Effect of Dietary Tyrosine on Behavior and Ruminal Meta-Taxonomic Profile of Altay Sheep with Different Temperaments.

The objective of this study was to evaluate the effect of tyrosine on behavior and ruminal meta-taxonomic profile of Altay sheep. Twelve rams with the lowest behavioral responses to humans and twelve rams with the highest behavioral responses were sorted into calm and nervous groups, respectively. Following the 2 × 2 factorial design, the rams from each group were equally assigned two treatments of a basal diet and a diet with an extra 4 g of tyrosine for 30 d.

Evaluation of the Antifungal Efficacy of Natural Gum Acacia and Aloe Vera against Candida albicans on Conventional and Digital Denture Base Materials: An In Vitro Study.

This study evaluated the efficacy of Acacia Arabica and aloe vera solutions versus commercial effervescent tablets on viability and adhesion to various denture bases with different materials and manufacturing techniques.A total of 96 square-shaped denture base specimens (24 per group) were fabricated from heat-cured polymethyl methacrylate (PMMA), thermoformed polyamide (FlexiUltra), milled computer-aided design and computer-aided manufacturing (CAD/CAM; Avadent), and 3D-printed (FormLabs) resins. Specimens were allocated into a control group (distilled water) and three experimental groups ( = 6 per group) based on the immersion solutions: Gum acacia (GA), aloe vera, and alkaline peroxide denture cleansers.

Artemisia lerchiana Based Green Synthesis of Silver Nanoparticles: TEM Microscopy, Physicochemical, and Spectroscopic Characterization.

Silver nanoparticles (AgNPs) have unique physicochemical characteristics that render them very appropriate for various biomedical applications. AgNPs were synthesized in a study by an environmentally friendly and cost-effective method where an aqueous extract of Artemisia lerchiana was used as a bioreducing and stabilizing agent. To characterize the synthesized nanoparticles, a conjunction of analytical methods was employed, such as UV-Visible spectrophotometry, Fourier Transform Infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and atomic force microscopy (AFM).

Impact of Acacia arabica Addition on Optical, Mechanical, and Fungicidal Properties of Polymethyl Methacrylate Denture Base Material.

The aim of the study was to evaluate the optical, mechanical, and microbiological performance of heat-cured polymethyl methacrylate (PMMA) modified by adding various gum (GA) concentrations.Specimens containing 1, 2.5, 5, 7.

Research note: Effects of fermented vegetable extract supplementation via drinking water on growth performance, immune function, and antioxidant status in broiler chickens.

This study investigated the effects of supplementing drinking water with fermented vegetable extract on growth performance, immune response, antioxidant activity, and hematological parameters in broiler chickens. A total of 240 one-day-old Cobb-500 broiler chicks were randomly allocated into four treatment groups, each comprising three replicates of 20 birds. The experimental groups were as follows: Group A (control, no extract), Group B (0.

Dietary Protein-Induced Changes in Archaeal Compositional Dynamics, Methanogenic Pathways, and Antimicrobial Resistance Profiles in Lactating Sheep.

Dietary protein levels greatly influence gut microbial ecosystems; however, their effects on gut archaea and associated functions in ruminants require further elucidation. This study evaluated the impact of varying dietary protein levels on gut archaeal composition, antimicrobial resistance (AMR) genes, virulence factors, and functional capacities in sheep. Eighteen ewes (Yunnan semi-fine wool breed, uniparous, 2 years old, and averaging 50 ± 2 kg body weight) were randomly assigned to diets containing an 8.

Exploring the 3D Printability of Engineered Cementitious Composites with Internal Curing for Resilient Construction in Arid Regions.

This study investigates the feasibility of pumice-based internal curing based on the 3D printability of engineered cementitious composites (ECCs) for water-scarce environments and arid regions. Natural river sand was partially replaced with the presoaked pumice lightweight aggregates (LWAs) at two different levels, 30% and 60% by volume, and 50% of the cement was replaced with slag to enhance sustainability. Furthermore, 2% polyethylene (PE) fibers were used to improve the mechanical characteristics and 1% methylcellulose (MC) was used to increase the rheological stability.

