Variations in Dentists' Thresholds for Restorative Treatment of Active Non-Cavitated Carious Lesions: A Multinational Cross-sectional Study.

Objectives: To assess patterns across 21 countries in dentists' thresholds for initiating operative treatment of active non-cavitated carious lesions and to evaluate the influence of caries risk, clinician characteristics, and geographic variation on decision-making in accordance with current guidelines.

Methods: A cross-sectional, vignette-style web-based survey was conducted between June and October 2023 across 21 countries. A standardized questionnaire, comprising theoretical radiographic scenarios of occlusal and approximal active non-cavitated carious lesions at four progressive stages (E1,E2,EDJ,D1), was distributed to general dentists and specialists.

In-silico modeling of SHLP6: A novel mitochondrial peptide controlling neurodegeneration and cellular aging.

Small humanin-like peptide-6 (SHLP6), is derived from the mitochondrial genome. The 3D structure of SHLP6 was evaluated using PEPstr, with homology modeling predicting a Cyt-C structure with a DOPE score of -645.717 and a GA341 score of 0.

Iron and Manganese Azooxime Complexes as Anti-Microbial Agents Against Antibiotics Resistant Wild Bacteria From Hospital Drainage.

Antibiotic resistance is the never-ending war among medical researchers and microbial life forms. The extensive evolving potential of the microorganisms, in combination with improper usage, storage and disposal of the marketed antibiotics generated from natural or artificial sources, always calls for the need for novel antimicrobial agents with different modes of action. In this project, azo-oxime complexes of iron and manganese (seven in total) have been applied to wild multidrug-resistant pathogenic bacterial strains (isolated from sewage water of hospital).

Assessing the Efficacy and Immunogenicity of Anticaries Vaccine-A Systematic Review and Meta-Analysis.

Objectives: The current systematic review and meta-analysis aims to assess the safety and immunogenicity of the anticaries vaccines currently available.

Materials And Methods: Electronic searches of PubMed, Scopus, Web of Science and Science Direct were performed. Studies assessing the safety and effectiveness of the anticaries vaccination, including the dose, plasmids, serum IgG and IgA levels after immunization, were included.

Hamamelitannin from Hamamelis virginiana Attenuates Ethanol-Induced Oxidative and Inflammatory Responses in Danio rerio Larvae.

Alcoholic liver disorder (ALD) is one of the most prevalent hepatic ailments worldwide, with oxidative stress and inflammation playing a vital role in disease progression. The current study intended to assess the anti-inflammatory nature of Hamamelitannin (HAM), a gallotannin from Hamamelis virginiana barks, which was predicted to possess anti-inflammatory properties based on in-silico docking analysis. To further explore its effects, we examined the therapeutic effect of HAM against ethanol-mediated inflammation using an in-vivo zebrafish larvae model.

Preclinical Safety Assessment of an Ayurvedic Dentifrice: Acute and 28-Day Oral Toxicity Studies in Wistar Albino Rats.

Herbal formulations with antimicrobial and anti-inflammatory properties are commonly used in traditional medicine for oral hygiene. Despite growing popularity, little or no research exists on the safety profile of these products to confirm their long-term safety. An ayurvedic dentifrice formulation was analyzed in Wistar albino rats for acute and subacute oral toxicity, with emphasis on the toxic effects of the product on physiological, hematological, biochemical, and histopathological parameters.

Imeglimin systematic review: a novel therapeutic approach for type 2 diabetes-unveiling benefits on β-cell function, insulin sensitivity, and potential long-term glycaemic control (HbA1c).

Background: The prevalence of diabetes mellitus has surged fourfold globally over the past 30 years, creating a major health concern. Imeglimin, a novel oral antidiabetic agent, has shown promising results in the management of type 2 diabetes mellitus (T2DM).

Objectives: This systematic review aimed to evaluate the efficacy and safety of imeglimin in patients with T2DM based on available clinical studies.

Guggulsterone as a dual-function steroidal scaffold: Cholesterol modulation and bioenhancement potential against 7-Ketocholesterol-Linked pathologies.

7-Ketocholesterol (7-KC), a cytotoxic cholesterol oxidation product, drives oxidative stress, inflammation, and apoptosis in cardiovascular, neurodegenerative, and metabolic disorders. Current lipid-lowering agents, such as statins, do not eliminate pre-formed oxysterols, highlighting an unmet therapeutic need. Guggulsterone(GGS), a steroidal phytoconstituent from Commiphora mukul, exhibits dual-function potential by reducing 7-KC formation through antioxidant, anti-inflammatory, and Nrf2-activating effects, while enhancing cholesterol efflux via LDLR and ABC transporters.

