The Effect of Stigmatization on Working Nurses' Willingness to Care for Patients with Psoriasis and Its Mediating Factors.

Psoriasis-related stigmatization affects nurses' willingness to provide care, potentially compromising patient outcomes. However, limited research has examined this issue. A cross-sectional survey of 1,873 nurses was conducted, which assessed 4 stigmatization dimensions and their correlation with the willingness to care for patients with psoriasis, and explored the roles of education, working environment, and self-reported psoriasis knowledge.

Children Treated for Slow-flow Vascular Malformations: Overall Description and Focus on Complications Such as Cellulitis.

Some patients with slow-flow vascular malformations (SFVMs) develop recurring cellulitis. The main objective of this study was to describe SFVMs in children. Other objectives were to determine the frequency of cellulitis episodes, and the factors associated with the occurrence of cellulitis.

Unlocking Superior Energy Storage: Multiscale Optimized BNT-Based Capacitors for Low-Field Applications.

Achieving superior energy storage performance in dielectric materials under low electric fields remains a challenge. Most recent advancements require high fields that limit device applicability. Developing dielectric capacitors with high recoverable energy density (W), efficiency (η), and energy-storage coefficient (W/E) at low/moderate fields is critical for safer, compact, and durable electronics.

2D Active Filler Modified Porous Polymer Network for Stabilizing Zn Anode Under Harsh Conditions.

Artificial porous polymer coatings are promising for alleviating the side reactions and dendrite growth on Zn anodes. Nevertheless, the low ion transport ability constrains their application under harsh conditions such as thin Zn foil, high current density, and high depth of discharge (DOD). Herein, a 2D active filler is introduced to optimize the Zn migration in porous polymer coating.

Foliar Application of SiO Nanoparticles Altered Rhizosphere Metabolite and Microbe Profiles: Surface Chemistry-Driven Biological Effects.

Silica nanoparticles (SiONPs), as emerging foliar nanofertilizers, demonstrate promising potential in agriculture. However, whether foliar application of SiONPs alters belowground soil metabolites and microbe composition and abundance remains largely unknown. In this study, 3-week-old cucumber plants were foliar-sprayed with fumed or Stöber SiO NPs dosing at -4 mg of NPs per plant for 5 days.

Composite endpoints in health technology assessment: part 2 - expanding the evidence base with a framework for best modeling practice.

The first paper of this two-part series critically examined the role of composite endpoints in health technology assessments (HTAs) and outlined strategies for determining whether to employ the composite estimate of treatment effect or disaggregate into the component endpoints of the composite and apply separate treatment effects within a modeling framework. In this second paper, we expand the discussion beyond a pivotal trial and consider the way in which additional evidence from the same indication for different drugs in the same class, or the same drug for different indications, could be employed within HTAs. We offer a continuation of the case study of dapagliflozin for the treatment of heart failure with preserved or mildly reduced ejection fraction, where the evidence base was expanded to consider empagliflozin for the same indication, as well as both dapagliflozin and empagliflozin for heart failure with reduced ejection fraction.

Composite endpoints in health technology assessment: Part 1 - an illustration of best modeling practice.

Composite endpoints amalgamate multiple clinical outcomes into a single measure, offering efficiency gains in clinical trials through increased event rates and reduced sample sizes, thus accelerating clinical development and regulatory approval. However, employing composite endpoints introduces complexities into health technology assessments (HTAs), particularly in economic modeling, due to the varying clinical significance and cost implications of the components. In this paper, we explore best modeling practice for HTAs that are based on clinical trials that employ composite endpoints.

Treg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR-Based Genetic Analyses and Experimental Models.

Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD. However, their role in neuroimmune interactions and behavioral outcomes remains poorly understood.

Surface Topography and Ultrastructure of the Spectacular Cells in the Eyes of Land and Sea Snakes (Squamata, Reptilia): Functional Adaptations of Micro-Ornamentation.

