Two-Decade Trends in MASLD and Its Complications in the Middle East and North Africa (2010-2021).

Background: The Middle East and North Africa (MENA) region is undergoing demographic shifts potentially increasing metabolic dysfunction-associated steatotic liver disease (MASLD) and its complications. We assessed MASLD prevalence and liver disease burden from 2010 to 2021.

Methods: Data from Global Burden of Disease (GBD), United Nations Population Division and NCD Risk Factor Collaboration covering 21 MENA countries were used for annual percent change (APC) trends per Joinpoint regression.

Experiences and Perceptions of Turkish Nursing Students During Their First Clinical Placement in Intensive Care Units: A Qualitative Study.

Background: Clinical practice in the ICU is critical in shaping nursing students' professional development and enhancing their understanding of patient care.

Aim: This study examined the feelings, thoughts and experiential reflections of nursing students during their initial exposure to the intensive care unit (ICU), focusing on their perspectives on the first and last day of clinical practice.

Study Design: The study employed a phenomenological design and was conducted in a province in north-eastern Turkey.

Variations in Dentists' Thresholds for Restorative Treatment of Active Non-Cavitated Carious Lesions: A Multinational Cross-sectional Study.

Objectives: To assess patterns across 21 countries in dentists' thresholds for initiating operative treatment of active non-cavitated carious lesions and to evaluate the influence of caries risk, clinician characteristics, and geographic variation on decision-making in accordance with current guidelines.

Methods: A cross-sectional, vignette-style web-based survey was conducted between June and October 2023 across 21 countries. A standardized questionnaire, comprising theoretical radiographic scenarios of occlusal and approximal active non-cavitated carious lesions at four progressive stages (E1,E2,EDJ,D1), was distributed to general dentists and specialists.

Regional Genetic Study: Monosymptomatic Nocturnal Enuresis and Array Technology.

Purpose: This study aimed to investigate the genetic heterogeneity of primary monosymptomatic nocturnal enuresis (PMNE) and assess potential genetic variants contributing to its etiology.

Materials And Methods: A total of 92 children aged 5-15 years with a positive family history of PMNE were evaluated. All patients underwent detailed urological and nephrological assessments to exclude organic causes.

Design, Synthesis, and Molecular Docking of Triazole-Coumarin Hybrids as Potent Breast Cancer Inhibitors Targeting Cell Cycle and Apoptosis.

Breast cancer continues to pose a significant global health burden, highlighting the urgent need for novel chemotherapeutic agents with improved selectivity and reduced toxicity. In this study, we rationally designed and synthesized six novel amide-bridged triazole-coumarin hybrids (5a-f) based on the known anticancer potential of both pharmacophores. The synthesized compounds were evaluated for their cytotoxicity in MCF-7 and MDA─MB─231 breast cancer cell lines and non-tumorigenic MCF-10A cells.

Dual application of β-sitosterol and biochar reduces copper toxicity in bamboo via improved redox homeostasis.

Introduction: Heavy metal pollution threatens ecosystems and agriculture, necessitating affordable solutions.

Methods: We evaluated the combined effect of β-sitosterol (Bs, 100 mg L) and eucalyptus biochar (Eb, 10%) on bamboo ( f. ) under copper stress (100 and 200 mg L Cu).

Cultivation factors affecting durum wheat performance under speed breeding conditions.

Introduction: This study examined the effects of pot size, soil type, fertilizer x dose interactions, and foliar fertilizer application on wheat growth under speed breeding conditions.

Methods: The study was conducted in 2020 in a semi-controlled greenhouse at Dicle University, Diyarbakır, Türkiye, with a 22-hour photoperiod, 22/17°C day/ night temperature, 70% humidity, and 316.15 µmol/m/s light intensity using a mix of white, red, yellow, and purple LED lamps.

Evaluation of the quality and reliability of using YouTube as a patient information source for gonioscopy-assisted transluminal trabeculectomy: A cross-sectional study.

This study aimed to evaluate the quality and reliability of YouTube videos related to gonioscopy-assisted transluminal trabeculectomy, particularly in terms of their suitability for patient information. On April 1, 2025, 2 independent ophthalmologists (E.H.

