Investigation of protonation induced metal-to-metal electron transfer in a cyano-bridged Mn-Fe dinuclear complex.

Reaction of [Mn(salophen)Cl] {salophen = -phenylenediamine bis(salicylidenaminato)} with a tricyano Fe(III) precursor complex, [Fe(bbp)(CN)] {Hbbp = bis(2-benzimidazolyl)pyridine}, affords a dinuclear cyano-bridged heterometallic Mn-(μ-NC)-Fe fragment in the complex salt [Mn(salophen)(HO)][Mn(salophen)(HO)(μ-NC)Fe(bbp)(CN)]·4HO (1). The title compound shows field-induced slow relaxation of magnetization below 2.8 K.

Spectrometric analysis of chemiluminescence resonance energy transfer on a smartphone-enabled analytical device.

The design of a smartphone-enabled analytical device (SEAD) is reported that detects and analyzes chemiluminescence resonance energy transfer (CRET) between donor and acceptor molecules during a chemical reaction process. The proposed analytical tool is compact, user-friendly, cost-efficient, and provides an alternative platform suitable for in-field investigations. The chemiluminescence (CL) reaction protocol adopted generates violet-blue light signal with peak wavelength emission at ~ 425 nm that occurs due to chemical excitation of the donor species.

CroPCS: Crop Plants Combined Stress Knowledgebase.

Plants, being sessile organisms, are continually exposed to diverse combinations of biotic and abiotic stresses in their natural habitats. Combined stresses are considered significant threats to plants, particularly in the context of today's climate change. Despite the vast amount of data generated by OMICS experiments, information remains widely dispersed and inaccessible within the literature.

Harnessing Infrared Radiation: Transforming Vegetable Oil Quality, Drying Kinetics, and Bioactive Potential.

Infrared (IR) radiation, a versatile and efficient heating method, has garnered significant attention in the food and oil processing industries because of its unique heat transfer mechanism and broad range of applications. IR is applied in drying, peeling, decontamination, enzyme inactivation, and roasting, underscoring its potential for energy-efficient, high-quality processing. Its application to oil-bearing materials improves moisture removal rates and supports the preservation of critical quality parameters.

Point-of-care biosensors for infectious disease diagnosis: recent updates and prospects.

The ongoing demand for rapid, accurate, accessible diagnostics has significantly increased point-of-care (POC) biosensors. This review provides an overview of diverse biosensors, focusing on their principles, components, detection mechanisms, and applications in infectious disease diagnosis. We explore how these biosensors utilize various transduction techniques-such as current modulation, refractive index shifts, and mechanical resonance to convert biorecognition events into measurable signals.

Common Nefafu ( L.)-Mediated Silver Nanoparticles for Physicochemical Insights into the Protein Corona Formation and Inhibition of Fibrillation of Human Serum Albumin.

Engineering nanomaterials with products isolated from natural resources is attractive for targeted therapeutic applications. Prior to the biomedicinal applications, one significant facet of nanoparticles is the understanding of protein corona formation and its relative binding aspects. In this perspective, we have synthesized two different silver nanoparticles, one with the extract of the leaves of a traditional herb , commonly known as "Nefafu", and the other with one of its major polyphenolic compounds, apigenin, and their complexations were studied with the model protein human serum albumin (HSA).

Zero mortality in 2024: Retrospective assessment of snakebite cases and their effective management at Demow rural community health centre, Sivasagar, Assam, India.

Assam, a state in North Eastern India, is a biodiversity hotspot and home to various venomous and non-venomous snakes. In 2024, approximately 11,000 snakebite cases and 36 mortalities have been reported from Assam. In this study, we report the success story of snakebite management resulting in "Zero Mortality" at Demow Rural Community Health Centre cum Model Hospital (DRCHCMH), Sivasagar, Assam for the fourth consecutive year (2021-2024).

Immobilization of crude cellulase from Aspergillus foetidus on agar xerogel and its application for carrot juice extraction.

This study investigates the immobilization of crude cellulase from Aspergillus foetidus, produced through solid-state fermentation by different methods, including entrapment in agar cube, adsorption on agar xerogel, and adsorption on agar xerogel pretreated with glutaraldehyde. The immobilization efficiency achieved was 90.80%, 84.

Interface-driven Pd-Ag-Cu/C nanocomposites with increased oxygen reduction reaction kinetics.

