Informative patterns of health care utilization preceding the recognition of adult-onset multiple sclerosis: A population-based study.

Background: Early recognition of multiple sclerosis (MS) remains a pivotal challenge. Little is understood about the trajectories of health care use before recognition of adult-onset MS, and the relationship of the trajectories with subsequent disability.

Methods: We accessed linked clinical and population-based health administrative data in British Columbia, Canada (1991-2020).

A global review of PCBs and halogenated flame retardants in indoor Air: Implication for human exposure risks.

Polychlorinated biphenyls (PCBs) and several halogenated flame retardants (HFRs) are chemicals of high environmental and human health concerns. Accidental indoor dust-ingestion and dietary intake currently account for the primary human exposure pathways. There is however increasing evidence of the importance of inhalation exposure to these chemicals.

Managing Scalp Psoriasis Through Ayurvedic Therapies: A Case Report.

Background: Psoriasis, a chronic inflammatory skin condition, poses significant management challenges due to its persistent nature, recurrences, and side effects associated with conventional therapies. Ayurveda correlates psoriasis with Ekakushtha (a type of skin disorder), primarily involving Vata-Kapha dosha imbalance.

Objective: To evaluate the efficacy of Ayurvedic therapies, including Shodhana (Vamana, Raktamokshana) and Shamana (pacification medications), in managing scalp psoriasis.

Reviving Ancient Wisdom: Exploring the Effectiveness of Jalaukavacharan in Pain Management and Wound Healing-A Case Series.

Background: Wound infections are a common complication of trauma or pathological disorders, posing significant treatment challenges. Historical medical texts describe around 60 procedures to facilitate wound healing, ensure proper tissue approximation, and achieve scar-free recovery. Among these, techniques involving bloodletting have proven particularly effective.

Unani Intervention to Treat Chronic Recurrent Aphthous Stomatitis: A Case Report.

Background: The need to investigate safe and innovative clinical therapies is highlighted by the fact that chronic recurrent aphthous ulcers, also known as recurrent aphthous stomatitis, are a very prevalent but poorly understood mucosal condition that significantly affects patients' quality of life with frequent recurrences. Although aphthous ulcers have received a lot of clinical and research attention, treatment is usually symptomatic. Despite a plethora of therapeutic options for oral ulcers in Unani medicine, there is little empirical evidence to support them.

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties.

Integrin α5β1 is crucial for cell attachment and migration in development and tissue regeneration, and α5β1 binding proteins can have considerable utility in regenerative medicine and next-generation therapeutics. We use computational protein design to create de novo α5β1-specific modulating miniprotein binders, called NeoNectins, that bind to and stabilize the open state of α5β1. When immobilized onto titanium surfaces and throughout 3D hydrogels, the NeoNectins outperform native fibronectin (FN) and RGD peptides in enhancing cell attachment and spreading, and NeoNectin-grafted titanium implants outperformed FN- and RGD-grafted implants in animal models in promoting tissue integration and bone growth.

Integrative Insights into Huqna (Enema) Therapy: Unani and Modern Paradigms.

Background: The Unani system of medicine is rooted in the Theory of Humors, where health is maintained through the balance of four bodily fluids (blood, phlegm, bile, and black bile). Its treatment approach is holistic, encompassing Ilaj bil Tadbeer (Regimental therapy), Ilaj bil Ghida (Dietotherapy), Ilaj bil Dawa (Pharmacotherapy), and Ilaj bil Yad (Surgery). Huqna (enema) is a key non-pharmacological regimen therapy in Unani medicine, used to cleanse the bowels and restore humoral balance.

Integrative Traditional Unani Medicine Management for Calcaneal Spur: A Case Report.

Background: Calcaneal spur refers to a condition in which a sharp bone growth occurs at the heel. In Unani, the calcaneal spur is best categorized under Waja'al-'Aqib (heel pain). This study aims to report the effect of traditional Unani medicine on severe heel pain due to calcaneal spur.

