Ultrastructural Alterations in Melanopsis praemorsa (Linnaeus, 1758) (Gastropoda: Prosobranchia) Induced by Imidacloprid and the Protective Role of Ascorbic Acid.

Imidacloprid, a neonicotinoid pesticide widely used for controlling agricultural pests, is known to exert toxic effects on non-target aquatic organisms. This study aimed to investigate the toxicological impact of imidacloprid and the potential protective effect of an antioxidant, ascorbic acid, in the freshwater snail Melanopsis praemorsa. Eight experimental groups were established: two controls; three groups exposed to imidacloprid at concentrations of 4.

Single and Combined Impact of Environmental Concentrations of Galaxolide (HHCB) and Tonalide (AHTN) on Melanopsis praemorsa: Evaluating Genotoxicity and Stress Response Mechanisms.

Synthetic musk compounds (SMCs), such as galaxolide (HHCB) and tonalide (AHTN), are commonly used fragrance ingredients in personal care products and are frequently detected in aquatic environments due to their persistence and bioaccumulative nature. This study aimed to evaluate the individual and combined toxic effects of HHCB (1000 ng L) and AHTN (400 ng L) on the freshwater gastropod Melanopsis praemorsa following a 7-day exposure. Five experimental groups were formed: control, vehicle control, HHCB, AHTN, and HHCB+AHTN.

Cultivation factors affecting durum wheat performance under speed breeding conditions.

Introduction: This study examined the effects of pot size, soil type, fertilizer x dose interactions, and foliar fertilizer application on wheat growth under speed breeding conditions.

Methods: The study was conducted in 2020 in a semi-controlled greenhouse at Dicle University, Diyarbakır, Türkiye, with a 22-hour photoperiod, 22/17°C day/ night temperature, 70% humidity, and 316.15 µmol/m/s light intensity using a mix of white, red, yellow, and purple LED lamps.

Comparison of the efficacy of mFOLFOX-6 and mDCF regimens in the treatment of metastatic gastric cancer: a multicenter retrospective study.

Background: Metastatic gastric cancer (GC) and gastroesophageal junction (GEJ) cancer are associated with a poor prognosis. Recent advancements in treatment have incorporated trastuzumab, anti-PD-1 agents, and anti-claudin therapies alongside chemotherapy (ChT), significantly improving outcomes. Contemporary studies predominantly employ doublet ChT as the backbone for these regimens, although historically triplet ChT regimens have been favored, particularly in younger patients requiring rapid tumor shrinkage.

Serum levels of GDF-15, betatrophin, TNF-α and IL-6 in diabetic patients with and without diabetic complications.

Objectives: To investigate serum levels of growth differentiation factor 15 (GDF-15), inflammatory biomarkers, and betatrophin in individuals with diabetes mellitus, both with and without complications.

Methods: A cross-sectional analysis was conducted involving patients with diabetes. Participants were categorized into 3 groups: Group 1 (30 healthy individuals without diabetes), Group 2 (30 diabetic patients without complications), and Group 3 (30 diabetic patients with complications).

Depression, Anxiety, and MSQOL-54 Outcomes in RRMS Patients Receiving Fingolimod or Cladribine: A Cross-Sectional Comparative Study.

: Multiple sclerosis (MS) is a chronic immune-mediated neurological disorder that primarily affects young adults and is frequently accompanied by psychiatric comorbidities such as depression and anxiety, both of which significantly diminish patients' quality of life (QoL). This study investigated the effect of two oral disease-modifying therapies (DMTs), fingolimod and cladribine, on mental health and QoL in patients with relapsing-remitting MS (RRMS). The aim of the study was to compare levels of depression, anxiety, and health-related quality of life (HRQoL) in RRMS patients treated with fingolimod or cladribine, and to evaluate their associations with clinical and radiological parameters.

Switching to Long-Acting Cabotegravir and Rilpivirine in Turkey: Perspectives from People Living with HIV in a Setting of Increasing HIV Incidence.

: Long-acting cabotegravir and rilpivirine (LA-CAB/RPV) offers an alternative to daily oral antiretroviral therapy (ART) for people living with HIV (PLWH). Although LA-CAB/RPV has been approved in Turkey, the country remains in the pre-rollout period, and national data on patient perspectives are lacking. This is the first nationwide study from Turkey, a setting of increasing HIV incidence, assessing PLWH perspectives on switching to LA-CAB/RPV and the influence of motivational factors on treatment preferences.

