Cisplatin-induced WWP1-eccDNA expression contributes to ovarian cancer resistance.

Background: Multidrug resistance remains a major obstacle in the treatment of ovarian cancer (OC) patients. Recent research has underscored the critical role of extrachromosomal circular DNA (eccDNA) in tumor initiation and progression. However, there is limited comprehensive understanding of the role eccDNA plays in tumor resistance.

Highly sensitive and high-throughput detection of human alkyladenine DNA glycosylase via hybridization chain reaction-assisted quantum dot fluorescent assay.

Human alkyladenine DNA glycosylase (hAAG) is an important enzyme in the base excision repair (BER) pathway, and its abnormal expression is correlated with various human diseases. While several methods have been developed for hAAG detection, constructing low-background, highly sensitive, and high-throughput techniques remains a significant challenge. Herein, we introduce a highly sensitive and high-throughput platform for hAAG activity detection, utilizing quantum dots (QDs) as the signal sensitizer, the hybridization chain reaction (HCR) for signal amplification, and microplate wells for high-throughput analysis.

Synthesis of Cyclopropyl Carbocyclic Nucleosides via P(NMe)-Mediated Reductive Cyclopropanation.

We have successfully developed P(NMe)-mediated reductive cyclopropanation, which provides a new, facile, and efficient protocol for the synthesis of cyclopropyl carbocyclic nucleosides, wherein the cyclopropyl group is linked to the nucleobase via a methylene group. This method utilizes safe, commercially available α-keto esters for metal-free cyclopropanation under mild conditions with high yield and diastereoselectivity, demonstrating broad applicability and practical utility in carbocyclic nucleoside synthesis.

The improvement effect of insoluble dietary fiber of on hyperlipidemia in high-fat diet mice via gut microbiota and metabolites.

Objective: is rich in insoluble dietary fiber (IDF), but its antihyperlipidemic effect remains unclear. This study investigated the antihyperlipidemic effect of 's IDF (PIDF) in high-fat diet mice.

Methods: Male C57BL/6 J mice were fed with a high-fat diet continuously for 8 weeks.

Application of PSO-integrated K-means algorithm in resident digital portrait classification.

As digital governance progresses rapidly, constructing digital portraits of residents has become instrumental in enhancing local-level administrative capabilities. Nonetheless, traditional K-means clustering algorithms struggle with the classification of high-dimensional and complex data, thereby limiting their effectiveness. To address this issue, this paper proposes a novel hybrid algorithm-PSO-KM-that integrates Particle Swarm Optimization with K-means to improve both accuracy and computational efficiency in clustering resident profile data.

Mechanical Behavior and Response Mechanism of Short Fiber-Reinforced Polymer Structures Under Low-Speed Impact.

Short fiber-reinforced polymer (SFRP) has been extensively applied in structural engineering due to its exceptional specific strength and superior mechanical properties. Its mechanical behavior under medium strain rate conditions has become a key focus of ongoing research. A comprehensive understanding of the response characteristics and underlying mechanisms under such conditions is of critical importance for both theoretical development and practical engineering applications.

Transport properties of group III doped double-walled SiC nanotubes: comparative study of in-wall and out-wall doping.

In this study, the effects of groupelement doping and the inter-wall coupling mechanism on the transport properties of double-walled silicon carbide (SiC) nanotubes are systematically investigated. The results indicate that doping with,, andenhances the conductivity of double-walled SiC nanotubes (SiCNTs) by increasing the carrier concentration, with boron doping exhibiting the most significant improvement. By comparing the electrical conductivity, carrier concentration, and mobility in group-doped single- and double-walled SiCNTs (DWSiCNT), it is found that inter-wall coupling enhances carrier concentration in DWSiCNTs, with a more pronounced effect observed when the inner wall is doped.

The development of chicken meat flavor from the interaction between Maillard reaction intermediates and enzymatically hydrolyzed-oxidized chicken fat.

Meat flavor production faces challenges of flavor instability from volatile Maillard reaction products (MRPs) and off-flavors from excessive high-temperature lipid oxidation (>140 °C). To address this, Maillard-lipid interaction system was established via the mixture containing Amadori rearrangement product, 2-threityl-thiazolidine-4-carboxylic acid and amino acids, named MRIs, and enzymatically hydrolyzed-oxidized chicken fat (EHOC) to elucidate their interaction mechanism and develop optimized chicken meat flavor. General analysis towards the flavor compounds derived from the MRIs suggested that higher temperature at 120 °C was more favorable for meat flavor formation.

Natural yam pigment as a dual-type ROS photosensitizer: mechanism, biosafety, and application in fresh-cut produce.

