confidence and experience with commercially available HCL systems. This survey aimed to evaluate UK HCPs' awareness, confidence, and training needs concerning commercial HCL systems.

Comparing Cystatin C Estimated GFR With Creatinine Estimated GFR in Acute Kidney Injury Recovery.

Introduction: Current guidelines recommend creatinine-based estimated glomerular filtration rate (eGFRcr) to assess kidney recovery after acute kidney injury (AKI); however, this may be inaccurate because of loss of muscle mass. Cystatin C-based eGFR (eGFRcys) is an alternative that is not similarly affected. In addition, simple calculations (e.

International expert consensus on a structured approach to robotic multiport right hemicolectomy with complete mesocolic excision and intracorporeal anastomosis.

Aim: To develop and operationally define 'performance metrics' that characterize a reference approach to robotic multiport right hemicolectomy with complete mesocolic excision (CME) and intracorporeal anastomosis (ICA) and to obtain evidence supporting face and content validity through a consensus meeting.

Method: Three expert colorectal surgeons with advanced minimally invasive surgical experience, a senior behavioural scientist and a colorectal surgeon with experience in performance metrics development formed the Metrics Group. Published guidelines, clinical evidence, training materials and unedited videos of robotic multiport right hemicolectomy were used to deconstruct the task-robotic right hemicolectomy with CME and ICA-into defined, observable performance units or metrics (i.

The impact of radiotherapy on trials of axillary management in early breast cancer.

The presence of metastatic disease in the axillary lymph nodes is one of the most important prognostic factors in early breast cancer but the management of the clinically and radiologically negative axilla (cN0) with positive nodes following sentinel lymph node biopsy (SLNB) is still a matter of debate. The presence of nodal macrometastases (>2mm) is often regarded as an indication for axillary lymph node dissection (ALND) but randomised studies have reported no benefit for ALND in terms of locoregional recurrence (LRR) or survival with a significant risk of long term arm lymphoedema. As a consequence, many centres offer axillary radiotherapy (ART) but as to whether this is required in patient with low burden axillary disease (1-2 involved nodes) is still debatable.

The prognosis of pain and function in people with hand and thumb base osteoarthritis: a systematic review.

Background: This systematic review has summarized evidence regarding the course of hand pain, hand function, and prognostic factors that predict changes in symptoms in people with hand and thumb base osteoarthritis.

Methods: A systematic search of electronic databases was conducted for longitudinal studies on hand osteoarthritis. Two reviewers assessed eligibility quality appraisal, and extracted data on pain, function and prognostic factors.

Real World Multi-centre UK Review of Nivolumab Monotherapy in Metastatic Endometrial Cancer With Mismatch Repair Deficiency During COVID-19.

Introduction: Immunotherapy checkpoint inhibition has shown improvement in efficacy and survival in patients with mismatch repair deficient (MMRd) advanced endometrial cancer (mEC) compared to chemotherapy. This is combined with chemotherapy in the first-line setting or as monotherapy in later lines of therapy.

Objective: To assess the efficacy, survival and toxicity of nivolumab monotherapy in metastatic endometrial cancer (mEC) in both first and later lines of therapy as used in the NICE COVID-19 systemic anti-cancer (SACT) guidelines.

Frailty and femoral periprosthetic fractures around the hip: outcomes in nonagenarians.

Objective: To present the clinical outcomes of patients above 90 years of age admitted with periprosthetic fractures around hip.

Methods: This was a retrospective study, of prospectively collected data, including patients treated at a single institution during 2014 to 2024. Data were assessed for fractures type, mode of treatment, time to surgery, length of stay, post-op complications, discharge destination, reoperation, and 30-day and 12-month mortality.

The auditory outcomes in non-blast related traumatic brain injury and the role of severity, aetiology and gender: a scoping review.

Introduction: Traumatic brain injury (TBI) can cause a wide range of auditory outcomes. This review aimed to investigate common auditory outcomes associated with TBI and explore variations based on severity, aetiology, and gender.

Methods: A scoping review was conducted using an established methodological framework, which involved electronic and manual searches of databases and journals.

Management of ileocolic anastomotic strictures in Crohn's disease: endoscopic or surgical intervention? A systematic review and meta-analysis.

Background: Intestinal strictures are one of the most intractable and common complications of Crohn's disease (CD), and their optimal management remains debatable. Endoscopic balloon dilatation (EBD) and stricturoplasty are advanced minimally invasive therapeutic tools in the management of Crohn's strictures and offer an alternative to surgery. We evaluated outcomes following endoscopic intervention compared with surgical resection in the management of ileocolic anastomotic strictures in patients with CD.

Description of probiotic use in preterm infants in England and Wales 2016-2022.

Objective: To describe the use of probiotics among preterm infants in neonatal units and explore factors that influence exposure.

Design: Observational study using prospectively recorded health data.

Setting: England and Wales.

