Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies.

Cancer continues to be a major global health challenge, necessitating the ongoing development of novel small-molecule therapeutics that can selectively target DNA and disrupt cancer cell proliferation. In this study we report the synthesis and characterization of novel guanidine derivatives (7a-j). Their DNA-binding potential was assessed through electronic absorption spectroscopy, revealing characteristic hypochromic shifts indicative of minor groove-binding interactions with salmon sperm DNA (SS-DNA).

Hydrothermal synthesis of FeO-AgO nanocomposites supported on pristine, N/S doped graphene oxide for photocatalytic and biological applications.

Addressing the dual challenges of industrial contamination in wastewater and antimicrobial resistance is crucial for environmental preservation and global health, aligning with sustainable development goals. This study investigated the biological and photocatalytic potential of pure bimetal oxides, nanocomposites (NCs) and their counterparts incorporating graphene oxide (GO) and nitrogen- and sulfur-doped GO. A set of samples, namely FeO-AgO, FeO-AgO@GO, FeO-AgO@N-GO, and FeO-AgO@S-GO NCs, was synthesized using the hydrothermal method.

Perylene-based Electron Transport Materials in Perovskite Solar Cells To Improve Power Conversion Efficiency.

Perovskite solar cells (PSCs) are highly efficient and flexible; thus, they have garnered a lot of focus. In the past, many fullerene compounds, such as PCBM, were employed as electron transport layers in PSCs. PCBM has several drawbacks, including surface trapping states, limited electron mobility, poor photochemical as well as thermal stability, a low open-circuit voltage, and significant recombination losses.

Physiological and biochemical alterations in soybean by banana peel biochar under different degrees of salt stress.

Salt influences cellular membranes by the excessive production of reactive oxygen species, while osmolytes play a vital role in protecting plants from oxidative stress caused by salt. Biochar may alleviate the effects of salinity-induced stress on crops. The study investigated the impact of biochar supplementation on osmolyte modifications and antioxidant activity in soybean (Glycine max cv.

Artemisia lerchiana Based Green Synthesis of Silver Nanoparticles: TEM Microscopy, Physicochemical, and Spectroscopic Characterization.

Silver nanoparticles (AgNPs) have unique physicochemical characteristics that render them very appropriate for various biomedical applications. AgNPs were synthesized in a study by an environmentally friendly and cost-effective method where an aqueous extract of Artemisia lerchiana was used as a bioreducing and stabilizing agent. To characterize the synthesized nanoparticles, a conjunction of analytical methods was employed, such as UV-Visible spectrophotometry, Fourier Transform Infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and atomic force microscopy (AFM).

MXene-nanoparticles foliar application improves wheat morpho-physiological and biochemical traits under cadmium (Cd) stress: A novel sustainable approach.

Cadmium (Cd) pollution is a persistent problem in the agricultural sector. Plants can be treated with nanoparticles (NP) to reduce heavy metal stress. MXene nanoparticles (MX-NPs) were tested for wheat Cd stress relief.

Green synthesis of curcumin nanoparticles, characterization, and their role in alleviating arsenic-induced oxidative stress by enhancing antioxidant defense, photosynthetic pigments, and agronomic traits in wheat.

Unlabelled: This study evaluates the potential of green-synthesized curcumin nanoparticles (Cur-NPs) for mitigating arsenic (As) stress in wheat cultivars Barani-70 and NARC-09. Cur-NPs were characterized by UV-visible spectrophotometry, XRD (36 nm), Fourier Transform Infrared (FTIR) spectroscopy, and Scanning Electron Microscopy (SEM), revealing well-dispersed, amorphous structures and functional groups. Both cultivars were subjected to 10 mg/L arsenic stress and treated with Cur-NPs at 50 mg/L and 100 mg/L through soil and foliar applications.

Synthesis, biological screening and computational analysis of Thiazole linked Thiazolidinone Schiff bases as anti-Alzheimer's drug candidates.

This study unveils the rational design and stepwise synthesis of new thiazole-based thiazolidinone Schiff base derivatives (1-15), harnessing 2-amino-5-nitrothiazole as a crucial precursor. These newly synthesized derivatives were structurally characterized through spectroscopic techniques HNMR, CNMR and HREI-MS. Moreover, consider the crucial role of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition in Alzheimer's disease (AD) therapy, the synthesized compounds were evaluated for their cholinergic enzyme inhibitory potential against AChE and BuChE, with Donepezil (IC = 5.

Effect of various parameters on the morphology of anodic WO nanostructure: transition from nanoflowers to nanosheets.