Comparative Evaluation of Autologous Platelet Aggregates Versus Blood Clot On The Outcome Of Regenerative Endodontic Therapy: A Systematic Review and Meta-Analysis.

Background: Regenerative endodontics represents a transformative approach to dental care, revitalizing necrotic teeth. This systematic review and meta-analysis evaluated the role of autologous platelet aggregates compared to the traditional blood clot method in regenerative endodontics.

Material And Methods: A systematic search was conducted in PubMed, Scopus, EBSCO, Open Grey, and Google Scholar between 1st-12th August 2024.

Augmented reality microscopy to bridge trust between AI and pathologists.

Diagnostic certainty is the cornerstone of modern medicine and critical for maximal treatment benefit. When evaluating biomarker expression by immunohistochemistry (IHC), however, pathologists are hindered by complex scoring methodologies, unique positivity cut-offs and subjective staining interpretation. Artificial intelligence (AI) can potentially eliminate diagnostic uncertainty, especially when AI "trustworthiness" is proven by expert pathologists in the context of real-world clinical practice.

Do clinical consequences of pulp involvement due to dental caries cause impact on quality of life of children and adolescents?

A Commentary On: Reis P P G, Jorge R C, Marañón-Vásquez G A, Fidalgo T K D S, Maia L C, Soviero V M. Impact of clinical consequences of pulp involvement due to caries on oral health-related quality of life in children and adolescents: a systematic review and meta-analysis. Caries Res 2025; 59: 71-83.

Symmetry-adjusted cryo-EM analysis unveils the detailed linker protein CsoS2 interactions within the α-carboxysome shell.

Excessive symmetry in cryo-EM data processing can distort key structural details of bacterial microcompartments, highlighting the importance of balanced symmetry for accurate structural insights.

Effectiveness of Different Categories of Light Oils in Partially Reactive Crumb Rubber-Modified Asphalt.

Rubber-modified asphalt (RMA) faces several challenges, including poor workability, difficult construction, and high energy consumption. The incorporation of renewable light oils offers a promising solution to address issues such as high viscosity and elevated carbon emissions in asphalt modified with a high dosage of rubber powder. The investigation of light oil and rubber powder composite-modified asphalt under low-temperature (160 °C) and short-term (30 min) shear processes is essential for understanding its rheological behavior and modification mechanism.

An Update on the Nutritional and Therapeutic Potential of .

L., also known as Cinnamon vine, has a longstanding history in traditional medicine due to its diverse bioactive compounds. However, comprehensive scientific evaluations of its phytochemical properties and therapeutic potential are still limited.

Fostering international mentorship and collaborations: evaluation of the Global Bridges program for early-career researchers in health care sciences.

The Strategic Research Area Health Care Science was funded by the Swedish government to build strong research environments in 2008. This was assigned to Karolinska Institutet and Umeå University. A major initiative was the development of the Global Bridges program at Karolinska Institutet.

High-performance electrochemical immunosensor for ultrasensitive detection of malachite green in food matrices using MOF-derived nanocomposites.

A highly specific and ultrasensitive electrochemical immunosensor for malachite green (MG) detection in complex food matrices is presented. The sensor was constructed through a stepwise assembly process incorporating gold nanoparticles, antibodies, and metal-organic framework (MOF)-derived Pd/CuO@NiO nanocomposites. Its structure and electrochemical performance were thoroughly validated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS).

Molecular Characterization, Antibiotic Resistance Pattern, and Biofilm Formation of Vibrio Parahaemolyticus Isolated from Tropical Seafood.

Background: Vibrio parahaemolyticus in seafood poses a major public health concern, particularly in tropical regions.

Objective: The present study aims to isolate, assess antibiotic susceptibility, and determine the biofilm-forming ability of V. parahaemolyticus strains isolated from seafood sold in Cochin, India.

Navigating the dual burden of dental and periodontal care in individuals who also smoke: an expert review.

