Circulating TNF-α levels in rheumatoid arthritis: a systematic review and meta-analysis and comparison to TNF-α levels in sepsis.

Background: Tumor necrosis factor-alpha (TNF-α) is implicated in the pathogenesis of autoimmune conditions and sepsis. Although anti-TNF-α therapies have demonstrated clinical efficacy in rheumatoid arthritis (RA), there is no established evidence for benefit in patients with sepsis.

Objectives: We sought to quantify circulating TNF-α in patients with RA and compare results to TNF-α levels in sepsis.

Writing about health inequality: recommendations for accurate and impactful presentation of evidence.

Health and development agendas and programmes often prioritize the reduction of unfair and remediable health inequalities. There is a growing amount of data pertaining to health inequalities. Written outputs, including academic research papers, are key tools for describing health inequalities.

Impact Of Spinal Flexion and Extension-Based Yoga Asanas on Autonomic Variables in Experienced Yogic Practitioners: Study Protocol for a Randomized Crossover Trial.

Background: The autonomic nervous system (ANS) is a complex network responsible for maintaining homeostasis. Yoga, as a traditional mind-body intervention, is known to modulate autonomic function in both healthy and clinical populations. However, the differential effects of forward versus backward-bending yoga asanas on autonomic parameters remain unexplored.

Implementation of smartphone application for reporting adverse events following immunization by the treating doctors in tertiary care teaching hospitals in Chennai, India: Pilot and feasibility study.

Background: Under-reporting of severe and serious Adverse Events Following Immunization (AEFIs) from tertiary care teaching hospitals is a pressing issue in India. This pilot study aimed to evaluate the feasibility of a smartphone-based reporting intervention to enhance AEFI surveillance by treating doctors in four public teaching hospitals in Chennai, India.

Methods: From August 2023 to March 2024, a digital intervention was implemented across four medical college hospitals involving pediatrics, community medicine, and pharmacology departments.

Silver Nanoparticles and Houttuynin Sodium-Based Fibrous Poly(L-lactide-co-glycolide)/Gelatin-Based Dressings for Infectious Wound Healing.

Bacterial infections present debilitating challenges for skin repair, particularly in managing complex microbial colonization and persistent inflammation that delay healing. To address this clinical gap, a dual-functional electrospun dressing (PG@AgH) was developed by incorporating silver nanoparticles (Ag NPs) and houttuynin sodium (H) into poly(L-lactide-co-glycolide)/gelatin (PG) fibers. Compared to conventional dual-agent systems, PG@AgH achieves spatiotemporally controlled release.

Comparative analysis of tuberculosis drug consumption data in public and private sectors across selected districts of Madhya Pradesh.

Objectives: This study aimed to compare drug consumption rates in public and private healthcare sectors between 2018 and 2022 in the Tikamgarh, Datia, and Niwari districts of Madhya Pradesh.

Design: A community-based survey methodology was employed, alongside an analysis of program data and evaluation of anti-TB drug sales and utilization from both healthcare sectors.

Materials And Methods: Data were collected from district hospitals in both the public and private sectors.

Valorization of Coffee Cherry Pulp into Potential Functional Poultry Feed Additives by Pectinolytic Yeast ST5.

Coffee cherry pulp (CCP), a coffee by-product rich in pectin and phenolic compounds, serves as a valuable substrate for microbial enzyme production, improving the nutritional and antioxidant properties of poultry feed. This study evaluated the potential of ST5 to produce pectin-degrading enzymes using CCP. Under unoptimized conditions, the pectin lyase (PL) and polygalacturonase (PG) activities were 3.

Oxytocin in prematurely born infants and their parents - A systematic review with clinical implications.

Introduction: The neuropeptide oxytocin (OT) is considered an important regulatory factor in mother-child bonding after birth. It is also thought to have neuroprotective effects, which could be particularly important for preterm born (≤ 37 weeks) infants, who are considered a high-risk group for several health issues. They are born when their own and their mother's OT-concentrations have not yet reached their maximum during pregnancy and often require neonatal intensive care, separating them from their parents.

