Management Protocols for Sepsis and Septic Shock after Craniotomy: Clinical Outcomes and Survival Analysis.

Objectives: Central nervous system infections are linked to a substantial rise in perioperative mortality, with postoperative neurosurgical infections being both prevalent and severe. Although the Surviving Sepsis Campaign (SSC) guidelines offer a framework for managing sepsis, their effect on clinical outcomes in neurosurgical patients has yet to be fully explored. The aim of this study was to compare mortality rates and clinical outcomes in neurosurgical patients with sepsis and septic shock treated according to the SSC protocol versus standard care.

End-Expiratory Occlusion Test and Tidal Volume Challenge Test for Evaluating Fluid Responsiveness in Severe Traumatic Brain Injury, Septic Shock, and Acute Respiratory Distress Syndrome.

Introduction: Fluid management in critically ill patients, particularly those with severe traumatic brain injury (TBI), septic shock, and acute respiratory distress syndrome (ARDS), presents a complex and multifaceted challenge. Dynamic tests such as the end-expiratory occlusion (EEO) test and tidal volume challenge (TVC) test are commonly used to assess fluid responsiveness, providing valuable insights into cardiovascular responses to changes in volume status. However, due to the unique risks and complications associated with these conditions, there is an increasing need to explore and evaluate alternative methods for predicting fluid responsiveness more safely and accurately in these critically ill patients.

Assessment of Microcirculatory Changes in Patients With Cervical Spinal Cord Injuries and Neurogenic Shock During the Acute Phase Using Near-Infrared Spectroscopy.

Background Cervical spinal cord injury (SCI) is a severe condition that can lead to neurogenic shock, a life-threatening complication. Neurogenic shock is characterized by a sudden impairment of sympathetic tone, resulting in vasodilation, hypotension, and bradycardia. This disruption can significantly affect blood flow dynamics, particularly in the microcirculation.

Impact of Perampanel for First-Episode Seizures versus Usual Care on Clinical Outcome and Safety Profile Aspects of the Thai Experience.

Background And Purpose: Epilepsy increases poor outcomes in patients with post-traumatic brain injury and brain tumor-related epilepsy, for whom early seizure control is essential. Perampanel (PER) was a known third-generation antiepileptic drug for treatment all types of seizures. The objective of the study is to compare clinical outcomes and safety of PER administration as monotherapy.

One-Hour Bundle Protocols for Surgical Sepsis and Septic Shock in Surgical Intensive Care Unit: Clinical Outcome Aspects in the Thai Context.

Background: Surgical sepsis is a syndrome occurring during the perioperative period with a high mortality rate. Since the one-hour bundle protocol was recommended to decrease sepsis-related morbidity and mortality in clinical practice, the protocol has been applied to surgical patients with sepsis and septic shock. However, clinical outcomes in these surgical patients remain unknown.

Treatment outcomes in cerebral artery dissection and literature review.

Methods Patients with cerebral artery dissections were reviewed in a hospital setting from 2008 to 2015. Clinical presentations, lesion locations, treatment modalities, functional outcomes, and mortality were reviewed. Parent artery occlusion was the first choice for surgery or endovascular treatment of a hemorrhagic dissecting cerebral artery.