Endo-histologic outcomes in patients with ulcerative colitis responding to tofacitinib.

Background: The therapeutic target for ulcerative colitis (UC) has shifted towards deeper disease control. The real-world data on efficacy of tofacitinib in inducing histologic remission (HR) remains limited. We evaluated the real-world efficacy of tofacitinib in achieving endoscopic remission (ER) and HR.

Effect of cultivar selection on symbiotic nitrogen fixation and yield traits of pea cultivars in intercropping with wheat.

In recent decades, agricultural practices have shifted from diverse cropping systems to monocropping, leading to soil degradation, nutrient depletion, and reduced biodiversity, which threaten long-term productivity and ecosystem sustainability. This study aimed to explore how legume cultivar selection influences pea ( L.)-wheat ( L.

Identification of novel candidate gene associated with early heading on chromosome 5B in wheat mutant .

Unlabelled: Heading date (HD) is a critical agronomic trait that influences wheat's adaptation to environmental conditions and plays a pivotal role in yield stability. In this study, an early-heading mutant was identified following γ-ray irradiation of the wild type (WT) wheat variety Jing411. This mutant headed 2-3 days earlier than the WT, with no significant differences in other yield-related traits.

Genetic parameters for quality attributes in individual pork primal cuts.

Heritabilites, genetic and phenotypic correlations were estimated for carcass and primal cut quality traits in 1118 commercial crossbred pigs (498 females and 620 males). A total of 22 traits, including loin, shoulder, ham and belly traits, were evaluated. Heritability estimates (±SE) for carcass traits ranged from 0.

Characterisation of the genome and secretome of and .

Pethybr. & Laff. and Pethybr.

Alanine aminotransferase contributes to hypoxia sensitivity and dormancy in barley seeds.

Seed dormancy is regulated by a combination of developmental and environmental cues to ensure seedling survival in a changing environment. In barley (Hordeum vulgare L.), the SD1 and SD2 (where SD is standard deviation) loci regulate dormancy and pre-harvest sprouting (PHS), though their role in physiological development remains unclear.

Azathioprine or Tofacitinib as Maintenance Therapy in Corticosteroid-Responsive Acute Severe Ulcerative Colitis.

Background: The optimal maintenance therapy for patients with acute severe ulcerative colitis (ASUC) remains unclear.

Aim: To evaluate the efficacy of azathioprine and tofacitinib in maintaining remission in patients with ASUC who respond to intravenous corticosteroids.

Methods: This propensity score-matched, retrospective cohort study evaluated the effectiveness and safety of azathioprine and tofacitinib as maintenance therapies in adult patients with ASUC responding to intravenous corticosteroids.

Adding information on multisite and widespread pain to the STarT back screening tool when identifying low back pain patients at risk of worse prognosis.

Objectives: The STarT Back screening Tool (SBT) captures patients with low back pain (LBP) at risk of worse prognosis. However, the SBT does not include assessment of multisite and chronic widespread pain (MS-CWP). The aim was to study the differences in prognostic factors in patients with LBP classified according to SBT or SBT in combination with MS-CWP, and the 1-year outcome regarding visits to physiotherapist and sickness absence, in relation to risk scorings.

A second gene for resistance to four pathotypes of identified in the cultivar 'Mendel'.

Clubroot, caused by the obligate parasite , poses a significant threat to the Canadian canola industry, resulting in substantial yield losses. Genetic resistance is an effective strategy for managing the disease. In this study, 137 doubled haploid (DH) lines derived from the European oilseed rape cultivar 'Mendel' were phenotyped against pathotypes 3D, 5C, and 8J, which are aggressive toward the first-generation clubroot-resistant canola cultivars, and were genotyped using genotyping-by-sequencing.

Metal-phenolic networks immobilized on Zein nanoparticles as an emerging photothermal sterilization for foods.

Bacterial-mediated food spoilage poses global challenges to food safety and waste. While biocompatible metal-phenolic network (MPN)-based photothermal platforms offer a promising alternative to conventional high-temperature sterilization, their pH-responsive disassembly significantly compromises effectiveness in acidic foods. To address this challenge, we developed a photothermal antibacterial nanoplatform composing of all-natural materials by covalently immobilizing epigallocatechin gallate (EGCG)/Fe networks onto zein nanoparticles (ZEF).

Dual JAK and ROCK inhibition with CPL'116 in patients with rheumatoid arthritis with inadequate response to methotrexate: a randomised, double-blind, placebo-controlled, phase 2 trial.

Background: Janus kinase (JAK) inhibitors are an effective treatment option in rheumatoid arthritis and other autoimmune diseases. However, the use of JAK inhibitors is associated with increased total cholesterol, LDL cholesterol, triglycerides, and creatinine kinase, reducing the net clinical benefit of using them. Adding Rho-associated protein kinase (ROCK) inhibition to JAK inhibition might provide cardioprotection as ROCK inhibitors have been shown to reduce vascular inflammation, improve endothelial function, and prevent cardiac remodelling in preclinical models.

Electrochemical Nitrogen Fixation Using CeFeO and CeO for Ammonia Synthesis and Nitrate Remediation.

