Analyzing the toxicological effects of PET-MPs on male infertility: Insights from network toxicology, mendelian randomization, and transcriptomics.

Current research indicates that polyethylene terephthalate microplastics (PET-MPs) may significantly impair male reproductive function. This study aimed to investigate the potential molecular mechanisms underlying this impairment. Potential gene targets of PET-MPs were predicted via the SwissTargetPrediction database.

Comparison of Navier-Stokes and lattice Boltzmann solvers for subject-specific modelling of intracranial aneurysms.

Modelling cardiovascular disease is at the forefront of efforts to use computational tools to assist in the analysis and forecasting of an individual's state of health. To build trust in such tools, it is crucial to understand how different approaches perform when applied to a nominally identical scenario, both singularly and across a population. To examine such differences, we have studied the flow in aneurysms located on the internal carotid artery and middle cerebral artery using the commercial solver Ansys CFX and the open-source code HemeLB.

Performance evaluation of a p-type co-axial HPGe detector: Long-term analysis of key parameters for gamma spectroscopy.

Accurate determination of the parameters of each high purity germanium, HPGe detectors ensure the precision of quantitative results obtained from spectrum analysis. This study presents a comprehensive performance evaluation and long-term quality control assessment of a high-purity germanium (HPGe) gamma spectrometry system that has been operational for over 15 years. Key spectrometric measures were recorded, including energy resolution, peak shape ratios, asymmetry, peak-to-Compton ratio, relative efficiency, electronic noise, minimum detectable activity (MDA), and repeatability and reproducibility of the system.

CRISPR/Cas9-mediated editing of COQ4 in induced pluripotent stem cells: A model for investigating COQ4-associated human coenzyme Q deficiency.

Pathogenic variants in the gene COQ4 cause primary coenzyme Q deficiency, which is associated with symptoms ranging from early epileptic encephalopathy up to adult-onset ataxia-spasticity spectrum disease. We genetically modified commercially available wild-type iPS cells by using a CRISPR/Cas9 approach to create heterozygous and homozygous isogenic cell lines carrying the disease-causing COQ4 variants c.458C > T, p.

A novel multimodal framework combining habitat radiomics, deep learning, and conventional radiomics for predicting MGMT gene promoter methylation in Glioma: Superior performance of integrated models.

Purpose: The present study aimed to develop a noninvasive predictive framework that integrates clinical data, conventional radiomics, habitat imaging, and deep learning for the preoperative stratification of MGMT gene promoter methylation in glioma.

Materials And Methods: This retrospective study included 410 patients from the University of California, San Francisco, USA, and 102 patients from our hospital. Seven models were constructed using preoperative contrast-enhanced T1-weighted MRI with gadobenate dimeglumine as the contrast agent.

Mechanistic roles of long non-coding RNAs in DNA damage response and genome stability.

To maintain genomic stability, cells have evolved complex mechanisms collectively known as the DNA damage response (DDR), which includes DNA repair, cell cycle checkpoints, apoptosis, and gene expression regulation. Recent studies have revealed that long non-coding RNAs (lncRNAs) are pivotal regulators of the DDR. Beyond their established roles in recruiting repair proteins and modulating gene expression, emerging evidence highlights two particularly intriguing functions.

Vanadium shows no effect in stress-induced hyperthermia and the tail suspension test in healthy mice.

Vanadium (V) is a trace element in the environment; it is detected in soil, water, air, dust, and food products. V-containing compounds have shown therapeutic potential in the treatment of diabetes. However, studies on the effects of V on animal behavior remain limited and sporadic.

Associations between element mixtures and biomarkers of pathophysiologic pathways related to autism spectrum disorder.

Objective: We previously documented that exposure to a spectrum of elements is associated with autism spectrum disorder (ASD). However, there is a lack of mechanistic understanding as to how elemental mixtures contribute to the ASD development.

Materials And Methods: Serum and urinary concentrations of 26 elements and six biomarkers of ASD-relevant pathophysiologic pathways including serum HIPK 2, serum p53 protein, urine malondialdehyde (MDA), urine 8-OHdG, serum melatonin, and urine carnitine, were measured in 21 ASD cases and 21 age-matched healthy controls of children aged 6-12 years.

Not all type of lepidic pattern is useful for distinguishing whether metachronous multiple lung adenocarcinomas are separate primary lung cancers.

Our research aims to ascertain the value of precursor and outgrowth lepidic in aiding the confirmation of multiple lung adenocarcinomas as separate primary lung cancers (SPLC). A total of 151 patients with metachronous multiple invasive adenocarcinomas were included in this study. Driver mutation tests（at least five genes: EGFR, ALK, KRAS, BRAF, and ROS1） were conducted on 302 tumors collected from 151 patients.

Intracellular Galectin-3 as a Crucial Regulator of Foam Cell Formation and Apoptosis Progression through the Modulation of Membrane Lipid Rafts.

Background: Atherosclerosis, a leading cause of cardiovascular disease (CVD) mortality worldwide, is characterized by dysregulated lipid metabolism and unresolved inflammation. Macrophage-derived foam cell formation and apoptosis contribute to plaque formation and vulnerability. Elevated serum galectin-3 (Gal-3) levels are associated with increased CVD risk, and Gal-3 in plaques is strongly associated with macrophages.

Effects of multi-component interventions on the lifestyle in pre-frail or frail older adults: A systematic review and meta-analysis.

Background: Frailty is defined as a biological syndrome characterized by a decreased reserve and resistance to stressors. Frailty is closely related to lifestyle, and improving lifestyle can effectively reduce the incidence of frailty and related adverse events. Multi-component interventions were an effective mean of improving lifestyle, which has been validated in studies of other populations.