Current activity concentrations of Ra, Th, K and Cs in beach sand samples from various coastal regions of Türkiye and associated health risk assessment.

In this study, gamma-spectrometry was used to determine the concentrations of Ra, Th, K, and Cs radioactivity in surface beach. Samples were collected from thirty-one coastal beaches across various cities in Türkiye. The results obtained were evaluated in the context of four geographical regions: Black Sea, Mediterranean, Marmara and Aegean.

Association of dietary inflammatory index with serum asprosin and omentin levels in women with prediabetes.

Background And Objectives: The objective of present study was to assess the relationship between the Dietary Inflammatory Index (DII) and the Glycemic Index (GI), serum TNF-α (tumor necrosis factor alpha), IL-6 (interleukin 6), serum asprosin, and omentin adipokines in prediabetic adult women.

Methods: The study included a total of 60 women: 30 women with prediabetes, aged 19-50 years, with a body mass index (BMI) ranging from 25 to 35 kg/m, and 30 healthy women with similar age and BMI as the control group. Dietary data for calculating DII and GI were obtained from food frequency questionnaires and food consumption records, respectively.

High-resolution DIC analysis of in situ strain and crack propagation in coated AZ31 magnesium alloys under mechanical loading.

Unlabelled: Biodegradable magnesium (Mg) alloys are promising for various biomedical applications but their susceptibility to corrosion poses significant challenges. This study systematically examines the microstructural integrity and failure mechanisms of electrochemically deposited phosphate- and fluorine-rich coatings on AZ31 Mg alloy subjected to three-point bending (3 PB) in both non-corrosive and physiological (HBSS) environments. High-resolution digital image correlation (HR-DIC) combined with scanning electron microscopy (SEM) enables in situ visualization and quantitative analysis of crack initiation, evolution, and propagation within the coatings.

Comparative clinical success of direct pulp capping materials: A network meta-regression of randomized clinical trials.

Objectives: This systematic review and network meta-regression (NMR) aimed to evaluate and compare the clinical effectiveness of various direct pulp capping (DPC) materials used in permanent teeth, incorporating follow-up duration as a covariate.

Materials And Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, Cochrane Library, Scopus, and Web of Science, without language restrictions. Only randomized clinical trials comparing at least two DPC materials with a minimum follow-up of three months were included.

Microplastic contamination in some herbal teas and human risk assessment: Türkiye.

Over the past ten years, plastic pollution has become a prominent and concerning environmental problem that our society must address. This study focuses on packaged herbal tea, investigating the prevalence and effects of microplastics (MPs) on selected herbal teas (green tea, sage tea, linden tea, and chamomile tea). This study offers the first information on MP pollution in four packaged herbal teas from five Turkish brands (A, B, C, D, and E).

A predictive enhanced PID-F control strategy for functional electrical stimulation based on the artemisinin optimization algorithm.

Functional electrical stimulation (FES) has demonstrated efficacy in enhancing comfort and mobility for individuals with paralysis, neurological diseases, and compromised muscle function. It facilitates motions that would otherwise be challenging or unattainable for these persons. Achieving optimal performance from FES systems necessitates the formulation of a strong and efficient control approach.

Piperonal-derived Schiff base molecules as potential multi-target therapeutic agents against Alzheimer's and diabetes.

Background: The dual burden of diabetes and Alzheimer's highlights the urgent need for multifunctional therapeutic agents. This study explores piperonal-derived Schiff base derivatives as potential dual-action enzyme inhibitors against -amylase (AA), -glucosidase (AG), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE), offers a promising strategy for managing both conditions.

Methods: Schiff base derivatives of piperonal (heliotropin) were synthesized, structurally characterized, and explored against established drug targets of diabetes mellitus (DM) and Alzheimer's disease (AD).

Comparative study by FEM of different liners of a transfemoral amputated lower limb.

The mechanical behavior of prosthetic liners significantly influences stress distribution, soft tissue protection, and the overall efficiency of the prosthetic. While extensive research has been conducted on liner materials, the impact of liner thickness (2 mm, 4 mm, and 6 mm) on biomechanical response remains underexplored. This study utilizes finite element analysis in Abaqus to investigate how liner material (Gel vs.