Narrative Review of Suddah (Obstruction) in Unani Medicine.

Background: Obstructive conditions represent a major challenge in global healthcare, contributing to significant morbidity and mortality. These include a spectrum of diseases such as vascular thrombosis, embolism, respiratory tract obstructions, hepatobiliary blockages, lymphatic stasis, and intestinal obstructions. While modern medicine classifies and treats these conditions based on anatomical and physiological disruptions, historical records indicate that traditional medical systems, like Unani Medicine, had already developed detailed theoretical frameworks to understand such pathologies.

Role of Phytoestrogens in Gynecological Disorders from the Lens of Unani System of Medicine-A Review.

Abstract: In recent years, there has been a surge of interest in alternative and natural techniques for preventing and treating gynecological disorders. Numerous studies have focused on exploring treatments that have less adverse impact than standard hormonal treatment. Although the etiopathogenetic processes of many gynecological illnesses, such as endometriosis and uterine fibroids, remain unclear, the significance of steroid hormones is undeniable.

Investigating the Effects of Vaccinium myrtillus Supplementation on Cardiometabolic Indices: A Systematic Review and Meta-Analysis.

Chronic diseases cause early death and financial strain worldwide. Cardio-metabolic health, crucial for preventing cardiovascular disease and type 2 diabetes, may benefit from bilberry's antioxidant and anti-inflammatory properties. This meta-analysis reviews studies of bilberry's impact on lipid profiles, glycemic indices, body composition, and inflammatory and oxidative factors.

Surface engineering of nano magnesium alloys for orthopedic implants: a systematic review of strategies to mitigate corrosion and promote bone regeneration.

Magnesium (Mg) alloys are transformative candidates for biodegradable orthopedic implants due to their bone-mimetic elastic modulus (10-30 GPa), biocompatibility, and osteogenic properties. However, rapid corrosion (>2 mm/year) and hydrogen gas evolution (0.1-0.

Comparison Between Various Immunosensor Methods for the Early Detection of Dengue Virus in Real Samples: A Systematic Review.

Dengue (DENV) is a mosquito-borne virus that spreads to humans through the bite of infected female Aedes mosquitoes, causing significant global health problems. This crisis has become more serious due to global warming and the increased prevalence of vector-borne diseases, such as those transmitted by mosquitoes. On the other hand, the request for early detection has increased due to the drawbacks of current serological and molecular procedures.

Medicinal Properties of Erysimum cheiri L. (Tudri surkh) - Insights from Traditional Unani Medicine and Modern Phytochemical Analyses: A Narrative Review.

Background: Plants provide us with significant therapeutic ingredients that serve as raw materials for both traditional and modern medicine. One such medication is Tudri surkh (Erysimum cheiri L), which can be used either alone or in compound pharmacopeial formulations. Tudri surkh is a perennial plant of the family Brassicaceae, originally a native of Europe.

Ayurvedic Management of Rare Genetic Condition-Huntington's Chorea: A Case Report.

Background: Huntington's Chorea is a progressive neurodegenerative disorder characterized by involuntary movements, cognitive decline, and psychiatric disturbances. It is caused by an autosomal dominant mutation in the HTT gene, leading to an abnormal expansion of CAG repeats. The disease typically manifests in mid-adulthood and gradually worsens over time.

The Psychosocial and Developmental Impact of Maternal Incarceration on Children: Legal and Ethical Implications.

The psychosocial and developmental impact of maternal incarceration on children presents profound challenges that intersect legal, ethical, medical, and social dimensions. Children of incarcerated mothers face severe psychological stress, emotional trauma, and developmental setbacks, with documented effects including cognitive deficits, emotional instability, and increased health risks. This paper explores the scope and prevalence of maternal incarceration, highlighting its significant rise globally and its disproportionate effect on women in socio-economically vulnerable positions.

A roadmap for T cell receptor-peptide-bound major histocompatibility complex binding prediction by machine learning: glimpse and foresight.