Evaluation of Post-Endodontic Pain Reduction Using Intracanal Cryotherapy in Symptomatic Apical Periodontitis.

This prospective experimental study evaluated the efficacy of intracanal cryotherapy in reducing postoperative pain in patients with symptomatic apical periodontitis. Ninety participants with necrotic pulp and preoperative pain (VAS ≥ 7) were randomised into two groups: Group A received room-temperature saline irrigation, while Group B received cryotreated saline (2.5°C) as the final irrigant.

Impacts of Protease Sources on Growth and Carcass Response, Gut Health, Nutrient Digestibility, and Cecal Microbiota Profiles in Broilers Fed Poultry-by-Product-Meal-Based Diets.

Background: The current study aimed to evaluate the effects of the supplementation of protease sources on growth and carcass response, gut health, nutrient digestibility, and cecal microbiota profiles in broilers fed poultry-by-product-meal (PBM)-containing diets.

Methods: In total, 800 one-day-old mixed-sex broilers (Arbor Acres) were weighed and allocated to one of the four dietary treatments in a completely randomized design, with eight replicates and 25 birds each per replicate. The treatments were as follows: (1) T, control diet (without protease supplementation and 3% PBM); (2) T, control diet supplemented with acidic protease at 100 g/ton (50,000 U/g); (3) T, control diet supplemented with alkaline protease at 200 g/ton (25,000 U/g); (4) T, control diet supplemented with neutral protease at 200 g/ton (25,000 U/g).

Epidemiology of Lumpy Skin Disease virus in large ruminants of Potohar region, Pakistan.

Lumpy Skin Disease (LSD) is a transboundary disease affecting large ruminants in different regions of the world including Asia, Europe and Africa. The current study investigated the seroprevalence and associated risk factors of LSD Virus (LSDV) in large ruminants of the Potohar region, Pakistan. For this purpose, a total of 800 blood samples were collected from large ruminants of the Potohar region including Rawalpindi, Attock, Jhelum and Chakwal from October-2022 to September-2023.

Uncovering the oxidative stress and hematological consequences of chronic cobalt exposure on atherosclerosis.

Overproduction of reactive oxygen species (ROS) causes oxidative stress, which is a significant risk factor for the onset and advancement of atherosclerosis. However, in current study, rats with experimentally generated atherosclerosis (EA) are used to examine the effects of prolonged cobalt nitrate exposure on oxidative stress and hematological markers. An atherogenic diet, methylprednisolone, alcohol, and mercazolil were all used in a polyetiological method to imitate atherosclerosis.

Pharmacokinetics and 180-day safety of diazepam nasal spray in pediatric patients with epilepsy aged 2-5 years.

Objective: Benzodiazepine immediate-use seizure medications (ISMs; also called rescue therapies) are used to treat seizure clusters/acute repetitive seizures in patients with epilepsy. In the United States, diazepam nasal spray is an approved ISM for patients ≥2 years of age. The primary objective was to assess diazepam nasal spray pharmacokinetics (PK) in patients 2-5 years of age; safety and tolerability were secondary objectives.

SEM-Based Foliar Micromorphology for Taxonomic Delimitation of Selected Herbaceous Species.

This study represents the first comprehensive effort to document the pollen taxonomy of plant species in the Hindukush-Karakoram-Himalaya region of northern Pakistan. The clarification of the leaf micromorphology of the selected herbaceous plants reveals characteristics like the stomata types, trichome types, and epidermal cell size and shape. The leaf micromorphology of 50 herbaceous plants revealed foliar anatomical traits, such as changes in epidermal cells, trichome morphology, and stomatal type.

