Development of Beta vulgaris L. extract-finished plasma-cured recycled linen fabrics as a chromogenic sensor for sweat sensing.

A novel smart textile swab was developed as an analytical tool for the onsite evaluation of biochemical changes in sweat toward potential applications in healthcare monitoring and drug testing. Betalain (BTA) was extracted from beetroot (Beta vulgaris L.) using a simple procedure.

Exploring the Topoisomerase II Inhibitory Potential of Steroidal Drugs as a Recommended Mechanism of Action for Their Anticancer Activity: In Silico and In Vitro Assessments.

Herein, and based on the pharmacophoric features of doxorubicin (Dox); 133 steroids were screened to assess their ability to act as TOP II inhibitors for the discovery of those with promising anticancer activity. The cytotoxic inhibitory concentration 50 (IC) of the investigated steroids was determined against H1299, CaCo2, MDA-MB-468, and FaDu cancer cell lines and compared to Dox. Fluticasone propionate and fusidic acid exhibited the most potent antiproliferative effect against the MDA-MB-468 with IC values of 10.

Novel deep learning for multi-class classification of Alzheimer's in disability using MRI datasets.

Introduction: Alzheimer's disease (AD) is one of the most common neurodegenerative disabilities that often leads to memory loss, confusion, difficulty in language and trouble with motor coordination. Although several machine learning (ML) and deep learning (DL) algorithms have been utilized to identify Alzheimer's disease (AD) from MRI scans, precise classification of AD categories remains challenging as neighbouring categories share common features.

Methods: This study proposes transfer learning-based methods for extracting features from MRI scans for multi-class classification of different AD categories.

Neuroplasticity and the microbiome: how microorganisms influence brain change.

Neuroplasticity, the brain's ability to reorganize and adapt, has traditionally been attributed to external stimuli, learning, and experience. However, emerging research highlights the gut microbiota as a key modulator of neuroplasticity through the gut-brain axis. This review examines the mechanisms by which intestinal microorganisms influence brain function, including microbial metabolite production, immune system modulation, neurotransmitter synthesis, and hormonal regulation.

Dietary Phytochemicals in Cardiovascular Disease Prevention and Management: A Comprehensive Review.

Cardiovascular disease (CVD) is the leading cause of death worldwide and a major public health issue. According to recent World Health Organization (WHO) estimates, CVD causes approximately 17.9 million deaths annually, accounting for 32% of global mortality.

Management of patulous Eustachian tube dysfunction following bariatric surgery: a case report.

Patulous Eustachian Tube (PET) dysfunction is a rare condition characterized by an abnormally open Eustachian tube, leading to symptoms such as autophony, auditory fullness, and pulsatile tinnitus. This case report describes a 48-year-old female weighing 72.4 kilograms who developed persistent autophony and hearing her own breathing and heartbeat sounds following significant weight loss after sleeve gastrectomy.

Excellent hydrogen storage capabilities and optoelectronic attributes of XClH (Li, Na, and K) perovskite hydrides for green energy technologies.

The high hydrogen storage capacity, stability, and reversibility of perovskite hydrides make them promising materials for the energy industry. They play a vital role in sustainable energy technologies, including fuel cells and hydrogen storage systems. This work offers a comprehensive understanding of the physical attributes of XClH (X = Li, Na, and K), utilizing the DFT-based Wien2K code.

Optimal estimation of power Chris-Jerry distribution parameters using ranked set sampling design with application.

Effective sample design has a major role in the quality of parameter estimation in statistical parameter estimation issues. The ranking set sampling (RSS) strategy is effective and a less costly option than simple random sampling (SRS). A novel mixture continuous lifetime distribution that has been proposed recently is the power Chris-Jerry distribution (PC-JD).

Predicting the Adsorption Behavior of Olaparib on Zinc Oxide Nanoparticles for Improved pH-Responsive Drug Delivery: Experimental and DFT Insights.

The development of efficient drug delivery systems for hydrophobic anticancer drugs like Olaparib (OLA) remains a critical challenge in cancer therapy. This study presents a comprehensive investigation of OLA-loaded zinc oxide nanoparticles (OLA@ZnO) through integrated experimental and computational approaches to optimize pH-responsive drug delivery. ZnO nanoparticles were synthesized via a sol-gel method and characterized using SEM, XRD, FTIR, and UV-Vis spectroscopy, revealing successful OLA loading through Zn²⁺-carbonyl coordination and π-stacking interactions.

