Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events in pediatric and adolescent epilepsy: a prospective, double-blind, randomized, placebo-controlled trial.

Background: Levetiracetam commonly causes neuropsychiatric adverse events (NPAEs) in pediatric patients, including irritability and aggression. This study evaluated pyridoxine supplementation for reducing levetiracetam-related NPAEs in children and adolescents with epilepsy.

Methods: We conducted a prospective, double-blind, randomized, placebo-controlled trial at Phramongkutklao Hospital, Thailand (January-June 2024).

Amniotic fluid stem cell therapy improves erectile function in a diabetic rat model.

Background: Current treatments for diabetic erectile dysfunction, such as phosphodiesterase type 5 inhibitors, penile injection, or vacuum erection devices, primarily offer symptomatic relief and do not address the underlying pathophysiology, which involves neural, vascular, and smooth muscle degeneration.

Objectives: This study aimed to evaluate the therapeutic potential of amniotic fluid-derived stem cells in a rat model of diabetic erectile dysfunction by assessing their impact on erectile function and penile tissue regeneration.

Methods: Male Sprague‒Dawley rats were divided into control, diabetic, and amniotic fluid-derived stem cell-treated diabetic groups.

Calcified Pulmonary Artery Conduit With Distal Embolism: Challenges in Adult Congenital Heart Disease Post-Rastelli.

Background: The Rastelli procedure is a standard surgical repair for congenital heart disease (CHD). Improved long-term survival has revealed rare complications previously unrecognized.

Case Summary: We report a unique case of a patient with a history of Rastelli repair who presented with left-sided heart failure.

Management Protocols for Sepsis and Septic Shock after Craniotomy: Clinical Outcomes and Survival Analysis.

Objectives: Central nervous system infections are linked to a substantial rise in perioperative mortality, with postoperative neurosurgical infections being both prevalent and severe. Although the Surviving Sepsis Campaign (SSC) guidelines offer a framework for managing sepsis, their effect on clinical outcomes in neurosurgical patients has yet to be fully explored. The aim of this study was to compare mortality rates and clinical outcomes in neurosurgical patients with sepsis and septic shock treated according to the SSC protocol versus standard care.

A predictive score model based on complete blood count for a single-unit red blood cell transfusion.

Background: Red blood cell (RBC) transfusions are life-saving options for those who are unable to carry oxygen. Although administering a single RBC unit usually elicits a sufficient response, identifying the optimal transfusion trigger can be challenging because this variable remains unknown.

Objectives: This study aimed to develop a one-unit RBC Transfusion Requirement Scoring Model (1RTRSM), a predictive scoring system through studying the value of each CBC parameter and basic demographics of the patients.

Comparison of radical prostatectomy and external beam radiotherapy in high-risk prostate cancer.

Purpose: We evaluated the clinical outcome of high-risk prostate cancer patients receiving radical prostatectomy (RP) or radiotherapy (RT).

Materials And Methods: Patients were classified as high-risk prostate cancer and received definitive treatment between 2013 and 2023. Patients with previous pelvic RT and incomplete medical record were excluded.

ILAE neuroimaging task force highlight: Tuberous sclerosis complex-related epilepsy.

The ILAE Neuroimaging Task Force publishes educational case reports that highlight basic aspects of neuroimaging in epilepsy consistent with the ILAE's educational mission. Tuberous sclerosis complex (TSC) is a rare, complex, and multisystem autosomal dominant genetic disorder that arises from variations in the TSC1 or TSC2 genes. While characterized by a wide range of clinical manifestations, TSC commonly presents with epilepsy, which is a clinically challenging feature of the condition.

Arthroscopic Medial Meniscal Posterior Root Reconstruction Using Gracilis Autograft via the Anterior-Medial Collateral Ligament Portal to Prevent Meniscal Tissue Cut-Through.

