Robotic versus laparoscopic total mesorectal excision for mid-low rectal cancer after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis of oncological, perioperative, and survival-related outcomes.

A major cause of cancer death, colorectal cancer is becoming more common in younger people. The comparative effectiveness of robotic versus laparoscopic total mesorectal excision (TME) as surgical interventions for mid-low rectal cancer following neoadjuvant chemoradiotherapy (nCRT) remains uncertain. To systematically evaluate oncological, perioperative, and survival outcomes of robotic versus laparoscopic surgery for mid-low rectal cancer following nCRT.

The role of NR2F2 in cancer (Review).

The incidence and mortality rates of tumors continue to show an annual upward trend. Since its discovery in 1986, nuclear receptor subfamily 2, group F, member 2 (NR2F2) has been shown to serve a key role in the transcriptional regulation of various genes. Furthermore, NR2F2 has a notable impact on the progression of tumors; however, its role in tumor progression it not yet fully understood.

Monoclonal gammopathy defines distinct clinical subsets in Chronic Lymphocytic Leukemia across therapeutic eras.

Monoclonal gammopathy (MG) in chronic lymphocytic leukemia (CLL) portends heterogeneous outcomes, yet its molecular drivers and therapeutic implications remain undefined. In this retrospective analysis of 2,075 CLL patients (1999-2024), MG was detected in 18.47% cases, with IgM (8.

Sevoflurane Suppresses Cardiomyocyte Pyroptosis in Myocardial Ischemia via NLRP3 Inflammasome Signaling.

The purpose of this study was to investigate the impact of sevoflurane (SEV) on cardiomyocyte (CM) pyroptosis following myocardial ischemia (MI). Reverse validation was performed by pharmacologically activating NLRP3 with monosodium urate (MSU) to confirm that SEV's cardioprotective effects were specifically mediated through the NLRP3 inflammasome pathway. Sprague Dawley rats were randomly assigned to sham (sham), model (conventional anesthesia + MI-reperfusion [MIR] injury modeling), SEV (SEV inhalation anesthesia + MIR injury modeling), and SEV + NLRP3 (SEV inhalation anesthesia + MIR injury modeling + NLRP3) groups.

Carotid Artery Stenting Versus Carotid Endarterectomy for Carotid Artery Stenosis: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Carotid artery stenosis is a significant risk factor for ischemic stroke. Two primary interventions, carotid artery stenting (CAS) and carotid endarterectomy (CEA), are commonly used to prevent stroke.

Aims: This study systematically reviews and compares the efficacy and safety of CAS versus CEA in preventing stroke and other related outcomes.

Inhibition of miR-378a-3p Protects Anesthesia-Induced Hippocampal Neurodegeneration.

Ketamine is widely used in pediatric anesthesia, but it may induce cortical neuronal damage, leading to apoptosis, neurofibrillary degeneration, and even cell death. miRNAs can regulate the neurotoxicity induced by ketamine in hippocampal neurons. This article explores the role of miR-378a-3p in ketamine-induced impairments, providing a reference for preventing hippocampal neurodegenerative lesions induced by anesthesia.

Global burden of hypertensive heart disease attributable to high body mass index from 1990 to 2021: a multidimensional analysis and public health response.

Background: As the global population of obese individuals surpasses 878 million, the impact of high body mass index (BMI) on hypertensive heart disease (HHD) has risen to the third position among all diseases. However, the specific contribution of high BMI to the burden of HHD remains unclear.

Methods: Data on deaths, disability-adjusted life years (DALYs), and their age-standardized rates (ASR) were obtained from the Global Burden of Disease (GBD) database.

Endovascular Therapy Versus Medical Management for Large Ischemic Infarct: 1-Year Outcomes of the ANGEL-ASPECT Trial.

Background: Several trials have shown the benefit and safety of endovascular therapy (EVT) compared with medical management (MM) of patients with a large ischemic core in the 90-day follow-up. However, the 1-year outcome comparison between EVT and MM in Asian patients with a large ischemic core has not been investigated. Our aim was to evaluate the 1-year outcomes of patients in the ANGEL-ASPECT trial (Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core).

