Post-recurrence Survival After Liver Transplantation for Hepatocellular Carcinoma.

Background: Mortality after liver transplantation (LT) for hepatocellular carcinoma (HCC) is mainly driven by HCC recurrence. We sought to determine whether post-recurrence survival (PRS) has improved during the last 2 decades.

Methods: Using the Scientific Registry of Transplant Recipients, we included all patients who underwent LT for HCC between 2003 and 2020 and experienced HCC recurrence.

Anatomy at the threshold: Teaching the human body in a hybrid age.

As emerging technologies reshape both the body and how we represent it, anatomical education stands at a threshold. Virtual dissection tools, AI-generated images, and immersive platforms are redefining how students learn anatomy, while real-world bodies are becoming hybridized through implants, neural interfaces, and bioengineered components. This Viewpoint explores what it means to teach human anatomy when the body is no longer entirely natural, and the image is no longer entirely real.

Inflammatory bowel disease vs. adverse in-hospital outcomes after radical prostatectomy.

Introduction: The effect of inflammatory bowel disease (IBD) on adverse in-hospital outcomes after radical prostatectomy (RP) for nonmetastatic prostate cancer (PCa) is not well known.

Materials And Methods: Descriptive analyses, propensity score matching and multivariable logistic regression models were used within the National Inpatient Sample (2000-2019) RP patients, after stratification according to Crohn's disease (CD) vs. ulcerative colitis (UC) vs.

T follicular helper cells (T): From physiological to pathological aging.

The fraction that the elderly represent in the world's population is growing rapidly; numerous alterations that impact all organs and systems, including the immune system, are related to aging. A complex process common in the elderly, known as immunosenescence, is characterized by a decreased ability to respond to vaccination as well as an increased risk of bacterial and viral infections, autoimmune, cardiovascular and neurodegenerative diseases. These processes are associated with alterations in the innate and adaptive immune system and lead to a condition of chronic low-grade inflammation, referred to as inflammaging.

Hyponatremia and bone pathophysiology: An integrated preclinical and clinical perspective.

Chronic hyponatremia is increasingly recognized as a potential contributor to impaired bone health, although the underlying pathophysiological mechanisms have not yet been fully elucidated. Experimental studies have demonstrated that low serum sodium levels affect both osteoclast and osteoblast function, resulting primarily in increased bone resorption and secondarily in reduced bone formation. In humans, however, evidence regarding the effects of hyponatremia on bone remains limited.

Three-dimensional assessment of the malar bone implant engagement of 100 zygomatic implants: a retrospective study.

This study was performed to evaluate the amount of bone implant engagement (BIE) of zygomatic implants (ZIs) at the malar bone level and its correlation with the ZAGA classification (zygoma anatomy-guided approach). One hundred ZIs placed in 32 patients with severe maxillary atrophy using a fully digital protocol were assessed: 80 placed in pairs (40 anterior (AI), 40 posterior (PI)) and 20 as single ZIs (SI). The ZAGA classification was determined preoperatively.

Metabolic and microbial responses of Ceratitis capitata to essential oil-based nano-emulsions: Implications for pest management.

Essential oils (EOs) are a promising alternative to conventional pesticides, but some challenges like high volatility, poor water solubility, and rapid degradation limit their use in Integrated Pest Management (IPM). To overcome these limitations, this study aimed to develop garlic, eucalyptus, and clove EO-based nano-emulsions (EO-NEs) in a bait treatment format through the high-pressure microfluidization technique and investigated the biological activities against Ceratitis capitata. In addition, the adverse effects of the most promising nano-emulsion were evaluated towards a non-target parasitoid Anagaspis daci.

Adoptive cellular therapies in non-Hodgkin lymphomas.

Lymphomas are a group of malignant proliferations of B, T or NK-lymphoid cells at different stages of maturation. While they primarily occur in lymph nodes or lymphatic tissues, they can also involve bone marrow, blood, or other organs. Despite advances in treatment, many patients experience relapse, or develop refractory disease, prompting the development of new therapies.

In silico search reveals the association of lichens with black yeast-like fungi in the order Chaetothyriales.

Lichens exemplify a unique symbiotic relationship between fungi and algae or cyanobacteria, where fungi (mycobionts) provide structural support, while algae or cyanobacteria (photobionts) provide nutrients. Recent discoveries in the order Chaetothyriales have led to the description of several lichenicolous species, underscoring an intricate relationship of some black yeast-like fungi with lichens. The present study aims to investigate public metagenomic data of lichens available in the SRA database, covering a total of 2888 samples.

Cyanidin 3-O-glucoside and other anthocyanins affect enniatins production in Fusarium avenaceum.

Fusarium Head Blight (FHB), caused by various Fusarium species, is a major threat to global cereal production. F. avenaceum is an important FHB pathogen producing enniatin mycotoxins.

KRAS mutations in Non-Small Cell Lung Cancer: translational aspects, current therapies and challenges for future research.

Mutations in the KRAS gene are prominent oncogenic drivers in non-small cell lung cancer (NSCLC), with multiple pathophysiological, clinical and prognostic implications. Although historically considered an "undruggable" target, recent research led to the development of specific KRAS-G12C inhibitors, like sotorasib and adagrasib which are currently approved for clinical use in patients affected by advanced NSCLC. However, the clinical utility of these drugs is often limited by resistance development through several biological mechanisms, including additional KRAS mutations, activation of compensatory pathways and metabolic reprogramming.

