Resveratrol as a naturally occurring inflammasome modulator: Implications for health and disease.

Inflammation plays a crucial role in the pathophysiology of diverse diseases, ranging from chronic disorders to acute inflammatory responses. Inflammasome, a multiprotein complex that controls the activation of pro-inflammatory cytokines and initiates immunological responses, has emerged as a critical regulator of inflammation. Resveratrol, a polyphenolic substance present in grapes, berries, and peanuts, has drawn significant attention due to its potential health benefits.

Comparison of casein phosphopeptide-amorphous calcium phosphate fluoride paste and a propolis-containing herbal toothpaste in dentinal hypersensitivity: A randomized trial.

Background: This study aimed to compare the efficacy of casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and propolis-based herbal toothpaste in the treatment of dentin hypersensitivity (DH).

Materials And Methods: In this clinical trial, 20 patients (7 men and 13 women) who met the inclusion criteria were randomly divided into two groups. One group received the herbal toothpaste containing propolis (Herbex), while the other received a paste containing CPP-ACPF (GC MI-Paste Plus).

Resveratrol in anti-biofilm therapy: Mechanisms, molecular derivatives, and emerging drug delivery strategies.

Microbial biofilms serve an important function in various aspects of human health, including infections, chronic diseases, and industrial processes, but their development poses significant challenges due to inherent resistance to traditional antimicrobial agents. Natural compounds are increasingly being investigated as potential anti-biofilm therapy. Resveratrol, a polyphenolic molecule found in many plants, has sparked widespread interest since it has numerous physiological properties, namely antibacterial characteristics.

Lipoprotein(a) in pregnancy: A systematic review and meta-analysis.

Introduction: Pregnancy induces significant metabolic changes, including altered lipid profiles, yet the role of lipoprotein(a) [Lp(a)] remains unclear. While Lp(a) levels rise during pregnancy and may be linked to complications like pre-eclampsia and gestational diabetes, existing studies show inconsistent findings. This meta-analysis aims to investigate Lp(a) levels in normal and high-risk pregnancy and its associated outcomes.

Exploring regional variations in probiotics: Implications for efficacy and application.

Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. These bacteria can affect health conditions by virtue of influencing immune system components, modulating of host signaling, and modifying the microbiota. Gut microbiota-microorganisms inhabiting the gastrointestinal tract-play crucial roles in health enhancement and can be modified via microbiome-based therapeutics-including probiotics-by strengthening the epithelial barrier, competitively excluding pathogens, and interacting with the brain-gut axis.

Navigating the future of oncology: the transformative role of microrobots in precision cancer therapy.

Systemic chemotherapy has long served as a cornerstone in the management of various malignancies. However, its inherent lack of specificity often leads to significant adverse effects, prompting the exploration of innovative nanomedicine strategies to enhance therapeutic precision. Among these advancements, the engineering of microrobots has emerged as a promising avenue, garnering increasing interest due to their unique capabilities.

Investigating the Effects of Vaccinium myrtillus Supplementation on Cardiometabolic Indices: A Systematic Review and Meta-Analysis.

Chronic diseases cause early death and financial strain worldwide. Cardio-metabolic health, crucial for preventing cardiovascular disease and type 2 diabetes, may benefit from bilberry's antioxidant and anti-inflammatory properties. This meta-analysis reviews studies of bilberry's impact on lipid profiles, glycemic indices, body composition, and inflammatory and oxidative factors.

Green-synthesized silver nanoparticles: a sustainable nanoplatform for targeted colon cancer therapy.

Green-synthesized silver nanoparticles (AgNPs), produced using natural sources like plants and algae, have emerged as promising agents for colon cancer therapy due to their distinctive properties and eco-friendly synthesis. This approach leverages bioactive compounds from natural extracts to precisely control nanoparticle size and morphology while enhancing biocompatibility and reducing toxicity. AgNPs exert potent anticancer effects against colon cancer cell lines primarily by inducing cell death through mechanisms including reactive oxygen species (ROS) generation, mitochondrial dysfunction, and apoptosis modulation, leading to significant reductions in cell viability.

Mechanistic insights into postbiotics as therapeutic agents in type 2 diabetes management.

The rising prevalence of type 2 diabetes mellitus (T2DM) alongside its associated morbidity and complications underscores the need for adjunctive therapies beyond glycemic control and lifestyle modification. Emerging evidence implicates gut microbiota-derived metabolites in the modulation of host energy homeostasis. One of these metabolites, postbiotics-the bioactive substances created during the fermentation of probiotics-have now become a promising therapeutic.

PEGylated PLGA nanoparticles: unlocking advanced strategies for cancer therapy.

Poly(lactic-co-glycolic acid) (PLGA) is a widely utilized biodegradable and biocompatible polymer in drug delivery systems, particularly for encapsulating drug molecules with poor solubility and permeability. PLGA nanoparticles, composed of polylactic acid (PLA) and polyglycolic acid (PGA), offer tunable properties such as controlled degradation rates and drug release kinetics. The PEGylation of PLGA nanoparticles results in the formation of a polyethylene glycol (PEG) corona on their surface, which enhances systemic circulation by reducing opsonization and immune system recognition.

Unveiling the power of polymeric nanoparticles: Pioneering advances in breast cancer treatment.

Breast cancer has become the most common type of cancer worldwide. Chemotherapy is a prevalent and efficacious treatment for breast cancer; yet, it presents several problems that might impact both the treatment's effectiveness and the patient's quality of life. Certain breast cancer cells exhibit inherent resistance to chemotherapeutic agents from the outset.

Phytochemicals as Modulators of NETosis: A Comprehensive Review on Their Mechanisms and Therapeutic Potential.

