Iron and Manganese Azooxime Complexes as Anti-Microbial Agents Against Antibiotics Resistant Wild Bacteria From Hospital Drainage.

Antibiotic resistance is the never-ending war among medical researchers and microbial life forms. The extensive evolving potential of the microorganisms, in combination with improper usage, storage and disposal of the marketed antibiotics generated from natural or artificial sources, always calls for the need for novel antimicrobial agents with different modes of action. In this project, azo-oxime complexes of iron and manganese (seven in total) have been applied to wild multidrug-resistant pathogenic bacterial strains (isolated from sewage water of hospital).

Designed Synthesis of Amino-Azo-Quinoline and Their Nickel(II) Complexes: Molecular Structure, Electrochemistry and an Insight Into Their In Vitro Anti-Cancer Activities.

Amino-quinolines are potential candidates that may provide some insight into the current chemotherapeutic research due to their demonstrated anti-cancer activity. This led us to synthesize and explore a new amino-azo-quinoline ligand HL 1 and its square planar nickel(II) complexes [Ni(HL) (OAc)], 2 and [Ni(HL)Cl], 3 and the structures were determined by Single Crystal X-Ray Diffraction. Theoretical investigation of redox orbitals of the complexes discloses that the reduction process is due to ligand reduction whereas both metal and ligand are contributing towards oxidation.