Effect of Empagliflozin on Cardiovascular Mortality and Heart Failure Hospitalizations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has demonstrated clinically meaningful benefits in patients with heart failure (HF). This systematic review and meta-analysis aimed to assess the effect of empagliflozin on cardiovascular mortality and hospitalization for heart failure (HHF) across randomized controlled trials (RCTs). A comprehensive literature search was conducted across PubMed, Embase, Scopus, and Google Scholar, identifying five eligible RCTs.

as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production.

Investigating ' is potential as a livestock feed additive, this review explores its nutritional and phytochemical profiles and its mechanistic roles, specifically focusing on its immunomodulatory and antioxidant properties. is a rich source of diverse bioactive compounds, including polyphenols, alkaloids, terpenoids, flavonoids (e.g.

Influence of virtual reality simulation (excluding augmented reality) on endodontic learning experiences of undergraduate dental students: a systematic review.

Background: Virtual Reality (VR) technology has demonstrated a promising prospect for enhancing endodontic learning in undergraduate dental students by boosting their procedural skills, accuracy, and confidence.

Aim: To systematically evaluate the effectiveness of virtual reality (VR) simulation in endodontic education among undergraduate dental students, with a specific focus on four key outcomes: procedural accuracy, enhancement of student confidence, reduction in procedural errors, and overall learner satisfaction.

Methods: An exhaustive literature search was carried out in December 2024 in PubMed, Cochrane Library, Embase, Scopus, and ClinicalTrials.

Regenerative potential of human dental pulp stem cells in scaffold-based alveolar and jaw bone reconstruction: a systematic review.

Background: Effective alveolar and jaw bone regeneration remains a clinical challenge, and the added value of incorporating human dental pulp stem cells (hDPSCs) or stem cells from exfoliated deciduous teeth (SHED) into scaffolds over traditional cell-free approaches has not been systematically evaluated in vivo, limiting evidence-based advancements in regenerative dental therapies. This review aimed to evaluate the outcomes of human dental pulp stem cells in conjunction with scaffolds for the regeneration of alveolar and jaw bone.

Materials And Methods: This systematic review followed PRISMA guidelines and used the PICO framework.

Multimodal Pain Management in Knee Osteoarthritis: A Comparative Study of Pregabalin and Duloxetine as Adjuncts to Naproxen.

Objective: This single-blinded, randomised, prospective study was carried out to investigate the effectiveness of a combination drug regimen including pregabalin and duloxetine as adjuncts to naproxen in pain management of patients with knee osteoarthritis (OA).

Methods: One hundred and five patients were inducted into the study following the inclusion and exclusion criteria. Using simple randomisation, patients were allocated into group A (naproxen only), group B (naproxen + duloxetine), and group C (naproxen + pregabalin).

Harnessing the application of halophytic flora biomass in the management of healthcare of local people in the Salt Range of Punjab.

The dependence of rural communities on salt-tolerant medicinal plants provides practical evidence of their utilization in healthcare systems in Salt ranges. Ethnomedicinal data were collected and documented by interrogating 138 local people and 13 traditional health practitioners using a visual appraisal approach, semi-structured interviews, rapid rural appraisal methods, and open-ended questionnaires, separately for each species and interviewee, in different localities of the Salt Range. Data was scrutinized quantitatively utilizing multiple quantitative indices, including frequency citation, use value (UV), informant consensus factor (ICF), and relative frequency of citation (RFC).

Correction: Association Between Body Mass Index and the Efficacy of Calcium Channel Blockers for Hypertension in Cardiovascular Disease Patients.

[This corrects the article DOI: 10.7759/cureus.81985.

Comparative analysis of shear bond strength and debonding characteristics of bioactive versus conventional orthodontic adhesives: An in-vitro study.

Adhesives are essential for attaching orthodontic brackets to the tooth surface and ensuring safe removal during debonding. ACTIVA™ BioACTIVE-Restorative (ABR) is a bioactive composite with potential advantages. The purpose of this study was to evaluate the shear bond strength (SBS) and adhesive remnant index (ARI) of ACTIVA™ BioACTIVE-Restorative (ABR) with conventional adhesives, including Transbond XT™ (TXT) and Orthocem™ (OC).