Medicinal plants have a longstanding history in the treatment of various diseases, including infectious and inflammatory disorders. These therapeutic effects are attributed to the presence of bioactive compounds. Among these, phytochemicals, particularly polyphenols such as curcumin, luteolin, resveratrol, alkaloids, and terpenoids, play a significant role as a secondary metabolites with potent NETosis-modulating properties.

Impact of resveratrol on neutrophil extracellular traps.

Neutrophil extracellular traps (NETs) and the process of NETosis have emerged as critical participants in various pathological conditions. Resveratrol, a natural polyphenol found in several plants, has received significant attention due to its potential therapeutic properties. The purpose of this review is to investigate how resveratrol affects NETs and NETosis.

Gastric mucosal differentially expressed genes after bariatric surgery: Effects on sterol-related pathways.

Obesity is currently recognized as a serious global health problem, which accounts for a considerable morbidity and mortality burden. Bariatric surgery is widely accepted as one of the most effective treatments for severe obesity. Roux-en-Y Gastric Bypass (RYGB) is a common type of bariatric surgery.

Neuroprotective effect of Kaempferol through modulation of autophagy.

Autophagy is a critical cellular mechanism that ensures the breakdown of damaged or unnecessary components. This process helps ensure cellular health by maintaining cellular balance, protecting cells from stress, and providing an alternative energy source during metabolic stress. Disruptions in autophagy have been linked to neurological disorders.

Effects of resveratrol supplementation on renal function in adults: a systematic review and dose-response meta-analysis.

The influence of resveratrol on renal function was previously examined; nevertheless, the findings are inconsistent. Therefore, this systematic review and dose-response meta-analysis was performed to evaluate the effect of resveratrol on renal function. A comprehensive search was performed in Web of Science, PubMed, Scopus, and Google Scholar up to March 1, 2025.

Nanocarriers for microRNA delivery: A review of applied platforms and perspectives.

MicroRNAs (miRNA) are non-coding, small RNA sequences which regulate the gene expression through binding to mRNA molecules without complementarity with mRNAs. Several therapeutic applications for miRNAs have been introduced for many diseases including cancers and neurodegenerative diseases. For the therapeutic purposes, miRNAs require efficient delivery systems to reach the therapeutic targets in the cell.

Sialic acid-functionalized nanomaterials for targeted cancer therapy, diagnosis, and theranostics.

Targeted cancer therapy, by leveraging the overexpression of specific molecules on tumors, such as sialic acid (SA), offers a promising strategy to enhance antitumor efficacy while minimizing off-target effects. SA modification of nanomaterials can target both tumor cells and tumor-associated immune cells, thereby improving drug delivery and therapeutic outcomes. Tumor cells with high SA expression bind to sialic acid-binding immunoglobulin-like lectins (Siglecs) and selectins expressed on tumor-associated immune cells, potentially contributing to immunosuppression.

Enhancing curcumin's efficacy with zinc oxide nanoparticles: A dynamic duo in combatting disease.

The combination of Zinc Oxide Nanoparticles (ZnO NPs) and Curcumin (Cur) has garnered significant attention due to its therapeutic potential (e. g., cancer treatment, wound healing, and antioxidant applications).

Exploring the hepatoprotective effects of apples: A comprehensive review of bioactive compounds and molecular mechanisms.

Liver dysfunction contributes to various hepatic disorders, including hepatic steatosis, non-alcoholic fatty liver disease (NAFLD), and hepatocellular carcinoma, posing significant global health challenges. This review aims to evaluate the hepatoprotective potential of apples and their bioactive compounds, such as phenolic acids, flavonoids, triterpenoids, and polysaccharides, by analyzing their molecular mechanisms, cellular effects, and therapeutic applications. These apple-derived compounds, particularly ursolic acid, procyanidins, quercetin, and polyphenolic extracts, exert their hepatoprotective effects by boosting the activities of antioxidant enzymes, lowering oxidative stress, and activating the Nrf2/ARE pathway.

Prooxidant-antioxidant balance as a predictor of mortality: findings from the Neyshabur Longitudinal study on Ageing.

Background: The aim of this study was to determine PAB levels as a predictor of all-cause and cause-specific mortality in adult and elderly subjects.

Methods: The data from 386 subjects who had died during the study were age- and sex-matched to 386 subjects that remained alive, and PAB levels were compared. PAB was evaluated using a mixed enzymatic/chemical method involving simultaneous oxidation and reduction of the chromogen 3,3',5,5'-tetramethylbenzidine by prooxidants and antioxidants, respectively, leading to measurable colorimetric changes.

Statins and adhesion molecules: a review of a novel pleiotropic property of statins.

Statins were introduced as lipid-lowering agents that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase; they are commonly administered to reduce cholesterol levels for cardioprotective purposes. Further studies suggested that statins have cholesterol-reducing-independent properties and exert pleiotropic therapeutic properties, including antioxidant, anti-inflammatory, anti-fibrotic, neuroprotective, and other beneficial effects. Adhesion molecules, including selectins, integrins, cadherins, CD44, and the immunoglobulin superfamily (IgSF) members, are essential mediators for those biological functions.

Effect of curcumin on cardiometabolic diseases in the elderly: A systematic review of randomized controlled trials.

Introduction: As people age, the incidence of cardiometabolic diseases rises, negatively impacting their quality of life; therefore, it is important to supplement the diet with compounds that can manage these conditions. Curcumin (Cur), a common dietary spice, may benefit the health of the elderly. This systematic review evaluates Cur's effectiveness in improving cardiometabolic disease symptoms.