Investigation of the Effect of Krill Oil on Sortilin in Liver and Adipose Tissue in Obese Rats.

Sortilin regulates lipid metabolism, adipogenesis, and inflammation in obesity. While the anti-inflammatory and lipid-modulating effects of krill oil (KO) on obesity are well known, its effects on sortilin remain insufficiently investigated. This study investigates the potential effects of KO supplementation on sortilin and pro-inflammatory cytokine levels in rats fed a high-fat diet (HFD).

Assessment of smoking exposure by urine cotinine levels in severe COVID-19 patients: a case-control study.

Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, has posed a significant global public health challenge, with long-term sequelae such as post-COVID-19 syndrome continuing to burden health systems. Tobacco use, a major preventable cause of morbidity and mortality, impairs the immune response and exacerbates respiratory diseases, including COVID-19. Passive smoking, an important but often overlooked public health problem, exposes non-smokers to harmful health risks and may contribute to worse outcomes in respiratory disease.

Comparative Analysis of Retrobulbar Blood Flow in Symmetric and Asymmetric Keratoconus Patients.

Keratoconus is a progressive corneal disorder characterized by thinning and conical protrusion of the cornea, resulting in visual impairment. This study aimed to evaluate retrobulbar blood flow characteristics in patients with symmetric and asymmetric keratoconus and to compare these parameters with those of healthy individuals. Participants aged 18-40 years were recruited and categorized into three groups: symmetric keratoconus, asymmetric keratoconus, and healthy controls.

Association of Low Free T3 with Disease Presence and Activity in Ankylosing Spondylitis.

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by axial skeletal involvement and systemic metabolic changes. While inflammation is central to its pathophysiology, the potential role of thyroid hormones, particularly free triiodothyronine (FT3), in disease risk and activity remains underexplored. The objective of this study is to evaluate the relationship between serum FT3 levels and both the presence and clinical activity of AS, while also examining other endocrine-metabolic parameters.

Morphological and Functional Analysis of Residual Lung After Pneumonectomy in Lung Cancer Surgery via 3D-CT Method.

Pneumonectomy is a major surgical option for non-small cell lung cancer (NSCLC). This study evaluates the predictive value of three-dimensional computed tomography (3D-CT)-based lung volume analysis for postoperative function and explores its potential role in preoperative planning, risk assessment, and surgical decision-making. We evaluated 59 NSCLC patients who underwent pneumonectomy.

Comparative Cranial and Postcranial Osteology of Species (Squamata: Amphisbaenia) from Türkiye: Insights from Morphological Evolution and Phylogeny.

The genus (Amphisbaenia: Blanidae) comprises fossorial, limbless reptiles with cryptic external morphology, making species delimitation particularly challenging. This study presents a comprehensive comparative osteological and geometric morphometric investigation of three species distributed in Türkiye-, , and . Using both dry and cleared-and-stained specimens, diagnostic variations in cranial and postcranial skeletal elements, especially elements within the nasal, maxilla, vomer, squamosal, dentary, and coronoid bones, as well as vertebral counts were identified.

Living with Hypertension: An Investigation of Illness Perception from a Primary Care Perspective.

This study aimed to assess the illness perceptions of patients diagnosed with hypertension from a primary care perspective. It also sought to identify the sociodemographic and clinical factors associated with illness perception. A cross-sectional descriptive study was conducted between February and March 2025, involving 116 hypertensive patients who attended family medicine outpatient clinics at Rize Training and Research Hospital, Turkey.

Endometrial sampling in the absence of hysteroscopy: Insights from more than 1000 dilatation and curettage cases.

Objectives: The aim of this epidemiological study is to present the distribution of histopathological results of endometrial biopsies performed for indications in women and their relationship with symptoms.

Methods: A retrospective analysis was conducted on patients with abnormal uterine bleeding (AUB) assessed by endometrial biopsy between January 2020 and July 2022. Analyzing the distribution and association of patients' demographic traits, biopsy motivations, and histopathologic findings was the main goal of the study.