Although the surface micro-ornamentation of the scales within the skin of snakes has been the subject of many previous studies, there has been little work done on the spectacle, a protective (keratinised) goggle separated from the underlying cornea by a sub-spectacular space. The surface ultrastructure of the "Oberhäutchen" of the spectacle is examined in nine species of snakes (five aquatic and four terrestrial) using light and electron microscopy, micro-computed tomography and gel-based profilometry. Significant topographic differences in cell size (increases of between 5.

Evaluation of Left Atrial Function in Patients with Hypertensive Heart Disease and Preserved Ejection Fraction Using Real-Time, Three- Dimensional Speckle Tracking Imaging.

Objective This research investigated the application of real-time, three-dimensional speckle tracking imaging (RT-3D-STI) to evaluate left atrial (LA) function in individuals suffering from hypertensive heart disease (HHD) and heart failure with preserved ejection fraction (HFpEF).Material and methods This retrospective study included 100 patients with HHD and HFpEF hospitalized from August 2023to June 2024 (HFpEF group). 100 healthy individuals undergoing physical examinations comprised the control group.

Decarboxylative Pyrazolylation of Aryl Carboxylic Acids via Synergetic Organic-Photoredox and Copper Catalysis.

The decarboxylative amination of aryl carboxylic acids with low toxicity, structural diversity, and ready availability remains relatively underexplored. Current protocols typically require the use of overstoichiometric metal additives and/or strong oxidants as well as high reaction temperatures. Herein we report decarboxylative amination of aryl carboxylic acids with pyrazoles via synergistic organic-photoredox and copper catalysis under mild conditions, employing air as a green oxidant.

An aptasensor-based fluorescent signal amplification strategy for highly sensitive detection of mycotoxins.

Aflatoxin B1 (AFB1) is one of the most toxic mycotoxins that pose great health threats to humans. Herein, an aptasensor-based fluorescent signal amplification strategy is developed for the detection of AFB1. Initially, the AFB1 aptamers labelled with carboxyfluorescein (FAM) are adsorbed onto graphene oxide (GO), triggering energy transfer.

Key locations of oxidative damage in human hair keratins after heat and ultraviolet light exposure.

Objective: This study investigated the locations of amino acid modifications within two major human hair keratins (Type I K31 and Type II K85) with probable implications for protein and hair structural component integrity. The particular focus was on cysteine modifications that disrupt intra-protein and inter-protein disulphide bonds.

Methods: Human hair was exposed to accelerated, sequential heat or UV treatments, simulating effects resulting from the use of heated styling tools and environmental exposure over a time frame approximating one year.

High-entropy spinel (FeCoNiMnCr)O nanoparticles supported on carbon nanotubes for enhanced electrochemical seawater oxidation.

High-performance, low-cost electrocatalysts are essential for freshwater-independent seawater electrolysis. We design a SWCNT-supported (FeCoNiMnCr)O high-entropy spinel oxide by a hydrothermal method and air-firing, where the conductive network enhances charge transfer and active site exposure. The catalyst achieves 282 mV@10 mA cm with 100 h stability in alkaline seawater.

BOLD Long-Range Temporal Correlations Reflect Changes in Language and Depression Across Intensive Aphasia Therapy.

Background: Intensive language-action therapy treats language deficits and depressive symptoms in chronic poststroke aphasia, yet the underlying neural mechanisms remain underexplored. Long-range temporal correlations (LRTCs) in blood oxygenation level-dependent signals indicate persistence in brain activity patterns and may relate to learning and levels of depression. This observational study investigates blood oxygenation level-dependent LRTC changes alongside therapy-induced language and mood improvements in perisylvian and domain-general brain areas.

Efficacy of Tenecteplase in Large Vessel Occlusion Stroke Within 24 Hours of Symptom Onset: The ETERNAL-LVO Randomized Controlled Trial.

Background: To assess the efficacy and safety of tenecteplase in patients presenting within 24 hours of symptom onset with a large vessel occlusion and target mismatch on perfusion computed tomography.

Methods: ETERNAL-LVO was a prospective, randomized, open-label, blinded end point, phase 3, superiority trial where adult participants with a large vessel occlusion, presenting within 24 hours of onset with salvageable tissue on computed tomography perfusion, were randomized to tenecteplase 0.25 mg/kg or standard care across 11 primary and comprehensive stroke centers in Australia.

