Cancer-specific mortality in secondary bladder cancer after nephroureterectomy for upper tract urothelial carcinoma.

Objective: To examine differences in cancer-specific mortality (CSM) in nonmetastatic upper tract urothelial carcinoma (UTUC) patients with vs. without secondary bladder cancer (BCa) after radical nephroureterectomy (RNU).

Methods: Within the Surveillance, Epidemiology, and End Results database (SEER 2000-2021), T1-T4N0M0 UTUC patients treated with RNU and diagnosed with secondary BCa were identified.

Predicting the indication for adjuvant radiation therapy according to EAU guidelines among patients with high-risk prostate cancer: a novel multivariable model.

Background: To develop a novel model for preoperatively predicting the indication for adjuvant radiation therapy after radical prostatectomy according to current guideline recommendations of the European Association of Urology (EAU) based on patient and clinical tumor characteristics in high-risk prostate cancer patients.

Methods: Within a high-volume center database (01/2010-08/2024), we identified high-risk prostate cancer patients. Univariable logistic regression models addressed indication for adjuvant radiation therapy.

Life Expectancy of Renal Cell Carcinoma with Variant Histology.

Background And Objective: The effect of variant histology in renal cell carcinoma (vhRCC) on survival relative to age- and sex-matched population-based controls is unknown. This study aims to analyze the life expectancy of vhRCC patients.

Methods: In the Surveillance, Epidemiology and End Results (SEER) database (2004-2016), we identified 2928 patients with vhRCC, including mesenchymal, collecting duct, medullary, mucinous, and neuroendocrine RCC, as well as RCC of sarcomatoid and rhabdoid differentiation.

The Effect of Chronic Liver Disease on Adverse In-Hospital Outcomes After Radical Cystectomy and Ileal Conduit Urinary Diversion.

Background: Radical cystectomy (RC) is the gold standard treatment for muscle-invasive bladder cancer (BCa). Chronic liver disease (CLD) may predispose to worse in-hospital outcomes after RC and ileal conduit, but this association has not been investigated. The current study addressed this knowledge gap.

Contemporary rates and predictors of prolonged hospital stay after radical cystectomy: a population-based analysis.

Objective: To test contemporary rates and predictors of prolonged hospital stay after radical cystectomy (RC) and ileal conduit in non-metastatic bladder cancer patients.

Methods: Within the National Inpatient Sample database (NIS, 2008-2019), we identified ileal conduit RC patients and tabulated length of stay (LOS) ≥ 75th percentile vs. others.

Robot-assisted vs. open radical cystectomy: octogenarians vs. non octogenarians.

Introduction: We quantified the effect of robot-assisted radical cystectomy (RARC) vs. open radical cystectomy (ORC) on adverse in-hospital outcomes in octogenarians (≥80 years) relative to non-octogenarians.

Material And Methods: Propensity score matching (PSM), multivariable logistic and Poisson regression models focused on adverse in-hospital outcomes in octogenarian and non-octogenarian patients treated with RARC vs.

Adverse In-hospital Outcomes According to Pelvic Lymph Node Dissection at Partial Cystectomy.

Objective: This study was designed to test the association between adverse in-hospital outcomes and pelvic lymph node dissection (PLND) at partial cystectomy (PC) for nonmetastatic bladder cancer (BCa).

Methods: We identified patients treated with PC for BCa (National Inpatient Sample 2012-2019). First, estimated annual percentage changes (EAPC) tested temporal trends of PLND at PC.

Years of Life Lost in Metastatic and Locally Advanced Prostate Cancer.

Background And Objective: Prostate cancer (PCa) is the second most common cancer-specific cause of death in the USA. However, the effects of metastatic or locally advanced PCa on individual years of life lost (YLL) have not been addressed.

Methods: Within the Surveillance, Epidemiology, and End Results (SEER) database 2004-2021, metastatic (cM1) and locally advanced (cT3/4, cN1) PCa patients aged 45-75 yr were included.

The Effect of Valvulopathy on Adverse In-Hospital Outcomes After Partial and Radical Nephrectomy.

Background: The effect of valvulopathy on adverse in-hospital outcomes after partial nephrectomy (PN) and radical nephrectomy (RN) is unknown.

Patients And Methods: Descriptive analyses, 1:2 propensity score matching and multivariable logistic and Poisson regression models were used to address National Inpatient Sample (2000-2019) patients with kidney cancer who underwent PN and RN, stratified according to presence or absence of valvulopathy.

Results: Overall, 38,673 patients underwent PN versus 92,072 RN.

Extracorporeal vs. intracorporeal urinary diversion at robot-assisted radical cystectomy: adverse in-hospital outcomes.

