The Immunohistochemical Demonstration of the Dlx-5, HLX and TLX1 Proteins in the Bovine Gastric Compartments Throughout Prenatal Development.

The homeobox gene subfamily members Dlx-5, HLX and TLX1proteins are known to regulate several embryonic development processes, including body axis formation, limb development and organogenesis, and play critical roles in cell proliferation and differentiation. This study was designed to investigate the localisation and expression density levels of Dlx-5, HLX and TLX1 proteins in cells of bovine stomach compartments during gestation and to compare the immunoexpression between the stomach compartments. A total of 30 foetuses, morphologically normal, from each period of gestation (10 foetuses from each period), were used in the study.

Shaping children's digital futures: The role of parenting strategies in regulating children's technology use.

Purpose: This study examines the influence of Digital Parental Awareness (DPA) and parenting strategies on children's Problematic Technology Use (PTU), emphasizing behavioral and relational attitudes. Recognizing the growing role of digital parenting in guiding children's technology use, the research considers two DPA sub-dimensions: Efficient Usage (leveraging technology for growth) and Protecting from Risks (preventing exposure to harmful content).

Methods: The research analyzed data from 314 parents through validated scales evaluating digital awareness, parenting attitudes, and PTU.

A manual three-step latent profile analysis to discover phubbing risk profiles among university students.

Phubbing, snubbing others in favor of one's smartphone, is a growing concern among university students. This cross-sectional study aimed to identify distinct phubbing profiles among university students and examine the influence of various factors on these profiles, as well as their associations with loneliness, communication skills, and happiness. Latent profile analysis (LPA) was conducted on a convenience sample of 691 university students (71.

Alpha-lipoic acid prevents doxorubicin-induced acute hepatorenal toxicity in rats by reducing oxidative and inflammatory stress to suppress autophagy.

Doxorubicin (DOX) is a commonly used medicine in cancer therapy. This drug accumulation in healthy tissues causes harmful clinical outcomes. Strategies that reduce oxidative damage, including alpha-lipoic acid (ALA) treatment, have been proposed to diminish toxic effects on healthy cells by raising the therapeutical effect of DOX on cancer cells.

Applying deep learning techniques to identify tonsilloliths in panoramic radiography.

Tonsilloliths can be seen on panoramic radiographs (PRs) as deposits located on the middle portion of the ramus of the mandible. Although tonsilloliths are clinically harmless, the high risk of misdiagnosis leads to unnecessary advanced examinations and interventions, thus jeopardizing patient safety and increasing unnecessary resource use in the healthcare system. Therefore, this study aims to meet an important clinical need by providing accurate and rapid diagnostic support.

Beyond skin deep: the unseen burden of hidradenitis suppurativa on sleep and quality of life.

Objectives: Hidradenitis suppurativa (HS) causes pain, discharge, odor, and scarring, potentially worsening sleep quality and psychological health. This study evaluated sleep, mood, and quality of life in HS patients compared to healthy controls, considering disease severity. We hypothesized that increased HS severity significantly impairs these outcomes.

The relationship between biological rhythm and breastfeeding success in lactating women.

This study aims to investigate the relationship between biological rhythm and breastfeeding success among breastfeeding women. Carried out as a descriptive and cross-sectional study, the present study was completed with 204 breastfeeding women. Data collection instruments included a "Personal Information Form," the "Biological Rhythm Interview of Assessment Scale (BRIAS)" scale, and the "LATCH Breastfeeding Assessment Tool.

Performance of AI Chatbots in Preliminary Diagnosis of Maxillofacial Pathologies.

BACKGROUND Artificial intelligence (AI) has shown significant potential in transforming healthcare by enabling accurate, data-driven decision-making. This study compared the performance of the AI chatbots ChatGPT, Grok, Blackbox, and Claude AI in preliminary diagnosis of maxillofacial pathologies. MATERIAL AND METHODS This study included 23 patients (9 cysts, 14 neoplasms) who underwent operations at Dicle University Faculty of Dentistry between 2017 and 2024 and had their diagnoses histopathologically confirmed.

Causes of diagnostic and treatment delays in locally advanced breast cancer: a nationwide multicenter survey and electronic health records analysis in Turkiye.