Background: Photodynamic inactivation (PDI) is an emerging non-thermal strategy for microbial control in food systems. However, few natural pigments are capable of generating both type I and type II reactive oxygen species (ROS), which limits their broad-spectrum antimicrobial efficacy.

Results: This study identified yam pigment (YP) as a dual-type ROS photosensitizer that can produce both singlet oxygen and free radicals under 450-nm blue light.

Unveiling the γ-carboxyl role of glutamic acid in pyrazine formation from N-(1-deoxy-α-d-ribulos-1-yl)-glutamic acid: Mechanistic insights via integrated experimental and density functional theory approaches.

This study deciphers the γ-carboxyl group's pivotal role in controlling pyrazine formation during thermal degradation of glutamic acid-derived Amadori rearrangement product (ARP). Integrated density functional theory (DFT) and pH-controlled experiments revealed γ-carboxyl deprotonation (pK = 4.29) initiates electronic effects that activate the amino group's nucleophilic capacity (-NH₃ to -NH₂-like reactivity) remotely through orbital polarization and highest occupied molecular orbital (HOMO) energy elevation (-1.

Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.

Eightly-four novel thioheterocyclic nucleoside derivatives were designed, synthesized, and evaluated for antitumor activity and . Most of the compounds inhibited the growth of HCT116 and HeLa cancer cells , among them and exhibited potent activity against HCT116 cells (IC = 0.27 and 0.

Cu-Based Diatomic Catalysts for Electrochemical Reduction of CO to Ethylene: A First-Principles Study.

Appropriate CO adsorption and facile C-C coupling are the core factors in the electro-reduction of CO into multicarbon (C) products. Diatomic catalysts possess the capability to precisely modulate the adsorption intensity of intermediates at two distinct active sites, which in turn effectively decreases the overpotential required for C-C coupling reactions. The first-principles study investigates the mechanism and activity of the CORR on M/Cu-NG (M = Zn, Pd, Sn, Ag, or Au).

Recent advances: How bioactive agents combine with packaging systems to impact preservation effects.

This review systematically combed the breakthrough achievements in the field of food active packaging over the past five years, comprehensively analyzed the advantages and limitations of the combination of bioactive agents within safe dosage ranges with six major categories of packaging systems, and deeply explored the interaction mechanisms between bioactive agents and packaging materials in different combinations and their impacts on packaging functions and application effects, so as to provide a scientific basis for the research and development of innovative and efficient active packaging systems. In addition, the review focused on expounding the key technical points in the matching of bioactive agents with specific packaging types and the optimal incorporation strategies of active agents for different food preservation needs. Based on the physicochemical properties of bioactive agents and the functional requirements of active packaging films, this study constructed a systematic selection framework for combination methods to provide a theoretical reference for the precise design and application of active packaging.

Global dynamic characteristics of a piecewise smooth rotor/stator rubbing system with high speed.

In this paper the global dynamic characteristics of a piecewise smooth rotor/stator rubbing system with high speed, which significantly differs from those of a low-speed system, are explored by numerical simulation and theoretical analysis. A sigmoid function is utilized to smoothen the governing equations, enabling the derivation and validation of bifurcation diagrams, as well as corresponding orbits, full spectra and Poincaré sections for both periodic and quasi-periodic motions. Additionally, the frequency relations of the quasi-periodic motions are determined.

DFT Exploration of a Pd-Doped InSe Monolayer as a Novel Gas Sensing Candidate upon SF Decomposition: SO, SOF and SOF.

Monitoring SF decomposition gases has emerged as a vital diagnostic technique for evaluating insulation conditions and identifying faults in SF-based electrical equipment. This study comprehensively explores the adsorption properties and sensing capabilities of a Pd-doped InSe (Pd-InSe) monolayer for SF decomposition gases, including SO, SOF, and SOF, through density functional theory calculations. The Pd-InSe monolayer is constructed by substituting one Se atom with a Pd atom in the pristine InSe structure.

Boundary delineation and stability assessment of post-inrush water-immersed coal pillars based on integrated microseismic monitoring and field analysis.

The stability of flooded coal pillars has long been a challenging issue in coal pillar research, especially during the recovery of production after water inrush disasters. Due to the harsh on-site conditions, it is difficult to directly collect samples for analysis, which brings numerous challenges in both design and production. Based on the engineering background of the 1314 working face of Xiaoyun Coal Mine, this paper proposes a clustering optimization algorithm and successfully uses microseismic data collected on-site to identify the boundary of the flooded coal pillar, validating the results through simulation comparisons.

Facile fabrication of net-like fluorescent microsphere/AuNP tags for a dual-modal colorimetric/fluorescence lateral flow assay.

