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Article Abstract
Overuse of doxycycline (DOXY) can cause serious problems to human health, environment and food quality. So, it is essential to develop a new sensing methodology that is both sensitive and selective for the quantitative detection of DOXY. In our current research, we synthesized a simple fluorescent probe 4,4'-bis(benzyloxy)-1,1'-biphenyl (BBP) for the highly selective detection of doxycycline by through fluorescence spectroscopy. The probe BBP displayed ultra-sensitivity towards doxycycline due to Forster resonance energy transfer (FRET). Fluorescence spectroscopy, density functional theory (DFT), H NMR titration, UV-Vis, and Job's plot were used to confirm the sensing mechanism. The charge transfer between the probe and analyte was further examined qualitatively by electron density differences (EDD) and quantitively by natural bond orbital (NBO) analyses. Whereas the non-covalent nature of probe BBP towards DOXY was verified by theoretical non-covalent interaction (NCI) analysis as along with Bader's quantum theory of atoms in molecules (QTAIM) analysis. Furthermore, probe BBP was also practically employed for the detection of doxycycline in fish samples, pharmaceutical wastewater and blood samples.
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Article Synopsis
- Overuse of doxycycline can negatively impact human health, the environment, and food quality, highlighting the need for effective detection methods.
- Researchers developed a fluorescent probe named BBP that utilizes fluorescence spectroscopy to selectively and sensitively detect doxycycline via Forster resonance energy transfer (FRET).
- The study confirmed the sensing mechanism through various methods including density functional theory (DFT) and practical applications of BBP for detecting doxycycline in fish, wastewater, and blood samples.