A new soft sensing method based on serial-parallel GRU with self-attention mechanism for complex multi-unit industrial processes.

With the deep digital transformation of traditional manufacturing industry and the continuous automation level improvement of production lines, it is more important to predict the Key Performance Indicators (KPIs) of processes in a timely and accurate manner. The traditional laboratory destructive test method for obtaining KPIs consumes a large amount of time and incurs high costs, which not only fails to provide timely and effective guidance for production processes but also results in significant losses for manufacturing enterprises. To address these issues, an online prediction soft sensor model for KPIs based on a serial-parallel gated recurrent unit with self-attention mechanism (SPGRU-SA) soft sensor model is proposed.

Multiomics approach to evaluating personalized biomarkers of allergen immunotherapy.

Recent advancements in genomics and "omic" technologies have ushered in a transformative era referred to as personalized or precision medicine. This innovative approach considers the unique genetic profiles of individuals, along with a range of variability factors, to devise tailored disease treatments and prevention strategies that cater to the distinct needs of each patient. Although the terms personalized medicine and precision medicine are frequently utilized interchangeably, it is essential to delineate the subtle distinctions between them.

Stable apelin-13 analogues promote cell proliferation, differentiation and protect inflammation induced cell death.

Emerging evidence indicates that apelin, an adipokine, plays a critical role in numerous biological functions and may hold potential for therapeutic applications; however, its efficacy is constrained by rapid plasma degradation. Thus, the search for novel apelin analogues with reduced susceptibility to plasma degradation is ongoing. We have previously shown novel modified apelin-13 analogues, providing exciting opportunities for potential therapeutic development against Alzheimer's disease.

Viral load differences associated with infection outcomes and resistance to white spot syndrome virus (WSSV) infection in mud crab, Scylla serrata.

White spot syndrome virus (WSSV), the causative agent of white spot disease, remains a serious threat to crustacean aquaculture. Infecting a wide range of crustaceans, host species exhibit varying susceptibility and mortality rates. Mud crabs, Scylla serrata, a high-value aquaculture commodity across the Indo-Pacific region, are known to be relatively resistant to WSSV.

Sensitivity of the Patient-Health Questionnaire (PHQ-9) items to change in three clinical trials in low- and middle-income countries.

Background: The 9-item Patient Health Questionnaire (PHQ-9) is a valid and widely used self-reported tool for assessing depressive symptoms. Although previous studies have demonstrated its sensitivity to change at the summary score level, there is limited investigation of the sensitivity of individual PHQ-9 items to change over time. This study aims to evaluate the sensitivity of PHQ-9 items to change using data from three separate samples.

Slow wave sleep is associated with a reorganisation of episodic memory networks.

Models of memory consolidation propose that newly acquired memory traces undergo reorganisation during sleep. To test this idea, we recorded high-density electroencephalography (EEG) during an evening session of word-image learning followed by immediate (pre-sleep) and delayed (post-sleep) recall. Polysomnography was employed throughout the intervening night, capturing time spent in different sleep stages.

Predicting Treatment Response in Retinal Vein Occlusions Using Baseline Optical Coherence Tomography Biomarkers: A Systematic Review.

This systematic review examines the prognostic value of baseline optical coherence tomography (OCT) biomarkers in predicting visual acuity (VA) outcomes for eyes with macular edema secondary to retinal vein occlusions (RVO) treated with anti-VEGF therapies, steroids, laser photocoagulation, or combination treatments. VA predictions at 6, 12, and 24 months post-treatment were assessed using a narrative synthesis approach and vote counting based on effect direction relative to a minimal clinically important difference. Certainty of evidence was evaluated using GRADE guidelines.

Overview of evidence synthesis types and modes.

Background And Objectives: Evidence syntheses systematically compile and analyze information from multiple sources to support health care decision making. As many different types of questions need to be answered in health care, different evidence synthesis types have emerged. In this article, we introduce the most common types of evidence synthesis.

E2027 (irsenontrine), a phosphodiesterase 9 inhibitor, enhances cholinergic function when combined with donepezil hydrochloride.

