Present status and future directions: Soft tissue management in prosthodontics.

During restorative dental procedures, complete control over the operative site is critical for patient comfort, safety, and the operator's access and visibility. The success of a fixed prosthesis depends on accurate impression making of the prepared finish lines on the abutment teeth. To optimise long-term outcomes for the fixed restoration, gingival retraction techniques should be used to decrease the marginal discrepancy among the restoration and the prepared abutment.

Precision at the apex: Apexification under magnification: A case report.

Background: Advanced materials and techniques are used to successfully manage the apexification of immature teeth with open apices. The use of mineral trioxide aggregate (MTA), bioceramic sealers, and sodium hypochlorite (NaOCl), combined with internal heating and ultrasonic activation, ensures that canals are cleaned, disinfected, and sealed properly. Magnification devices, such as dental operating microscopes (DOM), provide precise visualization for accurate material placement, while the micro apical placement system ensures void-free MTA delivery.

Comparative evaluation of retentive capacity of three different attachment systems for implant retained overdentures: An study.

Background: The primary issue in managing edentulous patients is the severely resorbed mandibular ridge, particularly in older individuals with diminished adaptive capacities. This compromised situation leads to the fabrication of inadequate dentures that lack retention and stability, potentially causing psychosocial issues.

Aim: To determine the difference in retentive capacity between three attachment systems in implant-retained overdentures.

New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee.

Outcomes for relapsed Ewing sarcoma remain consistently poor. Continued efforts to consider creative new approaches for the treatment of relapsed Ewing sarcoma are needed. The Children's Oncology Group Bone Tumor Committee convened a New Strategies for Ewing Sarcoma Task Force to systematically evaluate agents for inclusion in future Phase II or III clinical trials for relapsed Ewing sarcoma.

Metronidazole-induced cerebellar dysfunction: An underdiagnosed identity.

Metronidazole is a commonly used antibiotic in clinical practice. It is associated with neurological toxicity if used for a longer duration or at a higher dose. In our case, the patient was prescribed metronidazole for the treatment of amoebic liver abscess for 7 weeks and he developed metronidazole-induced cerebellar dysfunction and small fibre peripheral neuropathy.

Efficacy of Neuromuscular Training in Patients of Osteoarthritis Knee via Telerehabilitation.

Introduction: Osteoarthritis (OA) of the knee is a leading cause of pain and disability among adults, resulting in structural and functional compromise of synovial joints. Neuromuscular training (NMT) has demonstrated benefits in managing OA; however, its delivery through telerehabilitation remains underexplored. This study aimed to evaluate the effectiveness of NMT delivered via telerehabilitation in patients with primary knee OA.

Epilepsy Surgery in Tuberous Sclerosis Complex: A TSC Natural History Database Study.

Background: Only small series from tertiary care centers inform us on epilepsy surgery in tuberous sclerosis complex (TSC). The generalizability of these results to the wider epilepsy surgery community is unclear.

Methods: Epilepsy surgery data were collected from the National TSC Natural History Database (TSCNHD).

The Impact of Inflammatory Biomarker Subphenotypes on Acute Respiratory Distress Syndrome Prognosis: A Systematic Review and Meta-analysis.

Background And Aims: Acute respiratory distress syndrome (ARDS) is a syndrome that incorporates a wide group of patients with sign and symptoms of acute hypoxemic respiratory failure. Various studies describing hypo- and hyperinflammatory subphenotypes among ARDS cohorts have been performed. The objective of this systematic review and meta-analysis was to examine how biomarker-based subphenotypes of ARDS impact mortality.

Acute Liver Failure and Hepatic Encephalopathy Secondary to Extensive Liver Metastases from Breast Cancer Successfully Treated Using Dose Modified Weekly Nab-paclitaxel and Trastuzumab.

Unlabelled: Acute liver failure due to widespread carcinomatous infiltration of the liver by breast cancer carries a grave prognosis. The disease course is fulminant and deranged hepatic functions and poor performance status make chemotherapy difficult. Our patient was a 46-year-old lady with breast cancer who presented with acute liver failure and hepatic encephalopathy secondary to extensive liver metastases and who was successfully treated with chemotherapy (Nab-paclitaxel) and (immunotherapy) Trastuzumab.

SGLT2 inhibitors in translational medicine: A paradigm shift for diabetes and heart health.

Diabetes mellitus (DM) is a major contributor to a number of catastrophic health disorders, including heart attacks, strokes, kidney failure, blindness, and lower limb amputations. In 2023, DM was recognized by the World Health Organization (WHO) as a major cause of death. Diabetes is becoming more and more common, and any family member could be impacted.

Call to action: British and Irish hypertension society position statement on blood pressure treatment thresholds and targets.

In this position statement the British and Irish Hypertension Society (BIHS) present a review of the current evidence for blood pressure (BP) treatment thresholds and targets. The BIHS recommend initiating pharmacological antihypertensive therapy, irrespective of cardiovascular disease risk, following a confirmed diagnosis of hypertension (sustained out-of-office BP ≥ 135/85 mmHg despite diet and lifestyle advice). The BIHS recommend an on-treatment BP target < 130/80 mmHg or as low as reasonably achievable without causing unacceptable side-effects, within 6-months of initiating treatment, for all adults.

Prioritization of novel agents for further investigation in pediatric non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children's Oncology Group.

