Bacillus toyonensis BAR1, a yellow-pigment producing endophyte of Berberis aristata DC: a potential source of bioactive and antimicrobial compounds.

Herein, we report the isolation and characterization of an endophytic bacterium associated with the Berberis aristata roots to uncover bioactive compounds, particularly Antimicrobials, using submerged culture. The bacterial isolate was identified via 16S rDNA sequence analysis and characterized using morphological, microscopic, and biochemical techniques. It was identified as Bacillus toyonensis strain BAR1, a motile, gram-positive, halotolerant bacterium capable of producing yellow pigments.

A new iterative multi-step method for solving nonlinear equation.

This study introduces an advanced iterative technique designed to solve nonlinear equations with simple roots efficiently. The newly developed algorithm achieves an impressive convergence order of sixteen, utilizing only five functional evaluations per iteration. By incorporating appropriate finite difference approximations, the method avoids the need for second derivatives, enhancing its computational efficiency and broad applicability.

Green Synthesis and Characterization of Silver Nanoparticles Using Lespedeza juncea Extract: An Insight Into Its Antibacterial, Antifungal, and Enzyme Inhibitory Potential.

Herein, we adapted a quick, cost-effective, and environmentally friendly biological method for the synthesis of Ag-NPs using silver nitrate solution as a precursor, and the aqueous leaf extract of Lespedeza juncea (Chinese lespedeza) was exploited to synthesize Ag-NPs. Various physiochemical characterization techniques were used to characterize the nanoparticles. The UV spectrum revealed a resonance absorption peak at 428 nm, indicating successful synthesis of the nanoparticles.

Health Literacy and Physical Function Among Older Black and Hispanic Individuals With Heart Failure.

Background: Insufficient health literacy negatively impacts outcomes for heart failure (HF). Older adults with HF face significant barriers, including prevalence of multiple comorbidities, frailty and deficits in physical function, which can impact HF outcomes. Examination of the association between health literacy and physical function remains limited in older adults with HF.

Crown Ether-Modified Carbon Nitride for Augmented Visible-Light Photocatalytic H Production from Water Splitting.

Photocatalytic water splitting, which converts solar energy into hydrogen fuel, is one of the most viable methods to address future energy demands. Herein, by introducing 1,4,7,10,13,16-hexaoxacyclooctadecane (crown ether) on the surface of graphitic carbon nitride (CN) via H-bonding and CH-π interactions, we prepare highly efficient potassium-18-crown-6 ether-modified carbon nitride (CN/K-5CE) nanocomposite photocatalysts by a simple modification method for augmented photocatalytic hydrogen production. The optimized CN/K-5CE hybrid photocatalyst displays an enhanced photocatalytic hydrogen production rate of 126.

and are potential prognostic biomarker in hepatocellular carcinoma caused by HBV/HCV via lactylation.

Introduction: Hepatocellular carcinoma (HCC) is recognized as the prime and lethal form of liver cancer caused by the hepatitis B virus (HBV) and hepatitis C virus (HCV) globally. Lactate is an end product of glycolysis that influences epigenetic expression through histone lactylation. While and RACGAP1 play crucial roles in HBV- and HCV-related HCC.

Patterns of Cardiomyopathy in Patients Presenting to a Tertiary Care Hospital.

Background: Cardiomyopathy is a broad category of myocardial conditions that have a substantial effect on heart function. Improving patient treatment requires a knowledge of its epidemiology.

Objective: The aim of this study was to determine the pattern of cardiomyopathy in patients presenting to a tertiary care hospital in Peshawar, Pakistan.

Essential oils from Eucalyptus camaldulensis, Mentha piperita L., and Rosmarinus officinalis L.: a new frontier in combating antibiotic-resistant E. coli by inducing cellular components release.

Escherichia coli biofilms, a major cause of persistent infections, often exhibit resistance to conventional antibiotics. This study investigates the potential of essential oils derived from Eucalyptus camaldulensis, Mentha piperita L., and Rosmarinus officinalis L.

Essential oils of Citrus limon, Cymbopogon citratus, and Lavandula officinalis disrupt E. coli biofilms by inducing cellular damage.

Biofilms by E. coli is not only the primary cause of recurrent urinary tract infections, but also lead to medical device-associated infections. Ever increasing antibiotic resistance due to biofilms has sparked a search for plant-based replacements.

Comparison Between Efficacy Of Tympanoplasty With And Without Cortical Mastoidectomy In Tubo-Tympanic Otitis Media In Adults.

Background: Chronic suppurative otitis media (CSOM) tubo-tympanic type is a common ear condition in underdeveloped nations. Cortical mastoidectomy in conjunction with tympanoplasty has long been regarded as the preferred surgical procedure for patients with chronic non-cholesteatomatous otitis media. Studies contrasting tympanoplasty with and without cortical mastoidectomy improved hearing, but the results were comparable.

Analysis of the CRK expressions in bottle gourd (Lagenaria siceraria) under Fusarium oxysporum f. sp. lagenariae stress by using genome-wide identification strategy.

Background: The cysteine-rich receptor-like kinases (CRKs) family in plants have been reported to perform multiple functions against various stresses. However, the CRK family in bottle gourd (Lagenaria siceraria) has not been well-explored. Herein, a comprehensive genome-wide identification and characterization of the CRK gene family has been carried out in bottle gourd under Genome-wide characterization of CRK genes in bottle gourds under Fusarium oxysporum f.

Nigella sativa oil modulates neurobehavioral and neurochemical alterations in alcohol-exposed rats: An in vivo and in silico study.