Delays in breast cancer (BC) diagnosis and treatment negatively impact survival outcomes. Understanding patient- and provider-related factors behind these delays is crucial. This study aimed to identify nationwide reasons for delayed diagnosis and treatment of locally advanced BC in Turkiye.

A comparison of cyclophosphamide at different dose levels for stem cell mobilization in multiple myeloma.

Background: We conducted a multi-center retrospective non-randomized study to clarify roles of 2 and 3 gr/m doses of Cyclophosphamide (Cy) for stem cell mobilization in Multiple Myeloma.

Material And Methods: This study analyzed 169 adult patients who received Cy-based mobilization regimen at doses 2 and 3 gr/m between 2018 and 2024. All patients included in this study were 18 years old and older.

Aryl hydrocarbon receptor interacting protein and syndromic gene variants detected in Turkish isolated pituitary adenoma families by whole exome sequencing.

Genetic causes of familial isolated pituitary adenomas (FIPAs) remain mostly elusive. A cohort of 20 FIPA cases from 12 different geographical regions of Türkiye was included to characterize clinical and genetic features. Whole exome sequencing (WES) was performed on genomic DNA of index cases, followed by confirmation through Sanger sequencing utilizing indexes and their relatives to interpret disease associated variants.

Shedding Light on the Phytochemical and Biological Fingerprints of (L.) Medik Essential Oil as a Pharmacotherapeutic Agent.

Since plant essential oil contains medicinally valuable compounds, its usability as a pharmacotherapeutic agent has been the focus of attention within the century's needs. The lack of sufficient studies on the medical and pharmacological evaluation of (L.) Medik has made this plant the target of our study.

Safety and efficacy of immune checkpoint inhibitors in patients with cancer and hepatitis B: multicentre experience in a low-middle-income country.

Background: Immune checkpoint inhibitors (ICIs) are widely used in clinical practice. The primary objective of this study is to evaluate the safety and efficacy of ICIs in patients diagnosed with cancer who also have chronic hepatitis B virus (HBV) infection.

Methods: We reviewed the charts of patients who received an ICI between 2016 and 2023 at three tertiary cancer centers.

The effect of patıent advocacy on professıonal values in nurses: a correlatıonal study.

Background: Patient advocacy, which is an integral part of patient care processes, envisages the defense of patients on issues such as patient rights and ethical values and is a concept directly related to the core values of the nursing profession. It is thought that nurses' patient advocacy behaviors are linked to their perceptions of professional values. Therefore, this study aimed to determine the effect of nurses' patient advocacy behaviors on professional values.

Chemical composition, characterization, and antimicrobial properties of essential oil-based nanoemulsions and its application on curd cheese.

Background And Aims: L. has been widely recognized as a food additive due to its therapeutic benefits and low toxicity risk. This study focuses on the chemical constituents of essential oil, antimicrobial, and antioxidant properties of essential oil (EO)-based nanoemulsions (NEs) and for the first time their effect on the preservation of curd cheese.

Genotype, Phenotype Characteristics and Long-Term Follow-Up of Patients with Vitamin D-Dependent Rickets Type IA: A Nationwide Multi-Centre Retrospective Cross-Sectional Study.

Introduction: Vitamin D-dependent rickets type IA (VDDR1A) is an autosomal recessive disorder characterized by defects in the biosynthesis of its active form 1,25-dihydroxyvitamin D due to mutations in the CYP27B1 gene, which encodes for 1α-hydroxylase. The present study aimed to evaluate the clinical characteristics, molecular genetic aetiology, and long-term outcomes of a large nationwide cohort of children with VDDR1A from Turkey.

Methods: In this multi-centre retrospective cross-sectional study, we collected clinical characteristics, laboratory features, molecular genetic analysis results, and long-term follow-up of a nationwide cohort of patients with VDDR1A using a web-based research network, CEDD-NET, for paediatric endocrinology research.

Exploring the effects of curiosity and anxiety on Mathematics teaching efficacy beliefs in primary school teachers.