Phosphodiesterase 9 (PDE9) is an enzyme that hydrolyzes cyclic guanosine monophosphate (cGMP)-a second messenger that regulates neuronal plasticity and memory function. PDE9 inhibition has been shown to enhance cognitive function in rodents, underlining the potential of PDE9 inhibitors (PDE9Is) as novel therapeutics for cognitive dysfunction. Considering the critical role of nitric oxide (NO)-cGMP signaling cascade in acetylcholine (ACh) release, the combination of PDE9Is and acetylcholinesterase inhibitors may synergistically elevate ACh levels in the brain.

The Evidence for Biomechanical and Physiological Parameters as Biomarkers to Discriminate Between Individuals With and Without Non-specific Neck Pain Using Sensor Devices: A Systematic Review with Meta-analysis.

Neck pain is among the most prevalent musculoskeletal conditions worldwide. The underlying cause mostly remains unidentified, classified as non-specific neck pain. Pain can alter movement patterns and physiological responses, suggesting that certain biomechanical and physiological changes may serve as objective biomarkers for non-specific neck pain.

The good, the bad, and the successful: The Three Nightmare Traits and career success.

The Three Nightmare Traits (TNT; disagreeableness, carelessness, and dishonesty; aka the Three Nonnormative Traits) represent low levels of socially desirable self-control, i.e., unsuccessful socialization.

Boat noise alters behaviour of two coral reef macroinvertebrates, Lambis lambis and Tridacna maxima.

Boat noise has been shown to distract and cause harm to many marine organisms. Most of the study effort has focused on fish & marine mammals, even though invertebrates represent over 92 % of all marine life. The few studies conducted on invertebrates have demonstrated clear negative effects of anthropogenic noise pollution.

Effects of electromagnetic fields on flatfish activity levels.

The offshore renewable energy industry is expanding rapidly due to decarbonisation commitments and need for energy security. This will change the marine environment in ways that are not fully understood, including more subsea power cables in the sea. Movement of electricity through these cables generates an electromagnetic field (EMF), which might affect marine species.

Chemical alteration of UO micro-particles in model lung systems.

Uranium dioxide (UO) particles can be released from mines, nuclear fuel manufacturing, reactor accidents, and weapons use. They pose inhalation risks, yet their behavior in the human lung remains poorly understood. This study investigates the long-term chemical alteration and dissolution of µm-sized UO particles in two model lung fluids: Simulated Lung Fluid (SLF) and Artificial Lysosomal Fluid (ALF), representing extracellular and intracellular lung environments, respectively.

Effect-based and (non-)target chemical analyses reveal concerning levels of emerging contaminants in urban streams in Sub-Saharan Africa.

Water contamination by micropollutants is a global issue, yet there is limited information from low-income regions. To address this, we evaluated surface water quality in rapidly growing Sub-Saharan area of Malawi lacking wastewater treatment. Integrated assessment of passive sample extracts representing wet and dry seasons combined effect-based approach with in vitro bioassays, target and non-target chemical analyses (NTS).

The impact of human papillomavirus (HPV) vaccination on the risk of adverse obstetric outcomes: a data linkage study.

Background: Human papillomavirus (HPV) vaccination has reduced rates of cervical cancer. Research suggests that women with HPV, precancerous disease, and prior invasive treatments are at increased risk of preterm birth. This study aimed to determine if there is a reduction in adverse obstetric outcomes for HPV vaccinated women.

A qualitative exploration of parents' experiences of infant and toddler sleep and feeding during the United Kingdom COVID-19 lockdown(s).

COVID-19 restrictions had a significant impact on family life, including daily activities and routines. This study aimed to explore the impact of the COVID-19 pandemic on children's sleep and feeding behaviours, through undertaking reflexive thematic analysis of parents' open-text box responses to survey questions related to their child's sleep and feeding practices during COVID-19 restrictions. Six hundred and ninety one parents of children aged 0-24 months old who were living in the United Kingdom completed an online questionnaire between 14th December 2020 and 15th January 2021.

Atypical complications and co-morbidities of type 1 diabetes in young adults.

Aims: Our review aimed to determine the prevalence of - and factors associated with - hearing loss, oral and olfactory disease, frozen shoulder, trigger finger, and hair loss in young adults with type 1 diabetes. These conditions were selected based on research team interests, existing literature, and group discussion.

Methods: We conducted a quantitative narrative review using a systematic process to identify cohort and cross-sectional studies involving young adults with type 1 diabetes (mean age 18-30 years).