Safety and efficacy of glucagon-like peptide 1 receptor agonists in solid organ transplant recipients with diabetes mellitus: a systematic review and meta-analysis.

There is limited evidence to support the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in solid organ transplants (SOTs). This systematic review and meta-analysis aimed to assess the safety and efficacy of GLP-1RAs in this population. PubMed, Embase, and Cochrane databases were a thorough literature search until July 2024 for SOTs with pre- and posttransplant diabetes mellitus (DM).

Identification of JmjC-domain-containing histone demethylases in sweet cherry reveals PavJMJ12 is required for bud dormancy release.

Global warming poses significant challenges to plant physiology, particularly affecting bud dormancy and fruit yields in perennial fruit trees. JMJ-C domain containing histone demethylases, a family of enzymes that modulate gene expression by removing methyl groups from histone tails, have been the subject of extensive research in model plants like Arabidopsis and tomato. However, their functions in fruit trees, remains largely unexplored.

A Cost-Effective 3D-Printed Conductive Phantom for EEG Sensing System Validation: Development, Performance Evaluation, and Comparison with State-of-the-Art Technologies.

This paper presents the development and validation of a cost-effective 3D-printed conductive phantom for EEG sensing system validation that achieves 85% cost reduction (48.10 vs. 300-500) and 48-hour fabrication time while providing consistent electrical properties suitable for standardized electrode testing.

Factor VIII Inhibitors in the Context of Renal Cell Carcinoma and Hemophilia A: A Tale of Two Causes.

Hemophilia A (HA) is an X-linked recessive bleeding disorder caused by a deficiency of factor VIII (FVIII), leading to impaired secondary hemostasis. The cornerstone of HA management is replacement therapy; however, this can induce the formation of neutralizing inhibitors, resulting in a refractory FVIII deficiency that is unresponsive to recombinant therapy. This case report describes the postoperative development of FVIII inhibitors in a patient with mild HA and explores two likely etiologies contributing to inhibitor formation.

Effects of preoperative carbohydrate loading on postoperative outcomes in patients undergoing laparoscopic cholecystectomy: a systematic review and meta-analysis.

Background: Cholecystectomy is one of the most common procedures performed across the world. With efforts to maximize good postoperative status, one such technique involves preoperative carbohydrate loading.

Methods: A thorough literature search was performed across three databases to identify articles published up to August 2024.

Physiological and molecular responses of house fly (Musca domestica L.) to clove flower bud extracts.

The house fly, Musca domestica, is a major mechanical vector of several pathogens, posing significant public health risks. Due to the hazards associated with indoor use of synthetic insecticides, biopesticides offer an eco-friendly alternative. Clove (Syzygium aromaticum) flower bud extract contains bioactive insecticidal compounds; however, a comprehensive study of its sublethal effects on M.

Kaempferol alleviates cypermethrin induced reproductive toxicity in rats via Nrf2-mediated antioxidant and apoptotic regulation with histopathological evidence: in vivo and in silico study.

Cypermethrin (CYP), a common synthetic pyrethroid pesticide, is associated with oxidative stress-mediated female reproductive toxicity. With increasing concern over reproductive failures, exploring natural alternatives to mitigate this problem is crucial. For this purpose, thirty-six female SD rats were divided into six different (n = 6) groups such as negative control (group I), while disease control (group II) was treated to CYP-induced toxicity.

Peripartum hypertension and neonatal outcomes across races: 2016-2022.

Background: Maternal hypertension, a major pregnancy complication, can adversely affect newborn health. Our study investigated racial/ethnic disparities in neonatal outcomes among hypertensive pregnant women in the US.

Methods: Using data from the CDC WONDER Natality database, we conducted a retrospective cohort study focusing on live births to hypertensive mothers from 2016 to 2022.

A Case of Post-polypectomy Syndrome Following Endoscopic Resection of a Rectal Polyp.

Post-polypectomy syndrome (PPS) is a rare yet significant complication of endoscopic polypectomy that can clinically mimic intestinal perforation. This report presents the case of an 85-year-old female who developed PPS following an elective endoscopic mucosal resection (EMR) of a 3 cm mid-rectal polyp. Her past medical history included asthma and epilepsy.

Physiological and biochemical alterations in soybean by banana peel biochar under different degrees of salt stress.

Salt influences cellular membranes by the excessive production of reactive oxygen species, while osmolytes play a vital role in protecting plants from oxidative stress caused by salt. Biochar may alleviate the effects of salinity-induced stress on crops. The study investigated the impact of biochar supplementation on osmolyte modifications and antioxidant activity in soybean (Glycine max cv.

A double-edged sword? Exploring the heterogeneous effects of industrialization, energy efficiency, and disaggregated financial development on environmental management.

This study investigates the impact of industrialization, technological innovation, financial sector development, and energy efficiency on the ecological footprint within emerging and growth-leading economies (EAGLE) countries (i.e., Brazil, China, India, Indonesia, Mexico, Russia, and Turkey) over the period 1990-2022.

MXene-nanoparticles foliar application improves wheat morpho-physiological and biochemical traits under cadmium (Cd) stress: A novel sustainable approach.

Cadmium (Cd) pollution is a persistent problem in the agricultural sector. Plants can be treated with nanoparticles (NP) to reduce heavy metal stress. MXene nanoparticles (MX-NPs) were tested for wheat Cd stress relief.

Impact of Systemic Sclerosis-Associated Interstitial Lung Disease, With and Without Pulmonary Hypertension, on Survival: A Systematic Review.

