Publications by authors named "Hasher Irshad"
The potential of a novel thiazole-modified covalent triazine framework (S-CTF) as surface for the adsorption and sensing of the carcinogenic metabolites acrylamide (AM), 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MEIQX), 2-amino-1-methyl-6-phenylimidazole[4,5-f]pyridine (PhlP) and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) is explored. The selectivity, sensitivity, and adsorption properties of the S-CTF surface are investigated through noncovalent interaction (NCI), quantum theory of atoms in molecules (QTAIM) and symmetry adapted perturbation theory (SAPT0) analyses. All the analytes were found to be physiosorbed on the surface of the sensor with the following strength of interaction: MEIQX@S-CTF = PhlP@S-CTF > Trp-P-1@S-CTF > AM@S-CTF.
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- Excessive fluoride use and chloroform exposure pose health risks, prompting the need for effective sensors to monitor these substances.
- Researchers investigated etoricoxib (ECX) as a safe and available sensor, revealing its strong fluorescence response for detecting fluoride and chloroform at very low levels.
- Advanced analyses, including UV-Vis and DFT studies, confirmed that ECX operates through non-covalent interactions, making it a promising tool for real-time detection of fluoride and moisture in various samples.
Article Synopsis
- High concentrations of deferasirox (DFX) can lead to serious health issues in the liver, stomach, and kidneys, making it crucial to develop an effective detection method to safeguard public health.
- Researchers created a thiourea-based probe called MPT that detects DFX by utilizing fluorescence quenching, a process where light emission decreases due to interaction with DFX.
- Various analytical techniques, including H-NMR titration, dynamic light scattering, and electron microscopy, were used to confirm the interaction between MPT and DFX, demonstrating its ability to detect DFX in real samples like human plasma and artificial urine.
A combined experimental and theoretical approach for doxycycline sensing using simple fluorescent probe with distinct fluorescence change in wide range of interferences.
Spectrochim Acta A Mol Biomol Spectrosc
June 2024
Article Synopsis
- Overuse of doxycycline can negatively impact human health, the environment, and food quality, highlighting the need for effective detection methods.
- Researchers developed a fluorescent probe named BBP that utilizes fluorescence spectroscopy to selectively and sensitively detect doxycycline via Forster resonance energy transfer (FRET).
- The study confirmed the sensing mechanism through various methods including density functional theory (DFT) and practical applications of BBP for detecting doxycycline in fish, wastewater, and blood samples.
Extensive optical and DFT studies on novel AIE active fluorescent sensor for Colorimetric and fluorometric detection of nitrobenzene in Solid, solution and vapor phase.
Spectrochim Acta A Mol Biomol Spectrosc
May 2024
Article Synopsis
- - A new isophthalamide-based sensor called IPA has been developed that exhibits strong aggregation-induced emission (AIE) properties, emitting light at 438 nm, making it sensitive and selective in detecting nitrobenzene (NB) in various states (solid, solution, vapor).
- - The interaction between IPA and nitrobenzene has been characterized through various spectroscopic methods, revealing significant fluorescence quenching and allowing NB detection down to levels of 60 nM, along with additional studies confirming the type of interaction.
- - Advanced computational methods, including DFT calculations and NBO analysis, were employed to explore the thermodynamic stability and charge transfer interactions of IPA with nitrobenzene, demonstrating its potential for practical
An extensive experimental and DFT studies on highly selective detection of nitrobenzene through deferasirox based new fluorescent sensor.
Spectrochim Acta A Mol Biomol Spectrosc
February 2024
Article Synopsis
- - A new sensor called TAD, based on deferasirox and a substituted triazole amine, has been developed to detect nitrobenzene specifically in various samples.
- - TAD shows a strong selective response to nitrobenzene compared to other nitroaromatic compounds, with the detection mechanism involving a photoinduced electron transfer (PET) process supported by various analytical methods like UV-visible spectroscopy and DFT analysis.
- - The research also included in-depth analyses using non-covalent interaction studies and energy decomposition to understand how TAD interacts with nitrobenzene, and the sensor was successfully tested in real-world applications.
Triazine based fluorescent sensor for sequential detection of Hg and L-Cysteine in real samples and application in logic Gate: A combination of Extensive experimental and theoretical analysis.
Spectrochim Acta A Mol Biomol Spectrosc
November 2023
Article Synopsis
- A new fluorescent sensor called TBT was developed to detect mercury (Hg) ions and L-cysteine (Cys) sequentially, leveraging its sulfur moiety and molecular structure for effective sensing.
- When Hg is added to TBT, its fluorescence intensity increases due to the blocking of charge transfer and enhanced fluorescence, allowing for selective detection of both Hg and Cys through different mechanisms.
- Advanced studies, including NMR and DFT analyses, confirmed the interactions between TBT, Hg, and Cys, while the sensor demonstrated a low detection limit of 61.9 nM for Hg, and was utilized for both qualitative and quantitative analysis in real samples, integrating a logic
New fluorescent probe for sensing of mefenamic acid in aqueous medium: An integrated experimental and theoretical analysis.
Spectrochim Acta A Mol Biomol Spectrosc
November 2023
Article Synopsis
- * A new sensor, ECO, was designed to detect MFA using fluorescence spectroscopy, displaying a "turn-off" response based on a mechanism involving photoinduced electron transfer and hydrogen bonding.
- * The sensor's effectiveness was tested with human blood and urine samples, and its detection mechanism was supported by various analytical methods, including H NMR titration and density functional theory calculations.
Theoretical and experimental studies on mechanochromic triphenylamine based fluorescent "ON-OFF-ON" sensor for sequential detection of Fe and deferasirox.
Spectrochim Acta A Mol Biomol Spectrosc
September 2023
Article Synopsis
- - A novel TPA-based sensor called TTU was designed to show mechanochromic and AIEE properties, allowing it to detect iron (Fe) in water with high specificity due to its ability to form a complex with paramagnetic Fe.
- - When deferasirox (DFX) is introduced to the TTU-Fe complex, the fluorescence of TTU is restored, indicating that DFX displaces Fe, which indicates a potential method for detecting DFX.
- - The mechanisms behind the interactions of TTU with Fe and DFX were validated through H NMR titration and DFT calculations, and TTU proved effective in real water sample tests, also contributing to the development of a logic gate for sequential
AIEE active J-aggregates of naphthalimide based fluorescent probe for detection of Nitrobenzene: Combined experimental and theoretical approaches for Non-covalent interaction analysis.
Spectrochim Acta A Mol Biomol Spectrosc
April 2023
Article Synopsis
- A new fluorescent probe called NS was developed using a simple chemical reaction, showcasing impressive aggregation-induced emission enhancement (AIEE) in water due to the formation of J-aggregates.
- This probe can selectively and sensitively detect nitrobenzene (NB) by observing changes in fluorescence, with the size of NB allowing easy access into the probe's structure.
- The study incorporated various analytical methods, including spectroscopy and theoretical calculations, to understand the interactions between the probe and NB, demonstrating the probe's effectiveness in both solid and vapor-phase detection of NB, even in low concentrations within real samples.