The effects of missing data due to study dropout on longitudinal analysis inference using outcome-dependent sampling.

Background: Existing longitudinal cohort study data and associated biospecimen libraries provide abundant opportunities to efficiently examine new hypotheses through retrospective specimen testing. Outcome-dependent sampling (ODS) methods offer a powerful alternative to random sampling when testing all available specimens is not feasible or biospecimen preservation is desired. For repeated binary outcomes, a common ODS approach is to extend the case-control framework to the longitudinal setting.

Therapists' Role in Patient Adherence to Internet-Based Cognitive Behavioral Therapy: Qualitative Study.

Background: Internet-based cognitive behavioral therapies (iCBTs) are typically categorized into 2 types: therapist-assisted and self-guided. Both formats have accumulated substantial evidence supporting their cost-effectiveness and efficacy in treating a range of mental health conditions. However, therapist-assisted iCBTs tend to show lower dropout rates than self-guided versions.

Principles of Industry-Academic Partnerships Informed by Digital Mental Health Collaboration: Mixed Methods Study.

Background: Cross-sector collaboration is increasingly recognized as essential for addressing complex health challenges, including those in mental health. Industry-academic partnerships play a vital role in advancing research and developing health solutions, yet differing priorities and perspectives can make collaboration complex.

Objective: This study aimed to identify key principles to support effective industry-academic partnerships, from the perspective of industry partners, and develop this into actionable guidance, which can be applied across sectors.

Leveraging GPT-4o for Automated Extraction and Categorization of CAD-RADS Features From Free-Text Coronary CT Angiography Reports: Diagnostic Study.

Background: Despite the Coronary Artery Reporting and Data System (CAD-RADS) providing a standardized approach, radiologists continue to favor free-text reports. This preference creates significant challenges for data extraction and analysis in longitudinal studies, potentially limiting large-scale research and quality assessment initiatives.

Objective: To evaluate the ability of the generative pre-trained transformer (GPT)-4o model to convert real-world coronary computed tomography angiography (CCTA) free-text reports into structured data and automatically identify CAD-RADS categories and P categories.

A Self-Guided Digital Mental Health Promotion Service Targeting Young People: Protocol for a Randomized Controlled Trial.

Background: The high and increasing rate of poor mental health among young people is a matter of global concern. Experiencing poor mental health during this formative stage of life can adversely impact interpersonal relationships, academic and professional performance, and future health and well-being if not addressed early. However, only a few of those in need seek help.

Correction: Factors Affecting the Receptiveness of Chinese Internists and Surgeons Toward Artificial Intelligence-Driven Drug Prescription: Protocol for a Systematic Survey Study.

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Developing an Interprofessional Pediatric Rehabilitation Model of Care in Northern Cree First Nation Communities: Protocol for a Needs Assessment and Codeveloped Intervention With a Qualitative and Participatory Action Approach.

Background: In Canada, the Indigenous population is the youngest and fastest growing, yet ongoing health disparities for Indigenous peoples are widely recognized. There is a concerning lack of research on childhood disabilities and health conditions in Indigenous populations in Canada. For children with disabilities and chronic health conditions, ongoing access to rehabilitation services, such as occupational therapy, physical therapy, speech-language pathology, and audiology, is critical in promoting positive health and developmental outcomes.

Understanding and Addressing Challenges With Electronic Health Record Use in Gynecological Oncology: Cross-Sectional Survey of Multidisciplinary Professionals in the United Kingdom and Co-Design of an Integrated Informatics Platform to Support Clinical Decision-Making.

Background: Electronic health records (EHRs) are a cornerstone of modern health care delivery, but their current configuration often fragments information across systems, impeding timely and effective clinical decision-making. In gynecological oncology, where care involves complex, multidisciplinary coordination, these limitations can significantly impact the quality and efficiency of patient management. Few studies have examined how EHR systems support clinical decision-making from the perspective of end users.

Health Care Professionals' Experiences Regarding Facilitators of and Barriers to Sustained Use of Social Robot Ivy for People With Intellectual Disabilities: Qualitative Interview Study.

Background: Labor shortages in health care pose significant challenges to sustaining high-quality care for people with intellectual disabilities. Social robots show promise in supporting both people with intellectual disabilities and their health care professionals; yet, few are fully developed and embedded in productive care environments. Implementation of such technologies is inherently complex, requiring careful examination of facilitators and barriers influencing sustained use.

Deep Learning-Based Pattern Recognition for Detecting Penile Abnormalities: Protocol for Developing a Mobile App for Circumcision Eligibility.

Background: Circumcision is a widely practiced procedure with cultural and medical significance. However, certain penile abnormalities-such as hypospadias or webbed penis-may contraindicate the procedure and require specialized care. In low-resource settings, limited access to pediatric urologists often leads to missed or delayed diagnoses.

Quantifying Spatial Shadow Zones and Their Association With Hospital Falls in Acute Care Unit: Real-Time Location System Observational Study.

Background: Hospital falls represent a persistent and significant threat to safety within health care systems worldwide, impacting both patient well-being and the occupational health of health care staff. While patient falls are a primary concern, addressing fall risks for all individuals within the health care environment remains a key objective. Caregiver visibility and spatial monitoring are recognized as crucial considerations in mitigating fall-related incidents.

Utilizing Smart Televisions as Assistive Technology to Enhance Communication and Social Lives of Older Adults: Systematic Review.

Background: Over the past decade, the proportion of the world's population aged ≥65 years has grown exponentially, presenting significant challenges, such as social isolation and loneliness among this population. Assistive technologies have shown potential in enhancing the quality of life for older adults by improving their physical, cognitive, and communication abilities. Research has shown that smart televisions are user-friendly and commonly used among older adults.