30 Years of simultaneous crop & land cover land use maps for Middle Rio Grande from 1994 to 2024.

This study introduces the crop and land cover land use (CLCLU) dataset, a 30 m resolution product providing annual maps of CLCLU across the transnational Middle Rio Grande (MRG) region, spanning both the U.S. and Mexico from 1994 to 2024.

Transforming aquatic weeds into resources: Pontederia crassipes, water hyacinth mining for circular bioeconomy.

Globally, a positive shift to renewable and sustainable bioenergy usage has been witnessed over the years. An ideal resource should contribute equally to bioeconomy, circular economy and sustainable development. One such less explored resource is an aquatic weed, Pontederia crassipes, commonly known as water hyacinth, which is documented as one of the major invasive aquatic weeds due to its rapid reproduction, capacity to deplete nutrients from water bodies, and adaptation to new habitats.

Multifunctional bilayer dressings: a next generation biomaterial for enhanced wound healing.

Wound healing poses a considerable challenge in the healthcare sector, especially for chronic and infected wounds, requiring advanced technological alternatives that surpass conventional dressings. Bilayer dressings, which combine hydrogels and electrospun nanofibers together, have recently emerged as a next generation biomaterial that mimics skin to enhance wound healing. Herein, we first describe skin physiology and various steps that are involved in the wound healing process.

Development of PROTACs for targeted degradation of oncogenic TRK fusions.

Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRK) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. While first-generation TRK kinase inhibitors, such as entrectinib and larotrectinib, have shown positive responses in TRK fusion-positive cancers, resistance mutations against these inhibitors in the kinase domain limit their efficacy. Second-generation inhibitors are in clinical evaluation, highlighting a need for novel therapeutic modalities to achieve durable suppression of the oncogenic activity of TRK fusions.

An Active Spring Mass Model with Biomimetic Ground Reaction Forces for Multiple Terrains.

Unlabelled: Common activities of daily living naturally blend walking on level ground, stairs, and slopes. Predicting human locomotion behavior across these environments is critical for control design in lower-limb assistive devices. One approach to achieving this goal is to use feedforward simulation of conceptual gait models that capture the whole body dynamics of human locomotion.

Smart seat cushion mobile application with on-device posture prediction using TensorFlow lite.

Pressure injuries (PI) pose a significant risk for individuals with spinal cord injuries. While clinical guidelines recommend periodic pressure redistribution (PR), adherence is often low due to limited real-time monitoring and feedback. In this paper, we present an Android application, integrated with a machine learning-based posture prediction algorithm to enhance real-time monitoring and feedback in a smart seat cushion (SSC) system for wheelchair users.

In situ evaluation of genotoxicity and cytotoxicity associated with microplastics in an intertidal clam, Gafrarium divaricatum (Gmelin, 1791).

Microplastics (MP) are an emerging contaminant posing a significant threat to aquatic biota. While numerous studies have documented diverse pollutant abundances along the Maharashtra coast, in situ data on their impacts are lacking. This study presents the first comprehensive assessment of the spatial distribution of MP in water, sediments, and clams (Gafrarium divaricatum), and evaluates their toxicity.

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties.

Integrin α5β1 is crucial for cell attachment and migration in development and tissue regeneration, and α5β1 binding proteins can have considerable utility in regenerative medicine and next-generation therapeutics. We use computational protein design to create de novo α5β1-specific modulating miniprotein binders, called NeoNectins, that bind to and stabilize the open state of α5β1. When immobilized onto titanium surfaces and throughout 3D hydrogels, the NeoNectins outperform native fibronectin (FN) and RGD peptides in enhancing cell attachment and spreading, and NeoNectin-grafted titanium implants outperformed FN- and RGD-grafted implants in animal models in promoting tissue integration and bone growth.

Development of an adaptive spine board overlay for interface pressure reduction during long-range aeromedical evacuation: Implication for pressure injury prevention.