Nanomaterials with diverse morphologies have attracted considerable attention owing to their applications in numerous scientific disciplines. This study investigated the influence of various experimental parameters on the morphology of anodic WO nanostructures obtained in aqueous HNO. X-ray diffraction (XRD) analysis confirmed that WO comprises a monoclinic phase, while field-emission scanning electron microscope (FE-SEM) results revealed the formation of WO nanoflowers and nanosheets morphologies under optimized conditions.

Morphophysiological attributes of AMF inoculated tomato (Lycopersicon esculentum Mill.) ameliorated by resorcinol, biochar and nanobiochar.

Food consumption will rise rapidly as the global population grows over the next several decades. The current agricultural production system cannot solve this challenge, forcing crop growth to experience more adverse conditions. To promote the long-term sustainability of crop production and reduce reliance on excessive agrochemical use, the implementation of integrated nutrient management systems that involve the combination of chemical and biological fertilizers represents an enormous challenge.

's Antidiabetic Potential: Exploring Phytochemicals, Screening Antioxidant Activity, and Validating DPP-4 Inhibition Using In Vitro and In Silico Approaches.

Diabetes is a chronic metabolic disorder that affects an increasing number of people worldwide, frequently managed with synthetic drugs that have side effects and can be costly. (N.E.

Molybdenum carbide supported metal-organic framework-derived Ni, Co phosphosulphide heterostructures as efficient OER and HER catalysts.

Molybdenum carbide (Mo C) has gained attention for water splitting due to its electronic structure resembling to Pt and have high electrochemical performance. We designed porous nanostructured phosphorus/sulfur co-doped Ni, Co phosphosulphide and molybdenum carbide heterostructures Mo C(MoC-MoC) through confined carburization within a metal-organic framework (MOF) matrix combined with a phosphosulfurization strategy. Starting from a carbon source consisting of NiCo-MOF incorporating molybdenum trioxide, we prepared MOF-derived NiCo-Mo C nanorods carbonization, which exhibited decent electrocatalytic performance for the hydrogen evolution reaction (HER) by electrochemical water splitting.

Combine effects of Broussonetia papyrifera-derived biochar and selenium nanoparticles for lead-polluted saline soils remediation during barley cultivation.

Contamination of soil with lead (Pb) and salinity is a substantial concern, impacting plant health and yield. This research analyzes the synergistic use of Broussonetia papyrifera-derived biochar (BP-BC) and selenium nanoparticles (SeNPs) to alleviate the detrimental impacts of salinity and Pb on barley plants. Field trials in Pb-polluted saline soils showed the use of SeNPs (0, 10 and 20 mg L) and BP-BC (0, 5 and 10 t ha) markedly enhanced soil physicochemical attributes, such as soil ESP, pH and EC.

Uncovering the oxidative stress and hematological consequences of chronic cobalt exposure on atherosclerosis.

Overproduction of reactive oxygen species (ROS) causes oxidative stress, which is a significant risk factor for the onset and advancement of atherosclerosis. However, in current study, rats with experimentally generated atherosclerosis (EA) are used to examine the effects of prolonged cobalt nitrate exposure on oxidative stress and hematological markers. An atherogenic diet, methylprednisolone, alcohol, and mercazolil were all used in a polyetiological method to imitate atherosclerosis.

A Novel Variant in the Cyto-Tail of Gene Underlying Isolated Postaxial Polydactyly.

Background: Polydactyly is one of the most common hereditary limb malformations, characterized by presence of additional digits in hands and/or feet. It is present either in isolated form or in combination with other features. Preaxial polydactyly with extra digit on the outside of the thumb or big toe, and postaxial polydactyly with extra digit on the outside of the little finger or little toe are the two main forms of polydactyly.

SEM-Based Foliar Micromorphology for Taxonomic Delimitation of Selected Herbaceous Species.

This study represents the first comprehensive effort to document the pollen taxonomy of plant species in the Hindukush-Karakoram-Himalaya region of northern Pakistan. The clarification of the leaf micromorphology of the selected herbaceous plants reveals characteristics like the stomata types, trichome types, and epidermal cell size and shape. The leaf micromorphology of 50 herbaceous plants revealed foliar anatomical traits, such as changes in epidermal cells, trichome morphology, and stomatal type.

Facile indazole-endowed thiadiazole hybrid derivatives as antibacterial, anti-diabetic and thymidine phosphorylase inhibitors: An insight to experimental, in-vitro biological potential and computational approaches.

In this study, a series of newly synthesized indazole-based thiadiazole hybrid derivatives (1-13) were successfully synthesized from indazole-based thiosemicarbazides starting from the 5-methyl-1H-indazole-3-carboxylic acid. The structure of the synthesized compounds were confirmed through different spectroscopic techniques i.e.