In the pursuit of sustainable ammonia synthesis and nitrate remediation, electrochemical nitrate reduction to ammonia (eNORR) emerges as a promising alternative to the carbon-intensive Haber-Bosch process, which emits 1.6-2.0 tons of CO per ton of ammonia.

α-GalCer-LNP ehanced mRNA delivery and activates natural killer T cells for superior tumor immunotherapy.

Lipid nanoparticles (LNPs) have emerged as a clinically validated platform for cancer immunotherapy; however, challenges remain in optimizing RNA delivery and promoting synergistic immune activation. To address these issues, we developed a modified LNP system that incorporates α-galactosylceramide (α-GalCer), a CD1d-binding glycolipid known to activate invariant natural killer T (iNKT) cells. Through structural optimization, we created the α-GalCer-LNP (G-LNP), which offers three primary advantages over conventional four-component LNPs: (1) enhanced mRNA transfection efficiency due to improved endosomal/lysosomal escape, (2) increased capacity for in vivo DC transfection, leading to robust activation of tumor-specific CD8 T cells via MHC-I and iNKT cells via the CD1d pathway, and (3) reprogramming of the tumor microenvironment, resulting in a 1.

Elevated Mutation Burdens in Canadian Oat and Wheat Cultivars Released over the Past Century.

Modern high-yielding crop cultivars are known to have narrow genetic bases, making them vulnerable to biotic and abiotic stresses. However, little is known about the extent of deleterious genetic variants (or mutation burden) present in these cultivars. An attempt was made using RNA-Seq to screen genome-wide deleterious genetic variants in 141 oat and 142 wheat cultivars released through Canadian breeding programs over the past century.

Floorball goaltending movements during a game: A quantitative observational study.

Background: More knowledge about floorball goalkeepers' game movements and biomechanical demands is warranted. Therefore, the aim of this study was to observe type and frequency of female floorball goalkeepers' movements during a game.

Methods: Twelve female goalkeepers (mean age 22 years) were included.

Coordinated function of paired NLRs confers Yr84-mediated stripe rust resistance in wheat.

Cloning of resistance genes expands our understanding of their function and facilitates their deployment in breeding. Here we report the cloning of two genes from wild emmer wheat (Triticum turgidum ssp. dicoccoides) underlying Yr84-mediated stripe rust resistance using a combination of fine mapping, long-read sequencing and mutation-induced functional validation.

Analysis of chondroitin degradation by components of a Bacteroides caccae polysaccharide utilization locus.

The human gut microbiota (HGM) possesses an enormously diverse capacity to metabolize both host and dietary glycans. Glycosaminoglycans (GAG) are complex polysaccharides that may be in the diet (e.g.

Clinical spectrum of acute severe ulcerative colitis in the biologic era: a prospective cohort study from India.

Background/aims: Acute severe ulcerative colitis (ASUC) is a time-critical situation requiring urgent intervention. Limited data exist on the evolving clinical spectrum of ASUC in the era of advanced therapies.

Methods: This prospective real-world observational cohort study included 145 adult patients hospitalized with ASUC between January 2020 and June 2024.

Preparation and characterization of ovomucin-xanthan gum stabilized pickering emulsions: Microstructure, rheology, and stability.

Pickering emulsions are widely utilized in the food industry due to their excellent stability and inherent safety. Ovomucin (OVN), a natural protein recognized for biocompatibility, remains underexplored in emulsion stabilization. This study prepared ovomucin-xanthan gum (OVN-XG) nanoparticles via a pH cycling method and systematically evaluated their characteristics and stabilization efficiency in Pickering emulsions.

Separation and Identification of a Novel Antioxidant and Calcium-Binding Peptide Derived from Phosvitin Hydrolysates: and Prediction.

This study aimed to identify a novel peptide from phosvitin hydrolysates with enhanced antioxidant and calcium absorption-promoting properties. Simultaneous enzymatic hydrolysates (trypsin + alkaline protease) exhibited better bifunctional activity than sequential enzymatic hydrolysates. Three components of phosvitin hydrolysates (PPP0, PPP1, and PPP2) were isolated by anion-exchange chromatography, and PPP2 displayed the highest activity.

Transformer-based prototype network for Chinese nested named entity recognition.

Nested named entity recognition (NNER), a subtask of named entity recognition (NER), aims to recognize more types of entities and complex nested relationships, presenting challenges for real-world applications. Traditional methods, such as sequence labeling, struggle with the task because of the hierarchical nature of these relationships. Although NNER methods have been extensively studied in various languages, research on Chinese NNER (CNNER) remains limited, despite the complexity added by ambiguous word boundaries and flexible word usage in Chinese.

Polysaccharide from Aloe vera gel improves intestinal stem cells dysfunction to alleviate intestinal barrier damage via 5-HT.

Metabolites of dietary fibers which consist of non-digestible carbohydrates (usually as plant-based polysaccharides) exert many benefits on gastrointestinal health. Previous studies proved that polysaccharides can change intestinal metabolic pathways, increase metabolite levels and alleviate intestinal inflammation. Our previous studies have shown that polysaccharide from Aloe vera gel (AGP) alleviated intestinal barrier dysfunction.