The advantage of intracorporeal (ICUD) over extracorporeal urinary diversion (ECUD) at robot-assisted radical cystectomy (RARC) regarding adverse in-hospital outcomes is still under debate. We addressed these knowledge gap in the National Inpatient Sample (2016-2019). RARC patients receiving either ileal conduit or neobladder were stratified according to UD technique (ECUD vs.

Effect of sex on adverse in-hospital outcomes after radical cystectomy according to urinary diversion type.

Objective: To test for differences in adverse in-hospital outcomes between females vs. males after radical cystectomy (RC) according to specific urinary diversion type (neobladder vs. ileal conduit).

Cancer-Specific Survival of Trimodal Therapy Versus Radical Cystectomy in T2N0M0 Non-Urothelial Bladder Cancer.

Introduction: We hypothesized that, within organ-confined (OC, T2N0M0) non-urothelial carcinoma of urinary bladder (non-UCUB) patients, trimodal therapy (TMT) use does not differ from radical cystectomy (RC) regarding cancer control outcomes.

Methods: Within the SEER database (2004-2021), rates of TMT versus RC use in OC non-UCUB patients were calculated. Nearest-neighbor 1:1 propensity score matching (PSM) for age, sex, race/ethnicity, and histological subtype was applied.

Influence of Concomitant Androgen Deprivation Therapy and Its Duration for Salvage Radiation After Radical Prostatectomy: A Systematic Review and Network Meta-analysis According to Published Data.

Background And Objective: Recently published data comparing the impact and duration of androgen deprivation therapy (ADT) on metastasis-free survival (MFS), progression-free survival (PFS), and overall survival (OS) in patients undergoing salvage radiation therapy (sRT) after radical prostatectomy have not been compared directly; this study aims to address this knowledge gap.

Methods: We performed a systematic review and network meta-analysis (NMA) on MFS, PFS, and OS using data from the RADICALS-HD, NRG/RTOG 9601, RTOG 0534, and GETUG-AFU 16 trials, as well as three trials from the ARTISTIC meta-analysis (GETUG-AFU 17, RADICALS-RT, and RAVES) on adjuvant versus salvage radiotherapy. The primary outcome was MFS; the secondary outcomes were PFS and OS.

Cancer-Specific Mortality of Partial Cystectomy Versus Radical Cystectomy in T2N0M0 Urothelial Bladder Cancer.

Background: The authors hypothesized that for T2N0M0 urothelial carcinoma of urinary bladder (UCUB) patients, partial cystectomy (PC) does not differ from radical cystectomy (RC) regarding cancer-specific mortality (CSM).

Methods: Within the Surveillance, Epidemiology and End Results (SEER) database (2004-2021), rates of PC versus RC for T2N0M0 UCUB patients were tabulated. Nearest-neighbor 1:1 propensity score-matching (PSM) for age, sex, tumor size and site, race/ethnicity, chemotherapy, and pelvic lymph node dissection status was applied.

Costs of robot-assisted vs. open approaches for 5 major cancers.

To test for differences in total hospital cost (THC) between robot-assisted vs. open major cancer surgeries, colectomy, esophagectomy, radical hysterectomy, lung resection and pancreatectomy. Within the National Inpatient Sample (2016-2019), we identified all robot-assisted vs.

Oncological outcomes after non-surgical management versus radical cystectomy in non-organ-confined non-urothelial bladder cancer.

Introduction: We hypothesized that among non-organ-confined (NOC, T3-4 and/or N1-3) non-urothelial carcinoma of urinary bladder (non-UCUB) patients, bladder-sparing non-surgical management (NSM) provides cancer-specific mortality (CSM) rates comparable to those of radical cystectomy (RC).

Methods: Within the SEER database (2004-2021) rates of NSM vs. RC use in NOC non-UCUB patients were tabulated.

Effect of chemotherapy on cancer specific mortality in female locally advanced urethral cancer.

Objective: To quantify the effect of chemotherapy (CHT) in locally advanced female primary urethral cancer (fPUC).

Methods: In the Surveillance, Epidemiology and Ends Results (SEER) database (2000-2021), we identified 295 fPUC patients with locally advanced stage treated with local therapy (surgery or radiation or both) with or without CHT. Multivariable Cox regression models addressed cancer specific mortality free survival (CSM).

Comparison of In-Hospital Outcomes at Robot-Assisted Versus Open Partial Nephrectomy.

Objective: The aim of this work is to quantify the magnitude of improvement in in-hospital outcomes between historical and contemporary robot-assisted partial nephrectomy (RPN) versus historical and contemporary open PN (OPN).

Methods: Within the Nationwide Inpatient Sample (2010-2019), we identified patients who underwent RPN and OPN. Multivariable logistic regression models were fit.