Lateral flow assays (LFAs) offer a simple and rapid option for diagnosis, widely utilized for point-of-care or at-home testing. However, they often suffer from low sensitivity and high false positive owing to the single output signal. Herein, we developed a dual-mode colorimetry/fluorescence LFA via employing a novel net-like nanprobe as a reporter tag, which was obtained by coupling the fluorescent microspheres (FMs) with gold nanoparticles (AuNPs).

CDCP1 promotes the malignant phenotypes of nasopharyngeal carcinoma via the Wnt/β-catenin signaling pathway.

Background: CUB domain-containing protein 1 (CDCP1), a type I transmembrane glycoprotein, is abundantly expressed in various cancers. However, its role and mechanism in nasopharyngeal carcinoma (NPC) remain ambiguous.

Methods: The UALCAN and GEPIA databases were analyzed to explore CDCP1 expression and survival prognosis in head and neck squamous cell carcinoma (HNSC) patients.

Design and characterization of UV-driven rechargeable antibacterial nanofibrous membranes for food packaging applications.

This study utilized electrospinning to create in situ composite layers of polyvinyl alcohol (PVA) and polylactic acid (PLA) films. Through molecular grafting, the antimicrobial photoinitiator 3,3',4,4'-benzophenonetetracarboxylic dianhydride (BD) was anchored to the PVA surface, followed by chlorogenic acid (CA) attachment, forming a composite film with rechargeable photodynamic properties. Scanning electron microscopy showed that the nanofiber structure remained intact post-grafting, while nuclear magnetic resonance confirmed successful bonding of BD and CA with PVA.

Multi-Omics Landscape to Reveal the Discrepancy in the Accumulation of Flavonoids in Artemisia argyi Across Multiple Growth Stages.

Flavonoids are a major component of Artemisia argyi and play a crucial role in its pharmacological properties. However, the molecular mechanisms underlying flavonoid biosynthesis in A. argyi remain unclear.

Prediction of rock burst risk in underground openings based on intuitionistic fuzzy set.

Rock burst is a complex geological disaster caused by numerous factors in underground engineering construction, it is necessary to take measures to reduce disaster losses caused by rock burst under high crustal stress environment. In this paper, a model for risk prediction of rock burst is proposed based on intuitionistic fuzzy set theory. Considering the internal and external driving factors affecting rock burst, the uniaxial compressive strength [Formula: see text], uniaxial tensile strength [Formula: see text], maximum tangential stress [Formula: see text], burial depth H, brittleness index [Formula: see text], stress coefficient [Formula: see text], and elastic strain energy index [Formula: see text] were selected as the indices to analyze the risk of rock burst.

Effects and comparisons of a 16-week resistance training vs. yoga intervention on psychological distress in older adults.

Background And Aims: Although resistance (RT) and yoga (YG) interventions have had positive effects on psychological distress, examining the efficiency and practical utility between the two has yet to be established. Therefore, the main purpose of the study was to examine the effects of RT and YG interventions on psychological distress in older adults.

Methods: In this 16-week intervention study, participants were 86 community-dwelling older adults randomly assigned to the RT (N = 29), YG (N = 28) and control (CON, N = 28) groups.

Abnormal Brain Function in Systemic Lupus Erythematosus: A Meta-Analysis of Resting-State Functional Magnetic Resonance Imaging.

This meta-analysis investigated the neurophysiological underpinnings of systemic lupus erythematosus (SLE) by examining resting-state functional magnetic resonance imaging (rs-fMRI) profiles of SLE patients in comparison to healthy controls. Rs-fMRI studies up to November 10, 2022 were extracted from five principal databases: Medline, Web of Science, Embase, CNKI, and WanFang. The analysis included data from 13 distinct studies involving 934 participants.

The flavor properties of Amadori rearrangement products and their potentials in flavor replication of plant-based meat analogs: a review.

Plant-based meat analogs (PBMAs) are promising substitutes for balancing the global supply and demand of meat products. The urgent necessity of a meat-like flavor becomes prominent owing to the aroma and taste defects of plant-based meat analogs, which restricts the desire for consumption. As significant Maillard reaction intermediates, Amadori rearrangement products (ARPs) are key flavor precursors that contribute to the required flavor compounds and taste properties; flavor replication in PBMAs is expected.

[WW domain-containing ubiquitin E3 ligase 1 regulates immune infiltration in tumor microenvironment of ovarian cancer].

Objectives: To explore the association of the expression of WW domain-containing ubiquitin E3 ligase 1 (WWP1) with immune infiltration in tumor microenvironment (TME) of ovarian cancer.

Methods: Ovarian cancer patient data from The Cancer Genome Atlas (TCGA) were used to analyze the association of WWP1 expression with patient prognosis. TISCH2 was utilized to analyze the changes in immune cell subtypes in TME of metastatic tumor and after chemotherapy.