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This prospective experimental study evaluated the efficacy of intracanal cryotherapy in reducing postoperative pain in patients with symptomatic apical periodontitis. Ninety participants with necrotic pulp and preoperative pain (VAS ≥ 7) were randomised into two groups: Group A received room-temperature saline irrigation, while Group B received cryotreated saline (2.5°C) as the final irrigant. Pain was assessed preoperatively, at 24 h, and 48 h post-treatment using the Visual Analogue Scale. Results demonstrated significantly lower pain scores in the cryotherapy group at 24 h (p = 0.010) and 48 h (p < 0.001), with reduced analgesic use. Cryotherapy effectively mitigates post-operative pain in symptomatic apical periodontitis, offering a non-invasive adjunct to standard endodontic therapy.
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http://dx.doi.org/10.1111/aej.12983 | DOI Listing |
Aust Endod J
July 2025
Department of Pharmacy and Biotechnology, Alma Mater Studiorum - Università di Bologna, Bologna, Italy.
This prospective experimental study evaluated the efficacy of intracanal cryotherapy in reducing postoperative pain in patients with symptomatic apical periodontitis. Ninety participants with necrotic pulp and preoperative pain (VAS ≥ 7) were randomised into two groups: Group A received room-temperature saline irrigation, while Group B received cryotreated saline (2.5°C) as the final irrigant.
View Article and Find Full Text PDFClin Oral Investig
June 2025
Department of Endodontics, Faculty of Dentistry, Kutahya Health Sciences University, Kutahya, 43100, Turkey.
Objectives: This randomized controlled clinical trial aimed to evaluate the effect of intracanal cryotherapy using cold saline (2.5 °C) as a final irrigant on postoperative pain and analgesic consumption following single-visit nonsurgical endodontic retreatment of asymptomatic mandibular premolars.
Materials And Methods: Sixty systemically healthy patients with asymptomatic apical periodontitis in previously treated single-rooted mandibular premolars were enrolled and randomly assigned to two groups ( = 30 each).
Cureus
May 2025
Department of Conservative Dentistry and Endodontics, Karnavati School of Dentistry, Gandhinagar, IND.
Modern dentistry and endodontic practice is based on effective pain management, which highlights the necessity of a thorough, multifaceted framework to address both acute and chronic pain. In endodontic applications, this narrative review examines pharmacological, non-pharmacological, and integrative approaches for the regulation and reduction of pain sensations by synthesizing data from a variety of investigations. Apart from pharmaceutical treatments like corticosteroids, clonidine-enhanced local anesthetics, and innovative methods that target peripheral and central pain pathways, significant developments include the use of intracanal cryotherapy, low-level laser therapy (LLLT), and photobiomodulation.
View Article and Find Full Text PDFFront Dent Med
April 2025
Department of Conservative Dental Sciences, Qassim University College of Dentistry, Buraydha, Saudi Arabia.
Objectives: The present study aimed to assess the effects of intracanal cryotherapy on pain following single-visit non-surgical root canal treatment (NSRCT) of molar teeth with pulpal necrosis and symptomatic apical periodontitis (SAP).
Methods: This parallel-two arm, single-blind, randomized superiority clinical trial was registered at www.clincaltrials.
Dent J (Basel)
February 2025
Department of Restorative Dentistry, College of Dentistry, Umm Al-Qura University, Makkah 24382, Saudi Arabia.
Pain after root canal treatment is a common concern that can greatly affect a patient's quality of life. Identifying the factors contributing to this pain and focusing on those supported by high-quality research can lead to more effective pain management. This narrative review aims to analyze all available systematic reviews on this topic to determine what has been proven to help decrease pain following the root canal procedure.
View Article and Find Full Text PDF