Effect of a mixture of peppermint and clove oils on growth performance, carcass traits, blood parameters, and gut microbiota in broiler chickens.

This study aimed to assess the effect of supplementing Arbor Acre broiler chick diets with a blend of peppermint and clove oils on growth efficiency, blood indicators, and intestinal microbial communities. In a randomized experimental design, 250 unsexed, one-day-old Arbor Acre broiler chicks were allocated into 5 groups. Each group included 5 replicates, each containing 10 birds.

A Systems Biology Perspective on Childhood ADHD: Neurochemical Dysregulation, Brain-Behavior Interactions, and Emerging Therapeutics.

Attention deficit hyperactivity disorder (ADHD) is a pervasive neurodevelopmental condition that typically manifests during childhood. Its symptoms manifest much earlier-often before the age of seven. With the disorder's continuous patterns of inattention, hyperactivity, and impulsiveness, it gets in the way of academic, social, and occupational performance.

Efficient oxidative degradation of organic pollutants in real industrial effluents using a green-synthesized magnetite supported on biochar catalyst.

This study investigated the degradation of tetracycline (TCN) antibiotic catalytic activation of periodate (PI, IO ) using a novel composite catalyst composed of green-synthesized magnetite nanoparticles supported on water lettuce-derived biochar (MWLB). Characterization results revealed that the magnetic biochar possessed a porous structure, abundant surface functional groups, and high carbon and iron contents. Compared to conventional oxidants such as persulfate, hydrogen peroxide, and peroxymonosulfate, the PI-activated system demonstrated superior degradation efficiency.

Assessing the neurological impact of vitamin B12 deficiency among the population of Riyadh, Saudi Arabia.

Background: Vitamin B12 (cobalamin) deficiency can cause anemia, peripheral neuropathy, visual impairment and irreversible neurological damage. Little is known about public awareness of these neurological effects in Saudi Arabia. This study assessed awareness of the neurological impact of vitamin B12 deficiency among adults in Riyadh, Saudi Arabia.

Targeting the TRIB3-MYC axis in cancer: mechanistic insights and therapeutic disruption strategies.

The oncogenic transcription factor MYC drives proliferation, metabolism, and therapy resistance in the majority of human cancers, yet its large, nuclear protein-protein interface has long frustrated direct drug discovery. A pivotal breakthrough was the identification of Tribbles pseudokinase 3 (TRIB3) as a high-affinity scaffold that binds the helix-loop-helix/leucine zipper region of MYC, blocks the E3-ubiquitin-ligase, UBE3B, from tagging critical lysines, and thereby prolongs MYC protein half-life while enhancing MYC-MAX transcriptional output. This review integrates structural, biochemical, and in vivo data to show how genetic deletion or pharmacological eviction of TRIB3 collapses MYC levels, silences its gene program, and suppresses tumor growth in B-cell lymphomas and selected solid tumors.

Impact of Climate Change on the Composition and Bioactivity of Essential Oils: In Vitro, , and ADME Analysis.

Medicinal plants, rich in secondary metabolites, play a crucial role in drug development. Climate change, driven by industrialization, affects plant growth and the production of these metabolites. The research explores how climate change influences the phytochemical profile as well as the antioxidant and antidiabetic activities of The three samples were subjected to contrasting climatic conditions, ranging from a normal climate to progressively intensified combined heat and drought stress over 4 years (Sample 1 under normal seasonal temperature and rainfall; Sample 2 with a 5 C temperature increase and 50% reduced irrigation; and Sample 3 exposed to a 10 C temperature rise and 75% water deficit).

Investigating the Influence of Drying Methods on the Quality and Bioactive Properties of Hemp ( L.) Seed Oil.

This research investigates how oven and microwave drying methods influence mass reduction, oil yield, chemical composition, and bioactivity of seed oil, from two L. varieties-Beldia and Critical-grown in Ketama and Taounate, Morocco. Microwave drying resulted in greater mass loss (2.

Correction: Structure, magnetism and heating ability of pyrrole-functionalized magnetic biochar (PFMB) for magnetic hyperthermia.