Highly dispersed PdAgCu/C nanocomposites with enhanced catalytic activity and stability were synthesized a solvothermal method. Structural characterization confirms the formation of a multimetallic nanocomposite consisting of well-distributed Pd, Ag and Cu domains on the carbon support. The close proximity of these metal domains facilitates interface-driven electronic modulation, which contributes to improved oxygen reduction reaction (ORR) kinetics.

Flood-induced heavy metal contamination and associated human health risk assessment over a riverine settlement in mid-Brahmaputra Valley, India.

This study focuses on the rarely ventured assessment of the flood-induced heavy metal contamination in the water sources in a flood-prone region in India, emphasizing human health risks using average daily dose (ADD), hazard quotient (HQ), hazard index (HI), and carcinogenic risk (CR). Results showed children were more vulnerable to exposure than adults, and ingestion was the main route of exposure, followed by dermal and inhalation. The contribution of Cd to the cumulative HI for children was the highest, exceeding the maximum acceptable risk level of 1.

An effective framework to study signal transmission due to non-homogeneous extracellular space in neuron.

Nerve conduction velocity studies are essential to understanding neurological disorders like ALS, Guillain-Barré syndrome, Charcot-Marie-Tooth disease, carpal tunnel syndrome, sciatic nerve disorders, and multiple sclerosis, which are marked by slowed signal conduction. Various ions in the extracellular space (ECS) and the nerve fiber regulate signal propagation, making it crucial to analyze ECS's impact on signal transmission. This study examines how a non-homogeneous extracellular space affects nerve conduction velocity using a modified cable model that incorporates ECS parameters such as its diameter and resistance.

Seed-mediated synthesis and biosynthesis of iron oxide nanoparticles.

Metal-based nanoparticles, particularly iron oxide nanoparticles (IONPs), have attracted considerable attention due to their versatile applications in magnetic resonance imaging (MRI), magnetic hyperthermia, stem cell tracking, cancer therapy, and targeted drug delivery. However, achieving uniform, highly crystalline IONPs remains a significant challenge, as conventional synthesis methods are highly sensitive to variables, such as temperature, pH, and the types of stabilizing and reducing agents used. This review explores two prominent synthesis strategies-seed-mediated synthesis and biological (green) syntheses that have been widely adopted to overcome listed challenges and enable the controlled fabrication of isotropic and anisotropic IONPs with uniform size and morphology.

Compact and Affordable Raspberry Pi-Based Multimodal Imaging System With Remote Monitoring Capabilities for Bioimaging Applications.

The rapid advancements in smartphone camera features and accessibility have garnered significant attention for smartphone-based imaging systems in recent years. However, due to variations in dimensions and camera positions across different phones, they often suffer from compatibility issues. In the present work, these issues have been addressed by using a Raspberry Pi single-board computer (SBC) as the platform for the development of a multimodal microscopic system.

Impact of double split slot geometry on aerodynamic performance of modified airfoil for wind turbine blades.

Introducing a slot into an airfoil is a passive flow control technique that enhances aerodynamic performance by manipulating the boundary layers of fluid flow. This study investigates the aerodynamic performance of a novel double-split slot design using the NACA 0018 airfoil through a detailed 2D steady-state numerical analysis. A parametric study was conducted to evaluate the influence of key design parameters, including slot outlet location, outlet width, and wedge element length, on the force coefficients and the flow structure around the airfoil.

Impact of Rotavac Vaccine on Hospital-Based Disease Prevalence and Strain Diversity in India: A Systematic Review and Meta-Analysis.

Rotavirus (RV) is a major aetiology of childhood gastroenteritis worldwide. It is crucial to understand the hospital-based RV disease prevalence and its spatio-temporal genotype distribution during the period pre-and post-introduction of RV vaccines in India. A systematic review and meta-analysis were performed to extract information on literature related to the impact of vaccination on rotavirus disease prevalence and the distribution of genotypes from 1986 to 2022.

Phosphine Oxide Coordinated Mononuclear Ln(Ln = Dy, Er) Single-Ion Magnet with Pseudo-Pentagonal Bipyramidal Geometry.

Two mononuclear lanthanide complexes, [(L)Ln(PhPO)Cl]·CHOH] [Ln = Dy (1) and Er(2)], are isolated employing a pyridine-based ligand, [2,2'-{(1E, 1'E)-pyridine 2,6-diylbis(methaneylylidine}bis(azaneylylidine)diphenol] (HL) and triphenylphosphine oxide. Both complexes are characterized by single-crystal X-ray diffraction studies. Pseudo-pentagonal bipyramidal geometry (pseudo-D) around the lanthanide centers in both complexes is confirmed through SHAPE analysis.

