Burden of Alcohol-Related Liver Disease and Alcohol Use Disorder in Asia.

Background: As alcohol consumption continues to rise rapidly in Asia, research into its significant consequences, alcohol-related liver disease (ALD), and alcohol use disorder (AUD) is still limited.

Objective: This study examines the burden of alcohol-related liver disease and alcohol use disorder in Asia from 2000 to 2021.

Methods: We analyzed data from the global burden of disease (GBD) Study 2021 to assess age-standardized prevalence, incidence, and mortality rates for alcohol-related liver disease and alcohol use disorder in Asia from 2000 to 2021.

Alcohol-Attributable Cancer: Update From the Global Burden of Disease 2021 Study.

Background And Aims: Alcohol is a major risk factor for cancer development. Our study aimed to provide the updated global, regional and national burden of alcohol-attributable cancer.

Approach And Results: We analysed the Global Burden of Disease Study 2021 to determine the death and age-standardised death rate (ASDR) from alcohol-attributable cancer and the change of these measures between 2000 and 2021 (reflected as annual percent change [APC]), classified by region, nation and country's developmental status, which is based on the sociodemographic index (SDI).

Sex disparities in alcohol-associated liver disease and subtype differences in alcohol-attributable cancers in the United States.

Background/aims: Harmful alcohol use is a substantial contributor to liver diseases, liver cancer, and extrahepatic neoplasms. Patterns of alcohol consumption have shifted over recent decades. This study evaluates trends in alcohol-associated liver disease (ALD) and alcohol-attributable cancers in the United States (US) from 2000 to 2021.

Global Trend of MASH-associated Liver Cancer: A Systematic Analysis From the Global Burden of Disease 2021.

Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are the leading causes of liver disease and are emerging as the main risk factors for primary liver cancer (PLC). However, updated global data on MASH remain scarce.

Methods: This study analyzed data from the Global Burden of Disease study between 2000 and 2021 to assess the age-standardized incidence, mortality, and disability-adjusted life years (DALYs) from MASH-associated PLC, stratified by geographical region, sociodemographic index, age, and sex.