Prolonged immobilization during long-range aeromedical evacuation (LAE) is vital for stabilizing patients with spinal fractures, spinal cord injuries, and traumatic brain injuries. However, pressure injuries are a significant risk during long periods of immobilization, as continuous high pressure on soft tissues can lead to ulceration. This paper introduces a novel adaptive spine board (ASB) overlay, an air-cell-based support surface, designed to optimize interface pressure redistribution during LAE.

Sericin and Xanthan gum-based biopolymer films with enhanced stretchability and cell-proliferation capability.

Sericin (SER), a well-known globular protein, has garnered considerable interest owing to its biological activity and its availability as a by-product from the silk industry. It is a promising option for the synthesis of biomaterials due to its many therapeutic applications. However, the applicability of Sericin films is limited due to its inherent brittle nature.

Benchmarking Quantum Gates and Circuits.

Accurate noise characterization in quantum gates and circuits is vital for the development of reliable quantum simulations for chemically relevant systems and fault-tolerant quantum computing. This paper reviews a variety of key benchmarking techniques, including Randomized Benchmarking, Quantum Process Tomography, Gate Set Tomography, Process Fidelity Estimation, Direct Fidelity Estimation, and Cross-Entropy Benchmarking. We evaluate each method's complexities, the resources they require, and their effectiveness in addressing coherent, incoherent, and state preparation and measurement (SPAM) errors.

Beating the Ramsey limit on sensing with deterministic qubit control.

Qubit frequency shifts, which often contain information about a target environment variable, are detected with Ramsey interference measurements. Unfortunately, the sensitivity of this protocol is limited by decoherence. We introduce a new protocol to enhance the sensitivity of a qubit frequency measurement in the presence of decoherence by applying a continuous drive to stabilize one component of the Bloch vector.

Evaluating the Lethal Dose (LD50) of Ivermectin for Common Carp: Insights from Oral Toxicity Study.

Background: Ivermectin (IVM) is commonly used for the treatment of parasitic diseases in aquaculture and is administered either through oral or immersion methods, but it lacks regulatory approval.

Objective: The aim of the present study was to determine the acute oral toxicity of Ivermectin by estimating the 96 h median lethal dose (LD50) using mortality as endpoint, for an economically important freshwater fish, Cyprinus carpio.

Methods: Medicated feed was prepared by employing different doses of IVM top-dressed onto the commercial feed pellets.

Quantitative comparison of the performance of acoustic, optical and pressure sensors for pulse wave analysis.

Arterial pulse wave measurement is beneficial in clinical health assessment and is important for effectively diagnosing different types of cardiovascular disease. Computational pulse signal analysis utilizes sensors and signal processing techniques to understand, classify, and predict disease pulse patterns. However, the choice of sensor types impacts the measurement results.

Biopesticidal Efficacy and Safety of Azadirachtin: Broad-Spectrum Effects on Ectoparasites Infesting Goldfish, (Linn. 1758).

Ectoparasites are a serious concern for the ornamental fish industry, causing severe pathological and behavioral changes that diminish the aesthetic value of fish and adversely affect trade. Recently, phytotherapy, application of plant extracts or their active biomolecules, has gained attention for the control and treatment of various diseases of humans and animals, including fish. The present study evaluated the broad-spectrum antiparasitic activity of azadirachtin, a neem-based bioactive molecule, under condition against adult protozoan () and adult metazoans ectoparasites, including sp.

Modulating Coalescence Timing of Liquid Marbles via Wettability Adaptation.

Droplet coalescence is ubiquitous in nature, and its regulation is significant in industrial processes and biomedical applications. While bare droplets suddenly coalesce in contact, the droplets covered with liquid-repellent particles to form "liquid marbles (LMs)" are not. Previously, the external stimuli-responsive breakage of the particle layer enables the regulation of the coalescence timing.

Effect of ionic tooth brushes on gingivitis among Indian patients undergoing orthodontic treatment.

The aim of the study was to evaluate and compare the efficacy of ionic toothbrushes versus orthodontic toothbrushes on gingivitis in patients undergoing orthodontic treatment. The study included 50 patients who were divided into 2 groups: Ionic and Ortho toothbrush users group. The clinical parameters like gingival bleeding index, plaque control record, gingival enlargement index and patient hygiene performance were recorded at baseline, 7 days, 21 days, 45 days and 90 days.