PI3K/Akt1 Pathway Suppression by Quercetin-Doxorubicin Combination in Osteosarcoma Cell Line (MG-63 Cells).

: This study aimed to investigate the anticancer effects and potential synergistic interactions of quercetin (Q) and doxorubicin (Dox) on the MG-63 osteosarcoma (OS) cell line. Specifically, the effects of these agents on cell viability, apoptosis, reactive oxygen species (ROS) generation, antioxidant defense, and the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt1) signaling pathway were evaluated. : MG-63 cells were cultured and treated with varying concentrations of Q and Dox, both individually and in combination (fixed 5:1 molar ratio), for 48 h.

Genotypic and Phenotypic Characterization of Axonal Charcot-Marie-Tooth Disease in Childhood: Identification of One Novel and Four Known Mutations.

Charcot-Marie-Tooth disease (CMT) is a genetically and phenotypically heterogeneous hereditary neuropathy. Axonal CMT type 2 (CMT2) subtypes often exhibit overlapping clinical features, which makes molecular genetic analysis essential for accurate diagnosis and subtype differentiation. This retrospective study included five pediatric patients who presented with gait disturbance, muscle weakness, and foot deformities and were subsequently diagnosed with axonal forms of CMT.

Clonidine Protects Endothelial Cells from Angiotensin II-Induced Injury via Anti-Inflammatory and Antioxidant Mechanisms.

Cerebral aneurysm (CA) is a focal or diffuse pathological dilation of the cerebral arterial wall that arises due to various etiological factors. It represents a serious vascular condition, particularly affecting the elderly, and carries a high risk of rupture and neurological morbidity. Clonidine (CL), an α2-adrenergic receptor agonist, has been reported to suppress aneurysm progression; however, its underlying molecular mechanisms, especially in relation to cerebral endothelial dysfunction, remain unclear.

Cryogel-Immobilized Catalase as a Biocatalyst with Enhanced Stability Against Microplastics.

Catalase is a pivotal antioxidant enzyme that decomposes hydrogen peroxide and reduces oxidative stress. However, its low thermal and operational stability limits applications in challenging environments, particularly those contaminated with emerging pollutants such as polystyrene-based microplastics (PS-MPs). In this study, cryogels composed of Poly(2-hydroxyethyl methacrylate-co-allyl glycidyl ether) [Poly(HEMA-co-AGE)] were synthesized and evaluated as immobilization matrices to enhance catalase stability.

Automated Mucormycosis Diagnosis from Paranasal CT Using ResNet50 and ConvNeXt Small.

Purpose: Mucormycosis is a life-threatening fungal infection, where rapid diagnosis is critical. We developed a deep learning approach using paranasal computed tomography (CT) images to test whether mucormycosis can be detected automatically, potentially aiding or expediting the diagnostic process that traditionally relies on biopsy.

Methods: In this retrospective study, 794 CT images (from patients with mucormycosis, nasal polyps, or normal findings) were analyzed.

Synthesis of a novel multifunctional stationary phase derived from diethanolamine, HILIC/RPLC/WAX mixed-mode HPLC applications, and investigation of the retention mechanism.

Mixed-mode chromatography is increasingly valued for retaining analytes with diverse polarity and charge by integrating hydrophilic interaction (HILIC), reversed-phase (RPLC), and ion-exchange mechanisms. However, designing stationary phases that are both easy to synthesize and chromatographically versatile remains challenging. This study presents DEA-Mix-SP, a novel silica-based stationary phase functionalized with diethanolamine via [2-(3,4-epoxycyclohexyl)ethyl]trimethoxysilane, offering a simple synthetic route for broad-spectrum separation.

Moderating effect of self compassion on compassion fatigue and satisfaction among counselors.

Counselors are professionals who provide guidance and psychological counseling services in places such as educational institutions and guidance and research centers. The main purpose of this cross-sectional quantitative study was to investigate the relationship between compassion fatigue (CF) and compassion satisfaction (CS) among Turkish counselors and the moderating role of self-compassion in this relationship. A sample of 367 counselors (mean age 36.

Use of Fig Seed Meal as a New Alternative Feed Source in Quails: Effect on Growth Performance, Carcass Characteristics, Antioxidant Capacity and Serum Biochemistry.

