"Learning, Thinking & Conveying" training with experiential learning in the emergency department for undergraduate nursing students: A quasi-experimental study.

Background: "Learning, Thinking & Conveying" training with experiential learning was evaluated for its impact on the theoretical knowledge and clinical operation skills of undergraduate nursing students in the Emergency Department. This was a quasi-experimental study.

Methods: A total of 90 undergraduate nursing students in the emergency department of a tertiary care hospital in Wuhan were assigned to experimental and control groups between July and December 2023.

CDCP1 promotes the malignant phenotypes of nasopharyngeal carcinoma via the Wnt/β-catenin signaling pathway.

Background: CUB domain-containing protein 1 (CDCP1), a type I transmembrane glycoprotein, is abundantly expressed in various cancers. However, its role and mechanism in nasopharyngeal carcinoma (NPC) remain ambiguous.

Methods: The UALCAN and GEPIA databases were analyzed to explore CDCP1 expression and survival prognosis in head and neck squamous cell carcinoma (HNSC) patients.

Combined predictive value of prognostic nutritional index and neutrophil to lymphocyte ratio for all-cause mortality risk in maintenance hemodialysis patients: a cohort study followed for 5 years.

Background: To assess the prognostic value of the prognostic nutritional index (PNI) alongside the neutrophil-to-lymphocyte ratio (NLR) in forecasting all-cause mortality in patients undergoing maintenance hemodialysis (MHD), and to pinpoint independent risk factors linked to all-cause mortality, thereby facilitating the guidance of prompt clinical interventions.

Methods: A retrospective cohort investigation was carried out with the gathering of comprehensive demographic and clinical biochemical information. The follow-up period ended in December 2024, with all-cause mortality serving as the primary outcome measure.

Function and regulation of genes for 4-hydroxybenzoate catabolism in .

is a pathogen that causes tumors in plants. Phenolic acids present in the soil and rhizosphere may affect the interaction between and plants. An important pathway for microorganisms to degrade phenolic acids is the β-ketoadipate pathway, which has been annotated in the genome of .

Functional Differentiation and Regulatory Mechanisms of Ferrochelatases HemH1 and HemH2 in Under Iron and Oxidative Stress.

Ferrochelatase is the terminal enzyme in heme biosynthesis. (Bt) 97-27 contains two ferrochelatases, HemH1 and HemH2, but their regulatory mechanisms and functional differences under virous environmental stimuli remain unclear. This study confirmed that the iron uptake regulator protein (Fur) bound to the promoters of and , with Fe or Fe enhancing this binding.

A Chinese patient with cardiogenic stroke and warfarin resistance: a case report.

Background: Warfarin is the most commonly used oral anticoagulant drug in clinical practice due to its effective anticoagulant effect and low cost. Warfarin plays a crucial role in the anticoagulant treatment of patients with thrombotic diseases such as atrial fibrillation, heart valve replacement, and deep vein thrombosis. In general, low-dose warfarin can effectively achieve the optimal international normalized ratio (INR) for patients requiring anticoagulation therapy.

Establishment of a prognostic signature and immune infiltration characteristics for uterine corpus endometrial carcinoma based on a disulfidptosis/ferroptosis-associated signature.

Background: Disulfidptosis and ferroptosis are two different programmed cell death pathways, and their potential therapeutic targets have important clinical prospects. Although there is an association between the two, the role of genes associated with these two forms of cell death in the development of endometrial cancer remains unclear.

Methods: In this study, RNA sequencing (RNA-seq) and clinical data were obtained from public databases, and comprehensive analysis methods, including difference analysis, univariate Cox regression, and Least Absolute Shrinkage and Selection Operator (LASSO) analysis were used to construct a disulfidptosis/ferroptosis-related genes (DFRGs) prognostic signature.

Construction of folic acid modified fluoro-liposomes for oral delivery of erastin to achieve targeted anti-tumor therapy.

