Transmetatarsal amputation versus multiple toes amputations for non-ischemic diabetic foot infection management.

Background: The management of diabetic foot infections (DFIs) is a complex multidisciplinary process and often necessitates surgical interventions. Unfortunately, amputations such as single or multiple toes amputations (MTA) or full transmetatarsal amputation (TMA) are often the unavoidable solution. This study aimed to compare the clinical outcomes of TMA versus MTA in managing non-ischemic diabetic foot infections.

Design, synthesis and biological evaluation of triazolo[1,5-a]pyrimidine derivatives as new antiproliferative agents with multikinase inhibitory activity.

Two series of triazolo[1,5-a]pyrimidines were designed and synthesized as antiproliferative agents targeting multi kinase inhibition aiming to increase potency and combat drug resistance. The synthesized compounds were tested for their antiproliferative activity. The triazolopyrimidine derivatives 9b, 9c, 12b and 12c showed promising anticancer activities, in particular, compounds 12b and 12c displayed broad spectrum antiproliferative potential against NCI cancer cell lines with GI mean value of 10.

Complexation-based spectrofluorimetric method for besifloxacin determination: Combined experimental and computational insights.

Fluorescence-based analytical methods offer high sensitivity, cost-effectiveness, and simplicity for pharmaceutical analysis. Besifloxacin hydrochloride (Bfln.HCl), a fluoroquinolone antibiotic used to treat eye infections, exhibits native fluorescence that can be enhanced in acidic media.

Distribution of myogenic stem cell activator, hepatocyte growth factor, in skeletal muscle extracellular matrix and effect of short-term disuse and reloading.

Hepatocyte growth factor (HGF) is a key myogenic stem cell (satellite cells) activator, that resides in the extracellular matrix (ECM). However, HGF distribution in the ECM varies depending on the muscle fiber type. Furthermore, aging impedes the binding of HGF to its receptors owing to nitration by peroxynitrite (ONOO-).

Modulatory role of in oxidative stress, apoptosis, and gene expression in a rat model of dexamethasone-induced hepatotoxicity.

The rising prevalence of hyperlipidemia and hepatic disorders has intensified interest in the therapeutic use of functional foods and botanical drugs. , a blue-green microalga, is known for its antioxidant, anti-inflammatory, and lipid-lowering properties. However, its potential hepatoprotective effects, particularly against glucocorticoid-induced liver damage, remain underexplored.

A Novel Highly Sensitive Derivatization-Free Spectrofluorimetric Approach for Analysis of the Antifungal Terconazole in Dosage Forms, Biological Fluids, and Environmental Water Samples: Assessment of Greenness and Blueness Profiles.

In the current study, the triazole antifungal terconazole (TRZ) was determined using a novel, extremely sensitive, and environmentally friendly spectrofluorimetric approach. A methanolic solution of TRZ exhibited strong native fluorescence at 373 nm when excited at 241 nm. With a correlation coefficient of 0.

Multiple sclerosis patients' journey delay in diagnosis and treatment: a multicenter study.

Objective: To determine factors that contribute to delayed diagnosis and treatment of MS patients. Additionally, the study aimed to evaluate the correlation between diagnostic and therapeutic delay and disease outcome.

Methods: The current cohort observational multicenter study was performed at neurology clinics in four cities in Egypt.

Effect of using kiwi fruit and heart of date palm slurries as a novel acceleration ripening enzyme source on the physicochemical, textural, and sensorial properties of Ras cheese.

Ras cheese, a hard cheese typically consumed in the Middle East after a 6-month ripening period, is a rich source of casein. Microbial enzymes are commonly used to develop its distinct flavor, but plant-based enzymes offer a cost-effective alternative. Kiwi fruit and heart of date palm slurries contain substantial levels of protease activity, measured at 77.

Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria.

The escalating prevalence of multidrug-resistant (MDR) bacteria presents a critical global health challenge, necessitating the urgent development of alternative antimicrobial strategies. Silver nanoparticles (AgNPs) have emerged as promising antimicrobial agents due to their broad-spectrum activity, unique physicochemical properties, and multiple mechanisms of bacterial inhibition. Their nanoscale size, high surface area-to-volume ratio, and ability to generate reactive oxygen species (ROS) make them highly effective against both Gram-positive and Gram-negative bacteria.

Analgesic efficacy of different volumes in erector spinae plane block in patients undergoing single level lumbar spine fixation: a non-inferiority randomized trial.

Background: Using a lower volume (LVs) of local anaesthetic (LA) reduces the risk of toxicity, side effects, and cost. Our study assessed whether the lower LA volumes (10 or 15 ml) have the same analgesic efficacy as 20 ml of erector spinae plane block (ESPB) in single-level lumbar spine fixation.

Methods: Our non-inferiority, randomised, double-blind trial recruited sixty cases scheduled for single-level lumbar spine fixation.

Protective efficacy of nanoencapsulation of algal extract for preventing and controlling Clostridium botulinum in fish products.

Research is being conducted on the usage of algae extracts as natural preservatives in the storage of fish products to extend shelf life, maintain quality and safety, and satisfy consumer preferences. Laurencia obtusa (Hudson), Actinotrichia fragilis (Forsskål) Børgesen, and Gracilaria dendroids sp. nov.

Correction: modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis.

[This corrects the article DOI: 10.3389/fphar.2024.

Employing diclofenac sodium as a novel therapeutic frontier for Staphylococcus epidermidis infections.