Chlorophyllum molybdites-synthesized manganese oxide nanoparticles (MnO-NPs): morphology, biocompatibility, and anticancer properties against liver cancer (HepG2) cell line.

Nanoparticles synthesized from natural sources are gaining prominence for their unique physicochemical properties and biocompatibility. This study investigates the potential of wild mushrooms, specifically Chlorophyllum molybdites (Lepiota morganii, green-spored parasol), for the green synthesis of manganese oxide nanoparticles. Mycosynthesized nanoparticles (NPs) were characterized via spectroscopic techniques such as XRD, UV spectroscopy, FTIR, and microscopic techniques such as SEM, and EDX, confirming their crystalline structure, spherical morphology, and a nanoscale size of 19.

Mechanisms of azithromycin resistance in : molecular insights from dynamics behavior to clinical implications.

The widespread use of azithromycin during the COVID-19 pandemic has likely contributed to the increased resistance of to this antibiotic. This study focuses on the extensive drug resistance (XDR) of in Pakistan, analyzing 11,916 suspected typhoid fever cases, with 424 confirmed as and Paratyphi A. Through antimicrobial susceptibility tests and PCR-based Sanger sequencing, an R717L mutation in the gene was identified, signalling the emergence of azithromycin resistance.

PVDF-based solid polymer electrolytes for lithium-ion batteries: strategies in composites, blends, dielectric engineering, and machine learning approaches.

Solid polymer electrolytes (SPEs) present a viable alternative to organic carbonates typically used as liquid electrolytes in lithium-ion batteries (LIBs). Among various SPEs, poly(vinylidene fluoride) (PVDF)-based SPEs have received significant attention owing to their excellent film forming ability, chemical and thermal stability, mechanical strength, and electrochemical performance. This review focuses on recent innovative strategies in composites, blends, and dielectric engineering to achieve PVDF-based SPEs with enhanced electrochemical performance.

Environmental applications of magnetic nanohybrid materials.

The distinctive characteristics and versatile functionalities of magnetic nanoparticles (MNPs) position them as promising candidates for numerous environmental applications, attributed to their structural and physiochemical properties. Magnetic nanoparticles can integrate organic polymers, carbon-based materials, and metal oxides to form multifunctional composites that effectively adsorb and degrade pollutants. This review article discusses the magnetic nanomaterials and the techniques employed to functionalize and tailor these materials and their application for wastewater treatment, cleanup of oil spills, and photocatalytic degradation of pollutants of emerging concern.

WO/NbCT MXene 2D-2D heterojunction as a high performance photoanode for photoelectrochemical water splitting.

Photoelectrochemical (PEC) water splitting plays a key role in the production of green hydrogen, which is a sustainable energy source and non-exploitative to the environment. Therefore, the development of efficient photocatalysts is essential for enabling green hydrogen generation. In this work, the synergistic effect between tungsten oxide (WO) and NbCT (MXene) was explored for PEC water oxidation, and a composite catalyst was prepared using a hydrothermal and sonication approach to obtain a 2D/2D WO/NbCT heterojunction.

: a multifunctional botanical resource for sustainable agriculture, nutrition, and therapeutic applications, a review.

, widely recognized as the "miracle tree," has garnered significant scientific interest due to its exceptional nutritional, medicinal, and industrial properties. This study provides a comprehensive evaluation of its potential as a sustainable feed additive, antimicrobial agent, functional food ingredient, and a bioresource for agricultural and industrial advancements. Enriched with high-quality proteins, essential amino acids, vitamins, minerals, antioxidants, and bioactive compounds, exhibits remarkable benefits in aquaculture, livestock production, and human nutrition.

Magnetic hyperthermia-triggered multi-functional thermo-responsive lipid nanoparticles for enhanced paclitaxel release and cytotoxicity.

The inadequate safety and efficacy of chemotherapy have led cancer medicine to focus on localizing drug delivery to the target. Thermoresponsive nanocarriers (liposomes and polymeric networks) exploit local hyperthermia to trigger targeted payload release; however, their low stability and unpredictable fate have led to failure in clinical studies. To overcome these challenges, we reported first-of-its-kind thermoresponsive lipid nanoparticles (TLNs) that undergo solid-liquid phase transition under hyperthermia to release the payload.

Precision nanophytomedicine: Alginate-chitosan nanogels encapsulating Olea ferruginea ethyl acetate fraction for enhanced cardiovascular protection.

Cardiomyocyte death is a primary cause of cardiovascular diseases, including maladaptive cardiac hypertrophy (CH). Oxidative stress from excessive reactive oxygen species (ROS) contributes to cardiomyocyte apoptosis. Due to the limitations associated with conventional antioxidants, plant-derived therapeutics have emerged as promising alternatives.