Non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) is a group of over 70 tumors that occur across the age range and account for approximately 4 % of childhood cancers. Patients with metastatic or relapsed NRSTS have a dismal prognosis. The histologic, molecular, and clinical heterogeneity of NRSTS and the rarity of individual types pose unique challenges to the study of these diseases.

Investigation of Novel Etoricoxib Analogues as Potential COX-II Inhibitors through a Bioisosteric Strategy, ADMET Evaluations, Docking Studies, and Molecular Dynamics Simulations.

Background: Inflammation is a natural process; however, chronic inflammation may result in numerous health issues. Etoricoxib (ETX), a selective cyclooxygenase-2 (COX-2) inhibitor, serves as an anti-inflammatory agent for various types of arthritis. However, prolonged use of ETX is associated with several adverse effects, including cardiovascular toxicity.

Current Concepts in the Management of Hypertension in Hypertensive Disorders of Pregnancy - A Systematic Review of International Guidelines.

Background And Objective: Hypertensive disorders of pregnancy (HDP) are a leading cause of adverse maternal and perinatal outcomes worldwide. This systematic review aims to compare international practice guidelines for the management gestational hypertension (GH) and pre-eclampsia (PE). Our objective is to identify similarities and differences in the classification, diagnosis and management of these condition.

Epidemiology and Clinical Outcome of Common Multi-drug Resistant Gram-negative Bacterial Infections in a Network of Hospitals in India (IMPRES): A Multicenter Intensive Care Unit-based Prospective Clinical Study.

Background And Aims: India witnessed the exponential rise of antibiotic resistance due to the high burden of communicable disease. The Indian Council of Medical Research reported , and (PEAK organisms) as the most common gram-negative isolates, constituting 65.5% of total isolates.

Complete Response in Salivary Duct Carcinoma Ex Pleomorphic Adenoma With Upfront Combination of Trastuzumab and Chemo-Hormonal Therapy.

Salivary duct carcinoma (SDC) is one of the rarest malignancies. It can arise de novo or from pre-existing pleomorphic adenoma (carcinoma ex pleomorphic adenoma - CXPA) and can be very aggressive. Here, we present one such case of a 48-year-old male with relapsed, widely invasive SDC ex pleomorphic adenoma of the parotid that was locally advanced with intracranial extension that was refractory to chemo-radiation.

The impact of workplace support components on the mental health and burnout of UK-based healthcare professionals: Insights from the CoPE-HCP cohort study.

Study Objective: To evaluate the influence of the perceived level of workplace support and its individual components in improving mental health and reducing burnout among healthcare professionals (HCPs).

Design: In a cohort of 400 HCPs followed up since July 2020, a follow-up survey was done online (August 2023) containing detailed questionnaires regarding workplace support and mental health.

Participants: 400 UK-based HCPs.

Advance Care Planning Conversations in Pediatric Patients with Refractory Oncologic Disease.

Advance care planning (ACP) involves longitudinal communication between the patient and physician to explore the patient's wishes and goals while relaying accurate diagnostic and prognostic information to support informed and shared medical decision-making. In pediatrics, it also uniquely involves the parents or legal guardians as the primary medical decision-makers. ACP ideally leads to the implementation of advanced directives (ADs) and can be a difficult concept to discuss with pediatric patients and families with refractory oncologic disease, given the distinctive burdens that accompany this population.

Harnessing the power of iridium AIEgens for NAD(P)H detection in aqueous medium and living cells.

A rationally designed luminescent probe based on cyclometalated iridium(III) AIEgens was developed for the rapid, sensitive, and specific detection of NAD(P)H in aqueous media. This probe was successfully utilized for bioimaging of NADH within the mitochondria of living cancer cells, highlighting its potential as a valuable tool for investigating NADH-associated cellular processes.

Consensus recommendations regarding local and metastasis-directed therapies in the management of relapsed/recurrent Ewing sarcoma.

Limited randomized or prospective data are available to guide local/metastasis directed therapy (LMDT) in relapsed/recurrent Ewing sarcoma (RR-ES), resulting in uncertainty regarding best clinical practice for these patients. This report reviews the available literature on LMDT approaches and provides consensus recommendations regarding therapeutic decision making, timing, and indications for the use of LMDT in the management of RR-ES. LMDT should be considered on a case-by-case basis to assess appropriateness, optimal timing/modality, palliative versus curative intent, and its role in relation to chemotherapy.

Long-term benefits of atorvastatin on the incidence of cardiovascular events: the ASCOT-Legacy 20-year follow-up.

Aims: Cardiovascular (CV) deaths were reduced by atorvastatin during a 16-year follow-up of participants in the Anglo-Scandinavian Cardiac Outcomes Trial-lipid-lowering arm. We now extend these observations over 20 years and report both non-fatal and fatal CV outcomes.

Methods: A cohort of 4605 UK hypertensive participants with total cholesterol <6.

Assessing novel analogues of nilutamide as a human androgen receptor antagonist: A detailed investigation of drug design using a bioisosteric methodology including ADMET profiling, molecular docking studies and molecular dynamics simulation.

Cancer is a significant health and economic concern worldwide. Prostate cancer (PC) ranks as the fourth leading cause of global death and is the second most prevalent malignancy in males. Androgens are essential for the progress and growth of the prostate gland.