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Article Abstract
High concentrations of deferasirox (DFX) in living organisms cause hepatic, gastric and renal malfunctions. Therefore, it is significant to establish an accurate and efficient approach for the detection of deferasirox (DFX) to protect public health. Herein, we synthesized a thiourea-based diphenylacetamide probe MPT for the effective sensing of deferasirox through the fluorescence quenching phenomenon. The designed probe MPT shows a fluorescence quenching response toward deferasirox (DFX) through photo-induced electron transfer (PET). Furthermore, DFT studies were performed to support the experimental results. H-NMR titration experiment was used to explore the interaction type between probe MPT and DFX. The existence of non-covalent interactions was verified with spectroscopic studies that were assisted by NCI studies, QTAIM and SAPT0 analysis. Dynamic light scattering (DLS) analysis and scanning electron microscopy (SEM) were used to investigate the complexation of probe MPT with DFX. Moreover, the on-site solution phase and solid-state detection of DFX by probe MPT are executed. Additionally, the practical applications of probe MPT to sense DFX were also revealed in human plasma as well as in artificial urine samples.
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| http://dx.doi.org/10.1039/d4ra03548h | DOI Listing |
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Article Synopsis
- High concentrations of deferasirox (DFX) can lead to serious health issues in the liver, stomach, and kidneys, making it crucial to develop an effective detection method to safeguard public health.
- Researchers created a thiourea-based probe called MPT that detects DFX by utilizing fluorescence quenching, a process where light emission decreases due to interaction with DFX.
- Various analytical techniques, including H-NMR titration, dynamic light scattering, and electron microscopy, were used to confirm the interaction between MPT and DFX, demonstrating its ability to detect DFX in real samples like human plasma and artificial urine.