Endoscopic Transcortical Tubular-based Resection of a Third Ventricle Colloid Cyst: 2-Dimensional Operative Video.

We present a case of third ventricle colloid cyst surgical resection using a tubular-based endoscopic transcortical approach. Third ventricle colloid are rare benign lesions typically found in the anterolateral part of the third ventricle, close to the foramen of Monro. Several surgical approaches have been employed for their management.

Biogas slurry impregnation-driven hydrothermal synthesis of artificial humic acid: Mechanistic insights and agricultural implications.

In response to the challenges of nutrient limitations and low efficiency in synthesizing artificial humic acid (AHA) during the resource utilization of agricultural wastes, this study innovatively developed a process that integrates biogas slurry (BS) impregnation pretreatment with hydrothermal humification (HTH). Using steam-exploded corn straw (SES) as the raw material, the impregnation parameters were optimized (40 °C, liquid-to-solid ratio of 15:1, 18 h, 3 cycles), achieving an AHA yield of 40.61 %, which was over 15 % higher than that of the untreated group.

Management of recurrent venous thromboembolism during anticoagulant treatment in patients with cancer: a prospective cohort study.

Background: Recurrent venous thromboembolism (VTE) is a common complication in patients with cancer-associated VTE. Limited data are available on treatment, particularly in patients receiving direct oral anticoagulants (DOACs). We aimed to evaluate current management strategies and outcomes in patients with cancer and recurrent VTE during treatment with low-molecular-weight heparin (LMWH) or DOACs.

Evaluation of different platelet-dependent von Willebrand factor activity assays to assess the in vivo inhibitory effect of caplacizumab on the von Willebrand factor-platelet interaction.

Background: Caplacizumab, a humanized anti-von Willebrand Factor (VWF) Nanobody®, is employed for immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) treatment. Its binding to the VWF A1 domain sterically inhibits VWF interaction with platelet glycoprotein Ib (GPIb), counteracting microthrombosis and accelerating the normalization of the platelet count. In caplacizumab-treated iTTP patients with bleeding episodes, measuring platelet-dependent VWF activity (VWF activity) is crucial for monitoring treatment with VWF concentrates.

Systematic Literature Review of Real-world Outcomes of Benralizumab in Eosinophilic Granulomatosis with Polyangiitis.

Background: Several real-world cohorts and numerous case reports investigating benralizumab outcomes in eosinophilic granulomatosis with polyangiitis have been published. These studies complement the limited clinical trial data available by providing early insights on benralizumab use in a broader, real-world population.

Objective: The objective of this systematic literature review (SLR) was to provide an overview of the real-world outcomes of benralizumab in EGPA.

Real-World Experience with Intravitreal Pegcetacoplan for the Treatment of Geographic Atrophy in Age-Related Macular Degeneration.

Purpose: To report on the real-world experience of using intravitreal pegcetacoplan for the treatment of geographic atrophy (GA) in age-related macular degeneration (AMD).

Design: Retrospective interventional case series.

Methods: Eyes with symptomatic GA secondary to AMD were treated with 15mg of intravitreal pegcetacoplan and participated in an ongoing prospective swept-source optical coherence tomography angiography (SS-OCTA) imaging study.

Global burden of anxiety, depression, self-harm (1990-2021) and the impact of COVID-19 pandemic.

Background: Major depressive disorder (MDD), anxiety disorders, and self-harm are substantial contributors to the global disease burden, exacerbated by the COVID-19 pandemic.

Methods: We used Global Burden of Diseases Study (GBD) 2021 to estimate global, regional, and national prevalence, mortality, and disability-adjusted life years (DALYs) for MDD, anxiety disorders, and self-harm from 1990 to 2021. Annual percentage changes were calculated for pre-pandemic (1990-2019) and pandemic (2019-2021) periods.

Ketogenic Diets: Dietary Therapeutic Potential on Breast Cancer.

Among the various types of tumors, breast cancer (BC) has a high distribution in the world population and is responsible for a high mortality rate. Like other forms of cancer, BC is characterised by distinctive features such as high-energy metabolism in tumor cells, genetic mutations, and mitochondrial dysfunction that sometimes make conventional therapies less effective. However, there is a growing awareness of the vital role played by diet therapy in the overall management of the patient with BC, both by supporting standard therapy and by directly targeting aberrant biological processes involved in carcinogenesis.

Cerium Induces Biphasic Responses in Brassica rapa L. through Modulated Photosynthesis, Oxidative Homeostasis, and Gene Expression.

Cerium (Ce), the most abundant of the rare Earth elements (REEs), is increasingly recognized as an environmental contaminant due to its growing applications in various industrial and agricultural sectors. This study investigates the physiological, biochemical, and molecular responses of Brassica rapa L. plants to varying concentrations of Ce exposure to elucidate its effects on plant growth, metabolism, and stress responses.

Nanotechnology-based approaches to tackle bacterial infections.

Bacterial infections have emerged as a critical global health concern. More specifically, antibiotic resistant infections, severely compromise the effectiveness of standard antimicrobial therapies and prompting the exploration of alternative strategies. Among these, nanocarriers (NCs) have gained considerable interest due to their ability to improve drug solubility, stability, and targeted delivery while minimizing off-target effects.