Many people with systemic sclerosis-associated interstitial lung disease (SSc-ILD) deal with pulmonary hypertension (PH), which seriously reduces their chances of survival. The study aims to evaluate and compare survival outcomes and causes of mortality in patients with SSc-ILD with and without coexisting PH and to assess the implications for clinical management. A comparative review of observational studies and cohort data was conducted to analyze mortality patterns, underlying mechanisms, and treatment responses in SSc-ILD patients stratified by PH status.

Neurofibromatosis type 2: A challenging case report and multidisciplinary management approach.

Neurofibromatosis type 2 (NF2) is a genetic disorder characterised by multiple benign tumours in the nervous system. We present the case of a 16-year-old female with NF2, seen on April 29, 2023, at Nishtar Hospital, Multan, exhibiting symptoms such as swollen left eye, chronic headache, decreased vision, bilateral hearing loss, tinnitus, and gait issues. Diagnostic evaluation, including Magnetic Resonance Imaging (MRI), confirmed NF2 diagnosis based on National Institutes of Health (NIH) and Manchester criteria.

Deep reinforcement learning for identifying the global minima of platinum nanoclusters.

Prediction of stable nanocluster structures remains a significant challenge in materials and nanocluster research due to the complex nature of potential energy surfaces (PES). To overcome this complexity, a novel deep reinforcement learning (DRL) framework was employed to efficiently scan the PES and identify the global minimum of the Ptnanocluster alongside other low-energy configurations. The DRL agent iteratively learns to generate energetically favorable configurations by adjusting atomic positions based on feedback from a reward function designed to promote structural stability and discourage unrealistic geometries, such as overlapping or dissociating atoms.

Effect of Choline Proline Ionic Liquid Additives on Hydrogen Evolution in Alkaline Water Electrolysis.

Conventional hydrogen generation mostly depends on steam methane reforming (SMR), thereby contributing to greenhouse gas emissions. Alkaline water electrolysis using KOH is a promising method for green hydrogen production, but faces significant technical challenges such as high energy consumption and lower hydrogen production. Despite extensive research on various electrolyte modifications, a significant gap exists in the application of biodegradable and biocompatible amino acid-based ionic liquids as electrolyte additives.

Molecular Epidemiology and Genomic Insights Into Norovirus and Coinfections: A 2023 Tertiary Care Hospital Study on Pediatric Acute Gastroenteritis in Pakistan.

Background: Acute gastroenteritis remains a leading cause of morbidity in children under 5 in Pakistan, with rotavirus group A as a major pathogen. The contribution of norovirus is less understood.

Methods: In 2023, we analyzed stool samples from 248 rotavirus group A-negative pediatric patients hospitalized with acute gastroenteritis at a tertiary hospital in Punjab, Pakistan.

Two origins of the winter subsidence in and around the Arabian Peninsula.

Hydrological surface loads, such as snowpack and soil moisture, are the main drivers of seasonal crustal movements as seen by space geodetic techniques. In addition to that, seawater sometimes exerts additional forces for coastal stations, and the atmosphere often plays an important role for stations within continents. Here we report a case in and around the Arabian Peninsula.

Combine effects of Broussonetia papyrifera-derived biochar and selenium nanoparticles for lead-polluted saline soils remediation during barley cultivation.

Contamination of soil with lead (Pb) and salinity is a substantial concern, impacting plant health and yield. This research analyzes the synergistic use of Broussonetia papyrifera-derived biochar (BP-BC) and selenium nanoparticles (SeNPs) to alleviate the detrimental impacts of salinity and Pb on barley plants. Field trials in Pb-polluted saline soils showed the use of SeNPs (0, 10 and 20 mg L) and BP-BC (0, 5 and 10 t ha) markedly enhanced soil physicochemical attributes, such as soil ESP, pH and EC.

Efficacy and safety of perfluorohexyloctane (PFHO) in patients with dry eye disease (DED) due to meibomian gland dysfunction (MGD): Systematic review and meta-analysis.

Background: Dry eye disease (DED) associated with meibomian gland dysfunction lacks a conclusive treatment, placing existing solutions under the burden of side effects and limitations. This study seeks to assess the efficacy and safety of perfluorohexyloctane (PFHO) in treating DED associated with meibomian gland dysfunction.

Methods: A thorough search encompassing Medline, Cochrane Central Register, and Google Scholar was conducted until September 15, 2023.

Therapeutic efficacy of in subclinical mastitis: A biochemical and hematological assessment in lactating cattle.

Background And Aim: Subclinical mastitis (SCM) in dairy cattle significantly compromises milk quality, animal health, and farm profitability, often remaining undetected due to the absence of clinical signs. The increasing antimicrobial resistance associated with conventional treatments highlights the need for effective alternatives. This study aimed to evaluate the therapeutic potential of (CA), alone and in combination with tylosin, in managing SCM in lactating cows.

Osmotic Demyelination Syndrome Following Rapid Correction of Hyponatremia in a Young Woman: A Case Report and Review of Literature.

Osmotic demyelination syndrome (ODS) is a rare and devastating neurological condition linked with the rapid correction of serum hyponatremia. We present a case report of a young female patient who developed ODS following an aggressive correction of low serum sodium levels. ODS is characterized by demyelination in the central and extrapontine regions of the brain, resulting in disastrous outcomes.

A new iterative multi-step method for solving nonlinear equation.

This study introduces an advanced iterative technique designed to solve nonlinear equations with simple roots efficiently. The newly developed algorithm achieves an impressive convergence order of sixteen, utilizing only five functional evaluations per iteration. By incorporating appropriate finite difference approximations, the method avoids the need for second derivatives, enhancing its computational efficiency and broad applicability.