Multifunctional FeO mesocrystals for cancer therapy: integrating hyperthermia and targeted drug delivery.

Mesocrystals with hierarchical architecture and crystallographically aligned nanoparticles hold immense potential for advanced applications in catalysis, energy storage and biomedicine. However, challenges arise for biomedical applications due to their surfactant-controlled growth, lack of understanding of magnetic mesocrystals and their dopant effect. Herein, we report a facile, additive-free solvothermal synthesis of FeO mesocrystals (∼205 nm) and investigate their morphological evolution by correlating the structural changes with respect to magnetic properties.

Rombus-shaped α-Fe₂O₃ nanoparticles for antibacterial and anticancer applications.

Background: The increasing incidence of bacterial infections in cancer patients, combined with the growing limitations of conventional antibiotics such as poor site-specific targeting and antibiotic resistance, necessitates the development of advanced therapeutic strategies.

Methodology: Rhombus-shaped α-Fe₂O₃ nanoparticles (NPs) were synthesized via hydrothermal route and characterized for their structural, optical, and morphological properties. Lymecycline was encapsulated into NPs, and its pH-dependent release was assessed.

Calcific tendonitis of the shoulder; when should we operate?

Introduction: This study aimed to determine patient factors associated with the failure of nonoperative management of calcific tendonitis and subsequent operative intervention. The secondary aim was to assess whether the size of the calcific deposit can determine the need for surgery, as shown by previous studies in the literature.

Methods: A retrospective review of a prospectively maintained database of a consecutive series of patients diagnosed with calcific tendonitis attending a single hospital trust orthopaedic department between 2014 and 2018 was performed.

A Next-Generation Human Lymphatic Filariasis Vaccine Candidate, rHAXT, for Clinical Development.

This study was conducted to yield a robust and scalable manufacturing process for a candidate vaccine for human lymphatic filariasis (LF) - a tropical parasitic infection transmitted by mosquitoes. In previous studies, we demonstrated that removing an affinity purification tag from the fusion protein did not affect immunogenicity or vaccine efficacy. During scaled-up production of rHAXT, we noticed that significant amounts of the antigen aggregated, resulting in the loss of purified vaccine antigens.

Rhenium(I)-Based Tetranuclear Metallorectangles from Linear BODIPY and Bischelating Aminoquinonato Ligands: Anticancer Properties, Host-Guest Interactions, and Molecular Docking Studies.

Supramolecular metallorectangles - were successfully synthesized via a multicomponent coordination-driven self-assembly approach, combining Re(CO) with a boron dipyrromethene (BODIPY)-based ligand as a linear, ditopic linker, and an aminoquinonato ligand as a bischelating, tetratopic ligand in a single step. The metallorectangles were meticulously characterized through IR, NMR, UV-vis absorption and emission spectroscopy, elemental analyses, FESEM, and electrospray ionization mass spectrometry. The rectangular structural feature of metallacyclophane was theoretically rationalized using DFT calculations, and its theoretical and experimental IR spectra were coherent.