Erastin, as an effective ferroptosis inducer, has received extensive attention in anti-tumor research. To develop an oral nanocarrier for high efficient loading hydrophobic erastin, here we prepared a fluoro-liposome (FA-3 F-LS) by the self-assembly of the folic acid modified fluorinated amphiphiles-FA-3 F conjugates. The hydrophobic component of three perfluorooctyl chains endows the FA-3 F-LSs with high stability to resist the harsh gastrointestinal tract condition.

Effects of Baicalein Pretreatment on the NLRP3/GSDMD Pyroptosis Pathway and Neuronal Injury in Pilocarpine-Induced Status Epilepticus in the Mice.

Status epilepticus (SE) links to high mortality and morbidity. Considering the neuroprotective property of baicalein (BA), we investigated its effects on post-SE neuronal injury via the NLRP3/GSDMD pathway. Mice were subjected to SE modeling and BA interference, with seizure severity and learning and memory abilities evaluated.

Adversarial regularized autoencoder graph neural network for microbe-disease associations prediction.

Background: Microorganisms inhabit various regions of the human body and significantly contribute to numerous diseases. Predicting the associations between microbes and diseases is crucial for understanding pathogenic mechanisms and informing prevention and treatment strategies. Biological experiments to determine these associations are time-consuming and costly.

Transcriptional Landscape of Cotton Roots in Response to Salt Stress at Single-cell Resolution.

Increasing soil salinization has led to severe losses of plant yield and quality. Thus, it is urgent to investigate the molecular mechanism of the salt stress response. In this study, we took systematically analyzed cotton root response to salt stress by single-cell transcriptomics technology; 56,281 high-quality cells were totally obtained from 5-days-old lateral root tips of Gossypium arboreum under natural growth and different salt-treatment conditions.

Eradicating the Photogenerated Holes in a Photocatalyst-Microbe Hybrid System: A Review.

Finding advanced technologies to store solar energy in chemical bonds efficiently is of great significance for the sustainable development of our society. The recently reported photocatalyst-microbe hybrid (PMH) system couples photocatalysts intimately with microbes and endows heterotrophic microbes with light-harvesting capacity. Generally, when PMH systems are exposed to light, photocatalytic reactions occur on the surface of photocatalysts and the photogenerated electrons enter microbial cells to promote the generation of energy carriers (such as nicotinamide adenine dinucleotide phosphate hydrogen and adenosine triphosphate) and the following chemical synthesis.

Fabrication of Self-Assembled Graphene Oxide Film and Its Application in Aqueous Zinc Metal Batteries.

Fabrication of well-dispersed thin graphene oxide (GO) films (GOFs) has always been a challenge. Herein, a quick preparation method for GOFs was developed using our homemade GO with a large lateral size. The film can be prepared in less than 2 h via a metal framework-induced self-assembly process.

Identification of Yeast Strain YA176 for Bio-Purification of Soy Molasses to Produce Raffinose Family Oligosaccharides and Optimization of Fermentation Conditions.

Soybean molasses, which contains high levels of raffinose family oligosaccharides (RFOs) such as stachyose and raffinose, is subjected to a process of bio-purification to remove sucrose while maintaining the RFOs, consequently increasing its value. This study employed morphological observation, physiological and biochemical studies, and molecular biology techniques to identify YA176, a yeast strain renowned for its effective bio-purification of soy molasses. Through single-factor and orthogonal experiments, optimal bio-purification conditions were established.

Advances in Research on Bacterial Oxidation of Mn(II): A Visualized Bibliometric Analysis Based on CiteSpace.

Manganese (Mn) pollution poses a serious threat to the health of animals, plants, and humans. The microbial-mediated Mn(II) removal method has received widespread attention because of its rapid growth, high efficiency, and economy. Mn(II)-oxidizing bacteria can oxidize toxic soluble Mn(II) into non-toxic Mn(III/IV) oxides, which can further participate in the transformation of other heavy metals and organic pollutants, playing a crucial role in environmental remediation.