Cytotoxic T lymphocytes (CTLs) play a key role in the defense of cancer and infectious diseases. CTLs are mainly activated by T cell receptors (TCRs) after recognizing the peptide-bound class I major histocompatibility complex, and subsequently kill virus-infected cells and tumor cells. Therefore, identification of antigen-specific CTLs and their TCRs is a promising agent for T-cell based intervention.

Heterogeneity in health care pathways preceding the classical recognition of adult-onset multiple sclerosis: A multichannel state sequence analysis.

Introduction: Higher healthcare use before recognition of adult-onset multiple sclerosis (MS) raises the possibility of earlier disease detection.

Objective: To describe common clinical pathways before a first recorded demyelinating event or MS symptom onset.

Methods: We applied multichannel state sequence analyses to generate typologies of clinical pathways using linked clinical and population-based health administrative data in British Columbia, Canada (1991-2020).

The Diagnostic Utility of Brain Natriuretic Peptide in Heart Failure Patients Presenting with Acute Dyspnea: A Systematic Review and Meta-analysis.

Background: Patients with heart failure are often diagnosed based on clinical signs and serological markers. Finding biomarkers with greater sensitivity and specificity for heart failure patients who also have episodic dyspnea is a challenge for researchers. Thus, we conducted a systematic review and meta-analysis of previous research to determine the diagnostic value of B-type natriuretic peptide as a potential biomarker in heart failure patients experiencing acute dyspnea.

Evaluation of the HOPE spiritual assessment model: a scoping review of international interest, applications and studies over 20+ years.

Background: Evidence supports classifying spiritual health as a determinant of health and including spiritual care in comprehensive patient-centered care. Despite delineation of primary versus specialty palliative skills, including spiritual care, and availability of spiritual history/assessment communication tools designed for non-specialist (SH/SAs), medical teams continue to neglect patients' spiritual needs. A possible contributor is that consolidated evidence regarding uses and/or effectiveness of these SH/SA tools is lacking.

Does bilateral undescended testis have worst testicular function than unilateral cases? A meta-analysis of adult orchidopexy patients.

Introduction: Cryptorchidism, or undescended testis (UDT), is a congenital anomaly linked to an increased risk of infertility. The laterality of UDT, whether unilateral or bilateral, may influence post-orchidopexy outcomes. This meta-analysis compares testicular function and azoospermia rates between patients with bilateral and unilateral UDT post-orchiopexy.

Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes.

Aims/hypothesis: The aim of this study was to investigate effects of time of day on glucose management in individuals with type 2 diabetes undertaking high-intensity interval exercise. Additionally, the association between regular eating behaviour and mean amplitude of glycaemic excursions was examined. Specifically, the primary outcome was to determine the effect of the intervention on 24 h glucose levels.

Management of Epidermolysis Bullosa through Ayurveda- a case report of two siblings.

Epidermolysis bullosa (EB) is a group of inherited rare skin disorders that causes the skin to become fragile and blister easily due to minor trauma or friction. Blisters can appear anywhere on the body. There are limitations in treating this disease in the conventional system of medicine.

Mechanisms of Decidual Dysfunction and Infertility in Endometriosis: Roles of Prostaglandins and SASP.

Background: Endometriosis is a challenging disease to treat and one of the leading causes of infertility. Impaired endometrial receptivity, and particularly inadequate decidualization of endometrial stromal cells (ESCs), is a crucial component. Multiple inflammatory factors disrupt decidualization.

Parents' and Children's Experiences of Participation in the Family Centered Program for Problematic Gaming and Excessive Screen Use in Child and Adolescent Population.

Background: Screen use, including gaming and social media, has increased over the past decade, potentially having adverse effects on child development and mental health. To prevent the potential problems arising from excessive screen use (ESU) and problem gaming (PG) scholars have developed a Family centered program for PG and ESU (FAME) involving both children and at least one parent in the program. The aim of this study was to explore the experiences of children's and parents' participation in the pilot-FAME program.