Meniscal root repair is the treatment of choice for reparable meniscal root tears; however, the complete healing rate is less than 60%. To improve healing outcomes, meniscal root reconstruction may serve as a viable alternative. We present an arthroscopic reconstructive technique using a gracilis graft through the anterior-medial collateral ligament portal.

Expert recommendations for biomarker evaluation of advanced non-small cell lung cancer in Thailand.

Background: Growing understanding of the heterogenous molecular profiles of non-small cell lung cancer (NSCLC) has led to changes in the treatment landscape of advanced NSCLC towards precision medicine to target actionable gene alterations. Practical barriers, such as lack of awareness/understanding of biomarkers, suboptimal quality or sample management, inappropriate use of biomarker testing results, limited patient access to biomarker tests and targeted treatments, and reimbursement/payment challenges, hinder the wider adoption of guideline-recommended biomarker testing. Limited reimbursement of targeted therapies is a key consideration for Thai oncologists when making a treatment choice for their patients with advanced NSCLC in Thailand.

A Sequential Combination of Baveno VI Criteria With Spleen Stiffness Measurement Improves the Screening of High-Risk Esophageal Varices in Compensated Advanced Chronic Liver Disease.

Background: Detecting high-risk esophageal varices (HRV) in cirrhotic patients is crucial for intervention and preventing variceal bleeding. While endoscopy is the gold standard for diagnosis, it is invasive and carries risks. Spleen stiffness measurement (SSM) may improve HRV screening and increase the spared endoscopy rate (SER).

The association between serum leptin levels, body mass index, and disease activity in women with systemic lupus erythematosus.

Obesity is related to a dysregulation in circulating adipokines and might have a potential role in the pathogenesis of systemic lupus erythematosus (SLE). This study aimed to determine the association between serum leptin levels, body mass index (BMI), and disease activity in women with SLE. Female SLE patients were included in the study.

The Incidence of Cysts and Tumors Related to Impacted Mandibular Third Molars in the Thai Population.

Objective: To determine the frequency and types of cysts and tumors around the impacted mandibular third molars (IMTMs) in the Thai population.

Methods: This study was a retrospective study of the histopathologic results of the lesions associated with IMTMs from January 2022 to December 2023. In addition, the age and sex of the patients, panoramic radiographs were also reviewed.

Comprehensive Clinical Characteristics, Longitudinal Adaptive Functioning, and Electroencephalogram Activity in MAPK8IP3-Related Neurodevelopmental Disorder.

Mitogen-activated protein kinase 8-interacting protein 3-related neurodevelopmental disorder (MAPK8IP3-related NDD) results from heterozygous pathogenic or likely pathogenic variants in MAPK8IP3. We report on 32 individuals (median age 7.5 years, range 1.

Evaluation of medical student performance and satisfaction of simulator-based direct ophthalmoscopy training using a new refractive adjustment fundoscopic examination simulator-ICEyeModel: a comparative randomised crossover study.

Background: The use of simulators for ophthalmology training is growing globally. However, all developed simulators have certain limits based on different circumstances. The study aims to evaluate training performance and student satisfaction of the new refractive adjustment simulator "ICEyeModel" compared with a traditional simulator for direct ophthalmoscopy training among medical students.

Comparing Park Table - Augmented and Standard Surgical Doses in Acute Acquired Comitant Esotropia: A Retrospective Analysis.

Purpose: Acquired comitant esotropia (ACE) is a rare condition characterized by the sudden onset of inward eye deviation. In non-recovered cases, surgery was performed. The standard surgical dose typically leads to undercorrection, and multimodal approaches were used to enhance outcomes.

Functional outcomes following hip fracture with concurrent vertebral fracture within a fracture liaison service.

Fragility hip fractures in the elderly are associated with high mortality and a decline in functional outcome. Vertebral fractures are the most common osteoporotic fractures in the elderly population. Data is lacking on the association between hip fracture and osteoporotic vertebral compression fracture (OVCF), particularly regarding recovery and functional outcomes.

Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score-Matched Study of US National Database Analysis.