Effect of Open Flap Debridement with and without LLLT in Patients with Periodontitis on Wound Healing, GCF ALP Levels, and Clinical Parameters.

Aim: The tenet of the study is to evaluate the efficacy of low-level laser therapy (LLLT) as an adjunct to surgical periodontal therapy [open flap debridement (OFD)] on clinical parameters, gingival crevicular fluid (GCF) alkaline phosphatase (ALP) levels in GCF and wound healing.

Materials And Methods: Thirty subjects afflicted with chronic periodontitis showing evidence of horizontal bone loss on the radiograph, pocket probing depth (PPD) between 4 and 7 mm, and ≥20 natural teeth present in the oral cavity were included in the study. In every patient, OFD+LLLT was done in one quadrant and OFD in another was performed.

Limonoid-rich fraction from Azadirachta indica A. Juss. (neem) stem bark triggers ROS-independent ER stress and induces apoptosis in 2D cultured cervical cancer cells and 3D cervical tumor spheroids.

Background: The existing anticancer drugs in clinical practice show poor efficacy in cervical cancer patients and are associated with multiple side effects. Our previous study demonstrated the strong antineoplastic activity of crude extract prepared from the stem bark of Azadirachta indica (Neem) against cervical cancer. However, the active phytoconstituents of neem stem bark extract and its underlying anticancer mechanism are yet to be investigated.

Temporal adjustment approach for high-resolution continental scale modeling of soil organic carbon.

Open-source legacy data available for training soil organic carbon (SOC) models are limited and not uniformly distributed in space or time. While some process-based models predict SOC changes, most of the large-scale data-driven SOC modeling efforts overlook temporal shifts. Accounting for the expected temporal drift allows us to increase the accuracy of dataset available for machine learning models.

Ecological risk assessment of heavy metals in varied matrices of coastal environment of Maharashtra, India, and their effects on forked venus clam, Gafrarium divaricatum (Gmelin, 1791).

The spatial and seasonal variation of heavy metal contamination was assessed in the seawater, sediments, and clam samples collected from Ratnagiri, Bandra, and Aksa Beach, along Maharashtra Coast, India, during the different seasons. The concentrations of eleven heavy metals were analyzed using inductively coupled plasma-atomic emission spectroscopy (ICP-AES), and the metal concentrations were found in the order sediment > clam > seawater. Various pollution indices indicated that Cd and As mainly contributed to ecological risks, and Bandra was the most contaminated site.

Correlation of Serum Calcium and Vitamin D Levels in Patients with and without Periodontitis before and after Nonsurgical Periodontal Therapy.

Aim: To evaluate and correlate levels of serum calcium and 25-hydroxycholecalciferol (vitamin D) in subjects with periodontitis and in subjects with healthy periodontium before and following nonsurgical periodontal therapy (NSPT).

Materials And Methods: A total of 52 patients were enrolled in the study with 26 patients in each group. The control group included patients without periodontitis, whereas the study group included patients with periodontitis.

Enhancing water quality and well-being of Penaeus vannamei (Boone, 1931) in Inland saline systems using mixed biochar amendments.

An experiment was conducted for 60 days in a 500L capacity FRP tank containing inland ground saline water (fortified to a level of 50% potassium) with one control (sediment) and three treatments; T1(Paddy Straw Biochar (PSB) in sediment), T2 (Banana Peduncle Biochar (BPB) in sediment), and T3 (PSB + BPB in sediment). Biochar (100 g) was amended with sediment (25 kg) at 9 tons/ha. Shrimps of average weight 5 ± 0.

An innovative semiconducting Ni(II)-metallogel based robust random access memory (RRAM) device for advanced flexible electronics applications.

A highly effective method for creating a supramolecular metallogel of Ni(II) ions (NiA-TA) has been developed in our work. This approach uses benzene-1,3,5-tricarboxylic acid as a low molecular weight gelator (LMWG) in DMF solvent. Rheological studies assessed the mechanical properties of the Ni(II)-metallogel, revealing its angular frequency response and thixotropic behaviour.