The commercial polyvalent antivenom against the "Big Four" venomous snakes of India shows poor immune recognition and neutralization of lethality and toxicity of Trimeresurus popeiorum venom proteins in the mouse model.

In tropical areas, especially India, where the "Big Four" snakes cause most snakebite cases, envenomation is still a significant public health issue. Trimeresurus popeiorum (Pope's pit viper), a species prevalent in Northeast India, remains neglected despite its medical importance. This study examines the immunological cross-reactivity and efficacy of Indian commercial polyvalent antivenoms (PAVs) in neutralizing T.

Ultra-sensitive detection of mycobacterium cells on a smartphone through enhanced emission of autofluorescence signals.

Tuberculosis (TB) remains one of the deadliest infectious diseases of the 21st century, affecting millions of people worldwide each year. Traditional diagnostic methods primarily rely on light and fluorescence microscopy. However, the low sensitivity of light microscopy and the high cost and complexity associated with fluorescence microscopy limit their effectiveness in resource-limited settings.

Chemoselective, Dearomative Reduction of Epoxide-Tethered Indoles en Route to HFIP-Promoted Diastereoselective Synthesis of 1,7-Fused Indolines.

The reductive dearomatization reaction of N-alkylindoles represents an expedient approach to the generation of N-alkylindolines that are primed for elaboration into more complex target molecules but difficult to access in synthetically acceptable yields directly from (NH)-indolines via their N-alkylation. However, its application to obtain N-alkylindolines bearing reducible functional groups remains a more challenging and long-standing problem due to functional group compatibility issues. In this context, we have achieved a dearomative, chemoselective reduction of epoxide-tethered indoles promoted by NaBHCN/AcOH to obtain hitherto unreported trans-benzylic epoxide-tethered indolines.

Role of Solvents in Iron Nanoparticle Synthesis: Analyzing Water and 1‑Methyl-2-Pyrrolidone with Green Tea Extract as a Reducing Agent.

The choice of solvent in the synthesis of nanoparticles plays a pivotal role in influencing the nucleation and growth kinetics of nanoparticles. Deionized water (DI) due to its cost-effectiveness, low toxicity, and ability to dissolve precursor salts effectively makes an ideal solvent medium, while aprotic organic solvents such as -methyl-2-pyrrolidone (NMP) with high dipole moment also demonstrate their efficacy as dual solvent-reducing agents. Herein, this study aims to explore the effect of different solvent media on the biosynthesis of iron nanoparticles (FeNPs) and their impact on the optical, structural, and morphological properties.

Synergy of spiritual ambience, sattvic dietary regimen, homely care, and conventional medical therapy in the holistic rehabilitation of a terminally ill patient with post-traumatic complications: A case report.

Objective: To explore the integration of pharmacotherapy with a holistic approach incorporating a spiritual ambience, sattvic diet and homely care, in medical intervention of a complex multi-systemic post-trauma terminally ill patient.

Case Presentation And Outcomes: A 45-year-old female, declared terminally ill and presenting with progressively worsening symptoms twenty days post-road traffic accident, sought care at Baba Kinaram Hospital (BKH) on July 31, 2024. She exhibited severe hypoxia, severe respiratory distress, dilated cardiomyopathy (LVEF 35 %), dizziness, and neurological deficits, having received previously a dire prognosis from several multi-specialty hospital treatments.

Effect of heat treatment on physicochemical, interfacial, and encapsulation properties of pea and soy protein-based emulsions and their spray-dried powders.

Plant proteins are promising alternatives to animal proteins but often show limited emulsion stability after heat treatment. This study evaluated the impact of mild (65 °C) and moderate (85 °C) heating on pea protein concentrate and soy protein isolate emulsions containing sunflower oil, followed by spray-drying. Moderate heating reduced particle size and enhanced zeta potential, protein solubility, and emulsion stability over mild heating.

Proteomic profiling and biochemical characterization of enzymatic and non-enzymatic proteins of Heterometrus bengalensis venom and their pathophysiological functions in the Swiss albino mice model.

Due to its significant mortality and morbidity, scorpion sting is a public health concern worldwide, particularly in tropical and subtropical regions. Heterometrus bengalensis (HB) significantly impacts health; however, HB's venom composition is the least characterized. The present study provides a comprehensive insight into the HB venom (HBV) profile by in vitro enzyme assay and tandem mass spectrometry analysis of SDS-PAGE-separated venom proteins and peptides.