Publications by authors named "Thitiwan Simasathien"
Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events in pediatric and adolescent epilepsy: a prospective, double-blind, randomized, placebo-controlled trial.
Epilepsy Behav
September 2025
Background: Levetiracetam commonly causes neuropsychiatric adverse events (NPAEs) in pediatric patients, including irritability and aggression. This study evaluated pyridoxine supplementation for reducing levetiracetam-related NPAEs in children and adolescents with epilepsy.
Methods: We conducted a prospective, double-blind, randomized, placebo-controlled trial at Phramongkutklao Hospital, Thailand (January-June 2024).
Feasibility of mobile phone application "Epilepsy care" for self-management of children and adolescents with epilepsy in Phramongkutklao hospital: A randomized controlled trial.
Epilepsy Behav
February 2024
Epilepsy is a common neurological disorder in children. Mobile applications have shown potential in improving self-management for patients with chronic illnesses. To address language barriers, we developed the first Thai version of the "Epilepsy care" mobile application for children and adolescents with epilepsy in Thailand.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates the use of perampanel (PER) in children and adolescents (1 month to 18 years) with drug-resistant epilepsy who are awaiting surgery.
- The effectiveness of PER was measured by tracking the reduction in seizure frequency and the rate of seizure-free patients over a span of 180 days, with significant improvements noted at all intervals.
- Most patients tolerated PER well, with common side effects like drowsiness and ataxia, which improved when dosages were adjusted, indicating no need for discontinuation due to these effects.
Background: Anti-seizure medication (ASM) treatment is one of the significant risk factors associated with abnormal vitamin D status in epilepsy patients. Multiple studies have shown that adult epilepsy patients can exhibit vitamin D deficiency. However, there are few reports investigating pediatric epilepsy patients.
View Article and Find Full Text PDFObjective: To explore the prognostic implications of epilepsy duration and age at surgery for seizure outcomes after frontal lobe epilepsy (FLE) surgery.
Methods: We reviewed 158 patients who underwent FLE surgery from 1995 to 2010. The primary outcome was seizure freedom at last follow-up (Engel class IA).
Background: The clinical and laboratory findings and outcomes of methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) Staphylococcus aureus osteomyelitis have not been studied in Hawaii.
Methods: Retrospective inpatient chart reviews of 62 culture-proven osteomyelitis patients between 1996 and 2007 were performed.
Results: Fifteen patients (24%) had MRSA infection, and 47 patients (76%) had MSSA infection.