Adoption of nonwire localisation devices in UK breast units: an iBRA-NET survey to assess changes in practice.

Introduction: A national practice questionnaire in 2020 collected data from UK breast surgeons on breast localisation device use, and found that wires were used most frequently. The current study aimed to assess the change in device use since the previous questionnaire, impact on logistics and clinician feedback.

Methods: The 2020 national questionnaire was repeated, as well as adding qualitative questions to elicit themes important to clinicians in differentiating between the quality of localisation device experience.

Continuous glucose monitoring and automated insulin delivery systems in the management of diabetes among individuals with chronic kidney disease on dialysis.

Purpose Of Review: To describe the current evidence and emerging role of continuous glucose monitoring (CGM) and automated insulin delivery (AID) systems in the management of diabetes among individuals with advanced chronic kidney disease (CKD) undergoing dialysis.

Recent Findings: Recent studies have shown that CGM provides accurate and clinically useful glucose data in people with advanced CKD requiring dialysis. CGM enables the detection of glycaemic variability and hypoglycaemia patterns that are often missed by traditional monitoring methods, such as capillary blood glucose testing and haemoglobin A1c.

Calcific tendonitis of the shoulder; when should we operate?

Introduction: This study aimed to determine patient factors associated with the failure of nonoperative management of calcific tendonitis and subsequent operative intervention. The secondary aim was to assess whether the size of the calcific deposit can determine the need for surgery, as shown by previous studies in the literature.

Methods: A retrospective review of a prospectively maintained database of a consecutive series of patients diagnosed with calcific tendonitis attending a single hospital trust orthopaedic department between 2014 and 2018 was performed.

Cognitive impairment and health outcomes in non-dialysis chronic kidney disease: a systematic review and meta-analysis.

Background: Cognitive impairment is prevalent in individuals with chronic kidney disease (CKD), but its effects on health outcomes remain unclear. While cognitive impairment can affect self-management, its role in CKD has been insufficiently explored. This systematic review aimed to examine the association between cognitive impairment and health outcomes or self-management ability among persons with CKD.

Concordance of molecular microbiology and conventional culture techniques for infected diabetic foot ulcer management.

Aim: The management of infected diabetic foot ulcers (DFUs) requires balancing the need for timely interventions against the desire for targeted antibiotic therapy, which relies on laboratory results. This study aimed to evaluate concordance between molecular and conventional culture and sensitivity (C&S) methods in identifying bacteria from infected DFUs.

Methods: This study was conducted alongside CODIFI2, a Phase III randomised controlled trial comparing tissue sampling with wound swabbing.

Effect of haemodialysis on the brain and heart assessed using multiparametric MRI.

Background And Hypothesis: Haemodialysis (HD) patients often develop cognitive impairment, negatively impacting health-related quality of life. We use brain magnetic resonance imaging (MRI) measures to study the acute changes in cerebral water content during HD, alongside chronic changes in HD patients compared to healthy volunteers (HV) to assess whether the brain changes associated with ageing develop more rapidly in HD patients ('accelerated brain ageing'). We also study associated cardiac MRI measures.

Diagnostic Value of Swallow Tail Sign at Brain MRI in Patients with Clinically Uncertain Parkinsonian Syndrome.

Background Striatal dopaminergic deficits, established with iodine 123-2β-carbomethoxy-3β-(4-iodophenyl)--(3-fluoropropyl)-nortropan (I-FP-CIT) SPECT, support the diagnosis of Parkinson disease (PD) or atypical parkinsonian syndrome in clinical uncertainty. The swallow tail sign (STS) at susceptibility-weighted (SW) MRI helps differentiate patients with PD from controls, but its utility in clinically uncertain parkinsonian syndromes remains unclear. Purpose To compare the diagnostic performance of STS absence at SW MRI in diagnosing PD with that of I-FP-CIT SPECT in participants with clinically uncertain parkinsonian syndrome.

Quantifying association of early proteinuria and estimated glomerular filtration rate changes with long-term kidney failure in C3 glomerulopathy and immune-complex membranoproliferative glomerulonephritis using the United Kingdom RaDaR Registry.

Introduction: C3 glomerulopathy (C3G) and immune-complex membranoproliferative glomerulonephritis (IC-MPGN) are rare disorders that frequently result in kidney failure over the long-term. Presently, there are no disease-specific treatments approved for these disorders, although there is much interest in the therapeutic potential of complement inhibition. However, the limited duration and necessarily small size of controlled trials means there is a need to quantify how well short-term changes in estimated glomerular filtration rate (eGFR) and proteinuria predict the clinically important outcome of kidney failure.

Injury surveillance in The FA Walking Football Cup 2024.

Walking Football is an adaptation of Association Football, played primarily by middle-aged and older adults, with rule changes to enhance accessibility. Sport participation poses injury risks, yet the risk of injury in Walking Football has not been established. This study quantifies injury incidence, estimates injury burden, and examines injury characteristics.