Introduction: While gastrointestinal involvement is a common manifestation of systemic lupus erythematosus (SLE), the association between gastroparesis and SLE remains unclear.

Methods: We analyzed data from the National Inpatient Sample (NIS) database from 2016 to 2021. Patients with gastroparesis were categorized into SLE and non-SLE groups.

Gastrostomy tract metastasis presenting as a large abdominal wall mass following percutaneous endoscopic gastrostomy for esophageal squamous cell carcinoma: a case report.

Percutaneous endoscopic gastrostomy (PEG) is a standard method for providing enteral access in patients with obstructive aerodigestive cancer. However, gastrostomy tract metastasis is a rare but devastating complication in patient with aerodigestive cancers who have undergone PEG tube placement. Due to its rarity, the standard therapeutic approach remains undefined.

Development of a novel quantitative lateral flow assay for vancomycin for therapeutic drug monitoring.

Antibiotic optimisation through therapeutic drug monitoring (TDM) is a key strategy in tackling antimicrobial resistance. However, current quantification methods rely on laboratory-based equipment, delaying timely dose adjustments. We developed a novel point-of-care lateral flow assay (LFA) for the quantification of vancomycin in serum.

Comparative effectiveness of transforaminal epidural steroid injection: subpedicular versus Kambin's triangle technique: a single-centre experience.

Background: Transforaminal epidural steroid injection (TFESI) is a widely employed intervention for managing radicular pain associated with spinal pathology. Among the various techniques utilized for TFESI, the subpedicular and Kambin's triangle approaches are prominent. This study aims to comprehensively evaluate and compare the therapeutic effectiveness and safety profiles of these two techniques of TFESI in alleviating pain and improving functional outcomes.

Fusion Gene: A Rare Case Report of Adult Myeloid/Lymphoid Neoplasm With Eosinophilia and Tyrosine Kinase Gene Fusions.

Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (MLN-TK) represent rare hematological malignancies driven by pathological fusion genes involving tyrosine kinase genes. Among these, rearrangements of the gene, particularly the rearrangement, are frequently observed as pathogenic mutations. Conversely, instances of the fusion gene are rarely documented.

Burden of Alcohol-Related Liver Disease and Alcohol Use Disorder in Asia.

Background: As alcohol consumption continues to rise rapidly in Asia, research into its significant consequences, alcohol-related liver disease (ALD), and alcohol use disorder (AUD) is still limited.

Objective: This study examines the burden of alcohol-related liver disease and alcohol use disorder in Asia from 2000 to 2021.

Methods: We analyzed data from the global burden of disease (GBD) Study 2021 to assess age-standardized prevalence, incidence, and mortality rates for alcohol-related liver disease and alcohol use disorder in Asia from 2000 to 2021.

Comparison of obesity prevalence and associated factors among Thai patients with type 2 diabetes between 2014 and 2018.

Background: Obesity is an emerging public health issue and a significant risk factor for type 2 diabetes mellitus (T2DM). The growing prevalence of obesity in T2DM patients worsens disease outcomes, elevates medical expenses, and increases the risk of cardiovascular complications. Recognizing the trends and related factors of obesity in T2DM patients is essential for guiding specific interventions and public health strategies.

Intrinsic Capacity of Chinese Community-Dwelling Older Adults Using WHO Integrated Care for Older People (ICOPE) Framework: Structural Equation Model Analysis.

Objective: This study aimed to examine the intrinsic capacity in Chinese older adults and its determinants (sociodemographic, lifestyle-related, environmental, and health-related factors) based on the WHO Integrated Care for Older People (ICOPE) framework.

Methods: A cross-sectional community-based study was conducted among 485 community-dwelling older adults recruited from 4 community health service centers in Xinxiang City, Henan Province between August 2024 and February 2025. Intrinsic capacity was assessed across 5 domains: locomotion, cognition, vitality, psychology, and sensory capacity (hearing and vision).