This study aims to evaluate the potential of fig seed meal (FSM), which contains approximately 20% crude protein (CP) and provides 2106 kcal/kg of metabolizable energy (ME), as an alternative protein source in the diets of broiler Japanese quails (Coturnix coturnix japonica). One hundred sixty 1-day-old mixed-sex quails were divided into four groups, each with four replicates, and fed diets containing 0% (control), 2.5%, 5.

Comparison of incidentally detected focal FDG uptake in the thyroid gland on PET/CT with fine needle aspiration biopsy results.

Objectives: To compare the SUV-SUV values of the thyroid gland nodules and the SUV-SUV ratios of the nodules to normal thyroid gland with the fine-needle aspiration biopsy (FNAB) results, to determine the importance of nodule SUV value in the detection of malignancy.

Methods: This study included 788 patients without a diagnosis of thyroid cancer who exhibited focal uptake in the thyroid gland on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT. Of these, 131 patients underwent FNAB.

Investigation of the effects of MTHFR gene variations and homocysteine levels in hypertensive patients.

Objective: To investigate the effects of methylenetetrahydrofolate reductase (MTHFR) gene C677T/A1298C polymorphisms on serum homocysteine levels and hypertension.

Methods: Venous blood samples were collected in EDTA tubes from patients and controls (80 hypertensive patients and 67 healthy controls) and genomic DNA was isolated. The polymorphisms of MTHFR C677T and A1298C were identified using the polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) technique.

Psychiatric outcomes and quality of life in adolescents with moderate traumatic brain injury: a 6-month follow-up study.

Introduction: There is limited evidence regarding the association between traumatic brain injury (TBI) and the emergence of new-onset psychiatric disorders in adolescents. This prospective study analysed psychiatric disorders, quality of life, and emotional and behavioral difficulties in adolescents with TBI and orthopedic trauma at a 6-month follow-up.

Methods: Adolescents with TBI and a control orthopedic trauma group (without a history of psychiatric disorders) were evaluated using both the Strengths and Difficulties Questionnaire and the Paediatric Quality of Life Inventory.

Relationships among social support, healthy lifestyle beliefs, physical literacy, and enjoyment of physical activity: a moderated mediation model.

Objective: This study aims to examine the relationships between social support, physical literacy, and healthy lifestyle beliefs in adolescents and to investigate the moderating effect of enjoyment of physical activities on these relationships.

Method: The study was conducted with the participation of 1,349 adolescents. The ages of the participants ranged between 10 and 14 years, and 49.

Long-Term Outcomes of Necrotizing Pneumonia and Parapneumonic Effusion in Children.

Background: Complications such as parapneumonic effusion (PPE) and necrotizing pneumonia (NP) can be noted in 3% of patients with community-acquired pneumonia and may cause functional lung damage.

Objective: We aimed to investigate the short- and long-term effects of PPE and NP on lung function and the impact of treatment modalities and radiological sequelae on results.

Material And Methods: This multicenter retrospective study includes children aged 0-18 years hospitalized for PPE and NP after community-acquired pneumonia.

Unmet health-care needs: a study based on Turkey health survey (2019).

Objective: Reasons such as difficulty in payment, long waiting times, and the distance from health institutions and health-care needs of individuals may not be met. This study aims to determine the prevalence of health needs consisting of medical care, dental care, and prescribed drugs that are not met due to insolvency in Turkey and to evaluate whether features such as gender, age, education status, marital status, employment status, perceived health status, chronic disease status, and health insurance status affect these unmet health needs.

Methods: The study data consist of the Turkey Health Survey dataset conducted in 2019 on a sample determined in the Turkish population by the Turkish Statistical Institute.

The Relationship Between the Time Until Penile Fracture Repair and Post-Operative Erectile Dysfunction.

Aim: Although penile fracture is a rare condition, the damage it may cause afterwards is challenging for patients. We aimed to investigate the relationship between late presentation to the hospital and the frequency of erectile dysfunction (ED) in patients with penile fractures.

Methods: In our cross-sectional, retrospective study, the frequency and severity of ED were calculated according to the International Index of Erectile Function (IIEF) scoring in patients with penile fracture admitted to Dicle University Hospital in the inter-operative period between the event and the operation and the subsequent controls.

Nipple adenoma; a literature review and our experience with a rare feature.

With this review, we aimed to contribute to the literature by reviewing the studies on nipple adenoma and presenting a novel study regarding its occurrence in a male case, for which we have not found any publications worldwide. We have reviewed studies on nipple adenoma, which we rarely encounter in the literature. We also present a 41-year-old male patient, whom we operated on with a diagnosis of nipple adenoma.