The spread of biofilm-forming multidrug-resistant pathogenic bacteria is an alarming public health issue requiring significant research. Drug repurposing is a novel approach to combating bacterial infections that is currently being studied. Here, we explored diclofenac sodium's potential antibacterial and antibiofilm action on Staphylococcus epidermidis bacteria.

Lead Halide Perovskite Nanocrystals in Metal-Organic Frameworks: Synthesis, Properties, and Applications.

Halide perovskite nanocrystals (PeNCs) with their exceptional light absorption and tunable bandgap, are promising candidates for solar energy harvesting and high-performance photodetectors. However, the susceptibility of PeNCs to degradation limits their widespread application. The integration of halide perovskites within metal-organic frameworks (MOFs) has recently garnered significant attention as a strategy to create composite materials.

Detection and Genomic Characteristics of NDM-19- and QnrS11-Producing O101:H5 Strain Phylogroup A: ST167 from a Poultry Farm in Egypt.

This study describes the first complete genomic sequence of an NDM-19 and QnrS11-producing multidrug-resistant (MDR) isolate collected from a fecal swab from a poultry farm in 2019 in Egypt. The was identified by PCR screening and DNA sequencing. The isolate was then subjected to antimicrobial susceptibility testing, conjugation and transformation experiments, and complete genome sequencing.

The first link between ADAMTS-13 and apoptosis in type 1 diabetic liver injury.

Type 1 diabetes mellitus (T1DM) is associated with oxidative stress and inflammation in the liver, which contribute to hepatocellular damage. However, the molecular mechanisms driving this process remain poorly understood. ADAMTS-13, a metalloprotease involved in vascular homeostasis, has been implicated in tissue remodeling and apoptosis.

Enhancement of Growth Performance and Health Status in Heat-Stressed Growing Rabbits Using Alpha-Lipoic Acid-Loaded Chitosan Nanoparticles.

Objective: This study is the first to study the effect of Alpha-lipoic acid-loaded chitosan nanoparticles (ALA-CHNPs) on growth performance, feed utilization, and health in heat-stressed growing rabbits.

Methods: A total of one hundred healthy 5-week-old rabbits were randomly divided into four groups of 25, each receiving diets supplemented with 0, 100, 200, or 400 mg ALA-CHNPs per kilogram.

Results: The dietary supplementation significantly improved growth performance, feed conversion ratio, physiological responses, liver weight, and dressing percentage.

Deciphering the binding mechanism of tafamidis to calf thymus DNA: multimodal spectroscopic, thermodynamic, and computational perspectives.

The interaction between small molecules and biological macromolecules is a crucial area of research with significant implications across various scientific disciplines. Tafamidis is a clinically approved drug for transthyretin-mediated amyloidosis, yet its molecular interactions with biological macromolecules such as DNA remain unexplored. Investigating such interactions is crucial for understanding its broader pharmacodynamic profile and potential off-target effects.

Discovery of '-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling.

Wound healing poses a considerable challenge in the domain of medical science. In modern clinical practice, there is a growing trend towards using herbal compounds to aid in the repair process. Among these, coumarin, a phytochemical recognized for its antibacterial and wound-healing properties, has attracted significant interest.

Microscopic and ultrastructural insights into the protective role of melatonin against tartrazine-induced hepatotoxicity.

Tartrazine, a coal tar-derived azo color, is utilized in food, drinks, cosmetics, and pharmaceuticals. Its azo group catabolizes in the gut, poisoning the liver. This study investigated the efficacy of melatonin, an endogenous antioxidant from the pineal gland against hepatotoxicity in tartrazine-intoxicated rats.

Atypical Presentation of Behçet Disease Unmasked by Acute Coronary Syndrome.

Background: Behçet disease is a rare multisystem vasculitis that may affect the coronary arteries, presenting as acute coronary syndrome (ACS) in young patients without risk factors.

Case Summary: A 26-year-old man with recurrent oral ulcers experienced chest pain over 3 months. Coronary angiography revealed multivessel disease, and a subsequent angiogram showed coronary aneurysms, suggesting vasculitis.

Correction: Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen.

[This corrects the article DOI: 10.3389/fphar.2025.

Benchmarking the Structure-Based Virtual Screening Performance of Wild-Type and Resistant DHFR Using Docking and Machine Learning Re-Scoring.

Purpose: Malaria, caused by the parasite , remains a critical health challenge. Its enzyme Dihydrofolate Reductase (DHFR) is vital for the parasite's survival and a key target for antimalarial drugs. Mutations in DHFR are primary cause of drug resistance in malaria parasites, particularly to antifolate drugs, like pyrimethamine.

Comparative analysis of drying kinetics, diffusivity, and thermodynamic properties of hybrid solar and oven dryers for Egyptian sweet marjoram.

Egyptian sweet marjoram leaves (ESML) are aromatic herbs long valued for their ability to enhance flavor and extend shelf life by inhibiting the autoxidation of food lipids. Despite their widespread use, limited research exists on how various drying techniques, air temperatures, and thin-layer thicknesses affect the drying behavior, mathematical modeling, effective moisture diffusivity (EMD), activation energy, and thermodynamic properties of ESML. This study addresses this gap by examining the drying characteristics of ESML using a hybrid solar drying system (HSDS) at three air temperatures (50, 60, and 70 °C) and three layer thicknesses (1, 2, and 3 cm), comparing with a conventional oven drying (OD).