Background: Chronic alcohol (ethanol) drinking changes central serotonin and dopamine levels, and thereby the functioning of brain circuits that support cognition and anxiety. Previously, it has been proven that Nigella sativa oil (NSO) improves cognition and reduces anxiety by regulating the neurotransmission but the underlying mechanisms are unknown.

Methods: To address the knowledge gap, an in vivo experiment was done to investigate effects of NSO on behavior and neurotransmission in ethanol drinking Wistar male rats.

Evaluating the Safety and Efficacy of Ticagrelor vs. Clopidogrel Following Percutaneous Coronary Intervention in Chronic Coronary Disease.

Objective This study aimed to compare the safety and efficacy of ticagrelor and clopidogrel in reducing major adverse cardiovascular events (MACE) among patients undergoing percutaneous coronary intervention (PCI) for chronic coronary disease. Additionally, secondary endpoints, including adverse events such as major bleeding, minor bleeding, and dyspnea, were assessed to evaluate the overall safety profile of both antiplatelet therapies. Methodology A prospective cohort study was conducted at Kuwait Teaching Hospital, Peshawar, Pakistan, enrolling 300 patients (150 receiving ticagrelor and 150 receiving clopidogrel) from July 2023 to June 2024.

Emerging Trends in CdS-Based Nanoheterostructures: From Type-II and Z-Scheme toward S-Scheme Photocatalytic H Production.

Cadmium sulfide (CdS) based heterojunctions, including type-II, Z-scheme, and S-scheme systems emerged as promising materials for augmenting photocatalytic hydrogen (H) generation from water splitting. This review offers an exclusive highlight of their fundamental principles, synthesis routes, charge transfer mechanisms, and performance properties in improving H production. We overview the crucial roles of Type-II heterojunctions in enhancing charge separation, Z-scheme heterojunctions in promoting redox potentials to reduce electron-hole (e/h) pairs recombination, and S-scheme heterojunctions in combining the merits of both type-II and Z-scheme frameworks to obtain highly efficient H production.

Correlation Between Ischemia Time and Left Ventricular Failure After Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction (STEMI) Patients.

Background: Primary percutaneous coronary intervention (PPCI) is pivotal in treating ST-elevation myocardial infarction (STEMI) patients, yet ischemia time significantly impacts outcomes, particularly left ventricular failure (LVF).

Objective: This study aimed to investigate the impact of ischemia duration and other variables associated with severe left ventricular systolic dysfunction in STEMI patients receiving PPCI treatment.

Methodology: This prospective cohort was carried out at Lady Reading Hospital in Peshawar, Pakistan, from January to June 2023.

Efficacy of various amendments for immobilization of potentially toxic elements in wastewater contaminated soils.

Farmers are using municipal wastewater either treated or untreated for irrigation because of limited fresh water resources. Wastewater extensively used for irrigation purposes is enriched with many nutrients. The reuse of wastewater is imposing a negative impact on human health and the ecosystem.

Comprehensive analysis of potato () genes highlights their role in stress responses.

Abscisic acid (ABA) regulates plant development, seed germination, and stress responses. The PYR1-like (PYL) proteins are essential for ABA signalling. However, the evolution and expression of PYL genes in potato (Solanum tuberosum ) remain poorly understood.

Potential nanomedicinal applications and physicochemical nature of Hyphaene thebaica-reduced nano-samaria.

Herein we described the biofabrication of samarium oxide nanoparticles (HT-SmO NPs) by applying the aqueous fruit extract of Hyphaene thebaica was utilized as an eco-friendly chelating agent. The prepared NPs were subjected to various physicochemical properties and potential in biomedical applications. X-ray Diffraction (XRD) pattern revealed sharp peaks that corroborated with the Joint Committee on Powder Diffraction Standards (JCPDS) card no.

Interlayer Potassium Single-Atom-Coordinated g-CN for Significantly Boosted Visible Light Photocatalytic H Production.

In recent years, graphitic carbon nitride (g-CN) has attracted considerable attention because it includes earth-abundant carbon and nitrogen elements and exhibits good chemical and thermal stability owing to the strong covalent interaction in its conjugated layer structure. However, bulk g-CN has some disadvantages of low specific surface area, poor light absorption, rapid recombination of photogenerated charge carriers, and insufficient active sites, which hinder its practical applications. In this study, we design and synthesize potassium single-atom (K SAs)-doped g-CN porous nanosheets (CM-K, where X represents the mass of KHP added) via supramolecular self-assembling and chemical cross-linking copolymerization strategies.

Radial Artery Occlusion After Transradial Access for Coronary Interventions.

Background Transradial access (TRA) is a medical procedure primarily used for percutaneous coronary interventions (PCI) and cardiac catheterization. Based on the recently published Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX (MATRIX) trial, TRA is being used more frequently than transfemoral access (TFA) since it has reduced rates of bleeding and fatality. A structural complication of TRA is radial artery occlusion (RAO), which may cause temporary pain to limit TRA in the future.

Insight into the molecular mechanism, cytotoxic, and anticancer activities of phyto-reduced silver nanoparticles in MCF-7 breast cancer cell lines.

This contribution insight on the cytotoxic and anticancer activities and molecular mechanism of phyto-reduced silver nanoparticles (AgNPs) in MCF-7 breast cancer cell lines. A simple, entirely green synthesis process was optimized for the phyto-reduction of AgNP (~12.7 nm) using aqueous leaf extracts of Indigofera heterantha.