Drug-Eluting Resorbable Scaffold Versus Balloon Angioplasty for Below-the-Knee Peripheral Artery Disease: 2-Year Results From the LIFE-BTK Trial.

Background: Limited treatment options exist for infrapopliteal disease in patients with chronic limb-threatening ischemia (CLTI), a condition associated with a high risk of limb loss. Interventional management of diseased infrapopliteal vessels with percutaneous transluminal angioplasty (PTA) is associated with high rates of restenosis and reintervention. In the LIFE-BTK trial, the drug-eluting resorbable scaffold (DRS) demonstrated superior 12-month efficacy compared with PTA in a selected CLTI population with predominantly noncomplex, mildly to moderately calcified lesions.

Parasagittal dural space and arachnoid granulations morphology in pre-clinical and early clinical multiple sclerosis.

Background: There is limited knowledge on the post-glymphatic structures such as the parasagittal dural (PSD) space and the arachnoid granulations (AGs) in multiple sclerosis (MS).

Objectives: To evaluate differences in volume and macromolecular content of PSD and AG between people with newly diagnosed MS (pwMS), clinically isolated syndrome (pwCIS), or radiologically isolated syndrome (pwRIS) and healthy controls (HCs) and their associations with clinical and radiological disease measures.

Methods: A total of 69 pwMS, pwCIS, pwRIS, and HCs underwent a 3.

Perinatal Arterial Ischemic Stroke in Monochorionic Twins: A Retrospective Observational Single-Center Cohort Study.

Background: Monochorionic twins, characterized by placental sharing and vascular anastomoses, carry a high risk of brain injury, including perinatal arterial ischemic stroke (PAIS). However, the pathophysiology and timing-related risk factors of PAIS remain unclear.

Methods: Retrospective cohort of all monochorionic twins with neuroimaging-confirmed PAIS born from 2005 to 2024 and evaluated at a Dutch national referral center.

A myotropic AAV vector combined with skeletal muscle -regulatory elements improve glycogen clearance in mouse models of Pompe disease.

Pompe disease is a glycogen storage disorder caused by mutations in the acid α-glucosidase (GAA) gene, leading to reduced GAA activity and glycogen accumulation in heart and skeletal muscles. Enzyme replacement therapy with recombinant GAA, the standard of care for Pompe disease, is limited by poor skeletal muscle distribution and immune responses after repeated administrations. The expression of GAA in muscle with adeno-associated virus (AAV) vectors has shown limitations, mainly the low targeting efficiency and immune responses to the transgene.

Machine learning predicts improvement of functional outcomes in spinal cord injury patients after inpatient rehabilitation.

Introduction: Spinal cord injury (SCI) presents a significant burden to patients, families, and the healthcare system. The ability to accurately predict functional outcomes for SCI patients is essential for optimizing rehabilitation strategies, guiding patient and family decision making, and improving patient care.

Methods: We conducted a retrospective analysis of 589 SCI patients admitted to a single acute rehabilitation facility and used the dataset to train advanced machine learning algorithms to predict patients' rehabilitation outcomes.

Reducing motion artifacts in craniocervical background subtraction angiography with deformable registration and unsupervised deep learning.

Background: In clinical practice, digital subtraction angiography (DSA) often suffers from misregistration artifact resulting from voluntary, respiratory, and cardiac motion during acquisition. Most prior efforts to register the background DSA mask to subsequent postcontrast images rely on key point registration using iterative optimization, which has limited real-time application.

Purpose: Leveraging state-of-the-art, unsupervised deep learning, we aim to develop a fast, deformable registration model to substantially reduce DSA misregistration in craniocervical angiography without compromising spatial resolution or introducing new artifacts.

Safety of Acupuncture in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Introduction: Acupuncture has emerged as an effective adjunctive therapy for polycystic ovary syndrome (PCOS) with concern on the higher rate of adverse events (AE). In addition, timing of intervention, specific acupoints, and stimulation strength are concerning, as high-stimulation electroacupuncture (EA) may increase miscarriage risk. This review aims to systematically evaluate the safety profile of acupuncture in PCOS.