[This corrects the article DOI: 10.1039/D5RA04120A.].

Privacy-preserving dementia classification from EEG via hybrid-fusion EEGNetv4 and federated learning.

As global life expectancy rises, a growing proportion of the population is affected by dementia, particularly Alzheimer's disease (AD) and Frontotemporal dementia (FTD). Electroencephalography (EEG) based diagnosis presents a non-invasive, cost effective alternative for early detection, yet existing methods are challenged by data scarcity, inter-subject variability, and privacy concerns. This study proposes lightweight and privacy-preserving EEG classification framework combining deep learning and Federated Learning (FL).

Efficacy and safety of superior laryngeal nerve block in neurogenic cough: A systematic review and meta-analysis.

Background: Neurogenic cough is a chronic condition characterized by persistent coughing that is unresponsive to conventional treatments. It is thought to result from sensory neuropathy of the laryngeal nerves, leading to heightened cough reflex sensitivity. Current management strategies include neuromodulating medications and speech therapy, but these are often ineffective or associated with significant side effects.

Use of proper orthogonal decomposition and machine learning for efficient blood flow prediction in cerebral saccular aneurysms.

Accurate assessment of intracranial aneurysm rupture risk, particularly in Middle Cerebral Artery (MCA) aneurysms, relies on a detailed understanding of patient-specific hemodynamic behavior. In this study, we present an integrated framework that combines Computational Fluid Dynamics (CFD) with Proper Orthogonal Decomposition (POD) and machine learning (ML) to efficiently model pulsatile blood flow using a Casson non-Newtonian fluid model, without incorporating fluid-structure interaction (FSI). Patient-specific vascular geometries were reconstructed from DICOM imaging data and simulated using ANSYS Fluent to capture key hemodynamic factors, including velocity components, pressure, wall shear stress (WSS), and oscillatory shear index (OSI).

Unveiling the photothermal mechanism and therapeutic potential of quercetin-loaded MXene-ZMOF@Chitosan in MCF-7 breast cancer.

Breast cancer remains a significant global health challenge, necessitating innovative therapeutic strategies. This study introduces a novel Q-MX-ZMOF@CH nanocomposite, integrating MXene with zinc-based metal-organic frameworks (ZMOF) and chitosan (CH) to targeted quercetin (Q) delivery and enhanced photothermal therapy (PTT) for breast cancer therapy. TEM imaging of Q-MX-ZMOF@CH indicated spherical morphologies with size distribution (∼60 nm).

A correlational study of anxiety and motivation on learning Chinese as a foreign language.

Compared to existing research on foreign language anxiety (FLA) and motivation, which focus on learning English as a foreign language (EFL), research on anxiety and motivation in learning Chinese as second or foreign language remains limited. Therefore, this study aims to examine the impact of anxiety and motivation on learning Chinese as a foreign language (CFL), as well as investigate the relationship between anxiety and motivation among CFL learners, with the primary factors that could contribute to increasing anxiety and motivation levels. Employing a correlational design, 66 first-year intermediate school CFL learners participated in this study.

Correction: Multi-pronged molecular insights into flavonoid-mediated inhibition of squalene epoxidase: a pathway to novel therapeutics.

[This corrects the article DOI: 10.1039/D4RA09076D.].

Lysozyme-dequalinium encapsulation in a Zn-Fe LDH-chia seed matrix for enhanced antimicrobial dental therapeutics.

This study developed a lysozyme-dequalinium chloride-loaded Zn-Fe layered double hydroxide (LDH)-chia seed mucilage matrix for enhanced antimicrobial efficacy and sustained drug delivery. The optimized formulation (15% w/v Zn-Fe LDH-chia seed hybrid) achieved encapsulation efficiencies of 93.30 ± 1.

The electronic structure, optical, and thermoelectric properties of novel BiPbCh (Ch = Se, Te) materials: insights from first-principles study.

Ternary chalcogenides have attracted much interest because of their potential for use in sustainable energy applications due to their tunable electronic, optical, and transport characteristics. This work examined the structural, electronic, optoelectronic, and thermoelectric properties of novel BiPbSe and BiPbTe chalcogenides through density functional theory. The predicted energy gap values measured with the TB-mBJ and PBE-GGA are 1.