Caffeic acid tablets plus high-dose dexamethasone versus placebo plus high-dose dexamethasone in patients with newly diagnosed immune thrombocytopenia: A multicenter, double-blind, randomized, controlled, phase 2 trial.

Background: Standard initial therapy with intensive glucocorticoids requires further optimization due to high relapse rates and unsatisfying long-term outcomes in patients with primary immune thrombocytopenia (ITP). Caffeic acid (CA) has been reported to increase platelet counts in thrombocytopenia. This study investigated the efficacy and safety of CA tablets plus high-dose dexamethasone (HD-DXM) as a novel initial treatment for adults with newly diagnosed ITP.

Minimally invasive approaches to obesity: Evaluating the efficacy and safety of endoscopic gastroplasty.

Obesity is a major global health issue, contributing to numerous comorbidities such as type 2 diabetes mellitus, hypertension, and cardiovascular diseases. While bariatric surgery remains the gold standard for treating severe obesity, its invasive nature has led to the development of minimally invasive alternatives. Endoscopic sleeve gastroplasty (ESG) is a promising, minimally invasive procedure for weight loss, offering significant weight reduction without the need for surgical incisions.

Artificial Intelligence-Driven Ultrasound Identifies Rare Triphasic Colon Cancer and Unlocks Candidate Genomic Mechanisms via Ultrasound Genomic Techniques.

Colon cancer is a heterogeneous disease, and rare subtypes like triphasic colon cancer are difficult to detect with standard methods. Artificial intelligence (AI)-driven ultrasound combined with genomic analysis offers a promising approach to improve subtype identification and uncover molecular mechanisms. The authors used an AI-driven ultrasound model to identify rare triphasic colon cancer, characterized by a mix of epithelial, mesenchymal, and proliferative components.

A case report of dermatofibrosarcoma protuberans with osteolytic.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare, low-to-intermediate grade malignant soft tissue sarcoma that is prone to local recurrence after surgery but rarely metastasizes to distant sites. However, in this case, the tumor metastasized to the humerus and presented as a solitary lesion.

Case Presentation: A 42-year-old male patient presented with pain and limited mobility in the left upper limb, with a history of surgery for DFSP in the popliteal fossa.

Exploring the relationship between intestinal immunity and obesity: A bibliometric and knowledge-map analysis.

Background: This study aimed to identify influential researchers, institutions, and countries and reveal the evolution of research hotspots and themes in the field of the relationship between intestinal immunity and obesity through bibliometric analysis.

Methods: We searched and selected the Web of Science database for publications on intestinal immunity and obesity between 2004 and 2024, followed by bibliometric and visualization analysis using CiteSpace, GraphPad Prism 8, Gephi, and Charticulator.

Results: A total of 3333 publications involving 16,144 authors, 3372 research institutions, and 97 countries or regions were analyzed.

is Not Just a Contaminant: Experience with Antibiotic Treatment of Spondylodiscitis in an Immunocompetent Adult.

Background: is a commensal skin agent rarely described as a cause of infective spondylodiscitis. In this study, we report the first case of an infected patient who was successfully treated with conservative measures.

Case Presentation: A 54-year-old immunocompetent patient presented with progressive low back pain that had persisted for 1 month.

Effect of Transcutaneous Electrical Acupoint Stimulation at the Sanyinjiao Point on Preventing Bladder Spasm after Transurethral Laser Prostatectomy.

Background: Bladder spasm is a common complication after transurethral laser prostatectomy. Herein, we aimed to assess the effect of transcutaneous electrical acupoint stimulation (TEAS) at the Sanyinjiao point on relieving bladder spasm after transurethral laser prostatectomy.

Methods: The medical data of patients undergoing transurethral laser prostatectomy were retrospectively collected from May 2021 to May 2024.

Retracted: Protective Effects of Naringenin in a Rat Model of Sepsis-Triggered Acute Kidney Injury via Activation of Antioxidant Enzymes and Reduction in Urinary Angiotensinogen.

Retraction Notice: This publication has been retracted by the Editor due to the identification of non-original figure images and manuscript content that raise concerns regarding the credibility and originality of the study and the manuscript. Reference: Lin Mu, Guoxin Hu, Jian Liu, Yan Chen, Wenjuan Cui, Lujun Qiao. Protective Effects of Naringenin in a Rat Model of Sepsis-Triggered Acute Kidney Injury via Activation of Antioxidant Enzymes and Reduction in Urinary Angiotensinogen.