Urinary concentrations of mineral elements and their predictors in pregnant women in Jinan, China.

Background: The essential mineral elements play important roles in proper growth, development and maintenance of physiological homeostasis of an organism. Women are at greater risk of mineral deficiency during pregnancy. However, the predictors of mineral element levels in pregnant women remain unclear.

Exposure to a mixture of metal(loid)s and sleep quality in pregnant women during early pregnancy: A cross-sectional study.

Biological characteristics of pregnant women during early pregnancy make them susceptible to both poor sleep quality and metal/metalloid exposure. However, the effects of metal(loid) exposure on sleep quality in pregnant women remain unknown and unexplored. We aimed to examine the relationship between exposure to a mixture of metal(loid)s and pregnant women's sleep quality during early pregnancy.

Achievement of Efficient and Stable Nonflow Zinc-Bromine Batteries Assisted by Rational Decoration upon the Two Electrodes.

Aqueous zinc-bromine batteries (ZBBs) are highly promising because of the advantages of safety and cost. Compared with flow ZBBs, static ones without the assistance of pumping and tank components possess decreased cost and increased energy density and efficiency. Yet, the issues of Zn dendrites and shuttle effect of polybromide ions (Br) are more serious in nonflow ZBBs.

Saccharomyces cerevisiae cellular engineering for the production of FAME biodiesel.

The unsustainable and widespread utilization of fossil fuels continues to drive the rapid depletion of global supplies. Biodiesel has emerged as one of the most promising alternatives to conventional diesel, leading to growing research interest in its production. Microbes can facilitate the de novo synthesis of a type of biodiesel in the form of fatty acid methyl esters (FAMEs).

Rational Design Toward Advanced Non-Flow Aqueous Zinc-Bromine Systems Boosted by Alkaline-Neutral Decoupling Electrolytes.

Non-flow aqueous zinc-bromine batteries (AZBBs) are highly attractive owing to their lightweight construction and largely reduced cost compared with the flow ones. Yet, their development is restricted by the sluggish reaction kinetics of Br/Br, the shuttle of soluble polybromide species (Br , n is odd), and the poor stability of Zn-based anode. Herein, an effective alkaline-neutral electrolyte decoupling system is constructed to mitigate these issues, where nitrogen-doped carbon felt with high catalytic activity to Br/Br reaction is developed for cathode, a cost-effective cation exchange membrane (CEM) of polyethersulfone/sulfonated polyether ether ketone (PES/SPEEK-M) that can stop Br is used as separator, and glucose that can inhibit dendrites is introduced as anolyte additive.

Predictors of urinary heavy metal concentrations among pregnant women in Jinan, China.

Background: Toxic heavy metal exposure and insufficiency or excess of essential heavy metals may have negative effects on pregnant women's health and fetal growth. To date, the predictors of pregnant women's heavy metal exposure levels remain unclear and vary with different regions. The study intended to explore potential predictors of exposure to heavy metals individually and high co-exposure to heavy metal mixtures.

Synthesis and biological evaluation of folic acid-rotenol conjugate as a potent targeted anticancer prodrug.

Rotenone, a plant-based agricultural insecticide, has been shown to have anti-tumor activity through targeting mitochondrial complex I in cancer cells. However, off-target toxic side effect on nervous systems have greatly restricted the application of rotenone as anticancer drugs. Here, a folic acid-rotenol (FA-rotenol) conjugate was prepared by covalent coupling of the tumor-targeting ligand folic acid with rotenone derivative-rotenol to enhance its accumulation at tumor site.

Construction of Cation-Sieving Function Layers Enabling Dendrite-Free Zinc Metal Anodes for Durable Aqueous Systems.

Rechargeable aqueous zinc-ion batteries are considered as promising candidates for safe and green energy storage. Yet, Zn anodes still suffer from serious challenges. Herein, an effective cation-sieve of polyethersulfone-modified sulfonated polyether ether ketone is developed as protective coating layer of the Zn anodes.