Prognostic factors for incontinence-associated dermatitis (IAD): Results of an international expert survey.

Background: Incontinence-associated dermatitis (IAD) is a prevalent and distressing form of irritant contact dermatitis caused by prolonged exposure to urine and/or faeces. Not all incontinent individuals develop IAD, suggesting that additional prognostic factors contribute to its onset. The quality of empirical evidence supporting risk factors for IAD development is moderate to very low.

Valid measures of cognitive assessment with Aboriginal and Torres Strait Islander peoples are urgently needed: construct and concurrent validity of the Perceive, Recall, Plan and Perform Assessment (PRPP-A).

Purpose: Initial studies identified the Perceive, Recall, Plan and Perform Assessment (PRPP-A) as a cognitive assessment with potential for culturally safe use with Aboriginal and Torres Strait Islander peoples with neurocognitive impairments in the Northern Territory of Australia. This study examines construct and concurrent validity of the PRPP-A.

Methods: Data were collected from a medical record review.

The Volar Central Approach for Distal Radius Fracture: A Prospective Nerve Conduction Study of 38 Patients.

Background: In distal radius fracture (DRF) surgery with volar locking plates, the flexor carpi radialis approach is commonly used. However, the volar central approach (VCA), between the median nerve and the finger flexors, may improve visualization of the volar ulnar corner. A similar approach has been linked with a higher risk of iatrogenic median neuropathy.

Guidelines for Meta-analyses and Systematic Reviews in Urology.

Our guideline comprises points addressing the conduct and interpretation of systematic reviews and meta-analyses in urology. Application of the guideline would lead to a more considered interpretation of a smaller number of systematic reviews and meta-analyses, and could thus help in translating evidence into better decision-making for doctors and patients.

Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial.

Background: Preoperative physical frailty is a significant predictor of adverse postoperative outcomes in older patients undergoing cardiac surgery. Inflammation plays a crucial role in the development of frailty and contributes to postoperative complications. This study investigated the effects of preoperative beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine supplementation on inflammatory markers, nutritional status, and renal function in older patients undergoing cardiac surgery.

The Evidence for Biomechanical and Physiological Parameters as Biomarkers to Discriminate Between Individuals With and Without Non-specific Neck Pain Using Sensor Devices: A Systematic Review with Meta-analysis.

Neck pain is among the most prevalent musculoskeletal conditions worldwide. The underlying cause mostly remains unidentified, classified as non-specific neck pain. Pain can alter movement patterns and physiological responses, suggesting that certain biomechanical and physiological changes may serve as objective biomarkers for non-specific neck pain.

Entheseal structural damage according to OMERACT definitions unveils distinct ultrasound phenotypes in SpA: findings from the DEUS multicentre study.

Objectives: To explore the prevalence and distribution of ultrasound-detected lesions indicating structural damage at the enthesis (e.g., bone erosions, enthesophytes, and calcifications) in patients with spondyloarthritis (SpA), comparing those with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and to investigate the demographic, clinical, and metabolic factors linked to these lesions.

Clinicopathologic features and contralateral breast cancer risk in BRCA1/2 pathogenic variant carriers: a multicenter registry study of Japanese women.

Purpose: This large-scale study presents the clinicopathological characteristics and cumulative incidence of contralateral breast cancer (CBC) in Japanese BRCA1/2 pathogenic variant carriers, including cases diagnosed after the implementation of national insurance coverage.

Methods: We analyzed 2949 breast cancer cases from the registry database of the Japanese Organization of Hereditary Breast and Ovarian Cancer.

Results: BRCA1 carriers predominantly developed triple-negative breast cancer, whereas BRCA2 carriers more frequently developed luminal-type tumors, with a younger age of onset observed in BRCA1 carriers.

A Facile and Efficient Route to Achieve Polythiophene-Based Nanoparticles With Various Morphologies.

Polythiophene-based nanoparticles (PTNPs), a prominent class of conjugated polymer nanoparticles (CPNs) with remarkable optical and electronic properties, have gained significant attention in applications such as electronics and bioimaging. However, current methods in generating PTNPs have run into obstacles including low variety of morphologies, poor reproducibility, and low preparation efficiency, restricting their further application. In this study, we report a facile and efficient fabrication strategy based on template synthesis method.

Efficacy of peroneal nerve functional electrical stimulation (FES) for the reduction of bradykinesia in Parkinson's disease: an assessor-blinded randomised controlled trial (STEPS II)-study protocol.

Introduction: Difficulty with walking can lead to reduced quality of life for people with Parkinson's disease (pwPD); improving walking is considered a treatment priority. Drug therapies can control PD symptoms; however, pwPD often still experience mobility problems.Functional electrical stimulation (FES) induces movement in weak muscles via external electrical stimulation.

An Electronic Health Record-Wide Association Study to identify populations at increased risk of E. coli bloodstream infections.

Objectives: Escherichia coli bacteraemias have been under mandatory surveillance in the UK for fifteen years, but cases continue to rise. Systematic searches of all features present within electronic healthcare records (EHRs), described here as an EHR-wide association study (EHR-WAS), could potentially identify under-appreciated factors that could be targeted to reduce infections.

Methods: We used data from Oxfordshire, UK, and an EHR-WAS method developed for use with large-scale COVID-19 data to estimate associations between E.

Breaking points of human hamstring muscle-tendon complex: A cadaveric study.

Hamstring strain injuries frequently occur during the late swing phase of running; however, the breaking strength of the human hamstring muscle-tendon complexes remains unclear. This study aimed to determine the breaking strength of human hamstring muscle-tendon complexes. To this end, seven cadaveric specimens preserved using the Thiel's method were examined.