Backround: In the mathematics education literature, there is a limited number of comprehensive studies that examine the dynamic relationship between teacher efficacy beliefs and psychological variables such as curiosity and anxiety within the context of primary education. However, these variables have a wide sphere of influence, extending from instructional quality to student achievement, and they interactively shape teacher behaviors. Therefore, investigating the impact of primary teachers' mathematical curiosity and teaching anxiety on their beliefs about mathematics teaching efficacy emerges as a necessity for supporting professional development, restructuring teacher education programs more effectively, and contributing to the improvement of mathematics instruction.

The Relationship Between Preoperative Cyberchondria Levels and Death Anxiety of Liver Donors.

This descriptive and correlational study aimed to investigate the relationship between preoperative levels of cyberchondria and death anxiety in liver donors. It was conducted with 158 liver transplant donors hospitalized in the organ transplant clinics of a Liver Transplant Institute in eastern Turkey. The total score for the death anxiety scale was high (9.

Magnetic nanoparticle-based method for microorganism concentration in sterile body fluids: Validation and clinical applications.

Rapid and accurate detection of microorganisms in sterile body fluids, particularly cerebrospinal fluid (CSF), is crucial for effective diagnosis and treatment. Conventional methods, such as centrifugation, may result in low microbial recovery and false negatives, limiting diagnostic accuracy. An alternative, efficient, and accessible microbial concentration method is needed.

Musculoskeletal outcomes following thoracoscopic versus conventional open repair of esophageal atresia: A systematic review and meta-analysis from pediatric surgery meta-analysis (PESMA) study group.

Background And Objective: Thoracic musculoskeletal deformities are a recognized long-term complication after esophageal atresia (EA) repair. Although evidence remains limited, thoracoscopic repair (TR) is thought to reduce morbidity compared to conventional open repair (COR), with potential benefits including earlier recovery, reduced pain, improved cosmesis, and fewer musculoskeletal sequelae. This systematic review and meta-analysis aimed to compare the incidence of musculoskeletal deformities following EA repair via TR versus COR, emphasizing their long-term clinical implications.

Evaluation of BRAF and KRAS Gene Expression in Nasal Polyposis.

Objective: The goal of this study was to investigate the expression patterns and potential relationship of the Kirsten rat sarcoma viral oncogene homolog (KRAS) and B-raf proto-oncogene (BRAF) genes in nasal polyposis (NP).

Methods: Twenty-nine patients were included in the study. Small punch biopsies were collected from nasal polyps during each operation and immediately frozen in liquid nitrogen.

From Ethnopharmacology to Active Compound: Effects of Traditional Plant Extracts on Varicose Vein-Related Enzymes and Isolation of Active Flavonoids from DC. subsp. .

Varicose veins and chronic venous insufficiency are chronic venous disorders involving abnormalities in the venous system. Inflammation, an increase in proteolytic enzymes, and free radicals are important factors that play a role in the varicose vein pathology. In this study, the antioxidant properties and inhibitor activities of 17 plant extracts used to treat varicose veins in traditional medicine were evaluated against varicose veins-related enzymes (hyaluronidase, elastase, collagenase, lipooxygenase, prolylendopeptidase, and xanthine oxidase).

In Vitro Evaluation of Cytotoxic and Pro-Apoptotic Effects of Hesperidin Alone and in Combination with Cisplatin on Human Malignant Melanoma Cell Line (A431).

Melanoma is an aggressive skin cancer with high metastatic potential and poor prognosis in advanced stages. Hesperidin, a natural flavonoid, has shown anticancer properties across various malignancies. This study aimed to evaluate the antiproliferative and pro-apoptotic effects of Hesperidin, alone and in combination with Cisplatin, on the human epidermoid carcinoma cell line A431.

Antitumor Effects of Hesperidin and Cisplatin on Human Osteosarcoma Cells Through Inhibiting Proliferation and Inducing Mitochondrial-Mediated Apoptosis.

: Osteosarcoma is a primary malignant bone tumor characterized by the proliferation of malignant mesenchymal cells and primarily affects children and adolescents. Hesperidin (Hes) interacts with various cellular targets and inhibits cancer cell proliferation by inducing apoptosis. However, the precise mechanisms underlying Hes-induced cell death in osteosarcoma cells remain unclear.