Cancer-specific mortality in secondary bladder cancer after nephroureterectomy for upper tract urothelial carcinoma.

Objective: To examine differences in cancer-specific mortality (CSM) in nonmetastatic upper tract urothelial carcinoma (UTUC) patients with vs. without secondary bladder cancer (BCa) after radical nephroureterectomy (RNU).

Methods: Within the Surveillance, Epidemiology, and End Results database (SEER 2000-2021), T1-T4N0M0 UTUC patients treated with RNU and diagnosed with secondary BCa were identified.

Defining statistical cure in patients with T1 high-grade non-muscle-invasive bladder carcinoma treated with BCG immunotherapy.

Objective: To assess cure fraction and conditional survival probabilities for oncological outcomes in patients with T1 high-grade (T1HG) non-muscle-invasive bladder carcinoma (NMIBC) treated with adequate Bacillus Calmette-Guérin (BCG) immunotherapy.

Patients And Methods: This multi-institutional retrospective cohort study included 1403 patients with T1HG NMIBC treated between 2007 and 2020, adhering to modern guidelines including mandatory second transurethral resection of bladder tumour and adequate BCG, defined as at least five of six induction doses and at least two of three maintenance doses. Cure fraction, defined as the proportion of patients who will never experience the event of interest, was calculated for recurrence-free survival (RFS), progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS) using a mixture cure model.

The value of maintenance therapy in intermediate-risk non-muscle-invasive bladder cancer.

Objective: To evaluate which subgroups of patients with intermediate-risk non-muscle-invasive bladder cancer (IR-NMIBC) benefit from maintenance therapy based on the International Bladder Cancer Group (IBCG) risk stratification, as the role of a maintenance course in patients with IR-NMIBC is debated.

Patients And Methods: We relied on a prospectively maintained database of patients with IR-NMIBC who received intravesical chemotherapy or Bacillus Calmette-Guérin (BCG) (2010-2023). Patients were stratified according the IBCG prognostic algorithm (no, one to two, and three or more risk factors).

Life Expectancy of Renal Cell Carcinoma with Variant Histology.

Background And Objective: The effect of variant histology in renal cell carcinoma (vhRCC) on survival relative to age- and sex-matched population-based controls is unknown. This study aims to analyze the life expectancy of vhRCC patients.

Methods: In the Surveillance, Epidemiology and End Results (SEER) database (2004-2016), we identified 2928 patients with vhRCC, including mesenchymal, collecting duct, medullary, mucinous, and neuroendocrine RCC, as well as RCC of sarcomatoid and rhabdoid differentiation.

The Effect of Chronic Liver Disease on Adverse In-Hospital Outcomes After Radical Cystectomy and Ileal Conduit Urinary Diversion.

Background: Radical cystectomy (RC) is the gold standard treatment for muscle-invasive bladder cancer (BCa). Chronic liver disease (CLD) may predispose to worse in-hospital outcomes after RC and ileal conduit, but this association has not been investigated. The current study addressed this knowledge gap.

Contemporary rates and predictors of prolonged hospital stay after radical cystectomy: a population-based analysis.

Objective: To test contemporary rates and predictors of prolonged hospital stay after radical cystectomy (RC) and ileal conduit in non-metastatic bladder cancer patients.

Methods: Within the National Inpatient Sample database (NIS, 2008-2019), we identified ileal conduit RC patients and tabulated length of stay (LOS) ≥ 75th percentile vs. others.

Current practices and variability in dynamic sentinel node biopsy for penile cancer: A survey of European Referral Centers.

Background: Dynamic sentinel node biopsy (DSNB) is the currently preferred staging method of high-risk penile cancer (PeCa) patients with cN0 disease. Recently, there have been advancements in the surgical approach and techniques. This study aims to compare the contemporary DSNB practice and techniques amongst European referral centers.

Robot-assisted vs. open radical cystectomy: octogenarians vs. non octogenarians.

Introduction: We quantified the effect of robot-assisted radical cystectomy (RARC) vs. open radical cystectomy (ORC) on adverse in-hospital outcomes in octogenarians (≥80 years) relative to non-octogenarians.

Material And Methods: Propensity score matching (PSM), multivariable logistic and Poisson regression models focused on adverse in-hospital outcomes in octogenarian and non-octogenarian patients treated with RARC vs.

Comparative Assessment of Chemotherapy Followed by Consolidative Radical Cystectomy Versus Chemoradiation for Clinically Node-Positive Urothelial Carcinoma of the Bladder.

Context: Patients with bladder cancer and clinically positive pelvic lymph nodes (cN+) have poor prognosis, and the optimal definitive treatment method remains controversial.

Objective: To compare survival outcomes between chemotherapy followed by radical cystectomy (RC) and chemoradiation (CRT) in patients with cN+ bladder cancer.