Anti-SSA/Ro antibody-positive autoimmune myocarditis combined with complete atrioventricular block requiring implantation with a permanent pacemaker: A case report.

Background: Autoimmune myocarditis (AM) associated with autoimmune diseases can cause complete atrioventricular block (CAVB), but the related autoantigens and the underlying mechanisms are unclear. Anti-SSA/Ro antibodies may play an important role in this process, but cases of AM with positive anti-SSA/Ro antibodies are rare. In addition, arrhythmias, such as atrioventricular block, are very common in patients with autoimmune diseases, but severe atrioventricular block requiring permanent pacemaker implantation is extremely rare.

Efficacy and safety of anti-PD-1/PD-L1 antibodies in patients with relapsed refractory diffuse large B-cell lymphoma: A meta-analysis.

This article conducts a meta-analysis to evaluate the safety and efficacy of PD-1/PD-L1 inhibitors in patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). A total of 63 papers were initially retrieved, and eight clinical studies were collected. The estimated effect of ORR was [OR = 0.

[Reversed halo sign as imaging manifestation of primary Sjögren's syndrome with nonspecific interstitial pneumonia].

The reversed halo sign (RHS), also referred to as the atoll sign, represents a distinct imaging finding that was initially characterized in cryptogenic organizing pneumonia and has subsequently been observed in instances of fungal infections, tuberculosis, vasculitis, and tumor pathologies.This case report details the presentation of a patient with primary Sjögren's syndrome and non-specific interstitial pneumonia, who on imaging displayed the RHS-a relatively infrequent finding. Subsequent confirmatory testing, including anti-nuclear antibody panel, lip gland biopsy, and lung biopsy, ultimately confirmed the diagnosis.

Application value of serum miR-363 combined with arterial blood gas analysis parameters and lung ultrasound score in neonatal respiratory distress syndrome.

Neonatal respiratory distress syndrome (NRDS) is caused by a deficiency of alveolar surface-active substances. The aim of this study was to investigate the value of miR-363 combined with arterial blood gas analysis parameters and lung ultrasound (LUS) score for diagnosis and prognostic assessment in NRDS. In this study, 104 neonates with NRDS and 76 healthy were included as subjects.

Pediatric Posttraumatic Cerebral Venous Sinus Thrombosis: Successful Resolution With Rivaroxaban.

Cerebral venous sinus thrombosis (CVST) is rare in children (0.5%-1.0% of pediatric strokes) and uncommonly associated with closed traumatic brain injury.

EMT and cancer stem cells: Drivers of therapy resistance and promising therapeutic targets.

Cancer continues to be a primary cause of death, resulting in substantial mortality and illness globally. It remains a significant global health issue, greatly affecting morbidity and mortality across the world. Therapeutic resistance poses a major challenge to cancer treatments, acting as a significant barrier to the effectiveness of both standard and targeted therapies.

Efficacy and safety of triple therapy with vonoprazan for eradication: A multicenter, prospective, randomized controlled trial.

Background: () is a Gram-negative bacterium that relies on flagellar motility to colonize the stomach, damaging the gastric mucosa through various mechanisms and leading to various digestive disorders. Accurate assessment and precise treatment are essential in initial intensive therapy.

Aim: To investigate the efficacy and safety of a vonoprazan (VPZ)-based triple regimen for first-line eradication of in China.

Concurrent IgG4-related membranous nephropathy and proliferative diabetic kidney disease: a diagnostic dilemma and therapeutic strategy in long-standing diabetes.

Background: IgG4-related kidney disease (IgG4-RKD) overlapping with diabetic nephropathy (DND) poses diagnostic challenges in terms of histopathological mimicry. This report highlights the first case of concurrent IgG4-related membranous nephropathy (IgG4-MN) and proliferative diabetic kidney disease (DKD) in a patient with diabetes, emphasizing the use of multidisciplinary diagnostic approaches. A 74-year-old male with a 24-year history of diabetes presented with nephrotic syndrome (proteinuria: 6.