Objectives: Smoking poses a significant challenge to oral health, particularly in individuals with dental and periodontal disease. This expert review explores the dual burden of managing periodontal and dental care in smokers, emphasizing the impact of chronic tobacco exposure on disease progression and treatment outcomes.

Study Selection, Data, And Sources: Clinical trials, systematic reviews, and international guidelines were consulted where available.

Endocrine-Disrupting Chemicals and the Effects of Distorted Epigenetics on Preeclampsia: A Systematic Review.

Background: Preeclampsia (PE) is a critical complication of pregnancy that affects 3% to 5% of all pregnancies and has been linked to aberrant placentation, causing severe maternal and fetal illness and death.

Objectives: This systematic review aims to elucidate the association of in-utero endocrine-disrupting chemical (EDC) exposure and microRNAs and their imprinted genes from prenatal and maternal circulation of PE patients.

Methods: Databases such as PubMed, PubMed Central, ScienceDirect, the Comparative Toxicogenomics Database (CTD), ProQuest, EBSCOhost, and Google Scholar were utilized to search for articles that investigate the relationships between selected EDCs and epigenetic events such as DNA methylation and microRNAs that are associated with PE.

Chemistry and Pharmacology of Chenopodium album L. (BATHUA).

Introduction: Chenopodium album Linn. is a nutritionally and pharmacologically significant herb that generally grows in the winter season along with other crops. It is rich in fibers, protein, minerals (Mg, Ca, Fe, K, P, and others), vitamins (ascorbic acids, thiamine, riboflavin, and others), and several other biologically active chemical components like flavonoids, saponins, steroids and many more.

Pomegranate Extracts as Dual Regulators of Angiogenesis: A Systematic Review of Preclinical Evidence in Cancer and Chronic Wound Healing.

Angiogenesis plays a critical role in both tumor progression and wound healing. This systematic review investigates the effect of pomegranate (Punica granatum, PG) extracts as both anti- and pro-angiogenic agents in preclinical models of cancer and chronic wound healing (CWH), respectively. Following PRISMA guidelines, 14 studies (10 cancer, 4 CWH) were identified from PubMed, Scopus, and Google Scholar databases.

Cytokine Storms in COVID-19, Hemophagocytic Lymphohistiocytosis, and CAR-T Therapy.

Importance: Cytokine storm (CS) is a hyperinflammatory syndrome causing multiorgan dysfunction and high mortality, especially in patients with malignant hematologic neoplasms. Triggers include malignant neoplasm-associated hemophagocytic lymphohistiocytosis (MN-HLH), cytokine release syndrome from chimeric antigen receptor T-cell therapy (CAR-T CRS), and COVID-19, but the underlying mechanisms of inflammation and their impact on outcomes are poorly understood.

Objective: To delineate the inflammatory patterns characterizing different CS etiologies and their association with clinical outcomes.

Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals.

To evaluate the relationship between metformin and the outcome of coronavirus disease 2019 (COVID-19) infection. The study included 413 patients with type 2 diabetes among the 5217 patients enrolled in a COVID-19 study, and analyzed whether receiving metformin therapy prior to infection was associated with risk of ICU admission, development of pneumonia and length of hospital stay. The study also examined the correlation between metformin treatment and levels of IL-6, CRP, serum ferritin (SF), lymphocyte, CD4 at admission, as well as the increase in open reading frame 1ab gene cycle threshold (ORF1abCT) after one week of hospitalization.

Effects of green tea supplementation on antioxidant status and inflammatory markers in adults: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials.

Green tea, a plant rich in bioactive compounds, has been highlighted for its beneficial effects. In the present systematic review and meta-analysis of randomised controlled trials (RCTs), the impact of green tea on inflammatory and oxidative markers is investigated. Using pre-defined keywords, online databases (PubMed, Scopus, Web of Science Core Collection, and Google Scholar) were searched for relevant articles, published from inception up to February 2024.