Decoding Epigenetic Enhancer-Promoter Interactions in Periodontitis via Transformer-GAN: A Deep Learning Framework for Inflammatory Gene Regulation and Biomarker Discovery.

Background: Widespread tissue destruction and dysregulated immune responses are hallmarks of periodontitis, a chronic inflammatory disease. Although enhancer-promoter (E-P) interactions play a crucial role in gene regulation, little is known about how they affect the epigenetic regulation of periodontal inflammation. By combining DNA methylation and gene expression data using a novel deep learning framework, this study sought to decode the E-P regulatory landscape in periodontitis.

Assessing landfill wastes as a sustainable feeding substrate for black soldier fly larvae.

The rapid growth of the global population has led to an alarming increase in waste generation, with landfills continuing to serve as the primary waste management solution in many developing countries. This surge in solid waste accumulation is putting immense pressure on landfill capacities, underscoring the urgent need for innovative waste management strategies, especially in regions still heavily dependent on traditional systems. This study investigates the potential of black soldier fly larvae to process 3 distinct types of landfill waste: food waste, aged landfill waste, and municipal solid waste sludge.

Phytotherapeutic efficacy of for acute dermatolymphangioadenitis (ADLA).

This study extensively evaluated the therapeutic potential of in treating filariasis-induced secondary lymphedema, with a specific focus on validating its efficacy as a dermal application for acute dermatolymphangioadenitis (ADLA). The research investigated the effects of leaf extract, green-synthesized silver nanoparticles (Mp-AgNPs), and the primary alkaloid Mitraphylline through various assays. Silver nanoparticles were successfully synthesized from leaves, confirmed by observable color changes and UV-Vis spectroscopy, highlighting their potential as enhanced wound dressing components.

Comment on "Clinical Significance of Biochemical Pregnancy Loss in Recurrent Pregnancy Loss Patients: Insights From Euploid Embryo Transfers Minimizing Embryonic Bias".

This commentary addresses Kuwabara et al.'s study on biochemical pregnancy loss (BPL) in recurrent pregnancy loss (RPL) patients following euploid embryo transfers. While their methodology minimizes embryonic bias and strengthens maternal factor assessment, concerns regarding statistical interpretation and potential ascertainment bias limit generalizability.

Advancing dental precision: The synergy of magnification and artificial intelligence.

The article by Chauhan highlights the transformative potential of magnification tools in improving precision and outcomes across various dental specialties. While the authors discuss the advantages of magnification, they do not address the potential integration of artificial intelligence (AI) with magnification devices to further enhance diagnostic and therapeutic efficiency. This letter explores the synergy of AI with magnification tools, emphasizing its applicability in image-guided diagnostics, workflow optimization, and personalized treatment planning.

Carbon nanodots as nanoadsorbents: a novel approach for dye-polluted effluent remediation.

Dye pollution from industrial effluents poses a major environmental threat due to the toxicity, mutagenicity, and carcinogenicity of synthetic dyes. Conventional treatment methods-physical, chemical, and biological-often suffer from limited efficiency, high operational costs, and secondary pollution. Carbon-based nanomaterials have emerged as promising alternatives, with carbon nanodots (CNDs) gaining attention for their unique physicochemical properties.

Bionanoformulated creams of silver (AgNPs), gold (AuNPs) and bimetallic silver-gold composites (Ag-AuNCPs) for tissue regeneration of MDR Pseudomonas aeruginosa-infected excision wounds in Wistar Rats.

Multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative pathogen with advanced antibiotic resistance and biofilm-forming machineries that cause delayed infections (especially in human chronic wounds). Novel therapeutics such as antibiofilm agents, antimicrobial peptides and nanoformulated creams are being developed to treat P.

Neuroprotective effects of Tanshinone IIA in an acrylamide-induced in-vivo zebrafish model: Behavioral, biochemical and molecular restoration.

Acrylamide is a neurotoxic chemical widely present in carbohydrate-rich foods due to thermal processing. Chronic exposure to acrylamide can lead to oxidative stress, neuroinflammation, and neurodegeneration, resulting in motor dysfunction and cognitive impairments. In this study, we evaluated the neuroprotective potential of Tanshinone IIA (TIIA), a bioactive compound derived from Salvia miltiorrhiza (Danshen), on an adult zebrafish model induced with acrylamide.

Diagnosis and surgical management of impacted mandibular canines associated with a dentigerous cyst and odontoma: A case report.

In dental practice, impacted canines are common clinical conditions that compromise tooth mobility, thereby severely affecting functionality and esthetics. They also represent a significant challenge, particularly when associated with odontogenic pathologies such as dentigerous cysts and odontomas. These entities, despite benign, can cause complications, including tooth displacement, root resorption, and alterations in normal eruption, compromising both esthetics and function.