Methods: We queried the Surveillance, Epidemiology, and End Results (2000-2021) database to identify patients with cN+ bladder cancer treated with CRT or chemotherapy and RC.

Adverse In-hospital Outcomes According to Pelvic Lymph Node Dissection at Partial Cystectomy.

Objective: This study was designed to test the association between adverse in-hospital outcomes and pelvic lymph node dissection (PLND) at partial cystectomy (PC) for nonmetastatic bladder cancer (BCa).

Methods: We identified patients treated with PC for BCa (National Inpatient Sample 2012-2019). First, estimated annual percentage changes (EAPC) tested temporal trends of PLND at PC.

Years of Life Lost in Metastatic and Locally Advanced Prostate Cancer.

Background And Objective: Prostate cancer (PCa) is the second most common cancer-specific cause of death in the USA. However, the effects of metastatic or locally advanced PCa on individual years of life lost (YLL) have not been addressed.

Methods: Within the Surveillance, Epidemiology, and End Results (SEER) database 2004-2021, metastatic (cM1) and locally advanced (cT3/4, cN1) PCa patients aged 45-75 yr were included.

The Effect of Valvulopathy on Adverse In-Hospital Outcomes After Partial and Radical Nephrectomy.

Background: The effect of valvulopathy on adverse in-hospital outcomes after partial nephrectomy (PN) and radical nephrectomy (RN) is unknown.

Patients And Methods: Descriptive analyses, 1:2 propensity score matching and multivariable logistic and Poisson regression models were used to address National Inpatient Sample (2000-2019) patients with kidney cancer who underwent PN and RN, stratified according to presence or absence of valvulopathy.

Results: Overall, 38,673 patients underwent PN versus 92,072 RN.

Incidence and Predictors of Acute Kidney Injury and Acute Kidney Disease After Robot-assisted Radical Prostatectomy in Prostate Cancer Patients.

Background And Objective: Acute kidney injury (AKI) and acute kidney disease (AKD) are neglected complications of robot-assisted radical prostatectomy (RARP) that may lead to chronic kidney disease (CKD). We investigated their incidence and predictors in prostate cancer (PCa) patients undergoing RARP.

Methods: Overall, 3551 consecutive patients who underwent RARP at a high-volume tertiary center were evaluated.

Impact of timing of computed tomography staging and patient factors on the detection of 'true' cN+ bladder cancer.

Objectives: To evaluate whether computed tomography (CT) scans should be performed before or after transurethral resection of bladder tumour (TURBT) for accurate lymph node staging in clinically lymph node-positive bladder cancer (BCa). Additionally, to identify patient factors that can aid in predicting lymph node metastasis.

Patients And Methods: In this retrospective, multicentre study, we analysed patients with cN+ M0 BCa staged by CT and treated with upfront radical cystectomy (RC) and pelvic lymph node dissection.

Extracorporeal vs. intracorporeal urinary diversion at robot-assisted radical cystectomy: adverse in-hospital outcomes.

The advantage of intracorporeal (ICUD) over extracorporeal urinary diversion (ECUD) at robot-assisted radical cystectomy (RARC) regarding adverse in-hospital outcomes is still under debate. We addressed these knowledge gap in the National Inpatient Sample (2016-2019). RARC patients receiving either ileal conduit or neobladder were stratified according to UD technique (ECUD vs.

Head-to-head comparison of nephrometry scores for partial nephrectomy: implications for clinical guidelines.

Introduction: Several nephrometry scores aim to predict partial nephrectomy (PN) outcomes. Since consensus regarding the best score is lacking, we performed a prospective head-to-head comparison of the most widely used.

Materials And Methods: A dedicated uroradiologist prospectively reviewed preoperative CT scan to assign points to variables of interest included in RENAL, PADUA, SPARE, C-Index, DAP, and MAP score, in 202 renal cell carcinoma (RCC) surgical candidates.

The effect of race/ethnicity on systemic chemotherapy in urothelial carcinoma patients exposed to radiotherapy.

Introduction: Based on prospective trials' result, it is unknown whether race/ethnicity affects the magnitude of cancer-specific survival differences after trimodal therapy (TMT) versus external beam radiation therapy alone (EBRT) for urothelial carcinoma for urinary bladder (UCUB). We addressed this knowledge gap.

Materials And Methods: Within the Surveillance, Epidemiology, and End Results database (2004-2020), we identified patients with cT2-T4aN0M0 UCUB treated with either TMT or EBRT.

Development and External Validation of a Local Pelvic Recurrence Risk Score After Radical Cystectomy: Identifying the Ideal Candidate for Adjuvant Radiation Clinical Trials.

Objective: To develop a risk stratification tool for locoregional recurrence (LR) after radical cystectomy (RC). LR confers a poor prognosis and current risk stratification tools are lacking, representing a critical knowledge gap in facilitating trial design for adjuvant local therapy.

Methods: We reviewed our institutional Cystectomy Registry to identify factors associated with LR.