The association of the self-reported experience of the 10 steps to successful breastfeeding and sociodemographic characteristics with breastfeeding self-efficacy.

Background: The effect of Breastfeeding Self-efficacy (BFSE) and the Baby-Friendly Hospital Initiative's (BFHI) 10 Steps on breastfeeding initiation, continuation and exclusivity, is well established. However, direct evidence about the association between the experience of the 10 steps and self-efficacy is limited.

Objective: To assess the association between adherence to the 'Ten Steps to Successful Breastfeeding', sociodemographic factors and other predictors with breastfeeding self-efficacy (BFSE) at 48 h and at one month postpartum.

International Network of Antibiotic Allergy Nations (iNAAN): Protocol for a type 2 hybrid effectiveness-implementation multicentre prospective cohort and target trial emulation study evaluating penicillin allergy delabeling via direct oral challenge.

Background: Penicillin allergies are reported in 1 in 10 hospitalised patients globally and are associated with inferior patient and health service outcomes. However, more than 95% of low-risk penicillin allergies can be removed by direct oral challenge (DOC).

Objective: The International Network of Antibiotic Allergy Nations (iNAAN) aims to evaluate the utility of an audit and feedback (A&F) and education implementation strategy to increase the adoption of penicillin DOC in patients with a low-risk penicillin allergy, while concurrently assessing the impact of penicillin DOC on antibiotic prescribing and health service outcomes.

Cross-reactive IgE responses to cockroach, house dust mite, and seafood allergens in patients with allergic rhinitis.

Background: Cockroach allergens remain underrecognized in allergic diseases, despite growing evidence of their clinical impact. This study investigated cockroach sensitization prevalence in allergic rhinitis (AR) patients and its cross-reactivity with house dust mite (HDM) and seafood allergens.

Methods: 110 AR patients sensitized to at least one of eight allergens: (PA), (BG), (DP), (DF), (BT), shrimp, crab and squid were enrolled.

Reperfusion injury in STEMI: a double-edged sword.

Background: ST-elevation myocardial infarction (STEMI) is a major cardiac event that requires rapid reperfusion therapy. The same reperfusion mechanism that minimizes infarct size and mortality may paradoxically exacerbate further cardiac damage-a condition known as reperfusion injury. Oxidative stress, calcium excess, mitochondrial malfunction, and programmed cell death mechanisms make myocardial dysfunction worse.

The association between chronotype and dietary nutrient patterns.

This study examines how dietary nutrient patterns vary among individuals with different chronotypes. In other words, this research explores the potential connections between nutrient intake and circadian rhythm. In this secondary data analysis, we used data from 3,072 adult participants (mean age: 30.

Ethnic disparities, clinical and pathways to care characteristics associated with the offer, uptake, and type of psychological therapy during first-episode psychosis: examining the role of early intervention for psychosis.

Background: Psychological therapy (PT) along with antipsychotic medication is the recommended first line of treatment for first-episode psychosis (FEP). We investigated whether ethnicity, clinical, pathways to care (PtC) characteristics, and access to early intervention service (EIS) influenced the offer, uptake, and type of PT in an FEP sample.

Methods: We used data from the Clinical Record Interactive Search-First Episode Psychosis study.

Association between the Japanese version of the Montreal Test of Cognitive Abilities scores and intra-individual variability in reaction time: A one-year analysis.

Early detection is a critical issue in dementia prevention. This study utilizes intra-individual variability in reaction time (IIV-RT) as an indicator of cognitive function. By analyzing data over a one-year period, we examine the association between IIV-RT and the Japanese version of the Montreal Test of Cognitive Abilities (MoCA-J), a cognitive screening test.

Watermelon Rind: Nutritional Composition, Therapeutic Potential, Environmental Impact, and Commercial Applications in Sustainable Industries.

Citrullus lanatus (watermelon) is a fruit with remarkable therapeutic potential, as each part of itrind, peel, flesh, and seeds contain bioactive compounds. Despite its wide range of benefits, the utilization of watermelon, particularly its rind, remains limited due to a lack of awareness and an underrated perspective. The rind, situated between the green outer peel and the red flesh, is light green in color and rich in bioactive compounds, minerals, and phytochemicals.

N-Doped Graphene for Biomedical Applications: A Comparative Biocompatibility Assessment of Green and Chemical Exfoliation.

Graphene-based nanomaterials have transformed biomedical applications due to their exceptional physicochemical properties, and nitrogen (N)-doping further enhances the electrocatalytic activity of graphene. Driven by the demand for safer and more sustainable nanomaterials, in this work, we compared eco-friendly produced - doped graphene (bD) with conventionally synthesized - doped graphene (cD) in three different cell lines. Across all cell types and assays, cD was more toxic than bD.

Associations of Laboratory- and Field- derived Measurements of Critical Power with W'-kinetics during 40-km Cycling Time Trial Performances.

This study aimed to establish whether a laboratory (lab) based 3-minute all-out (3MT) protocol and a field-based 3MT protocol would yield similar peak power (P), critical power (CP), and curvature constant (W') profiles and the implications of parameter estimation for informing a 40-km time trial (TT) performance. Nine competitive male cyclists (mean ± SD: age 36.5 ± 10.

Health literacy, multimorbidity and its effect on mental health in South African adults: a repeated cross-sectional nationally representative panel study.

Objective And Methods: Health literacy is a key determinant of physical and mental health outcomes, particularly in low- and middle-income settings like South Africa, where multimorbidity is increasingly common. Limited health literacy may hinder effective management of multiple chronic conditions and worsen mental health. Using repeated cross-sectional nationally representative data, this study examined the relationship between health literacy and multimorbidity, with a specific focus on mental health among South African adults (18 years and older).